D:Tibial Fractures

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Disease Term
Synonyms Fracture Tibial, FRACTURES TIBIAL, TIBIAL FRACTURE
Documents 172
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tibial Fractures. They are ordered first by their relevance to Tibial Fractures and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT316598 Pth Regulation of Fgf23 1 0.10 0.28 0.03 5.00
2 INT302311 PTH Negative_regulation of Gene_expression of SOST 1 0.29 0.59 0 5.00
3 INT174532 PTH Positive_regulation of Transcription of IGF1 1 0.06 0.51 0 5.00
4 INT354566 F2 Positive_regulation of PRNP 1 0.00 0.05 0 5.00
5 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0 5.00
6 INT302321 Negative_regulation of Binding of Lrp6 and SOST 1 0.16 0.26 0 5.00
7 INT302322 Negative_regulation of Binding of Lrp5 and SOST 1 0.16 0.26 0 5.00
8 INT302320 Binding of Lrp6 and SOST 1 0.18 0.26 0 5.00
9 INT302323 Binding of SOST and Wnt2 1 0.02 0.26 0 5.00
10 INT302319 Binding of Lrp5 and SOST 1 0.18 0.26 0 5.00
11 INT316600 Binding of Acp5 and Matk 1 0.01 0 0 5.00
12 INT316599 Positive_regulation of Binding of Acp5 and Matk 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tibial Fractures. They are ordered first by their pain relevance and then by number of times they were reported in Tibial Fractures. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT105021 Binding of GOPC 187 0.40 60.39 20.38 99.52
2 INT18845 Regulation of IAPP 11 0.60 9 1.81 99.44
3 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42 98.60
4 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 97.12
5 INT133695 Transcription of Ibsp 4 0.36 5.7 1.32 94.52
6 INT316584 Gene_expression of Hopx 1 0.02 2 0 94.00
7 INT176513 Transcription of Spp1 5 0.63 4.32 0.67 93.40
8 INT121141 Transcription of Spp1 6 0.34 5.02 0.38 92.52
9 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09 86.48
10 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 83.52
11 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 79.56
12 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 79.56
13 INT316585 Regulation of Gene_expression of Hopx 1 0.01 0.63 0 58.72
14 INT109699 Regulation of BMP2 5 0.43 2.21 0.23 55.52
15 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 53.16
16 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 52.48
17 INT302314 Negative_regulation of SOST 5 0.44 2.22 0.33 48.40
18 INT302312 Localization of Bmpr2 4 0.46 0.47 0 44.20
19 INT150330 Gene_expression of BMPR2 7 0.29 4.22 0.34 30.40
20 INT150331 Positive_regulation of Gene_expression of BMPR2 2 0.02 0.59 0.19 30.40
21 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 28.80
22 INT114664 Binding of BMP2 12 0.37 6.54 0.91 27.44
23 INT174538 Transcription of RUNX2 1 0.26 0.59 0 20.08
24 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 15.00
25 INT252 Localization of GH1 529 0.80 227.4 122.05 7.96
26 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
27 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
28 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
29 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
30 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
31 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
32 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
33 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
34 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
35 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
36 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
37 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
38 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51 5.00
39 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
40 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 5.00
41 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
42 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 5.00
43 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
44 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
45 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
46 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
47 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
48 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
49 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 5.00
50 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
51 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 5.00
52 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
53 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
54 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
55 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 5.00
56 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
57 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 5.00
58 INT157941 Gene_expression of IL-17 65 0.65 20.39 9.89 5.00
59 INT102698 Binding of ACCS 54 0.42 66.73 9.06 5.00
60 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 5.00
61 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
62 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
63 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49 5.00
64 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
65 INT8916 Regulation of Igf1 45 0.60 13.06 5.81 5.00
66 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 5.00
67 INT4864 Regulation of BGLAP 22 0.34 10.8 5.07 5.00
68 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 5.00
69 INT68260 Localization of BGLAP 34 0.78 16.04 4.63 5.00
70 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 5.00
71 INT49360 Localization of Igf1 22 0.76 6.96 4.26 5.00
72 INT20981 Binding of HRAS 42 0.48 24.49 4.23 5.00
73 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
74 INT19491 Gene_expression of CD19 44 0.75 28.8 3.47 5.00
75 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46 5.00
76 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 5.00
77 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23 5.00
78 INT28094 Binding of PTH 29 0.37 13.57 3.09 5.00
79 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
80 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 5.00
81 INT113029 Negative_regulation of Myo5a 7 0.48 0.97 2.95 5.00
82 INT45575 Gene_expression of Ibsp 8 0.50 11.83 2.85 5.00
83 INT14448 Localization of COL5A2 34 0.67 17.35 2.85 5.00
84 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65 5.00
85 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
86 INT61465 Gene_expression of Acp5 22 0.75 7.06 2.55 5.00
87 INT157943 Positive_regulation of IL-17 10 0.58 6.65 2.43 5.00
88 INT42369 Localization of Ibsp 6 0.62 2.51 2.17 5.00
89 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
90 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
91 INT176510 Binding of Spp1 21 0.42 22.1 2 5.00
92 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93 5.00
93 INT176516 Localization of Spp1 28 0.76 19.39 1.9 5.00
94 INT167203 Binding of PRNP 25 0.48 20.09 1.84 5.00
95 INT160533 Gene_expression of NUDT6 24 0.20 18.6 1.7 5.00
96 INT38266 Localization of PTPRC 30 0.68 17.05 1.68 5.00
97 INT66709 Transcription of IGF1 13 0.71 5.65 1.64 5.00
98 INT3343 Regulation of PTH 24 0.62 11.18 1.62 5.00
99 INT243655 Positive_regulation of Gene_expression of IL-17 11 0.58 3.06 1.45 5.00
100 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 5.00
101 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24 5.00
102 INT45576 Positive_regulation of Ibsp 4 0.41 3.41 1.21 5.00
103 INT82214 Transcription of PTH 6 0.54 3.33 1.11 5.00
104 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04 5.00
105 INT116529 Binding of HMOX1 10 0.47 15.38 1.04 5.00
106 INT29788 Gene_expression of DNASE1L1 3 0.03 0.61 0.99 5.00
107 INT124374 Binding of Wnt2 21 0.31 10.16 0.99 5.00
108 INT42370 Negative_regulation of Ibsp 3 0.38 0.68 0.81 5.00
109 INT171096 Transcription of PDGFA 5 0.47 4.42 0.79 5.00
110 INT130797 Gene_expression of Fgf23 6 0.66 4.73 0.77 5.00
111 INT176528 Regulation of Spp1 9 0.45 9.05 0.77 5.00
112 INT151217 Phosphorylation of SIGMAR1 2 0.04 0.41 0.72 5.00
113 INT139205 Binding of NRP1 27 0.45 4.34 0.71 5.00
114 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68 5.00
115 INT174537 Positive_regulation of HEYL 7 0.39 3.07 0.68 5.00
116 INT235398 Regulation of Gene_expression of BGLAP 3 0.27 1.03 0.61 5.00
117 INT174540 Positive_regulation of Localization of COL5A2 2 0.04 2.44 0.6 5.00
118 INT9102 Negative_regulation of SLC9A3R2 2 0.31 1.62 0.55 5.00
119 INT85808 Localization of BMP2 7 0.77 1.94 0.51 5.00
120 INT188050 Regulation of Gene_expression of Wnt2 9 0.37 3.13 0.44 5.00
121 INT171922 Positive_regulation of Binding of GOPC 5 0.44 1.31 0.34 5.00
122 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34 5.00
123 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34 5.00
124 INT157605 Localization of COL3A1 3 0.80 0.55 0.29 5.00
125 INT157409 Negative_regulation of Fgf23 3 0.50 3.21 0.27 5.00
126 INT10425 Positive_regulation of Myo5a 5 0.66 0.41 0.21 5.00
127 INT130798 Positive_regulation of Gene_expression of Fgf23 2 0.59 1.12 0.2 5.00
128 INT135975 Binding of Ibsp 2 0.31 0.31 0.15 5.00
129 INT278037 Positive_regulation of Transcription of PDGFA 4 0.07 2.39 0.12 5.00
130 INT39866 Gene_expression of RUNX1T1 2 0.65 1.75 0.1 5.00
131 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09 5.00
132 INT302317 Positive_regulation of Gene_expression of SOST 4 0.60 1.58 0.08 5.00
133 INT302313 Gene_expression of SOST 6 0.67 2.06 0.08 5.00
134 INT254332 Negative_regulation of Gene_expression of Bmpr2 3 0.22 2.41 0.07 5.00
135 INT316587 Gene_expression of Matk 1 0.07 1.53 0.06 5.00
136 INT237839 Negative_regulation of Transcription of GOPC 4 0.37 0.29 0.05 5.00
137 INT302316 Negative_regulation of Gene_expression of SOST 4 0.51 1.36 0.05 5.00
138 INT316595 Transcription of Fgf23 1 0.61 0.44 0.04 5.00
139 INT316589 Negative_regulation of Transcription of Fgf23 1 0.50 0.44 0.04 5.00
140 INT302318 Regulation of SOST 2 0.34 0.46 0.04 5.00
141 INT278039 Phosphorylation of BMPR2 1 0.08 0.26 0.03 5.00
142 INT225689 Gene_expression of SMS 10 0.65 5.66 0.03 5.00
143 INT316576 Transcription of Acp5 1 0.11 0.79 0.03 5.00
144 INT316588 Positive_regulation of Fgf23 1 0.43 0.29 0.03 5.00
145 INT316593 Transcription of Matk 1 0.06 0.79 0.03 5.00
146 INT278034 Transcription of BMP1 1 0.07 0.25 0.03 5.00
147 INT278022 Phosphorylation of Bmpr2 1 0.21 0.27 0.03 5.00
148 INT316586 Regulation of Transcription of Ibsp 1 0.23 0.16 0 5.00
149 INT316591 Regulation of Gene_expression of Matk 1 0.04 0.06 0 5.00
150 INT316594 Negative_regulation of Binding of Ibsp 1 0.21 0.06 0 5.00
151 INT316596 Regulation of Transcription of Matk 1 0.03 0.16 0 5.00
152 INT316578 Regulation of Transcription of Spp1 1 0.09 0.16 0 5.00
153 INT316580 Binding of Acp5 1 0.06 0 0 5.00
154 INT316577 Positive_regulation of Binding of Acp5 1 0.08 0 0 5.00
155 INT316592 Negative_regulation of Binding of Matk 1 0.04 0.06 0 5.00
156 INT316597 Binding of Matk 1 0.03 0.06 0 5.00
157 INT316590 Positive_regulation of Binding of Matk 1 0.04 0 0 5.00
158 INT316579 Negative_regulation of Binding of Spp1 1 0.09 0.06 0 5.00
159 INT174535 Negative_regulation of Negative_regulation of NOS3 1 0.11 0.32 0 5.00
160 INT278035 Positive_regulation of Gene_expression of DNASE1L1 1 0.01 0.38 0 5.00
161 INT219929 Positive_regulation of Gene_expression of Bmpr2 3 0.15 0.9 0 5.00
162 INT294031 Negative_regulation of Gene_expression of Trip12 1 0.05 0.31 0 5.00
163 INT173445 Positive_regulation of TAB1 3 0.49 0.9 0 5.00
164 INT278040 Negative_regulation of Localization of BMP2 1 0.32 0.32 0 5.00
165 INT302315 Localization of SOST 1 0.61 0.11 0 5.00
166 INT316575 Regulation of Transcription of Acp5 1 0.06 0.16 0 5.00
167 INT79726 Binding of Spef1 2 0.05 0.44 0 5.00
168 INT294032 Gene_expression of Trip12 1 0.09 0.31 0 5.00
169 INT61467 Regulation of Gene_expression of Acp5 1 0.59 0.06 0 5.00
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