D:Trypanosomiasis

Disease Term Synonyms Trypanosomiases Documents 49 Hot Single Events 37 Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Trypanosomiasis. They are ordered first by their relevance to Trypanosomiasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT297558	Binding of APOL1 and SRA1	1	0.22	0.56	0	87.40
2	INT297562	TNF Positive_regulation of IFNA1	1	0.00	0.62	0.06	27.28
3	INT296114	Il4 Regulation of Gene_expression of Arg1	1	0.00	0.65	0.46	5.00
4	INT351565	Binding of LPAR6 and SFXN5	1	0.00	1.1	0.17	5.00
5	INT297589	Binding of HAT1 and Il10	1	0.00	1.14	0.08	5.00
6	INT275896	IFN1@ Positive_regulation of Gene_expression of TH1L	1	0.09	0.37	0.08	5.00
7	INT297559	Binding of IL6 and HAT1	1	0.00	1.13	0.08	5.00
8	INT296113	Fig4 Negative_regulation of Gene_expression of Csf2	1	0.01	0.91	0.04	5.00
9	INT296115	Fig4 Negative_regulation of Csf2	1	0.01	0.91	0.04	5.00
10	INT199041	AGRP Regulation of IGHE	1	0.00	1.39	0.03	5.00
11	INT192678	PTEN Regulation of Dync1h1	1	0.02	0.5	0.03	5.00
12	INT218240	Binding of SAE1 and Dync1h1	1	0.00	0.17	0	5.00
13	INT297560	Binding of HSD11B1 and APOL1	1	0.04	0.88	0	5.00
14	INT297563	Binding of HSD11B1 and TBPL1	1	0.01	0.41	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Trypanosomiasis. They are ordered first by their pain relevance and then by number of times they were reported in Trypanosomiasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT7397	Negative_regulation of Localization of GNRH1	86	0.59	15.45	29.78	99.98
2	INT7395	Localization of GNRH1	399	0.81	62.88	117.68	99.82
3	INT54204	Gene_expression of ZNF436	1	0.60	0.42	0	99.16
4	INT54203	Gene_expression of RAB8A	2	0.58	0.5	0	99.16
5	INT11370	Positive_regulation of LHB	15	0.28	5.45	4.01	97.92
6	INT22450	Gene_expression of GPI	31	0.58	18.77	6.71	97.80
7	INT5868	Positive_regulation of GNRH1	122	0.69	20.96	32.8	97.42
8	INT5130	Regulation of GNRH1	139	0.62	31.95	42.08	97.12
9	INT48953	Positive_regulation of Nos2	486	0.70	239.85	131.87	96.88
10	INT72337	Positive_regulation of Positive_regulation of Nos2	37	0.65	17.02	8.11	96.88
11	INT120811	Gene_expression of Gopc	1174	0.59	428.49	150.55	96.72
12	INT5059	Positive_regulation of TNF	1050	0.70	896.51	322.81	96.32
13	INT170054	Negative_regulation of Gopc	280	0.38	117.89	42.4	95.84
14	INT1648	Regulation of LHB	21	0.61	3.32	9.6	95.76
15	INT297583	Regulation of APOL1	1	0.40	0.57	0	95.68
16	INT72196	Transcription of LHB	1	0.02	0.28	0.43	95.28
17	INT6483	Gene_expression of TNF	3152	0.78	2515.62	929.82	94.64
18	INT33008	Gene_expression of Dync1h1	41	0.68	23.85	3.82	94.32
19	INT140394	Regulation of Dync1h1	7	0.39	2.59	1.25	94.32
20	INT9235	Negative_regulation of Gene_expression of TNF	346	0.59	252.98	118.61	91.04
21	INT172617	Positive_regulation of HAT1	7	0.33	5.47	0.54	90.48
22	INT65642	Binding of Dync1h1	27	0.41	15.83	2.68	88.28
23	INT238431	Binding of SRA1	8	0.37	2.53	0.25	87.40
24	INT127244	Binding of APOL1	1	0.33	3.29	0.09	87.04
25	INT68244	Positive_regulation of Ighg1	60	0.61	48.86	5.01	86.40
26	INT176594	Gene_expression of SRA1	20	0.35	9.65	1.15	85.84
27	INT201005	Gene_expression of APOL1	9	0.75	4.66	0.53	85.84
28	INT170332	Gene_expression of IFN1@	477	0.75	275.21	69.65	84.88
29	INT97438	Transcription of Il4	17	0.67	9.17	3.4	83.28
30	INT97436	Positive_regulation of Transcription of Il4	3	0.51	1.8	0.38	83.28
31	INT49490	Positive_regulation of Transcription of TNF	19	0.70	14.76	7.58	83.16
32	INT13354	Transcription of TNF	108	0.72	85.81	42.32	82.80
33	INT80110	Regulation of Positive_regulation of TNF	34	0.44	25.79	9.78	82.52
34	INT13186	Positive_regulation of Il4	113	0.68	71.22	31.4	82.40
35	INT6482	Positive_regulation of Gene_expression of TNF	659	0.70	569.88	210	82.00
36	INT142162	Binding of IL10	30	0.37	21.9	4.84	81.64
37	INT59817	Gene_expression of PLCB1	4	0.75	0.73	0.65	80.80
38	INT6849	Localization of IL1B	229	0.81	112.56	69.63	78.32
39	INT192674	Positive_regulation of Gene_expression of Dync1h1	1	0.32	1.67	0	77.88
40	INT173537	Binding of CCL16	18	0.40	13.02	7.36	74.80
41	INT203688	Positive_regulation of Hmgcr	10	0.17	6.08	0.52	67.88
42	INT2429	Negative_regulation of Mpo	128	0.59	93.76	39.57	67.16
43	INT137980	Positive_regulation of P2RX7	30	0.67	22.49	10	60.48
44	INT192564	Binding of HAT1	5	0.15	2.77	0.96	60.32
45	INT11554	Negative_regulation of CSF2	129	0.59	108.55	29.44	60.00
46	INT867	Gene_expression of IFNA1	930	0.78	594.85	168.03	59.52
47	INT34057	Negative_regulation of Gene_expression of IFNA1	65	0.58	43.46	17.25	59.52
48	INT172625	Regulation of HAT1	9	0.35	9.21	0.28	55.28
49	INT61949	Regulation of Nos2	74	0.58	34.08	16.7	53.28
50	INT48955	Gene_expression of Nos2	753	0.78	403.87	208.08	51.92
51	INT10000	Regulation of Gene_expression of IL2	56	0.45	15.33	16.2	47.88
52	INT5116	Gene_expression of IL2	670	0.78	291.13	146.69	47.12
53	INT46736	Negative_regulation of Odc1	10	0.51	7.6	1.39	46.96
54	INT4960	Positive_regulation of CSF2	285	0.70	256.73	65.73	41.92
55	INT151123	Negative_regulation of Gene_expression of Csf2	21	0.53	21.76	3.22	41.68
56	INT127710	Negative_regulation of Gene_expression of Hcrt	2	0.39	0.34	0.37	41.68
57	INT334562	Binding of Ism1	1	0.41	0.86	0	40.00
58	INT81153	Gene_expression of Hcrt	31	0.77	6.04	8.16	38.24
59	INT22939	Gene_expression of Csf2	164	0.78	85.1	32.22	37.36
60	INT127709	Positive_regulation of Gene_expression of Hcrt	3	0.45	0.55	0.84	34.88
61	INT334559	Regulation of Ism1	1	0.38	0.19	0	34.44
62	INT6481	Binding of TNF	624	0.48	510.2	214.82	34.28
63	INT6302	Binding of IFNA1	196	0.48	133.85	32.73	34.28
64	INT334561	Negative_regulation of Ism1	1	0.37	0.4	0	31.44
65	INT90792	Localization of Il10	144	0.80	87.88	30.03	27.76
66	INT5058	Positive_regulation of IFNA1	356	0.70	245.75	60.52	25.16
67	INT60197	Gene_expression of JUN	90	0.78	42.32	14.61	24.80
68	INT80685	Gene_expression of MAPK8	90	0.72	51.91	13.36	23.68
69	INT171924	Gene_expression of MAPK14	60	0.65	54.38	21.68	23.32
70	INT41874	Positive_regulation of GPI	9	0.49	9.97	2.79	20.36
71	INT59815	Positive_regulation of PLCB1	9	0.67	1.12	1.22	20.20
72	INT334558	Positive_regulation of Ism1	1	0.43	0.18	0.04	17.00
73	INT100603	Gene_expression of DCSTAMP	7	0.22	3.05	2.25	7.60
74	INT334560	Transcription of Ism1	1	0.59	0.18	0.04	7.48
75	INT9238	Gene_expression of IL6	1575	0.78	1135.66	424.22	5.00
76	INT2540	Negative_regulation of Calca	538	0.59	172.11	384.38	5.00
77	INT6852	Localization of TNF	883	0.81	705.95	270.84	5.00
78	INT9852	Positive_regulation of Gpt	563	0.70	364.64	146.82	5.00
79	INT60694	Gene_expression of Il10	567	0.78	369.48	143.69	5.00
80	INT17612	Gene_expression of CRP	676	0.78	580.61	119.03	5.00
81	INT62124	Gene_expression of NOS1	444	0.78	218.08	114.85	5.00
82	INT20374	Gene_expression of Il4	515	0.76	306.15	114.12	5.00
83	INT170025	Gene_expression of Fig4	588	0.67	183.27	113.32	5.00
84	INT12082	Localization of IL6	365	0.81	241.78	105.78	5.00
85	INT69440	Gene_expression of ROS1	752	0.78	477.64	103.83	5.00
86	INT18009	Positive_regulation of CRP	518	0.70	553.03	103.74	5.00
87	INT90091	Gene_expression of GOPC	967	0.67	366.22	103.6	5.00
88	INT74058	Gene_expression of Nos1	260	0.78	80.04	95.71	5.00
89	INT11587	Gene_expression of CSF2	645	0.78	544.38	93.89	5.00
90	INT48767	Negative_regulation of NOS1	312	0.59	154.25	90.32	5.00
91	INT3657	Gene_expression of Ins1	514	0.78	321.69	75.76	5.00
92	INT5969	Gene_expression of Il1a	221	0.75	96.31	71.38	5.00
93	INT17564	Gene_expression of Gpt	322	0.75	208.51	60.36	5.00
94	INT1200	Negative_regulation of Ins1	274	0.58	155.17	56.14	5.00
95	INT33567	Gene_expression of CALM1	139	0.67	48.85	56.14	5.00
96	INT48952	Negative_regulation of Nos2	204	0.59	101.73	53.15	5.00
97	INT49028	Positive_regulation of Nos1	102	0.70	34.73	51.05	5.00
98	INT170646	Negative_regulation of Fig4	213	0.37	81.29	46.92	5.00
99	INT16364	Gene_expression of HLA-DRA	234	0.78	118.81	45.01	5.00
100	INT4216	Gene_expression of CD40LG	328	0.78	256.02	44.23	5.00
101	INT73502	Positive_regulation of IL10	154	0.69	124.87	43.5	5.00
102	INT100939	Gene_expression of Il13	176	0.73	125.1	43.38	5.00
103	INT13556	Gene_expression of CD4	367	0.78	230.82	41.74	5.00
104	INT69437	Positive_regulation of ROS1	328	0.58	222.83	40.56	5.00
105	INT52732	Negative_regulation of CRP	169	0.59	138.47	40.33	5.00
106	INT11560	Positive_regulation of CASP3	236	0.70	184.33	39.38	5.00
107	INT72651	Gene_expression of TH1L	114	0.75	80.15	35.15	5.00
108	INT34729	Positive_regulation of IFN1@	233	0.67	128.04	30.38	5.00
109	INT15610	Localization of GOPC	223	0.65	68.26	28.7	5.00
110	INT19856	Gene_expression of CD8A	240	0.75	147.86	26.39	5.00
111	INT48766	Regulation of NOS1	73	0.61	37.01	24.59	5.00
112	INT86534	Positive_regulation of MAPK14	81	0.62	57.81	23.62	5.00
113	INT74423	Localization of IL10	91	0.80	61.6	22.95	5.00
114	INT8640	Positive_regulation of HSD11B1	332	0.67	377.84	22.36	5.00
115	INT5328	Positive_regulation of CD4	191	0.69	133.43	21.31	5.00
116	INT105021	Binding of GOPC	187	0.40	60.39	20.38	5.00
117	INT192409	Positive_regulation of Gene_expression of IFN1@	102	0.67	64.66	18.8	5.00
118	INT83198	Positive_regulation of Nos3	78	0.64	35.69	17.71	5.00
119	INT108588	Gene_expression of CASP3	126	0.78	84.49	16.2	5.00
120	INT11685	Regulation of CSF2	99	0.59	58.82	15.9	5.00
121	INT75540	Positive_regulation of TH1L	62	0.67	43.45	15.02	5.00
122	INT7776	Gene_expression of Abcb1b	63	0.75	21.35	14.92	5.00
123	INT10709	Negative_regulation of CD4	106	0.59	95.6	14.89	5.00
124	INT127046	Gene_expression of P2RX7	65	0.78	34.28	14.76	5.00
125	INT22301	Positive_regulation of Gene_expression of CSF2	66	0.63	59.49	14.24	5.00
126	INT69435	Negative_regulation of ROS1	74	0.51	50.38	13.71	5.00
127	INT5207	Negative_regulation of Alms1	70	0.41	41.56	13.68	5.00
128	INT1735	Gene_expression of HSD11B1	199	0.75	257.87	11.5	5.00
129	INT79835	Regulation of Il10	28	0.61	21.22	11.29	5.00
130	INT121796	Gene_expression of NeuN	92	0.78	23.18	10.53	5.00
131	INT58904	Localization of TH1L	40	0.68	27.11	10.52	5.00
132	INT1934	Positive_regulation of Cys1	68	0.68	60.56	10.47	5.00
133	INT71768	Regulation of Gene_expression of Il10	27	0.62	19.17	10.4	5.00
134	INT170333	Binding of IFN1@	68	0.47	49.01	9.72	5.00
135	INT62166	Positive_regulation of Gene_expression of Gpt	64	0.50	39.13	9.69	5.00
136	INT46273	Gene_expression of PRNP	103	0.78	110.34	9.25	5.00
137	INT14301	Binding of CSF2	82	0.48	67.95	8.98	5.00
138	INT79693	Regulation of Il4	30	0.51	21.96	8.6	5.00
139	INT119831	Gene_expression of PTEN	55	0.75	40.37	8.57	5.00
140	INT191765	Regulation of CALM1	15	0.52	9.52	8.56	5.00
141	INT177831	Gene_expression of HDAC1	24	0.65	21.37	8.37	5.00
142	INT102658	Negative_regulation of Gene_expression of CSF2	42	0.50	38.63	8.32	5.00
143	INT177759	Negative_regulation of IFN1@	51	0.57	31.81	7.76	5.00
144	INT153300	Negative_regulation of Gene_expression of CRP	48	0.58	39.97	7.58	5.00
145	INT91667	Localization of IL12A	39	0.74	25.51	7.36	5.00
146	INT3928	Localization of Bdkrb1	15	0.75	4.06	7.23	5.00
147	INT35584	Binding of ACLY	22	0.35	31.78	7.17	5.00
148	INT11747	Positive_regulation of IL2RA	22	0.67	16.55	6.95	5.00
149	INT17049	Localization of CD4	57	0.75	35.33	6.89	5.00
150	INT50255	Regulation of Cd4	39	0.49	29.73	6.77	5.00
151	INT207892	Binding of Tlr9	35	0.46	26.66	6.61	5.00
152	INT17086	Binding of HSD11B1	84	0.47	122.28	6.16	5.00
153	INT93658	Transcription of Nos1	16	0.72	6.85	6.16	5.00
154	INT15803	Regulation of IFNG	21	0.44	12.57	5.98	5.00
155	INT49566	Positive_regulation of LMOD1	16	0.61	5.74	5.92	5.00
156	INT84673	Localization of Nos1	19	0.80	5.01	5.62	5.00
157	INT81796	Binding of AGRP	62	0.36	37.19	5.3	5.00
158	INT73608	Localization of Nos2	21	0.75	9.58	5.05	5.00
159	INT60957	Negative_regulation of Abcb1b	18	0.57	6	4.73	5.00
160	INT104549	Localization of Il18	16	0.78	13.01	4.64	5.00
161	INT62684	Negative_regulation of TP53	66	0.58	66.09	4.62	5.00
162	INT182898	Regulation of Gene_expression of IFN1@	18	0.44	9.49	4.46	5.00
163	INT117920	Regulation of MAPK14	14	0.38	8.75	4.31	5.00
164	INT141665	Gene_expression of AGRP	83	0.67	43.43	4.24	5.00
165	INT186270	Regulation of Il13	13	0.43	11.58	4.19	5.00
166	INT117921	Positive_regulation of Positive_regulation of MAPK14	9	0.44	9.93	4.18	5.00
167	INT79413	Gene_expression of CAMP	13	0.75	8.3	4.02	5.00
168	INT127047	Negative_regulation of P2RX7	10	0.39	7.17	4.01	5.00
169	INT183207	Negative_regulation of USE1	14	0.18	10.97	4	5.00
170	INT170528	Negative_regulation of Gene_expression of CD4	25	0.41	17.98	3.6	5.00
171	INT176386	Positive_regulation of Gene_expression of TH1L	14	0.32	9.17	3.4	5.00
172	INT76869	Localization of PAEP	15	0.73	6.57	3.36	5.00
173	INT87517	Gene_expression of LDLR	73	0.69	37.35	3.32	5.00
174	INT29333	Positive_regulation of Enpep	8	0.70	3.22	3.25	5.00
175	INT126223	Binding of Nos2	17	0.37	6	3.22	5.00
176	INT164087	Gene_expression of TPI1	42	0.78	5.39	3.21	5.00
177	INT192676	Binding of PTEN	14	0.46	10.58	3.06	5.00
178	INT58756	Binding of GPI	10	0.48	7.17	3	5.00
179	INT202577	Localization of DIO2	9	0.56	1.3	2.97	5.00
180	INT187817	Regulation of Gene_expression of Il13	6	0.22	6.5	2.92	5.00
181	INT221097	Negative_regulation of Atp8a1	15	0.57	10.52	2.65	5.00
182	INT35465	Negative_regulation of Pfkm	8	0.57	3.84	2.6	5.00
183	INT119838	Positive_regulation of PTEN	25	0.67	21.71	2.5	5.00
184	INT136850	Positive_regulation of Arg1	10	0.50	6.96	2.47	5.00
185	INT16964	Binding of IFNG	27	0.48	14.31	2.45	5.00
186	INT74446	Positive_regulation of Dync1h1	25	0.59	13	2.38	5.00
187	INT137972	Binding of P2RX7	12	0.36	8.01	2.18	5.00
188	INT39453	Negative_regulation of TCN2	12	0.59	3.98	2.13	5.00
189	INT173647	Positive_regulation of Gene_expression of MAPK14	15	0.39	7.54	2.05	5.00
190	INT15580	Gene_expression of TCN2	16	0.44	7.59	1.97	5.00
191	INT36018	Negative_regulation of Gene_expression of CD8A	12	0.42	6.66	1.85	5.00
192	INT102843	Negative_regulation of PDC	5	0.57	4.26	1.82	5.00
193	INT192563	Gene_expression of HAT1	8	0.38	4.47	1.71	5.00
194	INT72676	Gene_expression of APOA1	34	0.75	34.15	1.67	5.00
195	INT2562	Positive_regulation of Gusb	9	0.69	2.92	1.59	5.00
196	INT192673	Gene_expression of Hdac5	6	0.61	2.84	1.51	5.00
197	INT61951	Regulation of Negative_regulation of Nos2	5	0.58	3.08	1.39	5.00
198	INT117014	Binding of TCN2	11	0.13	1.6	1.38	5.00
199	INT141131	Positive_regulation of Gene_expression of PRNP	12	0.61	16.6	1.36	5.00
200	INT132453	Binding of TF	31	0.36	12.98	1.22	5.00