D:Toothache

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Disease Term
Synonyms Odontalgia, ODONTALGIAS, Toothaches
Documents 408
Hot Single Events 31
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Toothache. They are ordered first by their relevance to Toothache and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT317184 BMS1 Regulation of Gene_expression of NAV1 1 0.03 1.94 1.62 5.00
2 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
3 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
4 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
5 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
6 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
7 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
8 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
9 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
10 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
11 INT350214 Binding of GPER and HSPG2 1 0.00 0.12 0.32 5.00
12 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29 5.00
13 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
14 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22 5.00
15 INT350220 Positive_regulation of HSPG2 Positive_regulation of Localization of ITPR3 1 0.05 0.09 0.09 5.00
16 INT350216 ITPR3 Regulation of Localization of TNIP3 1 0.01 0.08 0.09 5.00
17 INT350217 Positive_regulation of HSPG2 Positive_regulation of ITPR3 1 0.05 0.09 0.09 5.00
18 INT350218 Positive_regulation of HSPG2 Positive_regulation of Gene_expression of ITPR3 1 0.04 0.09 0.08 5.00
19 INT350219 ITPR3 Positive_regulation of CA2 1 0.22 0 0.05 5.00
20 INT172902 Binding of Bax and Bcl2 5 0.30 3.19 0.03 5.00
21 INT172906 Binding of Bax and Bcl2l1 2 0.16 2.03 0 5.00
22 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0 5.00
23 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
24 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
25 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0 5.00
26 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0 5.00
27 INT261844 Lyn Positive_regulation of Lyn Regulation of Trpv4 1 0.01 0.19 0 5.00
28 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Toothache. They are ordered first by their pain relevance and then by number of times they were reported in Toothache. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT118156 Binding of Prkcz 2 0.08 2.68 2.89 100.00
2 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.92
3 INT18539 Gene_expression of Pnmt 33 0.78 3.08 12.47 99.92
4 INT27260 Gene_expression of DYNLL1 8 0.75 7.72 2.78 99.70
5 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 97.16
6 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 96.68
7 INT219982 Transcription of THRA 1 0.15 0.72 0.45 96.64
8 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 96.56
9 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 95.56
10 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46 95.56
11 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 95.16
12 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25 92.88
13 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 91.04
14 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 90.80
15 INT144908 Gene_expression of SEA 15 0.52 3.81 0.79 90.80
16 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 90.20
17 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 90.20
18 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 90.20
19 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 90.16
20 INT4877 Gene_expression of MME 184 0.78 122.82 24.78 90.16
21 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 89.64
22 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 88.64
23 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7 88.24
24 INT121387 Negative_regulation of Gene_expression of CD5 3 0.40 2.6 0.25 88.12
25 INT97063 Gene_expression of CD5 16 0.77 13.81 3.13 87.32
26 INT169265 Binding of CD5 3 0.20 3.01 0.63 87.32
27 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 86.80
28 INT111533 Positive_regulation of Gene_expression of Nfkb1 27 0.52 17.32 7.89 86.80
29 INT88873 Negative_regulation of Gene_expression of Nfkb1 24 0.56 9.93 5.97 86.80
30 INT149518 Regulation of Gene_expression of NAV1 7 0.62 6.73 9.62 86.72
31 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 81.52
32 INT219983 Binding of THRA 1 0.08 1.08 0.82 80.00
33 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39 78.56
34 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 78.24
35 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 77.48
36 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 77.48
37 INT36970 Positive_regulation of Acpp 2 0.20 1.68 0.2 77.48
38 INT129927 Transcription of Ldha 3 0.42 1.41 0.18 77.48
39 INT129929 Transcription of LDHA 4 0.17 4.48 0.08 77.48
40 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95 76.48
41 INT44773 Negative_regulation of LBR 6 0.57 2.32 2.03 75.08
42 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 75.00
43 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 75.00
44 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18 74.72
45 INT273526 Positive_regulation of BRON-J 1 0.23 1.2 0.1 74.16
46 INT87212 Negative_regulation of Positive_regulation of Nfkb1 74 0.57 38.21 28.31 73.52
47 INT93481 Negative_regulation of Protein_catabolism of Nfkbia 14 0.39 7.24 7.21 73.52
48 INT101937 Negative_regulation of Protein_catabolism of Nfkb1 6 0.19 3.21 2.21 73.52
49 INT71877 Positive_regulation of Protein_catabolism of Nfkb1 9 0.24 2.73 3.06 72.92
50 INT88498 Protein_catabolism of Nfkbia 14 0.82 6.94 7.1 69.20
51 INT71878 Protein_catabolism of Nfkb1 24 0.65 10.85 9.46 68.64
52 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 67.96
53 INT129470 Regulation of RRM2 4 0.22 0.36 0.27 67.48
54 INT73112 Negative_regulation of Kcnk3 7 0.58 1.2 1.55 66.04
55 INT152712 Negative_regulation of Kcnk9 1 0.22 0.14 0.29 66.04
56 INT152711 Negative_regulation of Kcnk18 1 0.23 0.14 0.29 66.04
57 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 65.04
58 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 59.36
59 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 58.00
60 INT83601 Binding of CNR2 30 0.47 7.79 12.37 55.28
61 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 51.12
62 INT167177 Regulation of Gene_expression of Cdc2b 1 0.45 1.41 0.66 48.92
63 INT344882 Binding of GABRA1 1 0.24 0.09 0.21 48.84
64 INT167178 Gene_expression of Cdc2b 4 0.78 2.4 0.66 48.52
65 INT344883 Binding of TREX1 1 0.25 0.09 0.21 48.52
66 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 43.80
67 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 39.28
68 INT168681 Gene_expression of BMS1 5 0.37 2.7 1.62 32.32
69 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 32.04
70 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 31.96
71 INT172664 Gene_expression of ZBTB22 2 0.58 0.22 0.22 12.32
72 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
73 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
74 INT1352 Localization of Acot1 728 0.80 73.01 296.01 5.00
75 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
76 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
77 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
78 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 5.00
79 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 5.00
80 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
81 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
82 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
83 INT4822 Localization of Ca2 417 0.80 99.57 96.45 5.00
84 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
85 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
86 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
87 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
88 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
89 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65 5.00
90 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
91 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
92 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
93 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
94 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 5.00
95 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 5.00
96 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 5.00
97 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 5.00
98 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
99 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
100 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
101 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
102 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 5.00
103 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
104 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
105 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
106 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
107 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 5.00
108 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
109 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 5.00
110 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
111 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
112 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 5.00
113 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85 5.00
114 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
115 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
116 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
117 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
118 INT16194 Binding of CNR1 82 0.48 20.75 39.59 5.00
119 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
120 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
121 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
122 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78 5.00
123 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
124 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44 5.00
125 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 5.00
126 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
127 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
128 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19 5.00
129 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11 5.00
130 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
131 INT117632 Gene_expression of Trpm8 99 0.78 29.41 30.9 5.00
132 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
133 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 5.00
134 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 5.00
135 INT149387 Negative_regulation of Trpa1 55 0.59 21.91 28.31 5.00
136 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
137 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
138 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
139 INT123419 Binding of NAV1 37 0.48 7.09 26.43 5.00
140 INT112036 Phosphorylation of Trpv1 51 0.82 18.59 25.6 5.00
141 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92 5.00
142 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
143 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
144 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
145 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
146 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
147 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 5.00
148 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
149 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 5.00
150 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 5.00
151 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
152 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
153 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
154 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 5.00
155 INT90937 Negative_regulation of Gene_expression of Trpv1 34 0.59 22.74 18.12 5.00
156 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 5.00
157 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
158 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3 5.00
159 INT111416 Positive_regulation of Trpm8 65 0.70 14.62 17.13 5.00
160 INT17313 Positive_regulation of HSPG2 57 0.67 55.78 16.65 5.00
161 INT20216 Localization of NGF 40 0.80 18.16 16.61 5.00
162 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
163 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
164 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
165 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
166 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 5.00
167 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07 5.00
168 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 5.00
169 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 5.00
170 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
171 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
172 INT103547 Gene_expression of TRPV3 47 0.78 17.06 13.34 5.00
173 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
174 INT233113 Regulation of Trpm8 24 0.61 18.08 13.17 5.00
175 INT22213 Localization of Gpt 52 0.78 34.05 12.94 5.00
176 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
177 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32 5.00
178 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 5.00
179 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
180 INT143767 Negative_regulation of Trpm8 26 0.58 12.34 10.83 5.00
181 INT3535 Regulation of CA2 61 0.32 16.48 10.8 5.00
182 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39 5.00
183 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 5.00
184 INT80717 Gene_expression of Trpv3 20 0.72 10.05 9.96 5.00
185 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9 5.00
186 INT134597 Binding of Trpa1 21 0.48 9.41 9.74 5.00
187 INT66382 Positive_regulation of Phosphorylation of Prkaca 33 0.49 7.05 9.69 5.00
188 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65 5.00
189 INT3366 Localization of PLEK 44 0.78 15.83 9.55 5.00
190 INT81264 Positive_regulation of Localization of Ngf 13 0.58 9.82 9.53 5.00
191 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43 5.00
192 INT107898 Gene_expression of Trpv2 27 0.76 10.55 9.28 5.00
193 INT119098 Positive_regulation of TRPV3 20 0.68 10.12 9.01 5.00
194 INT49802 Localization of MUC1 75 0.81 44.74 8.87 5.00
195 INT71478 Positive_regulation of Positive_regulation of Prkaca 21 0.37 5.14 8.85 5.00
196 INT146241 Positive_regulation of Gene_expression of Trpa1 23 0.69 8.07 8.74 5.00
197 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 5.00
198 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
199 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
200 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 5.00
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