D:Tricuspid Valve Insufficiency

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Disease Term
Synonyms Incompetence Tricuspid, INCOMPETENCE TRICUSPID VALVE, INSUFFICIENCY TRICUSPID VALVE, Regurgitation Tricuspid, Regurgitation Tricuspid Valve, Tricuspid Incompetence, Tricuspid Regurgitation, TRICUSPID VALVE INCOMPETENCE, Tricuspid Valve Regurgitation, Valve Incompetence Tricuspid, VALVE INSUFFICIENCY TRICUSPID
Documents 175
Hot Single Events 43
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tricuspid Valve Insufficiency. They are ordered first by their relevance to Tricuspid Valve Insufficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT286902 Binding of PDGFA and VEGFA 1 0.24 1.1 0 99.76
2 INT286901 Binding of HBM and VEGFA 1 0.05 1.08 0.14 97.60
3 INT286900 Binding of HBM and PDGFA 1 0.04 1.08 0.14 97.60
4 INT286898 Binding of HBM and IL6 1 0.01 1.09 0.14 97.60
5 INT286899 Binding of IL6 and CCL2 1 0.03 0.92 0.08 60.76
6 INT309846 Binding of pad and Pah 1 0.03 0.98 0 16.04
7 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
8 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
9 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 0.08 0.25 0.64 5.00
10 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 5.00
11 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 5.00
12 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 5.00
13 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 5.00
14 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09 5.00
15 INT316552 Binding of SST and Sst1 1 0.03 0.53 0.09 5.00
16 INT273616 PVR Positive_regulation of Pah 1 0.10 0.86 0.07 5.00
17 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0 5.00
18 INT171404 ISYNA1 Positive_regulation of Negative_regulation of Ppap2a 1 0.05 0.23 0 5.00
19 INT256209 AVP Regulation of PVR 1 0.06 0.99 0 5.00
20 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tricuspid Valve Insufficiency. They are ordered first by their pain relevance and then by number of times they were reported in Tricuspid Valve Insufficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 100.00
2 INT15954 Gene_expression of Terc 6 0.66 4.99 2.29 100.00
3 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 100.00
4 INT33951 Regulation of TXNRD1 18 0.51 6.97 4.02 100.00
5 INT309845 Protein_catabolism of Terc 1 0.42 0.52 0 100.00
6 INT32519 Positive_regulation of Terc 5 0.36 4.41 1.41 100.00
7 INT100772 Negative_regulation of TXNRD1 10 0.41 3.47 4.74 100.00
8 INT309844 Localization of Terc 1 0.35 0.58 0 100.00
9 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 100.00
10 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 99.76
11 INT210390 Binding of PDGFA 12 0.36 6.78 0.63 99.76
12 INT93956 Binding of HBM 20 0.35 8.86 1.48 99.76
13 INT22429 Positive_regulation of PDAP1 34 0.61 22.58 2.91 99.66
14 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 99.58
15 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 99.42
16 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 99.40
17 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 99.28
18 INT240020 Regulation of Binding of IL6 4 0.36 4.38 0.46 99.28
19 INT286904 Regulation of Binding of PDGFA 1 0.30 0.74 0.04 99.28
20 INT86437 Binding of IL6 154 0.48 121.22 29.3 99.28
21 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.92
22 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 98.92
23 INT95118 Negative_regulation of Gene_expression of PDGFA 4 0.54 5.03 0.76 98.92
24 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.48
25 INT9210 Regulation of IL6 166 0.62 125.61 49.95 98.48
26 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 98.48
27 INT210392 Regulation of PDGFA 10 0.36 11.41 1.12 97.88
28 INT41892 Gene_expression of HBM 48 0.64 28.32 5.64 97.52
29 INT7105 Gene_expression of pad 54 0.77 63.68 8.8 96.12
30 INT45167 Positive_regulation of ASAP1 32 0.60 17.09 1.84 96.00
31 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 95.44
32 INT188317 Positive_regulation of Gene_expression of PDGFA 15 0.46 12.7 0.91 94.20
33 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 93.20
34 INT318168 Positive_regulation of Localization of Epo 1 0.01 1.54 0 92.88
35 INT55479 Localization of Epo 13 0.81 6.1 1.53 91.48
36 INT186460 Transcription of ASAP1 5 0.56 3.02 0.03 89.72
37 INT77952 Positive_regulation of Pphn 2 0.40 0.49 0.29 89.36
38 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 88.32
39 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 88.00
40 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 87.40
41 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 86.88
42 INT10835 Regulation of IL8 79 0.49 53.04 24.14 86.40
43 INT174948 Positive_regulation of ple 2 0.43 0.2 0 84.12
44 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 79.28
45 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 77.76
46 INT68032 Regulation of Hrct1 3 0.36 2.78 0.67 76.92
47 INT174947 Regulation of Gene_expression of ple 1 0.32 0.23 0.07 74.96
48 INT174944 Gene_expression of ple 2 0.58 0.23 0.07 74.96
49 INT443 Localization of POMC 1020 0.81 284.52 443.17 74.88
50 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 74.24
51 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29 74.24
52 INT1893 Localization of Gh 1041 0.79 340.23 256.58 71.36
53 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 70.72
54 INT156685 Regulation of ASAP1 8 0.22 1.94 0.71 70.24
55 INT425 Localization of PRL 455 0.81 189.64 144.8 69.20
56 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 69.20
57 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56 69.12
58 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 68.68
59 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 65.60
60 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 65.32
61 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 65.08
62 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72 64.28
63 INT291341 Phosphorylation of Ifnar1 2 0.03 0.99 0.22 62.04
64 INT65211 Binding of Prkcg 38 0.48 14.75 16.92 60.80
65 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 60.20
66 INT61685 Positive_regulation of Gene_expression of Pah 6 0.43 4.05 1.79 59.04
67 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 58.68
68 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 58.60
69 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 57.76
70 INT273614 Regulation of PVR 1 0.17 0.84 0.14 56.12
71 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9 54.44
72 INT29651 Regulation of Pah 11 0.37 9.95 2.79 54.28
73 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 54.16
74 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 53.52
75 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 52.68
76 INT18025 Binding of Pah 32 0.45 30.72 7.93 49.12
77 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 48.56
78 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 47.40
79 INT171772 Binding of CPB1 13 0.32 9.92 0.75 46.24
80 INT291340 Phosphorylation of Mpeg1 1 0.51 0.36 0.08 44.24
81 INT183568 Negative_regulation of Protein_catabolism of Prkcg 2 0.36 1.12 1.33 42.36
82 INT181668 Protein_catabolism of Prkcg 8 0.77 2.59 3.06 42.16
83 INT174946 Binding of ple 1 0.27 0 0 39.32
84 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 36.76
85 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 36.64
86 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 35.92
87 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 35.84
88 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 35.44
89 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 33.48
90 INT173234 Gene_expression of Sst1 2 0.14 0.88 0.63 31.96
91 INT36978 Localization of Pah 9 0.73 7.43 0.82 31.80
92 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 30.40
93 INT45168 Negative_regulation of ASAP1 23 0.58 10.15 2.44 29.12
94 INT43947 Localization of ASAP1 11 0.68 4.49 0.88 29.12
95 INT19541 Gene_expression of Ptgir 22 0.65 15.42 5.39 29.08
96 INT174945 Negative_regulation of ple 1 0.31 0.07 0.04 28.48
97 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 27.36
98 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 27.28
99 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 26.12
100 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 26.04
101 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 25.60
102 INT7894 Negative_regulation of Vip 59 0.59 11.76 27.36 25.20
103 INT234267 Binding of She 2 0.04 0.07 0.06 24.72
104 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49 21.12
105 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 18.72
106 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 18.72
107 INT20425 Localization of Cpe 23 0.81 5.18 9.14 13.32
108 INT34143 Regulation of IMPA1 14 0.44 4.83 0.58 12.32
109 INT291342 Negative_regulation of Mpeg1 3 0.40 5.76 0.2 11.04
110 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15 9.68
111 INT168933 Positive_regulation of Car5b 2 0.15 0.64 0.05 9.44
112 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
113 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
114 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
115 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 5.00
116 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
117 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
118 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
119 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
120 INT1438 Localization of Pomc 360 0.81 101.26 116.47 5.00
121 INT90 Localization of Gast 400 0.81 137.67 113 5.00
122 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
123 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 5.00
124 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
125 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
126 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 5.00
127 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
128 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
129 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
130 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17 5.00
131 INT462 Regulation of Pomc 157 0.62 41.67 67.27 5.00
132 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
133 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
134 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
135 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97 5.00
136 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
137 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
138 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
139 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
140 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 5.00
141 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
142 INT5454 Localization of CRH 124 0.79 79.18 41.53 5.00
143 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 5.00
144 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
145 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
146 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
147 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
148 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
149 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
150 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81 5.00
151 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
152 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
153 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
154 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 5.00
155 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01 5.00
156 INT10799 Localization of ENG 63 0.78 18.67 27.28 5.00
157 INT111081 Gene_expression of CA1 19 0.75 51.09 26.64 5.00
158 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
159 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9 5.00
160 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
161 INT79349 Gene_expression of Sert1 58 0.77 12.7 20.65 5.00
162 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
163 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
164 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
165 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66 5.00
166 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38 5.00
167 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
168 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 5.00
169 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
170 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
171 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8 5.00
172 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
173 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59 5.00
174 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
175 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
176 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94 5.00
177 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
178 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 5.00
179 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
180 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
181 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26 5.00
182 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
183 INT91774 Gene_expression of Nr3c1 27 0.78 16.14 10.7 5.00
184 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 5.00
185 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
186 INT8740 Localization of Gcg 65 0.78 19 9.81 5.00
187 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 5.00
188 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
189 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68 5.00
190 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
191 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 5.00
192 INT150867 Regulation of COPD 54 0.48 71.38 8.8 5.00
193 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71 5.00
194 INT26751 Regulation of Nr3c1 13 0.61 6.58 8.65 5.00
195 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
196 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
197 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 5.00
198 INT12292 Negative_regulation of Positive_regulation of GH1 22 0.58 5.02 8.28 5.00
199 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
200 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 5.00
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