D:Thyroid Nodule

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Disease Term
Synonyms Nodule Thyroid, Nodules Thyroid, Thyroid Nodules
Documents 123
Hot Single Events 33
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Thyroid Nodule. They are ordered first by their relevance to Thyroid Nodule and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT252213 INCENP Regulation of Lgals3 1 0.00 1.91 0.23 73.12
2 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
3 INT116124 Binding of AFP and HCC 2 0.20 1.72 0.15 5.00
4 INT308432 Binding of PDE4A and Aip 1 0.05 3.1 0.05 5.00
5 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0 5.00
6 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0 5.00
7 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0 5.00
8 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0 5.00
9 INT291335 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK3A 1 0.07 0.88 0 5.00
10 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0 5.00
11 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0 5.00
12 INT258525 IPMK Negative_regulation of DDR1 2 0.00 1.97 0 5.00
13 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0 5.00
14 INT291331 Negative_regulation of GSK3A Positive_regulation of Positive_regulation of RAF1 1 0.07 0.94 0 5.00
15 INT308426 Binding of Pde4a and Aip 1 0.02 0.89 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Thyroid Nodule. They are ordered first by their pain relevance and then by number of times they were reported in Thyroid Nodule. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT36952 Negative_regulation of Tg 3 0.43 1.9 0.34 99.08
2 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 98.08
3 INT74093 Positive_regulation of Si5lq3 1 0.00 1.07 0.2 96.68
4 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1 96.28
5 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 94.88
6 INT161382 Localization of KRT20 25 0.61 12.97 2.13 94.72
7 INT70021 Localization of BCL2 23 0.74 21.6 1.09 94.72
8 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 94.60
9 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 94.48
10 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 94.48
11 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 94.48
12 INT186520 Gene_expression of CHKA 8 0.56 8.22 1 94.48
13 INT125627 Gene_expression of TTF1 11 0.78 12.68 0.78 94.48
14 INT58615 Regulation of Tpo 2 0.26 0.6 0.14 93.72
15 INT137614 Gene_expression of Lgals3 70 0.77 66.13 12.53 91.88
16 INT12370 Gene_expression of TNS1 6 0.67 1.7 1.37 91.60
17 INT252209 Positive_regulation of Gene_expression of Lgals3 10 0.57 8.29 1.62 91.00
18 INT38672 Binding of KRT20 69 0.39 48.01 6.31 90.56
19 INT131931 Binding of KRT7 13 0.36 19.24 0.5 90.56
20 INT274661 Positive_regulation of Binding of KRT7 1 0.45 3.5 0.15 90.56
21 INT274662 Positive_regulation of Binding of KRT20 3 0.39 4.32 0.15 90.56
22 INT182810 Gene_expression of Cuzd1 5 0.44 1.49 0.53 89.68
23 INT47651 Gene_expression of DERL2 7 0.68 7.85 0.38 89.48
24 INT2137 Localization of Cea 27 0.70 19.22 6.14 88.96
25 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 88.08
26 INT252208 Gene_expression of Slc5a5 2 0.14 0.87 0.04 87.04
27 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 86.16
28 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 85.48
29 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 84.04
30 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 84.04
31 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 83.56
32 INT86247 Gene_expression of Bcl2l10 14 0.34 12.21 1.61 81.80
33 INT64224 Localization of FUT3 3 0.06 3.16 0.2 80.64
34 INT15654 Gene_expression of Tg 22 0.66 12.2 2.36 79.88
35 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 76.56
36 INT101047 Localization of Epgn 2 0.23 1.41 0.1 75.60
37 INT1921 Gene_expression of CEACAM7 47 0.78 43.23 2.53 75.20
38 INT892 Regulation of TRH 23 0.60 8.46 8.54 75.00
39 INT39463 Positive_regulation of Tg 15 0.69 11.49 2.46 75.00
40 INT68755 Regulation of us 3 0.04 1.24 0.84 75.00
41 INT1893 Localization of Gh 1041 0.79 340.23 256.58 73.68
42 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 72.64
43 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 69.84
44 INT308431 Gene_expression of CNC 1 0.01 2.84 0.18 69.84
45 INT105546 Gene_expression of Tpo 2 0.76 9.29 0.28 67.60
46 INT182806 Binding of Cuzd1 3 0.24 1.45 0.53 64.48
47 INT101048 Negative_regulation of Epgn 1 0.14 1.06 0 63.12
48 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 58.40
49 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 58.40
50 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 58.40
51 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 58.40
52 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98 55.20
53 INT33517 Gene_expression of TSHR 20 0.71 14.65 1.45 53.04
54 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 51.84
55 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 51.08
56 INT162533 Regulation of Lgals3 9 0.45 6.61 1.73 50.56
57 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 49.04
58 INT84409 Binding of TNS1 6 0.48 2.96 3.33 48.36
59 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 47.12
60 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 45.92
61 INT252 Localization of GH1 529 0.80 227.4 122.05 45.88
62 INT156165 Regulation of Gene_expression of NTRK1 2 0.37 1.91 0.27 45.68
63 INT425 Localization of PRL 455 0.81 189.64 144.8 45.56
64 INT208225 Positive_regulation of Gene_expression of TSHR 2 0.46 2.84 0.22 44.92
65 INT252210 Negative_regulation of Transcription of Lgals3 1 0.42 0.87 0.09 43.68
66 INT215858 Transcription of Lgals3 2 0.71 1.77 0.21 43.28
67 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 42.36
68 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1 41.28
69 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 37.60
70 INT42210 Positive_regulation of TSHB 6 0.49 3.48 1.01 34.88
71 INT70242 Localization of HCC 18 0.66 23.95 2.35 34.40
72 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 33.48
73 INT626 Localization of CALCA 289 0.81 125.39 221.15 28.56
74 INT443 Localization of POMC 1020 0.81 284.52 443.17 28.36
75 INT123885 Positive_regulation of Lgals3 23 0.57 24.38 6.32 28.32
76 INT236882 Binding of Tpo 1 0.47 2.5 0 27.44
77 INT252211 Negative_regulation of Lgals3 6 0.43 4.82 0.48 25.96
78 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72 22.32
79 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21 22.32
80 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 22.32
81 INT14397 Gene_expression of Serpinc1 27 0.46 14.54 3.32 22.32
82 INT252212 Negative_regulation of Gene_expression of Lgals3 5 0.43 4.82 0.88 10.04
83 INT137613 Regulation of Gene_expression of Lgals3 4 0.61 2.18 0.32 9.84
84 INT236883 Positive_regulation of Gene_expression of Tpo 1 0.49 0.78 0 5.12
85 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
86 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
87 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
88 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
89 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
90 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
91 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
92 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
93 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
94 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
95 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
96 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
97 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
98 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
99 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
100 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 5.00
101 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
102 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
103 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
104 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
105 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
106 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
107 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
108 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
109 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
110 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
111 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
112 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
113 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
114 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
115 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
116 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
117 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
118 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
119 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
120 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
121 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
122 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
123 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
124 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
125 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
126 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
127 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
128 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
129 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
130 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
131 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
132 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 5.00
133 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
134 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
135 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
136 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
137 INT82685 Gene_expression of Pecam1 36 0.76 27.95 9.01 5.00
138 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
139 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
140 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21 5.00
141 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
142 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 5.00
143 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
144 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
145 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 5.00
146 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21 5.00
147 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
148 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5 5.00
149 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
150 INT121801 Binding of Aip 18 0.36 24.1 5.26 5.00
151 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
152 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
153 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
154 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
155 INT67936 Transcription of JUN 18 0.52 9.52 4.13 5.00
156 INT40036 Binding of DLL1 10 0.36 2.88 3.95 5.00
157 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 5.00
158 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7 5.00
159 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
160 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47 5.00
161 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 5.00
162 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
163 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
164 INT16130 Binding of IGF1 67 0.48 27.43 2.95 5.00
165 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95 5.00
166 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 5.00
167 INT287307 Binding of ENO1 9 0.48 11.24 2.51 5.00
168 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 5.00
169 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32 5.00
170 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22 5.00
171 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 5.00
172 INT73476 Transcription of MYC 18 0.69 12.14 2.13 5.00
173 INT291336 Gene_expression of MAP2K6 4 0.70 7.8 2.13 5.00
174 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9 5.00
175 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
176 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 5.00
177 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
178 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66 5.00
179 INT98096 Positive_regulation of CHKA 14 0.42 12.23 1.61 5.00
180 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59 5.00
181 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
182 INT78097 Negative_regulation of Regulation of CALCA 2 0.42 2.02 1.37 5.00
183 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
184 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 5.00
185 INT114091 Negative_regulation of Aip 6 0.48 4.16 1.3 5.00
186 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
187 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3 5.00
188 INT44746 Localization of Ret 3 0.48 1.23 1.28 5.00
189 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 5.00
190 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14 5.00
191 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 5.00
192 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 5.00
193 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 5.00
194 INT45079 Binding of Ahr 21 0.44 10.07 1 5.00
195 INT153629 Negative_regulation of CHKA 3 0.12 2.33 0.92 5.00
196 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
197 INT89428 Regulation of TG 6 0.36 3.93 0.72 5.00
198 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 5.00
199 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7 5.00
200 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
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