D:Thyroid Neoplasm

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Disease Term
Synonyms ADENOMA THYROID, Anaplastic Carcinoma, Anaplastic Carcinomas, Cancer Of The Thyroid, CANCER OF THYROID, Cancer Thyroid, Carcinoma Thyroid, Follicular Carcinoma, FOLLICULAR CARCINOMAS, Medullary Carcinoma, Medullary Carcinomas
Documents 685
Hot Single Events 200
Hot Interactions 40

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Thyroid Neoplasm. They are ordered first by their relevance to Thyroid Neoplasm and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT258527 Binding of BRAF and RET 1 0.21 1.49 0.11 100.00
2 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0 100.00
3 INT258522 Binding of DDR1 and RET 1 0.03 1.05 0.1 100.00
4 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0 100.00
5 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0 100.00
6 INT286228 Binding of Tpo and Ceat1 1 0.00 1.28 0.04 100.00
7 INT252213 INCENP Regulation of Lgals3 1 0.00 1.91 0.23 99.82
8 INT252903 PTTG1IP Regulation of Gene_expression of SLC5A5 1 0.00 0.43 0 99.32
9 INT252899 PTTG1 Regulation of Gene_expression of SLC5A5 1 0.01 0.43 0 99.32
10 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24 99.12
11 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23 99.12
12 INT279145 Binding of VHL and RNF139 1 0.30 1.87 0 99.04
13 INT252895 PTTG1 Regulation of Gene_expression of VEGFA 1 0.03 0.15 0 98.96
14 INT199159 Binding of RET and Pheo 1 0.04 1.42 0.03 98.64
15 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0 98.60
16 INT258525 IPMK Negative_regulation of DDR1 2 0.00 1.97 0 98.60
17 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0 98.60
18 INT354115 MIR222 Regulation of Gene_expression of CDKN1B 1 0.07 0.98 0 98.54
19 INT252910 PTTG1 Negative_regulation of Transcription of SLC5A5 1 0.02 0.36 0 97.60
20 INT252905 PTTG1IP Negative_regulation of Transcription of SLC5A5 1 0.01 0.35 0 97.20
21 INT256549 Binding of Pten and Mtor 1 0.00 1.02 0.03 97.00
22 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11 96.96
23 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11 96.96
24 INT262756 STAT3 Positive_regulation of NFE2L2 1 0.31 1.55 0 96.24
25 INT263901 Binding of Ighg1 and Slc3a2 1 0.00 0.89 0.16 93.68
26 INT297376 Binding of RARS and Rxra 1 0.01 3.27 0.24 92.12
27 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0 91.68
28 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0 91.68
29 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0 91.68
30 INT326090 Binding of Erbb2 and Mmp2 1 0.09 1.39 0.31 90.88
31 INT116124 Binding of AFP and HCC 2 0.20 1.72 0.15 87.44
32 INT217136 Negative_regulation of MIR221 Negative_regulation of Gene_expression of KIT 1 0.18 0.74 0 86.16
33 INT217138 Negative_regulation of MIR222 Negative_regulation of Gene_expression of KIT 1 0.16 0.74 0 86.16
34 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0 84.44
35 INT241120 Binding of Sdhc and Sdhd 1 0.00 1.28 0 83.48
36 INT211883 Binding of RET and CDCP1 1 0.00 2.12 0 82.48
37 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0 81.28
38 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0 81.28
39 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0 81.28
40 INT211882 Binding of KIT and CDCP1 1 0.00 2.1 0 81.20
41 INT252906 Binding of SLC5A5 and PTTG1 1 0.01 0.69 0 78.72
42 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0 78.60
43 INT253023 Binding of PTTG1 and Myc 1 0.16 0.22 0.04 74.96
44 INT253003 Pttg1 Regulation of Gene_expression of Id3 1 0.08 0.07 0 74.96
45 INT252890 PTTG1IP Negative_regulation of SLC5A5 1 0.01 0.34 0 71.64
46 INT253008 PTTG1 Regulation of Gene_expression of Id3 1 0.03 0.2 0 71.12
47 INT239081 Binding of GH1 and MAS1 1 0.03 1.41 0.15 67.40
48 INT354126 Binding of IGFALS and MIR125A 1 0.23 0.7 0.07 62.32
49 INT354111 Binding of IGFBP3 and MIR125A 1 0.11 0.7 0.07 62.32
50 INT252886 PTTG1IP Positive_regulation of Binding of SLC5A5 and USF1 1 0.00 0.22 0 62.00
51 INT252887 PTTG1IP Positive_regulation of Binding of SLC5A5 and PAX8 1 0.01 0.22 0 62.00
52 INT354125 Binding of IGFBP3 and MIR15B 1 0.00 0.7 0.07 61.80
53 INT354109 Binding of IGFALS and MIR15B 1 0.00 0.7 0.07 61.80
54 INT252898 Binding of SLC5A5 and USF1 1 0.01 0.22 0 61.32
55 INT354113 Binding of IGFBP3 and MIR524 1 0.01 0.69 0.07 61.28
56 INT354116 Binding of IGFALS and MIR524 1 0.02 0.69 0.07 61.28
57 INT339979 Binding of PRDX2 and HDAC9 1 0.02 0.16 0.05 61.24
58 INT252888 Binding of SLC5A5 and PAX8 1 0.02 0.22 0 61.12
59 INT279144 RNF139 Regulation of TSN 1 0.24 3.47 0 60.72
60 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1 59.76
61 INT205057 MMP3 Negative_regulation of MMP2 1 0.35 3.02 0.2 59.12
62 INT205051 MMP3 Negative_regulation of TIMP1 1 0.36 3.02 0.2 59.12
63 INT217145 Gene_expression of MIR26B Negative_regulation of Gene_expression of MCL1 1 0.10 1 0 53.84
64 INT279143 Binding of TSN and RNF139 1 0.31 0.83 0 53.48
65 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0 50.32
66 INT217143 MIR29A Regulation of Gene_expression of MCL1 1 0.24 1 0 50.08
67 INT354120 Binding of IGF2 and IGFBP5 1 0.01 0.45 0.09 48.76
68 INT354124 Binding of IGF2 and IGFBP3 1 0.01 0.45 0.09 48.76
69 INT253018 Binding of PTTG1 and Zic2 1 0.01 0.76 0 47.96
70 INT253014 Binding of XRCC5 and Zic2 1 0.00 0.14 0 45.88
71 INT253013 Binding of PRKDC and Zic2 1 0.00 0.14 0 45.88
72 INT252904 Binding of PRKDC and XRCC5 1 0.00 0.14 0 44.72
73 INT200213 PAH Positive_regulation of SDHD 1 0.21 2.43 0.1 41.84
74 INT217139 Binding of MIR103A2 and MIR107 1 0.06 0.83 0 41.60
75 INT253016 Binding of PTTG1 and Id3 1 0.04 0.07 0 40.16
76 INT301401 Binding of Enpp1 and Enpp2 1 0.23 0.54 0 37.92
77 INT262758 MRGPRF Positive_regulation of Transcription of NFE2L3 1 0.01 1.25 0.09 35.28
78 INT262755 MRGPRF Positive_regulation of NFE2L2 1 0.18 1.24 0.09 33.36
79 INT262754 MRGPRF Positive_regulation of NFE2L3 1 0.01 1.24 0.09 32.80
80 INT334320 EGFR Positive_regulation of RASGRP1 1 0.05 0.76 0 29.92
81 INT334321 EGFR Positive_regulation of MAPK1 1 0.25 0.76 0 29.92
82 INT253005 Binding of Zic2 and Pttg1 1 0.02 0.57 0 28.36
83 INT315054 TP53 Positive_regulation of MIR34A 1 0.02 0.47 0 28.24
84 INT231392 Enpp2 Positive_regulation of Gene_expression of Lpar1 2 0.38 2.19 0.93 26.16
85 INT253021 PTTG1 Regulation of Gene_expression of Fgf2 1 0.04 0.35 0 24.92
86 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 16.92
87 INT354195 Binding of GH1 and Sstr5 1 0.00 0.1 0.17 16.92
88 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 15.28
89 INT354469 Binding of SDHC and Sdhb 1 0.08 1.82 0 15.12
90 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16 13.08
91 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13 13.08
92 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03 13.08
93 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03 12.44
94 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03 12.44
95 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03 12.12
96 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03 12.12
97 INT305001 Binding of ACAN and TNFAIP6 1 0.28 1.22 0.14 11.12
98 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
99 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
100 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
101 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
102 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
103 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
104 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57 5.00
105 INT236110 Binding of Ppara and Olfm4 1 0.00 1.22 0.4 5.00
106 INT236111 Binding of Pdpk1 and Ppara 1 0.26 1.21 0.39 5.00
107 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38 5.00
108 INT235432 Ppara Negative_regulation of Gene_expression of Cpox 1 0.01 1 0.37 5.00
109 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37 5.00
110 INT297352 KLF2 Regulation of PPARA 1 0.12 1.31 0.35 5.00
111 INT297351 EWSR1 Positive_regulation of PPARA 1 0.41 1.81 0.33 5.00
112 INT326089 Gopc Positive_regulation of Mmp9 1 0.03 0.63 0.33 5.00
113 INT235430 Il13 Positive_regulation of Gene_expression of Olr1 1 0.00 2.12 0.33 5.00
114 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
115 INT185531 Binding of GRPR and NMBR 1 0.03 0 0.28 5.00
116 INT237928 BCL2 Positive_regulation of FAS 1 0.02 1.41 0.26 5.00
117 INT237919 BAX Positive_regulation of Protein_catabolism of PARP1 1 0.03 1.41 0.26 5.00
118 INT237925 BCL2 Positive_regulation of Protein_catabolism of PARP1 1 0.02 1.42 0.26 5.00
119 INT237927 BCL2 Positive_regulation of BAX 2 0.24 2.22 0.26 5.00
120 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
121 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24 5.00
122 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24 5.00
123 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23 5.00
124 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21 5.00
125 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
126 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2 5.00
127 INT237924 PTPN1 Regulation of Gene_expression of CFLAR 1 0.01 0.7 0.19 5.00
128 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19 5.00
129 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19 5.00
130 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
131 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 5.00
132 INT326097 WAS Regulation of Gopc 1 0.01 0.55 0.16 5.00
133 INT287890 THEMIS Regulation of Gene_expression of EPHB2 1 0.00 0.87 0.14 5.00
134 INT287883 FOS Regulation of Gene_expression of EPHB2 1 0.01 0.87 0.14 5.00
135 INT252902 PTTG1 Regulation of MMP2 1 0.01 1.5 0.14 5.00
136 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13 5.00
137 INT253015 Egf Regulation of PTTG1 1 0.02 0.44 0.13 5.00
138 INT252901 PTTG1 Regulation of Gene_expression of TSC1 1 0.00 1.61 0.13 5.00
139 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
140 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13 5.00
141 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12 5.00
142 INT287881 THEMIS Positive_regulation of PRKCA 1 0.00 0.07 0.12 5.00
143 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11 5.00
144 INT354194 Mtpn Negative_regulation of MIR524 1 0.00 0.08 0.11 5.00
145 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
146 INT287893 VEGFA Positive_regulation of Localization of WISP1 1 0.03 1.23 0.1 5.00
147 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1 5.00
148 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
149 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1 5.00
150 INT239643 Binding of BCL2 and BCL2L11 3 0.16 2.26 0.09 5.00
151 INT287886 Negative_regulation of THEMIS Negative_regulation of PRKCA 1 0.00 1.19 0.08 5.00
152 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08 5.00
153 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08 5.00
154 INT277807 CD40LG Regulation of CD40 1 0.21 0.17 0.08 5.00
155 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08 5.00
156 INT301411 Enpp2 Positive_regulation of Csf2 1 0.04 0.59 0.07 5.00
157 INT301402 Enpp2 Positive_regulation of Lpar1 2 0.33 0.55 0.07 5.00
158 INT231440 PDGFA Positive_regulation of Gene_expression of HGF 1 0.16 0.83 0.07 5.00
159 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
160 INT231434 FN1 Positive_regulation of Gene_expression of PDGFA 1 0.04 0.83 0.07 5.00
161 INT301403 Enpp2 Positive_regulation of Tnfrsf11a 1 0.05 0.59 0.07 5.00
162 INT236932 Binding of Rxra and Pprc1 1 0.00 0.45 0.07 5.00
163 INT231436 FN1 Positive_regulation of Gene_expression of VEGFA 1 0.06 0.83 0.07 5.00
164 INT84622 Binding of RERE and KAL1 1 0.00 1.18 0.07 5.00
165 INT234381 Binding of CD40 and PPARA 1 0.19 1.39 0.07 5.00
166 INT236936 Ppara Positive_regulation of Mapk1 1 0.09 0.64 0.07 5.00
167 INT231442 FN1 Positive_regulation of Gene_expression of HGF 1 0.05 0.83 0.07 5.00
168 INT231441 PDGFA Positive_regulation of Gene_expression of VEGFA 1 0.17 0.83 0.07 5.00
169 INT236938 Binding of Akt1 and SPNS1 1 0.00 0.72 0.06 5.00
170 INT225262 Egf Regulation of Gene_expression of S100a7a 1 0.04 3.31 0.06 5.00
171 INT256548 Regulation of Cd320 Positive_regulation of Ppara 1 0.28 0.43 0.05 5.00
172 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05 5.00
173 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
174 INT287877 WNT1 Positive_regulation of Localization of WISP1 1 0.03 0.56 0.05 5.00
175 INT287889 WNT1 Positive_regulation of KRT20 1 0.00 0.56 0.05 5.00
176 INT262781 Birc5 Regulation of TEP1 1 0.00 0.49 0.05 5.00
177 INT256551 Cd320 Regulation of Cd320 Positive_regulation of Ppara 1 0.31 0.43 0.05 5.00
178 INT262780 Birc5 Regulation of CD163L1 1 0.00 0.49 0.05 5.00
179 INT225261 S100a7a Positive_regulation of Egf 1 0.07 1.13 0.05 5.00
180 INT308432 Binding of PDE4A and Aip 1 0.05 3.1 0.05 5.00
181 INT256547 Cd320 Positive_regulation of Ppara 1 0.47 0.43 0.05 5.00
182 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05 5.00
183 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04 5.00
184 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
185 INT234379 BAX Positive_regulation of CASP3 1 0.04 1.16 0.04 5.00
186 INT331172 Binding of IFNA1 and IL2 1 0.00 0.46 0.04 5.00
187 INT234382 Binding of TNF and TNFSF10 1 0.11 1.2 0.04 5.00
188 INT219875 Binding of KRT7 and Krt20 1 0.01 1.32 0.04 5.00
189 INT234380 Negative_regulation of Binding of CD40 and CD40LG 1 0.16 1.4 0.04 5.00
190 INT225259 Egfr Regulation of Gene_expression of S100a7a 1 0.04 0.98 0.04 5.00
191 INT252897 Binding of PTTG1IP and PTTG1 1 0.04 0.15 0.04 5.00
192 INT252892 PTTG1IP Regulation of PTTG1 1 0.05 0.49 0.04 5.00
193 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00
194 INT185529 Binding of P2RY14 and GPR87 1 0.03 0.07 0.04 5.00
195 INT235434 SSB Positive_regulation of Ppara 1 0.00 1.56 0.04 5.00
196 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04 5.00
197 INT234383 Positive_regulation of Binding of TNF and TNFSF10 1 0.15 1.2 0.04 5.00
198 INT219857 Binding of Krt20 and Nbr1 1 0.00 1.31 0.04 5.00
199 INT253017 PTTG1IP Regulation of Regulation of Fgf2 1 0.03 0.49 0.04 5.00
200 INT288135 Stip1 Regulation of Ifi35 1 0.00 0.85 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Thyroid Neoplasm. They are ordered first by their pain relevance and then by number of times they were reported in Thyroid Neoplasm. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 100.00
2 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 100.00
3 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 100.00
4 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 100.00
5 INT298656 Positive_regulation of Gene_expression of MIR221 2 0.21 12.91 0.42 100.00
6 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 100.00
7 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 100.00
8 INT217182 Gene_expression of MIR221 4 0.58 9.33 0.27 100.00
9 INT83461 Binding of RET 8 0.47 9.7 0.87 100.00
10 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 100.00
11 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 100.00
12 INT79140 Binding of HCC 36 0.31 46.96 1.87 100.00
13 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5 100.00
14 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21 100.00
15 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 100.00
16 INT211679 Positive_regulation of HEPACAM 6 0.02 8.25 0.11 100.00
17 INT252975 Positive_regulation of Gene_expression of PTTG1 36 0.28 31.96 0.74 100.00
18 INT156165 Regulation of Gene_expression of NTRK1 2 0.37 1.91 0.27 100.00
19 INT48212 Binding of ATM 5 0.47 3.89 0.57 100.00
20 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3 100.00
21 INT175995 Gene_expression of HEPACAM 12 0.28 12.45 0.58 100.00
22 INT252971 Positive_regulation of Gene_expression of PTTG1IP 1 0.11 1.37 0.09 100.00
23 INT78097 Negative_regulation of Regulation of CALCA 2 0.42 2.02 1.37 100.00
24 INT156307 Gene_expression of Xpr1 2 0.23 1.28 0.22 100.00
25 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66 100.00
26 INT84923 Transcription of NTRK1 2 0.67 1.65 0.33 100.00
27 INT175997 Localization of HEPACAM 6 0.31 5.91 0.39 100.00
28 INT114842 Localization of RET 3 0.71 5.98 0.71 100.00
29 INT21882 Negative_regulation of Localization of Dbi 3 0.45 0.28 0.55 100.00
30 INT23766 Binding of SERPINA7 3 0.36 1.66 0.2 100.00
31 INT178962 Gene_expression of Oca2 15 0.19 5.15 0.38 100.00
32 INT252954 Positive_regulation of Gene_expression of Oca2 2 0.03 2.21 0 100.00
33 INT23767 Positive_regulation of SERPINA7 6 0.67 1.96 1.2 99.96
34 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 99.92
35 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 99.92
36 INT215858 Transcription of Lgals3 2 0.71 1.77 0.21 99.92
37 INT252210 Negative_regulation of Transcription of Lgals3 1 0.42 0.87 0.09 99.92
38 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 99.90
39 INT2541 Binding of Calca 200 0.48 67.14 134.62 99.90
40 INT125627 Gene_expression of TTF1 11 0.78 12.68 0.78 99.90
41 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 99.90
42 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 99.90
43 INT186520 Gene_expression of CHKA 8 0.56 8.22 1 99.90
44 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.88
45 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 99.88
46 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 99.88
47 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 99.88
48 INT263904 Negative_regulation of Gene_expression of SLN 1 0.14 7.18 0.47 99.88
49 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 99.86
50 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32 99.84
51 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7 99.84
52 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 99.84
53 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 99.84
54 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59 99.84
55 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 99.84
56 INT252998 Gene_expression of PTTG1IP 1 0.17 2.06 0.17 99.84
57 INT236623 Positive_regulation of BRAF 3 0.45 2.05 0.32 99.84
58 INT338104 Transcription of RET 1 0.54 0.59 0 99.84
59 INT1571 Negative_regulation of Tshr 2 0.27 2.42 0.07 99.84
60 INT286209 Positive_regulation of Psmb9 1 0.67 5.66 0.54 99.84
61 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45 99.84
62 INT199146 Gene_expression of Pheo 3 0.18 3.57 1.63 99.80
63 INT224326 Binding of RAF1 3 0.13 3.11 0.05 99.80
64 INT242821 Negative_regulation of Localization of Fap 1 0.11 1.91 0 99.80
65 INT242820 Localization of Fap 1 0.20 1.9 0 99.80
66 INT15654 Gene_expression of Tg 22 0.66 12.2 2.36 99.78
67 INT97857 Gene_expression of Slc5a5 5 0.54 4.89 0.39 99.78
68 INT105546 Gene_expression of Tpo 2 0.76 9.29 0.28 99.76
69 INT39463 Positive_regulation of Tg 15 0.69 11.49 2.46 99.76
70 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 99.76
71 INT626 Localization of CALCA 289 0.81 125.39 221.15 99.70
72 INT443 Localization of POMC 1020 0.81 284.52 443.17 99.68
73 INT252737 Gene_expression of RAF1 12 0.58 10.97 0.42 99.68
74 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 99.68
75 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13 99.68
76 INT49676 Positive_regulation of TG 10 0.48 9.09 0.44 99.64
77 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33 99.64
78 INT258549 Regulation of Positive_regulation of Meta 3 0.44 2.31 0.4 99.64
79 INT259745 Phosphorylation of GSK3A 6 0.20 3 0.11 99.64
80 INT150959 Gene_expression of BCO2 4 0.25 2.21 0.08 99.64
81 INT338101 Positive_regulation of Gene_expression of BCO2 1 0.23 1.32 0.08 99.64
82 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 99.64
83 INT315113 Negative_regulation of MIR34A 1 0.14 2.08 0 99.64
84 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 99.60
85 INT11154 Binding of EGFR 149 0.48 96.23 6.29 99.60
86 INT162533 Regulation of Lgals3 9 0.45 6.61 1.73 99.60
87 INT93399 Gene_expression of Ccnd1 38 0.58 21 3.65 99.60
88 INT93396 Positive_regulation of Gene_expression of Ccnd1 13 0.52 8.59 2.26 99.60
89 INT217189 Gene_expression of MIR222 5 0.46 4.58 0.12 99.58
90 INT165054 Gene_expression of MIR146A 45 0.58 82.87 28.82 99.58
91 INT268552 Positive_regulation of Gene_expression of MIR222 4 0.21 4.06 0.12 99.58
92 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 99.58
93 INT300347 Positive_regulation of Gene_expression of MIR146A 23 0.35 25.04 9.62 99.58
94 INT149838 Binding of TSHB 5 0.14 3.27 1.1 99.58
95 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 99.56
96 INT36923 Binding of Mdk 7 0.35 3.81 2.58 99.56
97 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.56
98 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 99.56
99 INT205098 Positive_regulation of Gene_expression of MAFB 1 0.33 1.13 0.03 99.56
100 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 99.54
101 INT89428 Regulation of TG 6 0.36 3.93 0.72 99.52
102 INT11551 Localization of VHL 12 0.65 22.76 0.68 99.52
103 INT39462 Positive_regulation of Gene_expression of Tg 4 0.44 3.31 0.71 99.48
104 INT143953 Regulation of Positive_regulation of MMP2 3 0.44 2.25 0.69 99.48
105 INT124944 Regulation of KIT 15 0.60 11.84 0.24 99.48
106 INT5988 Localization of Dbi 74 0.81 17.52 24.09 99.48
107 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.46
108 INT291322 Negative_regulation of Chga 1 0.42 2.53 0 99.44
109 INT200218 Localization of SDHD 1 0.69 48.58 4.57 99.44
110 INT87707 Positive_regulation of Gene_expression of MASP1 4 0.09 2.43 0.25 99.44
111 INT195869 Positive_regulation of MASP1 3 0.08 1.58 0.03 99.44
112 INT201683 Phosphorylation of GSK 15 0.80 6.6 2.01 99.42
113 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 99.40
114 INT263905 Gene_expression of SLN 33 0.63 23.21 0.74 99.40
115 INT258547 Binding of Ephb2 2 0.35 1.61 0 99.40
116 INT148757 Negative_regulation of Gene_expression of CD97 2 0.48 1.47 0 99.40
117 INT102178 Gene_expression of CD97 10 0.73 6.68 1.7 99.40
118 INT315107 Negative_regulation of MIR100 1 0.09 1 0 99.40
119 INT217179 Negative_regulation of AXL 2 0.01 1.9 0 99.36
120 INT291337 Negative_regulation of Positive_regulation of AXL 1 0.00 0.79 0 99.36
121 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 99.34
122 INT92677 Positive_regulation of Gene_expression of Fgf2 11 0.69 4.25 1.68 99.34
123 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 99.32
124 INT201051 Gene_expression of SLC5A5 6 0.09 2.08 0 99.32
125 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 99.32
126 INT252208 Gene_expression of Slc5a5 2 0.14 0.87 0.04 99.32
127 INT201052 Negative_regulation of Gene_expression of SLC5A5 2 0.07 0.55 0 99.32
128 INT252956 Negative_regulation of Gene_expression of Slc5a5 1 0.06 0.38 0 99.32
129 INT153777 Gene_expression of SRL 2 0.65 1.72 0.06 99.32
130 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 99.30
131 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 99.30
132 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 99.28
133 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 99.28
134 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 99.20
135 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 99.20
136 INT217807 Regulation of MITF 20 0.00 18.57 0.36 99.20
137 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 99.20
138 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54 99.20
139 INT1923 Regulation of CEACAM7 9 0.41 7.36 0.31 99.18
140 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 99.16
141 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 99.16
142 INT205100 Gene_expression of MAFB 1 0.37 1.13 0.03 99.16
143 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 99.14
144 INT300623 Positive_regulation of Men1 1 0.35 10.65 0.57 99.08
145 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22 99.02
146 INT87705 Gene_expression of MASP1 4 0.12 2.42 0.25 99.02
147 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 98.96
148 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64 98.96
149 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 98.88
150 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 98.88
151 INT274661 Positive_regulation of Binding of KRT7 1 0.45 3.5 0.15 98.84
152 INT274662 Positive_regulation of Binding of KRT20 3 0.39 4.32 0.15 98.84
153 INT21294 Gene_expression of OGFR 32 0.78 5.75 6.41 98.84
154 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 98.82
155 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 98.82
156 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 98.80
157 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28 98.76
158 INT35104 Positive_regulation of GC 6 0.11 4.99 1.08 98.74
159 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66 98.70
160 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 98.70
161 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 98.70
162 INT113164 Regulation of Regulation of VEGFA 6 0.36 5.96 2.43 98.68
163 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 98.64
164 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59 98.64
165 INT258556 Negative_regulation of BRAF 4 0.42 2.48 0.03 98.60
166 INT258550 Negative_regulation of Negative_regulation of Ulbp1 1 0.41 1.23 0 98.56
167 INT73476 Transcription of MYC 18 0.69 12.14 2.13 98.52
168 INT67936 Transcription of JUN 18 0.52 9.52 4.13 98.52
169 INT347247 Positive_regulation of RNH1 1 0.12 3.29 0.36 98.48
170 INT228267 Positive_regulation of Gene_expression of TG 5 0.50 2.2 0.17 98.48
171 INT281889 Localization of PERP 2 0.35 1.34 0.47 98.48
172 INT132477 Negative_regulation of TSHB 5 0.45 3.24 0.05 98.46
173 INT127806 Negative_regulation of ASCL1 6 0.45 5.85 0.16 98.44
174 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 98.44
175 INT38672 Binding of KRT20 69 0.39 48.01 6.31 98.40
176 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 98.40
177 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 98.36
178 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7 98.36
179 INT164558 Binding of PERP 3 0.14 1.55 1.67 98.34
180 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 98.32
181 INT68443 Positive_regulation of METTL3 9 0.12 3.54 2.39 98.32
182 INT68564 Binding of Fap 6 0.32 6.75 0.65 98.30
183 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 98.28
184 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 98.28
185 INT219359 Localization of SMARCB1 7 0.66 4.17 0.09 98.26
186 INT141000 Negative_regulation of GSK 24 0.57 9.46 4.4 98.16
187 INT95939 Positive_regulation of GSK 19 0.67 10 1.33 98.16
188 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 98.08
189 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 98.08
190 INT329686 Gene_expression of CBX7 1 0.77 54.06 0.45 98.08
191 INT252745 Positive_regulation of Positive_regulation of RAF1 3 0.20 4.62 0.21 98.04
192 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 97.96
193 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 97.96
194 INT2137 Localization of Cea 27 0.70 19.22 6.14 97.96
195 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15 97.96
196 INT131931 Binding of KRT7 13 0.36 19.24 0.5 97.84
197 INT87963 Regulation of Tg 3 0.45 2.7 0.32 97.80
198 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 97.76
199 INT205081 Positive_regulation of Gene_expression of AXL 10 0.58 11.27 2.37 97.68
200 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 97.64
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