D:Trepenoma Infection

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Disease Term
Synonyms Acquired Syphilis, Argyll Robertson Pupil, CARDIOVASCULAR SYPHILIS, Chancroid, Condyloma Lata, Fluorescent Trepanomal Antibody Absorption, FTA ABS, Hatts, Late Syphilis, LUES, Meningovascular Neurosyphilis
Documents 573
Hot Single Events 66
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Trepenoma Infection. They are ordered first by their relevance to Trepenoma Infection and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT116792 Bsg Positive_regulation of Protein_catabolism of NOS2 1 0.23 0.18 0.09 91.04
2 INT116789 Bsg Positive_regulation of Gene_expression of Tgfb1 1 0.00 0.18 0.09 91.04
3 INT116788 Bsg Negative_regulation of Gene_expression of Ptges 1 0.00 0.17 0.09 85.44
4 INT221068 Cd79a Regulation of Gene_expression of IgG 1 0.01 0.93 0.1 74.08
5 INT221067 Cd79a Regulation of IgG 1 0.01 0.93 0.1 74.08
6 INT221066 Cd79a Regulation of Gene_expression of Ighm 1 0.01 0.93 0.1 73.88
7 INT188164 Binding of ALPP and HIVEP1 1 0.02 1.15 0 61.60
8 INT302468 INCENP Positive_regulation of Gene_expression of MMP9 1 0.01 0.72 0.26 12.36
9 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62 11.96
10 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 10.20
11 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 5.00
12 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
13 INT137141 Binding of HIVEP1 and ITIH4 2 0.16 1.44 0.56 5.00
14 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53 5.00
15 INT235956 Binding of Aqp4 and NMO-IgG 1 0.04 4.53 0.5 5.00
16 INT172023 Binding of FN1 and PRTN3 1 0.00 1.05 0.37 5.00
17 INT302466 Positive_regulation of F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.1 0.35 5.00
18 INT235971 Positive_regulation of Binding of Nqo1 and NMO-IgG 1 0.00 1.86 0.32 5.00
19 INT235958 Binding of Ighg1 and Aqp4 1 0.14 1.32 0.3 5.00
20 INT235977 Binding of AQP4 and Ighg1 1 0.03 1.31 0.3 5.00
21 INT235957 Binding of Mog and Bcr 1 0.02 1.13 0.29 5.00
22 INT235962 Binding of Bcr and Trav6-3 1 0.00 1.12 0.29 5.00
23 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29 5.00
24 INT235966 Binding of Mog and Trav6-3 1 0.01 1.07 0.29 5.00
25 INT235959 Nqo1 Positive_regulation of Localization of Aqp4 1 0.02 1.39 0.26 5.00
26 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24 5.00
27 INT172022 Binding of F13A1 and FN1 1 0.00 1.33 0.24 5.00
28 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24 5.00
29 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24 5.00
30 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24 5.00
31 INT235967 Binding of Ighm and Nqo1 1 0.00 1.45 0.23 5.00
32 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 5.00
33 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18 5.00
34 INT235961 Binding of Nqo1 and Aqp4 1 0.02 0.9 0.14 5.00
35 INT174820 IL6 Positive_regulation of VEGFA 1 0.20 3.32 0.12 5.00
36 INT174821 VEGFA Positive_regulation of Gene_expression of IL6 1 0.20 3.13 0.12 5.00
37 INT235964 Binding of Atp9a and Aqp4 1 0.01 0.55 0.08 5.00
38 INT186860 MIR181A2HG Regulation of Cd86 1 0.02 1.05 0.07 5.00
39 INT186814 MIR181A2HG Regulation of ICAM1 1 0.01 1.05 0.07 5.00
40 INT235963 Snta1 Regulation of Gene_expression of Aqp4 1 0.41 0.23 0.05 5.00
41 INT235969 Binding of Ighg1 and Nqo1 1 0.01 2.63 0.04 5.00
42 INT235968 NMO-IgG Positive_regulation of Nqo1 1 0.00 2.11 0.03 5.00
43 INT192678 PTEN Regulation of Dync1h1 1 0.02 0.5 0.03 5.00
44 INT302493 Binding of AGRP and IMPACT 1 0.25 0.53 0 5.00
45 INT344266 Binding of APOH and CD40LG 1 0.04 0.31 0 5.00
46 INT235960 Binding of Aqp4 and H47 1 0.01 0.13 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Trepenoma Infection. They are ordered first by their pain relevance and then by number of times they were reported in Trepenoma Infection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT275901 Gene_expression of Rprl1 1 0.07 1.24 0 100.00
2 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 100.00
3 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 100.00
4 INT246551 Negative_regulation of Serpinb12 1 0.01 2.57 0.17 99.96
5 INT39244 Gene_expression of TMPO 137 0.77 14.55 11.83 99.84
6 INT39243 Regulation of TMPO 20 0.61 5.66 2.67 99.14
7 INT310442 Gene_expression of POLA1 1 0.30 0.97 0 99.00
8 INT5433 Regulation of polymerase 8 0.03 4.2 0.15 99.00
9 INT310443 Negative_regulation of POLA1 1 0.16 0.31 0 99.00
10 INT39242 Negative_regulation of TMPO 29 0.58 5.15 7.04 98.98
11 INT185370 Gene_expression of ANC 28 0.65 13.28 0.4 98.96
12 INT264247 Positive_regulation of Gene_expression of ANC 5 0.38 1.71 0 98.96
13 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 98.80
14 INT199510 Negative_regulation of STIP1 15 0.47 20.99 1.12 98.76
15 INT211271 Regulation of Igh-VS107 1 0.01 1.96 0.44 98.64
16 INT310439 Regulation of POLA1 1 0.24 2.21 0 98.62
17 INT2065 Binding of BTG3 15 0.36 10.9 4.65 98.56
18 INT114993 Binding of Myo5a 15 0.30 11.46 5.48 97.44
19 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 97.08
20 INT203646 Gene_expression of STIP1 26 0.63 23.57 1.14 97.04
21 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 96.96
22 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 96.96
23 INT35584 Binding of ACLY 22 0.35 31.78 7.17 96.84
24 INT259037 Negative_regulation of Binding of ACLY 1 0.07 1.54 0.13 96.84
25 INT197024 Binding of STIP1 11 0.35 10.84 0.52 96.68
26 INT17276 Negative_regulation of Gene_expression of HIVEP1 27 0.42 26.85 2.61 96.44
27 INT269406 Binding of TMPO 35 0.31 1.43 1.82 96.32
28 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 95.96
29 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 95.84
30 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 95.68
31 INT203645 Localization of STIP1 2 0.61 2.08 0 94.92
32 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 94.52
33 INT206760 Localization of Nqo1 8 0.09 15.76 2.4 94.52
34 INT225965 Localization of Aqp4 26 0.81 18.85 3.75 94.20
35 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 94.00
36 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 93.84
37 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 92.96
38 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 92.96
39 INT33243 Localization of HP 17 0.12 9.7 2.2 92.52
40 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 91.72
41 INT310441 Regulation of EXTL3 1 0.26 0.97 0 91.40
42 INT1873 Gene_expression of MRAP 51 0.76 31.75 13.92 90.96
43 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93 90.64
44 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 90.28
45 INT310440 Positive_regulation of POLA1 1 0.18 0.09 0 89.84
46 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 89.48
47 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 89.36
48 INT178751 Positive_regulation of TMPO 51 0.44 1.47 4.41 89.36
49 INT269390 Regulation of Positive_regulation of TMPO 6 0.26 0.4 0.11 89.36
50 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 89.28
51 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 88.76
52 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 88.60
53 INT116790 Positive_regulation of Protein_catabolism of NOS2 1 0.49 0.18 0.09 88.60
54 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 88.56
55 INT102751 Positive_regulation of polymerase 7 0.10 3.06 1.81 88.32
56 INT310438 Positive_regulation of Regulation of polymerase 1 0.02 0.09 0 88.32
57 INT116791 Protein_catabolism of NOS2 1 0.96 0.18 0.09 88.28
58 INT116501 Binding of ANC 4 0.36 1.8 0.18 86.48
59 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13 86.32
60 INT106509 Negative_regulation of Gene_expression of Ptges 6 0.17 1.95 1.25 85.28
61 INT186882 Gene_expression of RTEL1 13 0.27 13.45 0.49 85.04
62 INT106510 Gene_expression of Ptges 70 0.75 36.18 9.75 84.88
63 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 84.64
64 INT140170 Binding of Nqo1 24 0.38 36.16 6.79 83.04
65 INT117083 Localization of RTEL1 5 0.60 9.1 0.8 82.28
66 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 80.28
67 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 79.68
68 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 78.92
69 INT324675 Localization of SNORA1 1 0.73 1.95 0.06 78.88
70 INT7383 Localization of VIP 53 0.81 17.7 22.65 78.72
71 INT88020 Positive_regulation of Fas 32 0.70 19.78 9.97 78.64
72 INT192674 Positive_regulation of Gene_expression of Dync1h1 1 0.32 1.67 0 78.56
73 INT56376 Negative_regulation of AMBP 29 0.35 21.49 2.59 78.48
74 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 77.84
75 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 77.60
76 INT16622 Positive_regulation of PLXNA3 6 0.67 5.2 1.69 77.12
77 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 76.00
78 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 75.96
79 INT10612 Localization of NLRP3 13 0.78 8.91 2.27 74.68
80 INT257406 Localization of TNFRSF1A 3 0.46 2.6 0.55 74.68
81 INT257407 Localization of MVK 1 0.22 1.78 0.18 74.68
82 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 74.64
83 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 74.40
84 INT80005 Gene_expression of MVK 4 0.09 1.79 1.34 74.24
85 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 74.20
86 INT1767 Positive_regulation of PROC 83 0.67 54.14 17 74.20
87 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 74.08
88 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 74.04
89 INT56374 Gene_expression of AMBP 34 0.54 35.85 6.25 73.92
90 INT225056 Positive_regulation of Gene_expression of AMBP 4 0.37 5.45 0.75 73.92
91 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 73.88
92 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 73.52
93 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 73.48
94 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 68.88
95 INT21156 Binding of PLXNA3 21 0.36 7.95 3.3 68.76
96 INT172035 Binding of HMGB2 1 0.09 1.67 0.28 67.36
97 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 67.32
98 INT717 Regulation of F2 29 0.61 17.46 6.99 67.20
99 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 66.12
100 INT14043 Binding of HP 52 0.30 26.56 7.76 65.20
101 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 64.48
102 INT137250 Gene_expression of Gzmb 3 0.05 2.78 0.38 64.48
103 INT8159 Binding of ELL 7 0.36 12.62 0.84 63.84
104 INT236972 Gene_expression of TST 8 0.58 1.02 0.04 62.72
105 INT56032 Positive_regulation of NCAM1 38 0.49 26.01 4.68 62.36
106 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 60.72
107 INT182215 Regulation of CXCR5 4 0.27 4.49 2.18 59.36
108 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 59.28
109 INT259030 Negative_regulation of Gene_expression of ACLY 1 0.07 1.95 0.08 58.84
110 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 57.88
111 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 57.84
112 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 57.80
113 INT203644 Negative_regulation of Gene_expression of STIP1 2 0.37 0.54 0 57.60
114 INT88694 Gene_expression of WT1 17 0.75 21.88 0.56 56.72
115 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 56.24
116 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 56.04
117 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 56.04
118 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 56.04
119 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 56.04
120 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 55.60
121 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 55.56
122 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 55.44
123 INT236839 Positive_regulation of CXCL13 14 0.44 19.27 5.81 55.20
124 INT236842 Positive_regulation of Gene_expression of CXCL13 6 0.32 3.91 2.55 55.20
125 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 55.12
126 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 55.12
127 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 55.12
128 INT89551 Gene_expression of NEFM 13 0.44 4.74 2.22 55.04
129 INT79358 Gene_expression of ERVW-1 65 0.75 29.9 1.31 55.04
130 INT108559 Gene_expression of Pol 46 0.45 30.07 1.14 55.04
131 INT216858 Negative_regulation of PID1 4 0.35 6.3 1.11 53.68
132 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96 53.44
133 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 51.64
134 INT235713 Binding of PID1 1 0.25 1.41 0 50.88
135 INT86128 Negative_regulation of ATP2C1 1 0.09 1.65 0.31 48.76
136 INT67279 Localization of PRTN3 11 0.50 14.18 4.3 47.04
137 INT36132 Negative_regulation of pid 12 0.43 15.15 1.73 46.52
138 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 46.20
139 INT174272 Negative_regulation of Gene_expression of F3 5 0.14 4.06 0.31 46.20
140 INT94438 Gene_expression of OLR1 86 0.78 80.38 11.03 45.36
141 INT28703 Negative_regulation of TFPI 29 0.38 19.81 4.93 44.96
142 INT344281 Positive_regulation of Negative_regulation of TFPI 1 0.38 1.47 0 44.96
143 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 43.44
144 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 42.72
145 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 42.60
146 INT60252 Binding of HIVEP1 59 0.32 65.12 5.06 41.28
147 INT238096 Positive_regulation of ELL 4 0.09 2.68 0.16 40.32
148 INT86437 Binding of IL6 154 0.48 121.22 29.3 39.76
149 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 39.28
150 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 38.32
151 INT172021 Localization of Hspa5 2 0.18 0.93 0.2 36.24
152 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 36.20
153 INT22277 Positive_regulation of Gene_expression of TBXA2R 13 0.69 5.95 2.92 35.20
154 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 34.88
155 INT22276 Gene_expression of TBXA2R 65 0.77 23.22 14.21 34.60
156 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 33.24
157 INT18773 Localization of ALB 117 0.80 69.18 13.8 31.20
158 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 30.84
159 INT62760 Localization of PLXNA3 3 0.78 2.06 0.8 29.20
160 INT35009 Binding of CSAD 12 0.41 10.74 3.21 28.72
161 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 28.64
162 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 24.80
163 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 24.36
164 INT38056 Localization of Crp 71 0.78 53.14 17.03 24.36
165 INT197337 Localization of TRMT2A 1 0.04 0.73 0.05 24.16
166 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 23.20
167 INT152276 Regulation of Positive_regulation of PLG 2 0.44 1.53 0.32 23.20
168 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 22.76
169 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 22.36
170 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36 21.88
171 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68 21.52
172 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 21.28
173 INT12564 Localization of Pthlh 23 0.81 4.37 5.82 20.12
174 INT4097 Localization of Pth 66 0.81 47.17 4.36 20.12
175 INT197194 Binding of DURS1 3 0.27 4.2 0.33 18.92
176 INT197196 Negative_regulation of DURS1 2 0.43 30.6 2.37 17.76
177 INT285960 Negative_regulation of WT1 6 0.47 10.02 0 17.52
178 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 15.96
179 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 15.96
180 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 15.76
181 INT61611 Positive_regulation of ANC 17 0.41 4.43 0.31 15.12
182 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 13.28
183 INT76092 Localization of ISYNA1 10 0.66 7.72 3.11 13.16
184 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 12.36
185 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 11.04
186 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 11.04
187 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 11.04
188 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 11.04
189 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 11.04
190 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 11.04
191 INT17009 Regulation of CADPS 2 0.08 1.97 0.24 10.76
192 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 10.64
193 INT111255 Transcription of Gnb5 3 0.66 2.81 1.66 10.48
194 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 10.36
195 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 9.92
196 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 8.60
197 INT151939 Gene_expression of NPCDR1 4 0.65 1.65 0 8.48
198 INT143337 Binding of Aqp4 30 0.40 23.73 4.24 8.12
199 INT79711 Binding of M1 11 0.27 3.77 0.58 8.12
200 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 6.52
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