D:Thrombotic Thrombocytopenic Purpura

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Disease Term
Synonyms Disease Moschkowitz, Moschcowitz Disease, Moschcowitz S Syndrome, Moschcowitz Syndrome, Moschkowitz Disease, Moschkowitz S Syndrome, Moschkowitz Syndrome, Purpura Thrombotic Thrombocytopenic, Purpura Thrombotic Thrombopenic, T T P Syndrome, Thrombocytopenic Purpura Thrombotic
Documents 120
Hot Single Events 29
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Thrombotic Thrombocytopenic Purpura. They are ordered first by their relevance to Thrombotic Thrombocytopenic Purpura and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT184468 Negative_regulation of CRX Negative_regulation of Vwf 1 0.02 0.1 0 99.08
2 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 82.40
3 INT184464 Gtf3a Positive_regulation of Adamts1 1 0.01 0.87 0.17 47.80
4 INT184467 Gtf3a Positive_regulation of Transcription of Adamts1 1 0.01 0.87 0.17 47.80
5 INT184458 Il17a Positive_regulation of Transcription of Adamts1 1 0.05 0.87 0.18 42.16
6 INT188903 MUC5AC Positive_regulation of LDHA 1 0.00 1.2 0.04 33.04
7 INT184460 Il1 Positive_regulation of Adamts1 1 0.04 0.99 0.4 13.32
8 INT184459 Il1 Regulation of Gene_expression of Adamts1 1 0.03 0.73 0.34 5.00
9 INT184466 Adamts1 Positive_regulation of Adamts4 1 0.13 1.03 0.3 5.00
10 INT184457 Adamts1 Positive_regulation of Positive_regulation of Adamts4 1 0.13 1.03 0.3 5.00
11 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
12 INT344266 Binding of APOH and CD40LG 1 0.04 0.31 0 5.00
13 INT184461 Binding of Adamts1 and Furin 1 0.09 0 0 5.00
14 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Thrombotic Thrombocytopenic Purpura. They are ordered first by their pain relevance and then by number of times they were reported in Thrombotic Thrombocytopenic Purpura. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 100.00
2 INT117455 Negative_regulation of Adamts13 7 0.53 9.69 0.95 99.96
3 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 99.96
4 INT129454 Negative_regulation of Adamts13 6 0.30 7.78 0.31 99.26
5 INT167637 Negative_regulation of Protein_catabolism of Vwf 1 0.08 3.35 0.19 99.26
6 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 99.26
7 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 99.10
8 INT82846 Negative_regulation of CRX 9 0.37 5.93 3.64 99.08
9 INT10146 Negative_regulation of Vwf 27 0.40 17.11 3.69 99.04
10 INT10893 Binding of VWF 27 0.47 25.02 2.82 98.52
11 INT167638 Regulation of Protein_catabolism of Vwf 1 0.05 1.61 0.1 98.38
12 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1 98.24
13 INT21299 Negative_regulation of Hp 14 0.44 10.97 2.97 98.14
14 INT167636 Protein_catabolism of Vwf 5 0.52 5.09 0.41 98.06
15 INT110259 Negative_regulation of Vwf 6 0.42 3.3 1.1 98.02
16 INT43931 Binding of CFH 49 0.48 31.85 3.96 96.76
17 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 96.60
18 INT10888 Binding of Vwf 32 0.46 22.87 5.21 95.60
19 INT2920 Regulation of F8 7 0.45 2.9 0.79 94.72
20 INT116459 Negative_regulation of VWF 8 0.58 5.66 0.89 94.24
21 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 93.68
22 INT10516 Localization of Vwf 30 0.79 7.54 2.77 90.36
23 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 89.40
24 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 89.24
25 INT654 Localization of REN 250 0.81 75.12 47.86 88.88
26 INT338740 Transcription of Src 1 0.43 1.24 0.07 86.52
27 INT108917 Positive_regulation of CRX 23 0.50 21.32 10.5 81.08
28 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 80.88
29 INT184433 Positive_regulation of Adamts4 1 0.27 2.48 0.75 80.76
30 INT100222 Binding of Src 9 0.26 5.41 5.37 79.52
31 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 79.12
32 INT184439 Protein_catabolism of Adamts1 1 0.51 1.08 0.23 77.76
33 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 72.92
34 INT100051 Binding of MUC5AC 20 0.32 14.21 1.14 72.88
35 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 71.48
36 INT184449 Regulation of Adamts1 6 0.44 5.05 0.68 71.20
37 INT17081 Binding of Ttpa 7 0.27 2.12 0.34 69.52
38 INT184436 Regulation of Gene_expression of Adamts1 6 0.60 9.53 0.62 64.20
39 INT107376 Negative_regulation of P2ry12 12 0.43 4.39 1.5 63.84
40 INT133889 Gene_expression of Adamts1 78 0.76 48.05 6.58 63.64
41 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52 60.80
42 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 60.76
43 INT756 Gene_expression of C3 138 0.75 100.6 19.2 60.28
44 INT18412 Binding of PLEK 49 0.47 17.82 10.72 59.64
45 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 56.48
46 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 55.44
47 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 54.00
48 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11 53.60
49 INT184451 Gene_expression of Adamts2 6 0.51 2.51 1.42 53.60
50 INT661 Gene_expression of REN 100 0.78 48.21 11.36 53.20
51 INT35584 Binding of ACLY 22 0.35 31.78 7.17 52.36
52 INT9254 Negative_regulation of LDHA 23 0.43 13.3 2.2 50.00
53 INT184432 Negative_regulation of Protein_catabolism of Adamts1 1 0.29 0 0 49.28
54 INT184443 Negative_regulation of Positive_regulation of Adamts1 2 0.37 2.12 0 49.28
55 INT29402 Gene_expression of Src 16 0.74 4.57 2.29 47.92
56 INT184440 Positive_regulation of Adamts1 18 0.68 13.28 1.87 47.80
57 INT184431 Transcription of Adamts1 9 0.67 4.94 1.35 47.80
58 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 40.64
59 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 35.60
60 INT154986 Binding of CRX 3 0.24 3.87 0.53 35.28
61 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 33.52
62 INT24042 Gene_expression of MUC5AC 98 0.77 74.99 6.18 33.52
63 INT29094 Binding of C3 39 0.37 12.65 2.27 32.88
64 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01 29.92
65 INT259036 Transcription of SH2B2 2 0.55 7.01 1.46 24.48
66 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 21.68
67 INT259032 Binding of PEX1 2 0.01 4.67 0.15 21.24
68 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 19.12
69 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 18.80
70 INT3179 Positive_regulation of SCT 15 0.50 4.79 1.98 18.08
71 INT168152 Binding of ACAN 3 0.36 0.88 0.73 17.72
72 INT173878 Gene_expression of ACAN 32 0.75 9.35 3.55 17.12
73 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 15.60
74 INT184456 Positive_regulation of Osm 3 0.24 1.41 0.54 15.60
75 INT184442 Protein_catabolism of Ighd 1 0.14 0.16 0.03 15.60
76 INT117998 Positive_regulation of Gene_expression of Src 4 0.36 1.45 0.51 13.04
77 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 11.68
78 INT283060 Positive_regulation of Atp5s 1 0.20 1.81 0 10.96
79 INT184437 Regulation of Osm 2 0.19 0.61 0.27 10.16
80 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 9.36
81 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 9.24
82 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 8.56
83 INT338741 Negative_regulation of Binding of Src 1 0.30 0.75 0 7.48
84 INT2409 Binding of SCT 7 0.48 2.69 1.94 6.24
85 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
86 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
87 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
88 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
89 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
90 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
91 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
92 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
93 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
94 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
95 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
96 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
97 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
98 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
99 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
100 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
101 INT25607 Binding of Il1 82 0.47 64.4 23.9 5.00
102 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 5.00
103 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
104 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
105 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
106 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
107 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 5.00
108 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
109 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
110 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
111 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 5.00
112 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
113 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
114 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 5.00
115 INT22276 Gene_expression of TBXA2R 65 0.77 23.22 14.21 5.00
116 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
117 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
118 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
119 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
120 INT4047 Binding of F13A1 105 0.43 66.54 11.81 5.00
121 INT39712 Binding of pad 82 0.48 110.92 10.33 5.00
122 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
123 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61 5.00
124 INT3366 Localization of PLEK 44 0.78 15.83 9.55 5.00
125 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 5.00
126 INT7105 Gene_expression of pad 54 0.77 63.68 8.8 5.00
127 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 5.00
128 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 5.00
129 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 5.00
130 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 5.00
131 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
132 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 5.00
133 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
134 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
135 INT63822 Gene_expression of Mmp23 23 0.43 14.15 5.96 5.00
136 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 5.00
137 INT28703 Negative_regulation of TFPI 29 0.38 19.81 4.93 5.00
138 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 5.00
139 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 5.00
140 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 5.00
141 INT9842 Binding of F2 36 0.47 22.79 4.42 5.00
142 INT35609 Negative_regulation of F10 37 0.57 17.15 4.41 5.00
143 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 5.00
144 INT144396 Positive_regulation of P2rx1 11 0.49 3.25 4.23 5.00
145 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 5.00
146 INT156131 Binding of Hand2 14 0.25 10.35 3.99 5.00
147 INT28802 Binding of F2 15 0.47 8.8 3.47 5.00
148 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
149 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 5.00
150 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
151 INT38030 Positive_regulation of P2RY1 15 0.67 5.54 3.17 5.00
152 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
153 INT130603 Binding of Timp1 9 0.35 8.52 3.04 5.00
154 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 5.00
155 INT22277 Positive_regulation of Gene_expression of TBXA2R 13 0.69 5.95 2.92 5.00
156 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 5.00
157 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
158 INT45612 Negative_regulation of pad 8 0.37 6.74 2.57 5.00
159 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47 5.00
160 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 5.00
161 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12 5.00
162 INT17268 Localization of PLG 9 0.78 11.71 2.06 5.00
163 INT138490 Positive_regulation of Il13 9 0.36 5.42 2.06 5.00
164 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98 5.00
165 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
166 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93 5.00
167 INT169352 Negative_regulation of Timp3 10 0.58 6.94 1.92 5.00
168 INT14182 Gene_expression of CPB1 26 0.67 10.06 1.9 5.00
169 INT52965 Negative_regulation of TNXA 18 0.43 8.38 1.9 5.00
170 INT172961 Localization of Egf 26 0.71 16.74 1.81 5.00
171 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72 5.00
172 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
173 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65 5.00
174 INT12035 Regulation of F2 21 0.45 12.66 1.47 5.00
175 INT181868 Localization of ACLY 5 0.62 6.36 1.4 5.00
176 INT236277 Positive_regulation of Gene_expression of CADPS 5 0.42 9.17 1.29 5.00
177 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21 5.00
178 INT162141 Localization of CRX 3 0.11 4.24 1.16 5.00
179 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
180 INT209503 Positive_regulation of CADPS 3 0.42 7 1.11 5.00
181 INT140052 Binding of Cish 12 0.39 1.63 1.1 5.00
182 INT133888 Negative_regulation of Adamts1 6 0.50 18.52 1.04 5.00
183 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 5.00
184 INT184435 Negative_regulation of Binding of Il1 4 0.41 2.64 1 5.00
185 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
186 INT184427 Negative_regulation of Gene_expression of Adamts1 3 0.57 9.47 0.88 5.00
187 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 5.00
188 INT76751 Negative_regulation of Protein_catabolism of F13A1 7 0.13 5.16 0.79 5.00
189 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 5.00
190 INT83194 Binding of APOH 4 0.17 3.92 0.66 5.00
191 INT18008 Negative_regulation of IL3 4 0.40 1.5 0.62 5.00
192 INT184445 Binding of Adamts1 7 0.38 1.24 0.61 5.00
193 INT52740 Binding of ACLS 5 0.31 3 0.54 5.00
194 INT184454 Positive_regulation of Gene_expression of Adamts2 2 0.40 0.84 0.53 5.00
195 INT184447 Negative_regulation of Adamts2 1 0.44 0.54 0.47 5.00
196 INT114247 Gene_expression of Nprl3 2 0.05 1.1 0.46 5.00
197 INT259035 Localization of SH2B2 3 0.43 1.77 0.42 5.00
198 INT184444 Binding of Timp3 3 0.47 0.25 0.41 5.00
199 INT184434 Localization of Adamts1 5 0.63 1.95 0.41 5.00
200 INT200523 Regulation of F7 2 0.01 1.82 0.38 5.00
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