D:Toxicity

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pChart

Disease Term
Synonyms Drug Safety, Drug Toxicities, DRUG TOXICITY, Safety Drug, TOXICITIES DRUG, Toxicity Drug
Documents 13566
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Toxicity. They are ordered first by their relevance to Toxicity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT186889 Binding of AHR and PC 1 0.05 1.06 0 100.00
2 INT172836 Binding of INS and T2dm2 1 0.00 1.65 0.08 100.00
3 INT338941 Binding of Ggh and Mtx1 1 0.30 0.47 0.27 100.00
4 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38 100.00
5 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89 100.00
6 INT349586 Aap Regulation of Gene_expression of Ros1 1 0.03 0.56 1.17 100.00
7 INT243524 Positive_regulation of Binding of NTF3 and SOX10 1 0.01 0.54 0.14 100.00
8 INT243525 Binding of NTF3 and SOX10 1 0.01 0.54 0.14 100.00
9 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49 100.00
10 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0 100.00
11 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49 100.00
12 INT145433 Binding of CPOX and HMOX2 1 0.01 0.42 0.49 100.00
13 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47 100.00
14 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47 100.00
15 INT64735 Mptp1 Positive_regulation of Mpz 1 0.22 0.59 0.14 100.00
16 INT173725 Binding of Gucy2c and Ccl4 1 0.08 0.53 0.12 100.00
17 INT342223 Binding of TRNAI1 and Ppara 1 0.03 0.18 0 100.00
18 INT342224 Negative_regulation of Binding of TRNAI1 and Ppara 1 0.03 0.18 0 100.00
19 INT172818 Binding of T2dm2 and Hypism 1 0.00 3.62 0.1 99.96
20 INT167355 VEGFA Regulation of RYBP 1 0.01 0.53 0.68 99.96
21 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24 99.96
22 INT172835 Binding of AGT and T2dm2 1 0.00 1.73 0 99.96
23 INT160829 Tyr Regulation of RYBP 1 0.04 0.75 0.53 99.96
24 INT108438 Grin2b Regulation of Pdyn 1 0.16 0.25 0.9 99.96
25 INT342230 Binding of ARC and PKD1P4 1 0.01 5.72 0.07 99.92
26 INT301665 CYP2C9 Regulation of Binding of Ppara 1 0.26 1.79 0.34 99.92
27 INT194865 Binding of SIGMAR1 and Positive_regulation of IL1B 1 0.01 0.62 0.35 99.92
28 INT194862 SIGMAR1 Positive_regulation of IL1B 1 0.01 0.62 0.35 99.92
29 INT128684 Binding of TGM1 and RETNLB 1 0.00 2.46 0.72 99.82
30 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94 99.76
31 INT144282 ACP1 Negative_regulation of Positive_regulation of PHOSPHO2 1 0.05 0.58 0.94 99.76
32 INT341316 Negative_regulation of Binding of RTN4R and HCC 1 0.02 0.79 0 99.74
33 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09 99.64
34 INT34825 Aap Negative_regulation of Gsr 1 0.01 0.3 0.75 99.64
35 INT250669 Binding of TP53 and ST8SIA4 1 0.02 0.51 0 99.64
36 INT337047 Art2b Positive_regulation of Gene_expression of S100a8 1 0.00 1.03 0.42 99.60
37 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48 99.58
38 INT354710 Pick1 Regulation of ASIC1 1 0.37 1.12 0.21 99.56
39 INT341315 Binding of RTN4R and HCC 1 0.02 0.74 0 99.56
40 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19 99.46
41 INT317313 Atp13a2 Negative_regulation of Snca 1 0.13 0.59 0 99.40
42 INT329265 Binding of Ptk2 and Wnt2 1 0.05 1.04 0.07 99.36
43 INT93388 Rbm39 Positive_regulation of Positive_regulation of Pdyn 1 0.03 0.32 1.4 99.36
44 INT144284 ACP1 Negative_regulation of PHOSPHO2 1 0.05 0.58 0.93 99.36
45 INT172839 Binding of ANGPT2 and T2dm2 1 0.00 1.72 0 99.32
46 INT167747 Negative_regulation of Nfkb1 Negative_regulation of Positive_regulation of Nfe2l2 1 0.45 0.41 0.11 99.32
47 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0 99.32
48 INT212083 Binding of SSRP1 and NOXO1 1 0.02 0.67 0 99.28
49 INT354719 Binding of ASIC1 and Pick1 1 0.40 2.34 0.4 99.24
50 INT77098 Nlrp1a Negative_regulation of Positive_regulation of Ppig 1 0.47 0.68 0.53 99.24
51 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0 99.16
52 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27 99.12
53 INT349537 Smcp Positive_regulation of Tnfsf10 1 0.38 3.48 0.28 99.08
54 INT349585 Aap Positive_regulation of Etf1 1 0.00 1.68 1.94 98.94
55 INT161082 asp3 Regulation of Gpt 1 0.23 0.67 0.4 98.92
56 INT167745 Negative_regulation of Nfkb1 Negative_regulation of Nfe2l2 1 0.45 0.41 0.11 98.92
57 INT322558 Binding of AKT1 and TNFSF10 1 0.05 1.59 0 98.92
58 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08 98.88
59 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93 98.88
60 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98 98.72
61 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03 98.68
62 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64 98.68
63 INT345209 Repin1 Positive_regulation of Positive_regulation of Trib3 1 0.00 0.88 0.18 98.60
64 INT146112 Binding of Il1b and Tnf 1 0.32 1.19 0.56 98.56
65 INT310231 INS Negative_regulation of Binding of SUCLA2 1 0.06 0.46 0 98.56
66 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99 98.52
67 INT193778 ITIH4 Positive_regulation of CASP3 1 0.03 0.98 0.03 98.44
68 INT324692 Binding of Cd14 and Sod1m 1 0.01 1.07 0.03 98.36
69 INT193784 ITIH4 Positive_regulation of YWHAZ 1 0.04 1.21 0.34 98.32
70 INT215286 Siglec1 Negative_regulation of Gene_expression of Ros1 1 0.00 2.76 0.25 98.30
71 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33 98.24
72 INT124377 Prodh2 Negative_regulation of Defb40 1 0.00 0.66 0.33 98.24
73 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33 98.24
74 INT277433 Wibg Positive_regulation of Gdnf 1 0.01 0.6 0.13 98.20
75 INT277430 Wibg Positive_regulation of Gene_expression of Gdnf 1 0.01 0.6 0.13 98.20
76 INT237979 PPARA Negative_regulation of Birc5 1 0.49 1.26 0 98.20
77 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59 98.16
78 INT310229 Binding of INS and SUCLA2 1 0.07 4.69 0 98.08
79 INT74872 Igh-Dex Positive_regulation of Chd7 1 0.01 0.5 0.89 97.92
80 INT249117 Binding of Abl1 and Bcr 4 0.36 2.22 0.09 97.84
81 INT231305 Positive_regulation of Binding of Prnp and Helt 1 0.03 1.63 0.19 97.80
82 INT233304 Binding of SRY and SLC22A8 1 0.34 0.93 0 97.76
83 INT349535 Binding of Smcp and Tnfsf10 1 0.36 6.79 0 97.76
84 INT349532 Positive_regulation of Binding of Smcp and Tnfsf10 1 0.35 2.16 0 97.76
85 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35 97.60
86 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08 97.56
87 INT114735 Mtx1 Regulation of Ptgs1 1 0.01 0.31 0.69 97.56
88 INT242165 Wnt2 Positive_regulation of Gene_expression of Fzd1 1 0.15 0.26 0 97.52
89 INT121382 Casr Positive_regulation of Abcc3 1 0.32 0.25 0.19 97.32
90 INT121381 Casr Positive_regulation of Positive_regulation of Abcc3 1 0.30 0.25 0.19 97.32
91 INT121380 Casr Positive_regulation of Positive_regulation of Cyp3a11 1 0.15 0.25 0.18 97.32
92 INT346418 Sv2a Positive_regulation of Binding of Tesc 1 0.02 0.1 0.04 97.32
93 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34 97.28
94 INT337917 Binding of sb and Tgfbr1 1 0.00 1.06 0 97.20
95 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41 97.16
96 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95 97.16
97 INT260439 Positive_regulation of Binding of IFNA1 and Il6 1 0.01 1.08 0.07 97.08
98 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57 97.00
99 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7 96.80
100 INT281881 Binding of Aco1 and Ros1 1 0.01 1.93 0.1 96.76
101 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0 96.76
102 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0 96.76
103 INT284393 Positive_regulation of Binding of ABCA1 and Vegfa 1 0.00 0.36 0 96.48
104 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65 96.44
105 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19 96.44
106 INT349511 Ptpn2 Positive_regulation of Ptpn2 Negative_regulation of Th 1 0.16 1.3 0.03 96.44
107 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 0.06 0.73 1.85 96.40
108 INT260442 Binding of IFNA1 and Il6 1 0.01 1.07 0.07 96.40
109 INT337066 Binding of DPYD and FRA1E 1 0.19 0.8 0 96.32
110 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06 96.24
111 INT168010 Asap1 Positive_regulation of HBG2 1 0.01 3.03 1.82 96.24
112 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52 96.00
113 INT85742 Pdyn Positive_regulation of Rbm39 1 0.01 0.17 1.29 96.00
114 INT173977 Binding of TNF and Ighg1 1 0.03 0.28 0.39 96.00
115 INT353203 TNNT1 Regulation of Tnnt3 1 0.26 0.19 0.04 96.00
116 INT353204 TNNT1 Regulation of Chkb 1 0.08 0.19 0.04 96.00
117 INT207251 TXNIP Positive_regulation of ZNF236 1 0.03 0.84 0 95.92
118 INT354712 Pick1 Positive_regulation of Gene_expression of ASIC1 1 0.39 0.74 0.11 95.88
119 INT109098 Binding of ABL2 and PON1 1 0.36 1.32 0.28 95.84
120 INT239501 Binding of Adora2a and Mtx1 1 0.24 0.95 0.64 95.68
121 INT239503 Binding of Adora2a and Aes 1 0.24 0.85 0.35 95.68
122 INT186381 TNF Positive_regulation of Nos2 1 0.04 1.17 0 95.68
123 INT284392 Binding of ABCA1 and Vegfa 1 0.00 0.71 0 95.64
124 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1 95.56
125 INT242166 Fzd1 Positive_regulation of Positive_regulation of Wnt2 1 0.13 0.24 0 95.44
126 INT250247 FCGR3A Negative_regulation of AQP4 1 0.01 0.87 0.62 95.44
127 INT88500 RYBP Negative_regulation of Positive_regulation of Gtf3a 1 0.00 0.19 0.73 95.40
128 INT313306 KEAP1 Positive_regulation of SPARC 1 0.02 0.37 0 95.36
129 INT154236 Binding of TBX3 and Ugt2b7 1 0.41 0.74 1 95.28
130 INT242159 Wnt2 Positive_regulation of Localization of Casp3 1 0.05 0.25 0 95.28
131 INT194858 Binding of IL1B and SIGMAR1 1 0.01 0.55 0.3 95.12
132 INT317320 Binding of Snca and Atp13a2 1 0.08 0.58 0 95.12
133 INT239560 MSC Regulation of Gene_expression of IFN1@ 1 0.11 0.87 0.04 95.04
134 INT303815 Binding of Igfals and Tdp1 1 0.11 1.68 0.1 95.00
135 INT147179 Esr1 Regulation of Gene_expression of Penk 1 0.01 0.68 0.46 94.88
136 INT220524 Ppara Negative_regulation of Positive_regulation of Gdf15 1 0.01 0.56 0.17 94.88
137 INT220516 Ppara Negative_regulation of Positive_regulation of Atf3 1 0.10 0.56 0.17 94.88
138 INT183322 Binding of CNNM4 and RBM4B 1 0.12 0.59 0.46 94.84
139 INT336179 Binding of CACNA1F and DLST 1 0.01 1.6 0 94.68
140 INT215272 Siglec1 Regulation of Mpz 1 0.01 0.67 0.03 94.60
141 INT349587 Binding of Aap and Csf2 1 0.04 0.41 1.18 94.56
142 INT354682 Binding of ASIC1 and PKN1 1 0.01 0.19 0.04 94.40
143 INT250253 Binding of AQP4 and SLC1A2 1 0.30 2.95 1.09 94.32
144 INT353191 Renbp Regulation of Gene_expression of Yif1 1 0.00 0.55 0 93.84
145 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4 93.76
146 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37 93.76
147 INT265451 CSPG4 Positive_regulation of RNGTT 1 0.03 0.24 0.04 93.76
148 INT265457 CSPG4 Negative_regulation of IL6 1 0.06 0.24 0.04 93.76
149 INT95206 Binding of CSF2 and IL2 1 0.40 1.81 0.4 93.60
150 INT354715 Binding of PKN1 and Pick1 1 0.01 0.19 0.04 93.52
151 INT153728 RYBP Positive_regulation of Gpt 3 0.03 2.01 2.36 93.36
152 INT315267 Gopc Negative_regulation of Gene_expression of Nfe2l2 1 0.09 0.48 0 93.28
153 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13 93.20
154 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13 93.20
155 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14 93.08
156 INT335840 Binding of GAST and Sult1e1 1 0.03 1.15 0.12 92.92
157 INT353872 Binding of KCNH1 and KCNH2 1 0.25 0.98 0 92.84
158 INT353870 Binding of KCNH1 and KCNH2 Negative_regulation of KCNH1 1 0.28 0.98 0 92.84
159 INT353871 Negative_regulation of Binding of KCNH1 and KCNH2 1 0.30 0.98 0 92.84
160 INT227484 pk Regulation of Proc 1 0.00 0.27 0 92.80
161 INT212085 Regulation of Binding of NOVA2 and SSRP1 1 0.03 0.71 0 92.64
162 INT212082 Binding of NOVA2 and SSRP1 1 0.03 0.71 0 92.64
163 INT312573 AMBP Negative_regulation of IL6 1 0.11 1.41 0.32 92.52
164 INT312571 AMBP Negative_regulation of Positive_regulation of IL6 1 0.11 1.41 0.32 92.52
165 INT315262 Negative_regulation of Keap1 Negative_regulation of Gene_expression of Nfe2l2 1 0.30 0.48 0 92.36
166 INT164618 Binding of SLCO2B1 and Positive_regulation of ABCC1 1 0.52 0.18 0 92.32
167 INT164621 Binding of SLCO2B1 and Positive_regulation of Gene_expression of ABCC1 1 0.52 0.18 0 92.32
168 INT202808 Binding of Pin1 and Hnrpd 1 0.08 0.84 0.22 92.32
169 INT164624 Binding of SLCO2B1 and Positive_regulation of ABCC4 1 0.41 0.09 0 92.32
170 INT164620 Binding of SLCO2B1 and Positive_regulation of ABCC5 1 0.41 0.09 0 92.32
171 INT275398 Binding of ITIH4 and Htatsf1 1 0.02 5.05 2.24 92.16
172 INT52585 RPL35AP35 Positive_regulation of Positive_regulation of Ca2 1 0.00 0.34 0.24 92.12
173 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08 92.08
174 INT342231 Binding of SEPP1 and ARC 1 0.04 3.84 0.08 92.00
175 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46 91.84
176 INT164622 SLCO2B1 Positive_regulation of Gene_expression of ABCC1 1 0.52 0.18 0 91.56
177 INT164625 SLCO2B1 Positive_regulation of ABCC1 1 0.52 0.18 0 91.56
178 INT164623 SLCO2B1 Positive_regulation of ABCC5 1 0.41 0.09 0 91.56
179 INT164619 SLCO2B1 Positive_regulation of ABCC4 1 0.41 0.09 0 91.56
180 INT315261 Gopc Regulation of Gene_expression of Rela 1 0.03 0.6 0 91.36
181 INT315268 Gopc Positive_regulation of Binding of Nfe2l2 1 0.10 0.09 0 91.20
182 INT117412 RYBP Negative_regulation of LIG4 1 0.00 0.42 0.76 91.16
183 INT354721 Pick1 Regulation of Gene_expression of ASIC1 1 0.37 1.1 0.2 91.12
184 INT334765 Ednra Positive_regulation of Positive_regulation of Car2 1 0.02 0.24 0.14 91.12
185 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14 91.12
186 INT334772 Ednra Positive_regulation of Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14 91.12
187 INT201722 Myc Regulation of Gene_expression of Ccnd1 1 0.03 0.79 0.13 91.08
188 INT231301 Prnp Regulation of Regulation of Grin1 1 0.26 0.24 0.08 91.04
189 INT336388 Binding of IL2 and ALPK1 1 0.06 0.73 0.05 90.96
190 INT317396 Binding of Car2 and Prkag1 1 0.07 0.31 0 90.96
191 INT349576 Binding of Ugt2b and Sult1a1 1 0.00 0.45 1.03 90.72
192 INT268629 Mpz Regulation of Phosphorylation of Gsk3b 1 0.26 1.05 0.03 90.72
193 INT307602 Binding of ACHE and LRP5 1 0.01 0.17 0 90.68
194 INT261893 Binding of Htt and Hap1 1 0.13 0.49 0 90.44
195 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45 90.40
196 INT28864 Mtx1 Negative_regulation of Dhfr 1 0.19 0.87 0.44 90.40
197 INT210225 Ptpn2 Positive_regulation of Gene_expression of Ifng 1 0.15 1.44 0.42 90.40
198 INT193779 Positive_regulation of ITIH4 Positive_regulation of CXCR4 1 0.19 0.83 0.15 90.36
199 INT256587 Binding of ALB and TTR 1 0.35 0.69 0 90.36
200 INT88310 ITIH4 Positive_regulation of CXCR4 2 0.27 1.98 0.23 90.36

Single Events

The table below shows the top 200 pain related interactions that have been reported for Toxicity. They are ordered first by their pain relevance and then by number of times they were reported in Toxicity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
2 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 100.00
3 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 100.00
4 INT119544 Gene_expression of Nfe2l2 50 0.77 19.32 4.19 100.00
5 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 100.00
6 INT65500 Gene_expression of App 605 0.78 429.94 98.31 100.00
7 INT192806 Binding of SSRP1 11 0.27 9.12 0.37 100.00
8 INT192807 Gene_expression of SSRP1 14 0.49 19.28 1.15 100.00
9 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87 100.00
10 INT183333 Positive_regulation of Gene_expression of CNNM4 1 0.34 2.85 0 100.00
11 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 100.00
12 INT101818 Gene_expression of NFE2L2 48 0.78 23.8 0.66 100.00
13 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 100.00
14 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67 100.00
15 INT144623 Negative_regulation of Gene_expression of Nfe2l2 10 0.47 3.6 1.17 100.00
16 INT80037 Gene_expression of BAK1 58 0.75 39.49 9.08 100.00
17 INT178587 Positive_regulation of DPYD 4 0.50 4.7 0.74 100.00
18 INT161107 Gene_expression of Ptpn2 58 0.58 49.92 7.4 100.00
19 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 100.00
20 INT4977 Binding of ITIH4 60 0.46 42.48 15.65 100.00
21 INT7029 Regulation of Pdyn 51 0.61 12.89 40.34 100.00
22 INT143357 Binding of Ros1 48 0.36 27.76 6 100.00
23 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62 100.00
24 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 100.00
25 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 100.00
26 INT201130 Localization of AES 31 0.63 25.45 5.12 100.00
27 INT101832 Positive_regulation of Gene_expression of NFE2L2 16 0.67 7.41 0.12 100.00
28 INT212098 Positive_regulation of NOXO1 1 0.06 0.88 0 100.00
29 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 100.00
30 INT187489 Localization of ATIC 1 0.07 4.03 1.81 100.00
31 INT72055 Gene_expression of ATP6AP1 1 0.29 0.65 0.49 100.00
32 INT155093 Positive_regulation of CFLAR 6 0.67 5.02 0.88 100.00
33 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76 100.00
34 INT160828 Regulation of Gene_expression of Ros1 29 0.21 13.97 3.75 100.00
35 INT315237 Negative_regulation of Gene_expression of Keap1 4 0.38 1.55 0 100.00
36 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83 100.00
37 INT159494 Gene_expression of CDAN1 8 0.65 4.55 0.58 100.00
38 INT247824 Positive_regulation of CDAN1 4 0.33 2.4 0.32 100.00
39 INT161501 Binding of PC 20 0.47 5.74 0.72 100.00
40 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04 100.00
41 INT207292 Gene_expression of ZNF236 1 0.04 5.78 1.05 100.00
42 INT212090 Regulation of Gene_expression of SSRP1 2 0.33 1.02 0.09 100.00
43 INT212091 Negative_regulation of Binding of SSRP1 1 0.12 0.57 0 100.00
44 INT151978 Negative_regulation of Positive_regulation of Cys1 3 0.41 4.15 0.24 100.00
45 INT172784 Binding of Iapp 3 0.31 3.56 0.12 100.00
46 INT29373 Negative_regulation of Antxr2 1 0.58 0.77 0.25 100.00
47 INT243548 Positive_regulation of Gene_expression of PSPH 1 0.04 0.69 0 100.00
48 INT173519 Positive_regulation of Localization of IFNA1 27 0.49 24.48 3.9 100.00
49 INT284672 Gene_expression of ZFAND2B 1 0.11 1.03 0.04 100.00
50 INT251607 Transcription of Msn 1 0.57 0.93 0.46 100.00
51 INT5988 Localization of Dbi 74 0.81 17.52 24.09 100.00
52 INT11769 Regulation of Mptp1 8 0.60 6.38 2.68 100.00
53 INT24711 Negative_regulation of Spna1 22 0.35 14.75 3.59 100.00
54 INT124375 Gene_expression of Wnt2 67 0.56 38.03 4.67 100.00
55 INT75802 Regulation of Cyp2g1 2 0.45 0.54 1.12 100.00
56 INT193809 Regulation of Binding of ITIH4 2 0.31 1.82 1.59 100.00
57 INT117548 Positive_regulation of SETBP1 2 0.45 0.57 1.34 100.00
58 INT38037 Regulation of Rac2 2 0.38 0.79 0.57 100.00
59 INT207274 Negative_regulation of Gene_expression of ZNF236 1 0.03 1.33 0 100.00
60 INT130198 Negative_regulation of Binding of PTGS1 3 0.34 2.6 1.16 100.00
61 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 100.00
62 INT101815 Binding of KEAP1 6 0.44 5.29 0.39 100.00
63 INT149066 Regulation of CA3 5 0.44 0.89 2.02 100.00
64 INT243535 Regulation of CA4 1 0.09 0.7 0.15 100.00
65 INT230487 Positive_regulation of KIDINS220 1 0.10 0.63 0 100.00
66 INT107576 Gene_expression of Atf3 114 0.78 72.42 38.64 100.00
67 INT23782 Positive_regulation of Spna1 58 0.50 35.41 6.94 100.00
68 INT210032 Binding of Serpina5 4 0.18 1.87 0.12 100.00
69 INT32707 Positive_regulation of Sln 2 0.49 1.3 0.32 100.00
70 INT145654 Negative_regulation of Sod2 4 0.59 2.81 1.33 100.00
71 INT281868 Negative_regulation of Park7 1 0.00 1.69 0.14 100.00
72 INT323218 Gene_expression of ZC3H15 1 0.05 2.59 0.07 100.00
73 INT4631 Positive_regulation of Sst 127 0.70 17.37 83.29 100.00
74 INT36356 Positive_regulation of Gene_expression of Mptp1 1 0.10 0.89 0.22 100.00
75 INT251603 Positive_regulation of Transcription of Msn 1 0.41 0.42 0.29 100.00
76 INT7673 Negative_regulation of ENG 31 0.42 7.9 8.61 100.00
77 INT81921 Gene_expression of HSF1 17 0.76 9.19 1.08 100.00
78 INT219657 Regulation of H2BFS 3 0.06 0.83 0 100.00
79 INT349574 Transcription of Aap 1 0.17 0.45 1.23 100.00
80 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 100.00
81 INT18025 Binding of Pah 32 0.45 30.72 7.93 100.00
82 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7 100.00
83 INT134375 Gene_expression of Cflar 14 0.58 8.4 2.66 100.00
84 INT268616 Positive_regulation of Gene_expression of Ptpn2 7 0.43 8.14 2.08 100.00
85 INT5647 Positive_regulation of Mptp1 5 0.30 3.6 2.01 100.00
86 INT124373 Positive_regulation of Gene_expression of Wnt2 14 0.42 8.28 0.6 100.00
87 INT26294 Regulation of Gem 2 0.18 1.73 0.6 100.00
88 INT114093 Regulation of Cish 4 0.20 1.77 0.42 100.00
89 INT194050 Positive_regulation of PM20D2 5 0.05 2.16 0.32 100.00
90 INT266972 Positive_regulation of Atn1 1 0.12 0.88 0.28 100.00
91 INT174925 Binding of Hspg2 3 0.05 1.11 0.24 100.00
92 INT113024 Regulation of Gene_expression of Xdh 1 0.03 0.1 0.16 100.00
93 INT320580 Negative_regulation of Gene_expression of Agxt 1 0.04 0.1 0.11 100.00
94 INT249943 Positive_regulation of Binding of Hspg2 1 0.03 0.28 0.05 100.00
95 INT307613 Phosphorylation of LRP5 1 0.08 0.1 0 100.00
96 INT355163 Regulation of Localization of AES 1 0.28 1.13 0 100.00
97 INT203702 Protein_catabolism of BGLAP 4 0.52 0.35 0 100.00
98 INT325763 Negative_regulation of Binding of Omd 1 0.02 0.81 0 100.00
99 INT192916 Gene_expression of MIER3 1 0.04 2.47 0 100.00
100 INT355161 Regulation of Localization of RASSF1 1 0.44 1.13 0 100.00
101 INT355162 Regulation of Localization of CDKN2A 1 0.40 1.13 0 100.00
102 INT307611 Positive_regulation of Phosphorylation of LRP5 1 0.05 0.1 0 100.00
103 INT254046 Protein_catabolism of EBF1 1 0.19 0.1 0 100.00
104 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 99.98
105 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 99.98
106 INT94784 Binding of ROS1 113 0.40 71.57 10.26 99.98
107 INT91899 Binding of Sod1 17 0.47 11.56 2.63 99.98
108 INT131596 Positive_regulation of Gene_expression of Keap1 6 0.52 2.09 0.16 99.98
109 INT4060 Gene_expression of Bche 17 0.70 5.23 6.59 99.98
110 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 99.98
111 INT77076 Positive_regulation of Ppig 16 0.49 13.54 5.91 99.98
112 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 99.98
113 INT29745 Binding of APP 47 0.48 26.49 12.4 99.98
114 INT49866 Negative_regulation of Parp1 53 0.58 35.37 8.84 99.98
115 INT147471 Positive_regulation of Gene_expression of Nfe2l2 10 0.57 4.18 1.43 99.98
116 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11 99.98
117 INT94441 Regulation of Gene_expression of Tcf21 1 0.11 0.51 0.58 99.98
118 INT219713 Negative_regulation of Gene_expression of Spna1 4 0.29 2.63 0.52 99.98
119 INT200373 Binding of Omd 7 0.34 7.03 0.34 99.98
120 INT351824 Regulation of Binding of HLA-E 1 0.03 0.89 0.03 99.98
121 INT203263 Binding of Clptm1l 1 0.00 0.52 0 99.98
122 INT22967 Positive_regulation of RYBP 94 0.56 37.04 85.92 99.96
123 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 99.96
124 INT18884 Regulation of RYBP 25 0.38 11.43 23.2 99.96
125 INT18526 Positive_regulation of Aap 19 0.56 12.28 14.57 99.96
126 INT91158 Regulation of Ros1 26 0.25 17 4.23 99.96
127 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 99.96
128 INT243538 Regulation of SOX10 1 0.31 3.27 0.48 99.96
129 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28 99.96
130 INT243533 Positive_regulation of SOX10 1 0.35 3.93 0.92 99.96
131 INT167739 Positive_regulation of Negative_regulation of Nfe2l2 3 0.48 2.08 0.52 99.96
132 INT165597 Positive_regulation of Htt 8 0.60 4.27 0.44 99.96
133 INT20274 Regulation of Aap 9 0.45 5.55 7.27 99.96
134 INT2619 Positive_regulation of TGM1 7 0.49 5.97 1.41 99.96
135 INT133842 Binding of SOX10 3 0.38 5.79 1.02 99.96
136 INT34370 Positive_regulation of Cfp 26 0.46 15.21 6.12 99.96
137 INT70314 Positive_regulation of SUCLA2 5 0.10 3.91 0.58 99.96
138 INT78733 Gene_expression of Iapp 20 0.78 12.99 3.33 99.96
139 INT72081 Positive_regulation of Positive_regulation of Aap 1 0.02 0.37 0.25 99.96
140 INT5648 Negative_regulation of Mptp1 7 0.37 6.64 3.08 99.96
141 INT165914 Positive_regulation of Negative_regulation of Nfkb1 2 0.48 1.01 0.34 99.96
142 INT172794 Localization of Iapp 2 0.72 3.18 0.48 99.96
143 INT36355 Gene_expression of Mptp1 3 0.39 3.01 0.88 99.96
144 INT262097 Gene_expression of Clta 1 0.08 0.64 0.34 99.96
145 INT5512 Negative_regulation of Dbi 32 0.36 7.33 9.1 99.96
146 INT47348 Binding of Ccl4 8 0.37 3.24 1.08 99.96
147 INT291915 Positive_regulation of Regulation of RYBP 1 0.01 0.57 0.58 99.96
148 INT100480 Negative_regulation of Mpz 8 0.37 4.2 1.08 99.96
149 INT310233 Positive_regulation of Positive_regulation of SUCLA2 1 0.10 0.87 0 99.96
150 INT265485 Positive_regulation of Localization of BAK1 4 0.50 5.17 0.12 99.96
151 INT229200 Gene_expression of Pc 13 0.65 8.96 2.32 99.96
152 INT186121 Gene_expression of Agxt 6 0.65 2.77 0.39 99.96
153 INT308111 Positive_regulation of Localization of PGF 2 0.49 0.88 0.12 99.96
154 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 99.92
155 INT138556 Positive_regulation of TYMP 23 0.58 12.9 0.28 99.92
156 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 99.92
157 INT154198 Binding of Pick1 9 0.48 6.91 3.16 99.92
158 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 99.92
159 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 99.92
160 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51 99.92
161 INT121943 Positive_regulation of Nr1i2 64 0.68 19.22 8.39 99.92
162 INT186912 Protein_catabolism of EIF1 1 0.10 1.88 0.39 99.92
163 INT64787 Regulation of ITIH4 7 0.38 5.61 1.82 99.92
164 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 99.92
165 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39 99.92
166 INT66857 Regulation of CCL2 39 0.53 28.55 18.35 99.92
167 INT373 Regulation of Ldha 37 0.61 17.86 11.41 99.92
168 INT193806 Positive_regulation of Positive_regulation of MAP3K4 1 0.03 1.03 0.04 99.92
169 INT243550 Gene_expression of PSPH 7 0.25 7.49 0.4 99.92
170 INT38038 Negative_regulation of Rac2 1 0.36 0.79 0.55 99.92
171 INT131335 Negative_regulation of Regulation of Ldha 1 0.25 0.56 0.06 99.92
172 INT193811 Localization of CXCR4 6 0.75 7.68 0.58 99.92
173 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 99.92
174 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 99.92
175 INT102255 Regulation of Prnp 35 0.62 18.97 3.25 99.92
176 INT169352 Negative_regulation of Timp3 10 0.58 6.94 1.92 99.92
177 INT105012 Negative_regulation of Atr 1 0.34 0.35 0.16 99.92
178 INT876 Localization of Gh1 843 0.80 67.75 340.82 99.92
179 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 99.92
180 INT105760 Negative_regulation of Casr 5 0.58 0.93 2.17 99.92
181 INT191845 Regulation of Negative_regulation of CYP2E1 1 0.45 0.26 0.03 99.92
182 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 99.90
183 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 99.90
184 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 99.90
185 INT156489 Positive_regulation of Gene_expression of Bace1 67 0.69 41.07 7.02 99.90
186 INT212088 Positive_regulation of Gene_expression of SSRP1 3 0.37 3.53 0.41 99.90
187 INT123242 Negative_regulation of Casc5 1 0.04 0.95 1.13 99.90
188 INT167049 Binding of Ednra 3 0.07 3.47 6.84 99.90
189 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 99.90
190 INT203813 Negative_regulation of Lna1 1 0.17 1.73 0.42 99.90
191 INT72054 Positive_regulation of Clybl 1 0.18 0.37 0.26 99.90
192 INT190335 Negative_regulation of Positive_regulation of IFN1@ 16 0.42 4.6 1.29 99.90
193 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4 99.90
194 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51 99.90
195 INT105697 Negative_regulation of KLK4 7 0.43 2.78 0.93 99.90
196 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 99.88
197 INT232362 Gene_expression of Mgmt 10 0.76 8.08 0.41 99.88
198 INT232363 Positive_regulation of Gene_expression of Mgmt 8 0.49 6.01 0.28 99.88
199 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76 99.88
200 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57 99.88
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