D:Triple Negative Breast Cancer

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Disease Term
Synonyms Tn Breast Cancer, Triple Negative Breast, Triple Negative Mammary, Triple Negative Tn Breast, Triple Negative Tn Mammary, Triple Negative Tumor, Triple Negative Tumour
Documents 6
Hot Single Events 25
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Triple Negative Breast Cancer. They are ordered first by their relevance to Triple Negative Breast Cancer and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT221684 Binding of Bcl2 and FRTS 1 0.01 1.19 0.11 95.72
2 INT221683 Binding of Mki67 and FRTS 1 0.01 1.18 0.11 94.80
3 INT221682 Binding of Esr1 and FRTS 1 0.01 0.15 0.03 85.68
4 INT221685 Binding of pr and FRTS 1 0.00 0.15 0.03 85.16
5 INT222301 Binding of ERBB2 and ESR1 5 0.36 5.07 0.29 5.00
6 INT71904 Binding of ESR1 and PGR 6 0.34 3.79 0.27 5.00
7 INT351086 Negative_regulation of ERBB2 Positive_regulation of Gene_expression of ESR1 1 0.10 0.75 0.19 5.00
8 INT351089 FOXO3 Positive_regulation of Gene_expression of ESR1 1 0.04 0.74 0.19 5.00
9 INT351088 Negative_regulation of ERBB2 Positive_regulation of FOXO3 1 0.17 0.66 0.18 5.00
10 INT222300 Binding of ERBB2 and PGR 2 0.34 1.89 0.17 5.00
11 INT341827 Binding of ESR1 and TNC 1 0.14 0.63 0.11 5.00
12 INT341826 Binding of ERBB2 and TNC 1 0.18 0.63 0.09 5.00
13 INT341825 Binding of TNC and PGR 1 0.14 0.63 0.09 5.00
14 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04 5.00
15 INT351090 Phosphorylation of TXK Positive_regulation of EGFR 1 0.04 0.33 0 5.00
16 INT234182 Binding of BRCA2 and PALB2 1 0.41 1.43 0 5.00
17 INT234180 Binding of BRCA1 and BRIP1 1 0.33 1.37 0 5.00
18 INT294088 Binding of ERBB2 and ERBB4 2 0.13 0.88 0 5.00
19 INT234178 Binding of BRCA1 and BRCA2 2 0.40 1.52 0 5.00
20 INT234179 Binding of DDR1 and ESR1 1 0.05 0.86 0 5.00
21 INT287268 Binding of ERBB2 and ERBB3 5 0.16 2.74 0 5.00
22 INT351085 Binding of EGFR and Positive_regulation of Phosphorylation of TXK 1 0.04 0.35 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Triple Negative Breast Cancer. They are ordered first by their pain relevance and then by number of times they were reported in Triple Negative Breast Cancer. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 100.00
2 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 99.96
3 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 99.58
4 INT172529 Negative_regulation of Gene_expression of PGR 24 0.48 16.69 1.04 99.58
5 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 99.58
6 INT96838 Negative_regulation of Gene_expression of ERBB2 25 0.57 15.83 1.34 99.58
7 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 99.46
8 INT57252 Negative_regulation of PGR 22 0.43 12.95 3.33 99.38
9 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 98.88
10 INT175002 Positive_regulation of Mki67 10 0.31 5.7 0.26 98.88
11 INT167085 Negative_regulation of ERBB2 67 0.57 44.6 1.48 98.68
12 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 96.08
13 INT101902 Negative_regulation of Mki67 12 0.39 7.92 0.34 95.16
14 INT14514 Regulation of FRTS 10 0.44 2.39 1.56 89.04
15 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9 86.32
16 INT221676 Protein_catabolism of Bcl2 4 0.24 2.77 0.48 86.32
17 INT221679 Protein_catabolism of pr 2 0.46 0.49 0.3 86.32
18 INT221678 Protein_catabolism of Mki67 3 0.33 1.78 0.09 86.32
19 INT221680 Negative_regulation of Protein_catabolism of pr 1 0.04 0.15 0.03 86.32
20 INT221673 Negative_regulation of Protein_catabolism of Bcl2 1 0.11 0.15 0.03 86.32
21 INT221677 Negative_regulation of Protein_catabolism of Esr1 1 0.08 0.15 0.03 86.32
22 INT221675 Negative_regulation of Protein_catabolism of Mki67 1 0.16 0.15 0.03 86.32
23 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 85.68
24 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 85.52
25 INT37296 Binding of Esr1 117 0.43 62.51 27.33 80.24
26 INT172855 Binding of Bcl2 37 0.32 23.41 1.09 79.60
27 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 75.52
28 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 75.20
29 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 66.56
30 INT213917 Negative_regulation of Phosphorylation of ERBB2 9 0.54 8.68 0.91 64.24
31 INT176588 Phosphorylation of ERBB2 27 0.78 16.37 0.81 64.24
32 INT81396 Regulation of Gene_expression of ERBB2 14 0.43 10.73 0.74 61.84
33 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 53.00
34 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 53.00
35 INT90875 Negative_regulation of CCND1 31 0.42 26.22 2.66 53.00
36 INT52962 Binding of ERBB2 77 0.47 50.03 1.49 34.44
37 INT2038 Localization of Esr1 104 0.79 40.12 13.27 29.24
38 INT221674 Localization of Erbb2 2 0.38 1.28 0.07 29.08
39 INT97446 Localization of Mki67 9 0.46 3.74 0.46 28.16
40 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 27.08
41 INT21788 Positive_regulation of ERBB2 49 0.66 28.88 1.68 27.08
42 INT21789 Positive_regulation of ERBB3 7 0.47 4.26 0.29 27.08
43 INT191252 Localization of DDR1 4 0.45 3.15 0.04 25.68
44 INT192676 Binding of PTEN 14 0.46 10.58 3.06 25.64
45 INT82795 Binding of MYC 16 0.47 6.1 0.9 25.64
46 INT80018 Binding of ERBB4 5 0.35 2.84 0.09 25.64
47 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 25.56
48 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25 25.56
49 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 14.40
50 INT10353 Positive_regulation of PGR 34 0.70 21.84 3.28 14.40
51 INT20462 Binding of ESR1 210 0.44 102.7 26.34 9.24
52 INT92354 Localization of ESR1 77 0.75 33.04 15.51 6.68
53 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
54 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
55 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
56 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
57 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 5.00
58 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
59 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
60 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
61 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
62 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
63 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 5.00
64 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 5.00
65 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
66 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 5.00
67 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
68 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
69 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
70 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
71 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 5.00
72 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 5.00
73 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 5.00
74 INT139613 Binding of pr 16 0.47 5.52 8.46 5.00
75 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 5.00
76 INT10284 Binding of ORM1 16 0.48 0.98 7.73 5.00
77 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
78 INT15007 Gene_expression of Pbrgcsf1 31 0.49 17.82 6.99 5.00
79 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
80 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
81 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
82 INT80421 Positive_regulation of IFI27 26 0.65 15.32 3.93 5.00
83 INT28546 Regulation of SHBG 23 0.54 16.35 3.88 5.00
84 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45 5.00
85 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
86 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 5.00
87 INT117348 Regulation of EGFR 75 0.61 47.73 3.09 5.00
88 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78 5.00
89 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 5.00
90 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 5.00
91 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5 5.00
92 INT172559 Localization of Proc 16 0.02 21.49 2.08 5.00
93 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 5.00
94 INT12942 Regulation of ITGAL 8 0.35 3.29 1.57 5.00
95 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54 5.00
96 INT19109 Positive_regulation of CYP3A5 7 0.67 1.48 1.51 5.00
97 INT15048 Regulation of Cacna1c 4 0.29 3.26 1.47 5.00
98 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45 5.00
99 INT172953 Binding of Trp53 33 0.37 20.76 1.41 5.00
100 INT119062 Negative_regulation of BRCA1 12 0.49 13.7 1.36 5.00
101 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3 5.00
102 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12 5.00
103 INT66452 Positive_regulation of Cacna1c 6 0.19 2.56 1.08 5.00
104 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 5.00
105 INT71649 Localization of ERBB2 23 0.78 13.63 0.83 5.00
106 INT147433 Gene_expression of BRCA2 7 0.62 7.02 0.79 5.00
107 INT119834 Phosphorylation of PTEN 12 0.79 6.78 0.75 5.00
108 INT44478 Negative_regulation of PTEN 32 0.57 27.45 0.63 5.00
109 INT142184 Regulation of TXK 10 0.11 8.25 0.59 5.00
110 INT155490 Binding of Mki67 13 0.19 13.38 0.41 5.00
111 INT192343 Positive_regulation of Phosphorylation of TXK 4 0.06 1.42 0.37 5.00
112 INT199559 Binding of Erbb2 5 0.36 4.23 0.36 5.00
113 INT192347 Phosphorylation of TXK 12 0.22 6.71 0.36 5.00
114 INT257764 Positive_regulation of Positive_regulation of PIK3CA 5 0.44 2.72 0.31 5.00
115 INT173223 Negative_regulation of BRCA2 7 0.54 6.79 0.25 5.00
116 INT251788 Gene_expression of ESYT1 8 0.06 7.29 0.23 5.00
117 INT19359 Binding of BRCA2 5 0.47 2.63 0.19 5.00
118 INT221268 Localization of BRCA1 7 0.63 4.83 0.18 5.00
119 INT219470 Positive_regulation of FOXO3 6 0.61 2.83 0.18 5.00
120 INT181787 Transcription of ERBB2 13 0.71 10.03 0.16 5.00
121 INT239373 Positive_regulation of Positive_regulation of PTEN 3 0.25 4.98 0.12 5.00
122 INT190553 Regulation of Siva1 2 0.16 1.05 0.09 5.00
123 INT234175 Regulation of Fam89b 1 0.01 0.59 0.08 5.00
124 INT8099 Binding of ERBB3 7 0.36 3.09 0.08 5.00
125 INT234184 Gene_expression of PALB2 2 0.55 1.95 0.07 5.00
126 INT234186 Localization of BRCA2 2 0.69 1.48 0.07 5.00
127 INT351092 Localization of CYP2C19 1 0.26 0 0.07 5.00
128 INT83483 Regulation of Regulation of ITGAL 2 0.01 0.3 0.04 5.00
129 INT105948 Gene_expression of AURKA 5 0.65 4.26 0.03 5.00
130 INT105949 Positive_regulation of Gene_expression of AURKA 3 0.49 1.91 0.03 5.00
131 INT234191 Positive_regulation of Localization of BRCA2 1 0.46 0.68 0 5.00
132 INT298206 Positive_regulation of Positive_regulation of IFI27 2 0.10 0.35 0 5.00
133 INT351091 Negative_regulation of Binding of PTEN 1 0.09 0.23 0 5.00
134 INT189353 Binding of RAD51 11 0.40 0.93 0 5.00
135 INT234185 Binding of PALB2 1 0.29 0.71 0 5.00
136 INT234190 Gene_expression of BRIP1 1 0.55 0.6 0 5.00
137 INT234187 Positive_regulation of Gene_expression of NRG1 1 0.02 0.32 0 5.00
138 INT234188 Positive_regulation of Localization of BRCA1 1 0.42 0.68 0 5.00
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