D:Toxic Megacolon

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pChart

Disease Term
Synonyms None
Documents 52
Hot Single Events 1
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Toxic Megacolon. They are ordered first by their relevance to Toxic Megacolon and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT229098 Binding of TP53 and IER3 1 0.01 1.47 0.03 15.04
2 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
3 INT294681 Tlr4 Positive_regulation of Positive_regulation of NFKB1 1 0.02 0.27 0.1 5.00
4 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08 5.00
5 INT294679 GPI Positive_regulation of Gene_expression of Il12a 1 0.00 0.69 0.08 5.00
6 INT294680 Binding of TLR2 and Tlr4 1 0.09 0.58 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Toxic Megacolon. They are ordered first by their pain relevance and then by number of times they were reported in Toxic Megacolon. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 87.72
2 INT12082 Localization of IL6 365 0.81 241.78 105.78 70.72
3 INT10763 Localization of IL2 157 0.80 81.11 33.21 66.28
4 INT4931 Localization of IFNG 53 0.78 33.25 13.65 66.28
5 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 52.72
6 INT107400 Localization of Das 4 0.28 2.95 1 42.84
7 INT6852 Localization of TNF 883 0.81 705.95 270.84 29.68
8 INT6849 Localization of IL1B 229 0.81 112.56 69.63 29.68
9 INT258482 Gene_expression of NCKAP1 1 0.02 1.52 0.08 24.16
10 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 23.36
11 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 23.36
12 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 23.36
13 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 22.88
14 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 22.88
15 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 22.88
16 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 22.40
17 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 22.40
18 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 22.40
19 INT70896 Gene_expression of PDGFB 48 0.65 33.55 8.39 22.08
20 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 17.92
21 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 10.56
22 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 7.24
23 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
24 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
25 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
26 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
27 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
28 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
29 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 5.00
30 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
31 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
32 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6 5.00
33 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
34 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 5.00
35 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 5.00
36 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
37 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 5.00
38 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
39 INT66208 Positive_regulation of Positive_regulation of NFKB1 45 0.68 20.17 22.62 5.00
40 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
41 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
42 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
43 INT35086 Positive_regulation of Gene_expression of Ifng 40 0.69 22.55 18.35 5.00
44 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
45 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
46 INT10870 Regulation of IgG 67 0.59 43.27 12.74 5.00
47 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65 5.00
48 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 5.00
49 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
50 INT91337 Gene_expression of CCL4 29 0.75 16.23 8.64 5.00
51 INT30526 Negative_regulation of PTAFR 15 0.58 8.15 8.19 5.00
52 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
53 INT22450 Gene_expression of GPI 31 0.58 18.77 6.71 5.00
54 INT207892 Binding of Tlr9 35 0.46 26.66 6.61 5.00
55 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4 5.00
56 INT48234 Negative_regulation of Gene_expression of PTAFR 11 0.57 3.97 6.25 5.00
57 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95 5.00
58 INT24889 Negative_regulation of CABIN1 36 0.48 16.76 4.73 5.00
59 INT135990 Positive_regulation of Gene_expression of Cd86 34 0.69 12.02 4.53 5.00
60 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52 5.00
61 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
62 INT93912 Positive_regulation of CD80 11 0.56 7.01 1.88 5.00
63 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86 5.00
64 INT23932 Negative_regulation of ST8SIA2 4 0.22 1.26 1.73 5.00
65 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61 5.00
66 INT45230 Regulation of CD79A 20 0.44 9.3 1.59 5.00
67 INT209896 Positive_regulation of Gene_expression of CD80 19 0.49 11.9 1.59 5.00
68 INT190367 Gene_expression of Defa1 10 0.75 8.92 1.5 5.00
69 INT97142 Localization of IL12B 5 0.73 1.73 1.46 5.00
70 INT155845 Transcription of SOAT1 6 0.67 2.89 1.4 5.00
71 INT262876 Localization of ST8SIA2 2 0.16 1.41 1.39 5.00
72 INT262878 Gene_expression of ST8SIA2 7 0.39 4.7 1.01 5.00
73 INT107107 Gene_expression of DEFA1 4 0.01 3.37 1 5.00
74 INT262858 Positive_regulation of Defa1 2 0.67 1.54 0.89 5.00
75 INT191533 Gene_expression of TRAF3IP2 2 0.36 1.83 0.62 5.00
76 INT138676 Localization of ADAM17 4 0.73 4.91 0.5 5.00
77 INT353074 Negative_regulation of TRAF3IP2 1 0.23 0.23 0.33 5.00
78 INT262877 Negative_regulation of Gene_expression of DEFA1 1 0.01 0.92 0.19 5.00
79 INT294675 Localization of Il12b 2 0.78 1.15 0.19 5.00
80 INT262875 Positive_regulation of DEFA1 2 0.17 0.58 0.06 5.00
81 INT262879 Regulation of Gene_expression of ST8SIA2 2 0.10 1.24 0.03 5.00
82 INT262874 Positive_regulation of Gene_expression of ST8SIA2 3 0.11 1.82 0 5.00
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