D:Tonic-clonic Epilepsy

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pChart

Disease Term
Synonyms Convulsion Disorder Tonic Clonic, Convulsion Disorders Tonic Clonic, Convulsion Grand Mal, Convulsion Syndrome Tonic Clonic, CONVULSION SYNDROMES TONIC CLONIC, Convulsion Tonic Clonic, Convulsions Grand Mal, Convulsions Tonic Clonic, CRYPTOGENIC TONIC CLONIC EPILEPSIES, Cryptogenic Tonic Clonic Epilepsy, Disorder Tonic Clonic Convulsion
Documents 13
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tonic-clonic Epilepsy. They are ordered first by their relevance to Tonic-clonic Epilepsy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27 5.00
2 INT180246 Binding of Tbca and Uchl1 1 0.00 0.47 0.27 5.00
3 INT180247 Binding of Gad1 and Tbca 1 0.02 0.22 0.22 5.00
4 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21 5.00
5 INT180252 Negative_regulation of Gad1 Positive_regulation of CP 1 0.03 0.75 0.14 5.00
6 INT198595 Binding of CFH and CFHR1 3 0.41 1.36 0.03 5.00
7 INT198593 Binding of CFH and VHL 1 0.02 0.27 0 5.00
8 INT198594 Binding of CFH and MIR1197 1 0.01 0.48 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tonic-clonic Epilepsy. They are ordered first by their pain relevance and then by number of times they were reported in Tonic-clonic Epilepsy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 94.80
2 INT116540 Binding of Twist1 35 0.48 16.32 2.85 94.80
3 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 89.56
4 INT28314 Negative_regulation of Gene_expression of Gabrg1 29 0.44 12.56 13.8 89.56
5 INT16427 Negative_regulation of Positive_regulation of Csf2 2 0.43 1.5 1.2 89.56
6 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 89.16
7 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 89.16
8 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 89.16
9 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 87.96
10 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 87.96
11 INT173336 Gene_expression of GLUL 16 0.27 6.74 2.78 87.56
12 INT180234 Negative_regulation of Gene_expression of Plp1 1 0.08 1.54 0.42 85.88
13 INT48687 Gene_expression of Plp1 7 0.54 3.51 1.03 85.48
14 INT90567 Negative_regulation of Gene_expression of Gad1 4 0.41 2.88 1.36 74.40
15 INT180239 Negative_regulation of Gene_expression of Gad2 2 0.42 1.59 0.55 74.40
16 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4 73.76
17 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53 73.76
18 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 70.76
19 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 62.64
20 INT756 Gene_expression of C3 138 0.75 100.6 19.2 43.60
21 INT198606 Localization of CFH 8 0.65 4.37 0.04 34.24
22 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 26.00
23 INT180249 Negative_regulation of GLUL 5 0.15 0.69 1.46 21.28
24 INT159645 Negative_regulation of Uchl1 8 0.31 6.84 2.14 10.12
25 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 7.84
26 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
27 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
28 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 5.00
29 INT28315 Regulation of Gene_expression of Gabrg1 20 0.60 4.78 7 5.00
30 INT3309 Binding of CP 25 0.47 17.87 6.62 5.00
31 INT43931 Binding of CFH 49 0.48 31.85 3.96 5.00
32 INT42251 Regulation of Gad1 10 0.44 5.25 3.45 5.00
33 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
34 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
35 INT70596 Regulation of Uchl1 5 0.39 3.87 3.11 5.00
36 INT165514 Regulation of Gad2 7 0.45 3.15 2.76 5.00
37 INT42255 Negative_regulation of Gad1 7 0.56 4.83 2.54 5.00
38 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
39 INT17598 Positive_regulation of CFHR1 11 0.50 2.6 2.38 5.00
40 INT8466 Binding of Plp1 5 0.48 5.07 2.29 5.00
41 INT42256 Positive_regulation of Gad1 4 0.66 1.1 2.09 5.00
42 INT17596 Gene_expression of CFHR1 24 0.67 3.07 1.61 5.00
43 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 5.00
44 INT96642 Transcription of Gad2 4 0.59 0.88 1.59 5.00
45 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59 5.00
46 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
47 INT51591 Regulation of GLUL 3 0.11 2.62 1.15 5.00
48 INT90568 Regulation of Gene_expression of Gad1 3 0.27 0.46 0.89 5.00
49 INT180240 Binding of Gad1 7 0.47 2.99 0.86 5.00
50 INT17597 Positive_regulation of Gene_expression of CFHR1 3 0.50 0 0.85 5.00
51 INT39586 Transcription of CP 5 0.67 1.7 0.83 5.00
52 INT70744 Regulation of CFH 12 0.41 7.38 0.8 5.00
53 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 5.00
54 INT95699 Binding of Gad2 5 0.40 1.14 0.73 5.00
55 INT180244 Positive_regulation of Gad2 4 0.49 1.07 0.61 5.00
56 INT162843 Negative_regulation of Gene_expression of CP 2 0.11 2.79 0.45 5.00
57 INT180236 Binding of Etv5 2 0.36 1.09 0.18 5.00
58 INT146898 Positive_regulation of Binding of CFH 3 0.44 2.01 0.17 5.00
59 INT146899 Positive_regulation of Positive_regulation of CFH 2 0.50 1.37 0.17 5.00
60 INT180242 Positive_regulation of Binding of Gad1 1 0.49 0.86 0.17 5.00
61 INT180237 Binding of Tbca 2 0.03 1.08 0.15 5.00
62 INT180233 Negative_regulation of Negative_regulation of Uchl1 1 0.14 0.6 0.14 5.00
63 INT198600 Negative_regulation of Gene_expression of CFH 4 0.41 3.25 0.12 5.00
64 INT180243 Phosphorylation of Gad2 1 0.52 0.48 0.06 5.00
65 INT179307 Regulation of GNAS 7 0.01 1.93 0.05 5.00
66 INT198598 Transcription of CFH 3 0.69 3.21 0.05 5.00
67 INT180241 Positive_regulation of Binding of Gad2 1 0.39 0.29 0.03 5.00
68 INT180232 Protein_catabolism of Gad1 1 0.87 0.52 0 5.00
69 INT180251 Gene_expression of ERCC4 1 0.65 0 0 5.00
70 INT198599 Transcription of CFHR1 1 0.69 0.14 0 5.00
71 INT198601 Positive_regulation of MIR1197 1 0.01 0 0 5.00
72 INT198602 Positive_regulation of Positive_regulation of CFHR1 1 0.50 0.23 0 5.00
73 INT198603 Positive_regulation of Transcription of CFH 2 0.50 2 0 5.00
74 INT198605 Gene_expression of CFHR3 1 0.63 0 0 5.00
75 INT198607 Regulation of Gene_expression of CFH 2 0.27 2.16 0 5.00
76 INT198608 Positive_regulation of Transcription of CFHR1 1 0.50 0.14 0 5.00
77 INT198609 Positive_regulation of Gene_expression of CFHR3 1 0.47 0 0 5.00
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