D:Tooth Loss

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pChart

Disease Term
Synonyms Loss Tooth
Documents 145
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tooth Loss. They are ordered first by their relevance to Tooth Loss and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131130 Binding of PKD1 and Krt16 1 0.01 1 0.08 52.48
2 INT166145 Binding of Rrad and Rce1 1 0.04 0 0.14 46.12
3 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67 5.00
4 INT128644 Binding of Icam1 and Selp 2 0.39 0.57 0.25 5.00
5 INT349475 Regulation of Bax Regulation of Bcl2 1 0.07 1.35 0.17 5.00
6 INT349476 Bax Regulation of Bcl2 1 0.07 1.33 0.15 5.00
7 INT310804 SFTPA1 Negative_regulation of Gene_expression of Ptges2 1 0.00 0.14 0.03 5.00
8 INT354919 Uvbs1 Positive_regulation of Binding of VDR and Uvbs1 1 0.00 0.13 0 5.00
9 INT354923 Binding of VDR and Uvbs1 1 0.00 0.83 0 5.00
10 INT193308 Binding of PRNP and TGFB1 1 0.01 0 0 5.00
11 INT255385 Binding of COL1A2 and DSPP 1 0.40 0.12 0 5.00
12 INT255384 Binding of AKR1C2 and DSG1 1 0.01 1.54 0 5.00
13 INT310805 MAPK8 Regulation of Regulation of Ptges2 1 0.01 0 0 5.00
14 INT193307 Binding of PDGFA and PRNP 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tooth Loss. They are ordered first by their pain relevance and then by number of times they were reported in Tooth Loss. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT192671 Negative_regulation of Dntcs1 1 0.01 0.84 0 100.00
2 INT53240 Positive_regulation of Localization of SFTPA1 11 0.11 7.99 7.15 99.80
3 INT8835 Localization of SFTPA1 65 0.68 32.81 38.65 99.70
4 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.32
5 INT192670 Binding of Dntcs1 1 0.01 0.83 0 99.20
6 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 97.96
7 INT164425 Regulation of Gene_expression of SFTPA1 5 0.44 2.46 1.9 95.92
8 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 95.36
9 INT125381 Regulation of Dh 3 0.29 1.07 0.49 94.80
10 INT167564 Regulation of Xhs1 1 0.03 0.79 0.1 94.80
11 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 94.36
12 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 94.36
13 INT97695 Positive_regulation of Dh 3 0.33 1.44 1.1 94.04
14 INT77667 Positive_regulation of Xhs1 2 0.03 1.67 0.92 93.88
15 INT212930 Localization of ELL 2 0.15 0.87 0.04 86.88
16 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 85.68
17 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 85.32
18 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 84.76
19 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 83.76
20 INT90664 Transcription of SFTPA1 4 0.50 0.61 1.48 82.76
21 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 82.48
22 INT105551 Transcription of Tnfsf11 6 0.69 4.21 1.38 82.48
23 INT105552 Positive_regulation of Transcription of Tnfsf11 3 0.31 2.94 1.17 82.48
24 INT156850 Binding of VDR 40 0.47 24.86 4.87 76.96
25 INT102638 Regulation of VDR 21 0.44 9.92 2.54 75.96
26 INT119700 Gene_expression of VDR 88 0.75 65.33 11.5 74.72
27 INT287118 Negative_regulation of Gene_expression of VDR 3 0.36 3.53 0.66 74.72
28 INT354920 Negative_regulation of Positive_regulation of VDR 1 0.21 1.96 0.04 72.80
29 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 69.88
30 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 69.88
31 INT213286 Positive_regulation of Binding of INS 6 0.50 4.85 0.45 60.96
32 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 60.76
33 INT14572 Binding of INS 205 0.48 175.43 13.38 60.64
34 INT89732 Binding of Rce1 2 0.28 0.2 0.41 58.88
35 INT24886 Negative_regulation of SFTPA1 11 0.12 4.35 5.03 56.64
36 INT166144 Positive_regulation of Protein_catabolism of Rrad 1 0.05 0.06 0.16 56.56
37 INT166140 Binding of Rrad 2 0.12 3.54 0.6 54.56
38 INT166141 Protein_catabolism of Rrad 1 0.09 0.05 0.16 53.36
39 INT212929 Positive_regulation of CAPNS2 1 0.42 0.51 0 50.12
40 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 50.00
41 INT22454 Regulation of Crp 213 0.62 160.67 49.24 50.00
42 INT2774 Binding of Crp 241 0.48 195.89 44.39 50.00
43 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27 49.64
44 INT211332 Binding of Gfi1 1 0.11 0.09 0.09 49.52
45 INT211331 Binding of Nfia 1 0.22 0.09 0.09 49.52
46 INT211330 Binding of Cfi 1 0.21 0.09 0.09 49.52
47 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 48.64
48 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 45.92
49 INT182351 Positive_regulation of Gene_expression of Apoe 38 0.50 19.78 6.72 45.92
50 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 45.84
51 INT35486 Regulation of PTGER2 39 0.36 19.03 6.75 45.84
52 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 44.24
53 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14 44.24
54 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 40.52
55 INT166138 Positive_regulation of Rce1 1 0.38 0 0.13 37.96
56 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 34.76
57 INT812 Localization of INS 1026 0.81 515.6 145.31 34.32
58 INT186523 Binding of ETFDH 10 0.25 5.63 0.72 29.28
59 INT121834 Gene_expression of IAPP 24 0.66 20.96 0.26 26.68
60 INT183063 Regulation of Gene_expression of IAPP 2 0.27 1.07 0 26.68
61 INT1214 Gene_expression of PGE 70 0.72 29.07 16.22 26.32
62 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 26.28
63 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 25.68
64 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 25.00
65 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94 25.00
66 INT134296 Positive_regulation of Ptges2 20 0.19 14.85 3.8 19.68
67 INT205888 Positive_regulation of Gene_expression of Pla2g4a 7 0.67 8 0.9 19.68
68 INT310797 Positive_regulation of Gene_expression of PTGES3 1 0.17 0.7 0.23 19.68
69 INT310800 Positive_regulation of PTGES3 1 0.24 0.7 0.23 19.68
70 INT92311 Regulation of SIL1 7 0.44 6.2 1.61 19.44
71 INT134298 Gene_expression of Ptges2 96 0.54 56.52 17.19 19.28
72 INT180580 Binding of HEYL 7 0.17 4.49 1.15 18.52
73 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07 18.16
74 INT139886 Gene_expression of PTGES3 11 0.72 1.5 1.27 18.16
75 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19 13.16
76 INT141750 Positive_regulation of Localization of Syt1 10 0.67 5.53 5.28 9.88
77 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 9.16
78 INT141751 Localization of Syt1 21 0.78 11.19 5.98 8.92
79 INT150395 Binding of MEFV 55 0.44 31.18 3.42 8.72
80 INT116420 Localization of Elane 16 0.14 7.8 6 6.96
81 INT234940 Regulation of DSG1 2 0.21 2.29 0 6.72
82 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 6.64
83 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 6.08
84 INT56985 Gene_expression of MEFV 56 0.71 46.71 9.47 5.76
85 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.24
86 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
87 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
88 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
89 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
90 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
91 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
92 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
93 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
94 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 5.00
95 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
96 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
97 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
98 INT65500 Gene_expression of App 605 0.78 429.94 98.31 5.00
99 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
100 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
101 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
102 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 5.00
103 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
104 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
105 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
106 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
107 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
108 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
109 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
110 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 5.00
111 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
112 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
113 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
114 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
115 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
116 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
117 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
118 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 5.00
119 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
120 INT47939 Gene_expression of Selp 171 0.76 87.54 39.03 5.00
121 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
122 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
123 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 5.00
124 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
125 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
126 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 5.00
127 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 5.00
128 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
129 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35 5.00
130 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 5.00
131 INT17625 Localization of GCG 210 0.80 55.69 24.97 5.00
132 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 5.00
133 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 5.00
134 INT63419 Gene_expression of PTGES 109 0.77 40.83 23.67 5.00
135 INT134651 Binding of TLR4 89 0.48 66.96 23.19 5.00
136 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
137 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
138 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89 5.00
139 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
140 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
141 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
142 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
143 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
144 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
145 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53 5.00
146 INT35487 Localization of PTGER2 103 0.46 51.24 17.45 5.00
147 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
148 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
149 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
150 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
151 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
152 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
153 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 5.00
154 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
155 INT71510 Positive_regulation of Selp 47 0.68 30.43 12.8 5.00
156 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
157 INT4460 Regulation of Mpo 44 0.62 31.16 12.11 5.00
158 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
159 INT13287 Gene_expression of Cpb2 27 0.56 7.84 11.95 5.00
160 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
161 INT1762 Negative_regulation of PTGER2 64 0.43 28.21 11.27 5.00
162 INT81531 Positive_regulation of Gene_expression of Nfkb1 27 0.69 13.9 11.04 5.00
163 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 5.00
164 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
165 INT15026 Negative_regulation of Localization of NA 26 0.36 3.76 10.69 5.00
166 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38 5.00
167 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 5.00
168 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 5.00
169 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28 5.00
170 INT13467 Positive_regulation of ABCB1 36 0.68 9.68 8.95 5.00
171 INT92822 Negative_regulation of Gene_expression of Crp 36 0.49 29.5 8.83 5.00
172 INT116605 Binding of Nos2 28 0.37 16.88 8.18 5.00
173 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96 5.00
174 INT62944 Regulation of Icam1 33 0.47 23.52 7.94 5.00
175 INT91417 Positive_regulation of PTGES 36 0.68 18.45 7.64 5.00
176 INT81537 Regulation of Gene_expression of Nfkb1 10 0.57 7.09 7.48 5.00
177 INT70252 Gene_expression of Ugt1a6 20 0.77 3.89 7.45 5.00
178 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 5.00
179 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
180 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 5.00
181 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14 5.00
182 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
183 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7 5.00
184 INT60475 Gene_expression of Ugt1a1 17 0.77 4.26 5.62 5.00
185 INT162328 Regulation of Ptges2 21 0.19 12.07 5.56 5.00
186 INT98685 Positive_regulation of Gene_expression of PTGES 28 0.68 9.46 5.55 5.00
187 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
188 INT145929 Regulation of Bax 20 0.60 18.12 5.35 5.00
189 INT144946 Localization of Icam1 21 0.75 21.84 5.33 5.00
190 INT73608 Localization of Nos2 21 0.75 9.58 5.05 5.00
191 INT134297 Positive_regulation of Gene_expression of Ptges2 22 0.41 13.12 4.97 5.00
192 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82 5.00
193 INT62291 Gene_expression of PTGES2 14 0.68 8.34 4.75 5.00
194 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 5.00
195 INT25634 Binding of Mpo 21 0.48 14.78 4.39 5.00
196 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28 5.00
197 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28 5.00
198 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 5.00
199 INT106274 Positive_regulation of Syt1 16 0.67 9.76 4.1 5.00
200 INT192970 Negative_regulation of Hp 7 0.22 6.99 4.06 5.00
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