D:Tuberous Sclerosis

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Disease Term
Synonyms ADENOMA SEBACEUM, Adenoma Sebaceum Syndrome, Bourneville Brissaud Disease, BOURNEVILLE DISEASE, Bourneville Phacomatosis, Bourneville Phakomatosis, Bourneville Pringle Syndrome, Bourneville S Disease, Bourneville Syndrome, BRAIN SCLEROSIS, Cerebral Sclerosis
Documents 218
Hot Single Events 113
Hot Interactions 23

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tuberous Sclerosis. They are ordered first by their relevance to Tuberous Sclerosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT331221 Binding of Akt1 and Tsc1 1 0.03 0.33 0 98.80
2 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0 98.60
3 INT290435 Positive_regulation of Binding of Mtor and Utp3 1 0.01 0.26 0 98.60
4 INT290436 Binding of Mtor and Utp3 1 0.00 0.26 0 98.60
5 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0 97.80
6 INT329216 Prkag1 Regulation of Mtor 1 0.01 0.35 0.04 92.12
7 INT329223 Prkag1 Regulation of Rps6kb1 1 0.14 0.35 0.04 92.12
8 INT271999 Binding of Fkbp1a and Positive_regulation of Negative_regulation of Mtor 1 0.00 0.18 0 91.28
9 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09 91.00
10 INT74015 Binding of VHL and XRCC1 1 0.07 3.51 0.09 91.00
11 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0 88.80
12 INT271978 Positive_regulation of Racgap1 Regulation of Mtor 1 0.00 0.54 0 88.64
13 INT241120 Binding of Sdhc and Sdhd 1 0.00 1.28 0 88.48
14 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0 88.28
15 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0 88.28
16 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0 87.76
17 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0 87.20
18 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0 87.20
19 INT351099 EPAS1 Regulation of Gene_expression of CRTC1 1 0.00 0.8 0 86.64
20 INT271994 Binding of Fkbp1a and Mtor 1 0.00 0.22 0 85.56
21 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0 84.84
22 INT286564 Pkd1 Regulation of Mtor 1 0.00 0.51 0 84.84
23 INT331223 Negative_regulation of Tsc1 Positive_regulation of Positive_regulation of Mtor 1 0.01 0.33 0 83.32
24 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0 73.12
25 INT272016 Mtor Negative_regulation of INS 1 0.00 0.61 0 62.64
26 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0 56.20
27 INT329226 Negative_regulation of ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04 54.64
28 INT329229 ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04 54.64
29 INT329230 Negative_regulation of ATIC Positive_regulation of Trp53 1 0.00 0.58 0.04 54.64
30 INT329231 ATIC Positive_regulation of Psmd9 1 0.01 0.58 0.04 54.64
31 INT329228 ATIC Positive_regulation of Trp53 1 0.01 0.58 0.04 54.64
32 INT329227 Negative_regulation of ATIC Positive_regulation of Tpt1 1 0.01 0.58 0.04 54.64
33 INT331222 Tsc1 Negative_regulation of Mtor 1 0.00 0.68 0 51.96
34 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23 50.36
35 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1 50.00
36 INT272012 Binding of TSC1 and Lsamp 1 0.03 2.1 0.08 50.00
37 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07 50.00
38 INT272009 Binding of YWHAQ and Tsc1 1 0.37 0.14 0.03 50.00
39 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0 50.00
40 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0 50.00
41 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0 50.00
42 INT272015 Pkd1 Positive_regulation of Localization of TSC1 1 0.18 0.65 0 50.00
43 INT272017 TBC1D7 Positive_regulation of Protein_catabolism of Tsc1 1 0.08 0.46 0 50.00
44 INT271982 Binding of Skp2 and Psmd9 1 0.01 0.68 0 50.00
45 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0 50.00
46 INT272000 Binding of Skp2 and Hecw1 1 0.01 0.11 0 50.00
47 INT271985 Tsc1 Regulation of Cdkn1b 1 0.04 0.1 0 50.00
48 INT271979 Skp2 Positive_regulation of Protein_catabolism of Psmd9 1 0.01 0.35 0 50.00
49 INT272008 Tsc1 Negative_regulation of Binding of HERC1 1 0.01 0.32 0 50.00
50 INT272014 Binding of RB1CC1 and Tsc1 1 0.05 0.44 0 50.00
51 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0 50.00
52 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0 50.00
53 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0 50.00
54 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0 50.00
55 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0 50.00
56 INT272005 Phosphorylation of Tsc1 Regulation of Binding of Cdk1 and Plk1 1 0.02 0.3 0 50.00
57 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0 50.00
58 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0 50.00
59 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0 50.00
60 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0 50.00
61 INT271986 Tsc1 Regulation of Skp2 1 0.13 0.14 0 50.00
62 INT173123 Binding of HNF4A and PPARA 1 0.10 0.19 0 46.20
63 INT282995 Binding of Bcl2 and Becn1 21 0.03 9.8 0 43.40
64 INT331231 Binding of Bcl2 and Mapk8 1 0.01 0.77 0 38.80
65 INT331230 Binding of Mapk8 and Becn1 1 0.02 0.77 0 38.80
66 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0 38.32
67 INT329219 Ins1 Positive_regulation of Gene_expression of Slc2a4 1 0.04 0.93 0.05 34.24
68 INT329222 Positive_regulation of Car2 Regulation of Camkk1 1 0.07 0.08 0.04 30.64
69 INT329220 Car2 Regulation of Camkk1 1 0.04 0.08 0.04 30.64
70 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4 26.00
71 INT331237 Negative_regulation of IMPA1 Negative_regulation of Itpr3 1 0.00 0.52 0 13.24
72 INT173130 Binding of INS and PPARA 2 0.04 1.8 0.08 11.20
73 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21 10.40
74 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0 10.08
75 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
76 INT197379 Tbs1 Positive_regulation of Ltp 6 0.07 1.87 2.21 5.00
77 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11 5.00
78 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93 5.00
79 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72 5.00
80 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
81 INT242635 Binding of Bdnf and Ntrk3 3 0.25 0.98 0.64 5.00
82 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6 5.00
83 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47 5.00
84 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46 5.00
85 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41 5.00
86 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41 5.00
87 INT319313 Socs4 Positive_regulation of Mapk14 1 0.02 0.68 0.41 5.00
88 INT264209 Binding of Igh-Lev and Sv2a 1 0.17 1.78 0.38 5.00
89 INT276214 Binding of Nos2 and Nfkb1 1 0.12 0.31 0.34 5.00
90 INT276209 Negative_regulation of Binding of Nos2 and Nfkb1 1 0.14 0.31 0.34 5.00
91 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29 5.00
92 INT319311 Binding of Glud1 and Ptk2b 1 0.36 0 0.19 5.00
93 INT319307 Rbm39 Regulation of Bdnf 1 0.00 0.76 0.18 5.00
94 INT354968 Shank3 Positive_regulation of Gene_expression of Gria2 1 0.05 0 0.15 5.00
95 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
96 INT319314 Binding of Ptk2b and Rbm39 1 0.01 0.08 0.14 5.00
97 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
98 INT319316 Binding of GRIN1 and Ptk2b 1 0.52 0.08 0.14 5.00
99 INT173200 PPA1 Positive_regulation of Myc 1 0.08 0.5 0.12 5.00
100 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 0.18 0.48 0.12 5.00
101 INT173129 PTGS2 Regulation of IER3 1 0.01 0.36 0.12 5.00
102 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
103 INT173122 PPA1 Positive_regulation of HRAS 1 0.08 0.5 0.12 5.00
104 INT173125 PPA1 Positive_regulation of JUN 1 0.06 0.5 0.12 5.00
105 INT173119 PPA1 Regulation of IER3 1 0.00 0.36 0.12 5.00
106 INT328143 Gabrb3 Positive_regulation of Ube3a 1 0.56 0.99 0.11 5.00
107 INT319315 Binding of Ap2a2 and Htt 1 0.28 0.64 0.11 5.00
108 INT328146 Gabrb3 Negative_regulation of Ube3a 1 0.48 0.99 0.11 5.00
109 INT173126 CYP8B1 Positive_regulation of PPARA 1 0.25 0.39 0.1 5.00
110 INT241248 Binding of Pkd1 and Pkd2 3 0.22 1.52 0.1 5.00
111 INT173124 PPA1 Regulation of ZFP37 1 0.00 0.44 0.1 5.00
112 INT286568 Car2 Positive_regulation of Positive_regulation of Pkd1 1 0.03 0.16 0.09 5.00
113 INT286565 Pkd2 Positive_regulation of Positive_regulation of Pkd1 1 0.21 0.11 0.09 5.00
114 INT354962 Gene_expression of Shank3 Positive_regulation of Gusb 1 0.10 0.45 0.08 5.00
115 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
116 INT319309 Egr2 Regulation of Ptk2b 1 0.29 0.37 0.07 5.00
117 INT328150 H2-Q13 Positive_regulation of Gene_expression of Ube3a 1 0.55 1.23 0.07 5.00
118 INT319306 Egr2 Regulation of Pitpnm2 1 0.12 0.37 0.07 5.00
119 INT329225 Prkag1 Positive_regulation of Akt1 1 0.09 1.27 0.07 5.00
120 INT328148 H2-Q13 Positive_regulation of Ube3a 1 0.55 1.23 0.07 5.00
121 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
122 INT328145 H2-Q13 Positive_regulation of Atp10a 1 0.54 1.23 0.07 5.00
123 INT328144 H2-Q13 Positive_regulation of Gene_expression of Atp10a 1 0.54 1.23 0.07 5.00
124 INT286592 Binding of PKD1 and P1Ehs1 1 0.00 0.16 0.06 5.00
125 INT286563 Binding of Id2 and P1Ehs1 1 0.00 0.17 0.06 5.00
126 INT286591 Binding of PKD1 and Id2 1 0.07 0.17 0.06 5.00
127 INT331227 Binding of Becn1 and Pink1 1 0.03 1.13 0.05 5.00
128 INT329218 Phosphorylation of Ppara Positive_regulation of Prkag1 1 0.34 0.2 0.05 5.00
129 INT354963 Binding of Cttn and Shank1 1 0.12 0 0.04 5.00
130 INT354971 Binding of HOMER1 and Shank1 1 0.01 0 0.04 5.00
131 INT276211 Pdpk1 Regulation of Akt1 1 0.07 0.72 0.04 5.00
132 INT354965 Binding of Gria2 and Sh3 1 0.01 0 0.04 5.00
133 INT173199 CNOT4 Regulation of Regulation of Myc 1 0.01 0.66 0.03 5.00
134 INT290437 Gene_expression of Mef2c Negative_regulation of Upf1 1 0.02 0.25 0.03 5.00
135 INT331234 Binding of Becn1 and Pik3c3 Positive_regulation of Pik3c3 1 0.00 0.47 0 5.00
136 INT331226 Binding of Becn1 and Pik3c3 1 0.02 0.47 0 5.00
137 INT331238 Binding of ULK1 and Pik3r1 1 0.09 0.48 0 5.00
138 INT319310 Binding of Eno2 and Glud1 1 0.36 0.24 0 5.00
139 INT331232 Binding of Atg12 and Atg16l1 1 0.03 0.08 0 5.00
140 INT306677 Binding of Mapt and Atxn3 1 0.07 0.49 0 5.00
141 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0 5.00
142 INT329215 Prkag1 Negative_regulation of Acaca 1 0.08 0.26 0 5.00
143 INT286571 Binding of Prkd1 and Pkd1 1 0.05 0.76 0 5.00
144 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
145 INT290439 Negative_regulation of Mef2c Positive_regulation of Gene_expression of Ppargc1a 1 0.21 0 0 5.00
146 INT290441 Mef2c Regulation of Mef2b 1 0.09 0.11 0 5.00
147 INT331225 Binding of Atg5 and Atg16l1 1 0.05 0.08 0 5.00
148 INT173127 Binding of INS and SORBS1 1 0.02 0.22 0 5.00
149 INT351097 RRAD Negative_regulation of EIF4EBP1 1 0.00 0 0 5.00
150 INT354966 Binding of Rapsn and Dlgap1 1 0.01 0.09 0 5.00
151 INT290438 Mef2c Regulation of Mef2a 1 0.26 0.11 0 5.00
152 INT328142 Binding of Atp10a and Snrpn 1 0.30 0.3 0 5.00
153 INT331228 Atg5 Positive_regulation of Atg12 1 0.06 0.08 0 5.00
154 INT354967 Binding of Psd and Dlgap1 1 0.15 0.09 0 5.00
155 INT351093 RRAD Regulation of RRAD Negative_regulation of EIF4EBP1 1 0.00 0 0 5.00
156 INT351100 RRAD Regulation of EIF4EBP1 1 0.00 0 0 5.00
157 INT286574 Gene_expression of Pkd1 Negative_regulation of Cdk2 1 0.10 0.09 0 5.00
158 INT286570 Pkd2 Positive_regulation of Binding of Pkd1 1 0.21 0.73 0 5.00
159 INT286501 Binding of PKD1 and LILRB1 1 0.01 1.07 0 5.00
160 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0 5.00
161 INT329224 Prkag1 Positive_regulation of Localization of Ins1 1 0.03 1.14 0 5.00
162 INT264210 Binding of Aes and Igh-Lev 1 0.07 0.41 0 5.00
163 INT328141 Binding of Chrne and Gabrb3 1 0.41 0.08 0 5.00
164 INT286593 Binding of Pkd1 and GOPC 1 0.02 1.13 0 5.00
165 INT286589 Binding of PKHD1 and Pkd2 1 0.09 0.52 0 5.00
166 INT351098 MTOR Regulation of Binding of EPAS1 1 0.08 0.95 0 5.00
167 INT257243 Binding of COL5A2 and FN1 1 0.01 0.67 0 5.00
168 INT286573 Pkd2 Regulation of Pkd1 1 0.12 0.25 0 5.00
169 INT286590 Binding of ID2 and Pkd2 1 0.13 0.13 0 5.00
170 INT276212 Binding of Akt1 and Gsk3a 1 0.11 0 0 5.00
171 INT354969 Binding of Rapsn and Psd 1 0.01 0.09 0 5.00
172 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0 5.00
173 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0 5.00
174 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0 5.00
175 INT351094 RRAD Negative_regulation of RRAD Regulation of EIF4EBP1 1 0.00 0 0 5.00
176 INT286594 Binding of LILRB1 and Pkd1 1 0.01 1.07 0 5.00
177 INT329221 Prkag1 Negative_regulation of Hmgcr 1 0.06 0.48 0 5.00
178 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tuberous Sclerosis. They are ordered first by their pain relevance and then by number of times they were reported in Tuberous Sclerosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13 100.00
2 INT214073 Binding of TSC1 9 0.37 22 1.34 100.00
3 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13 100.00
4 INT118791 Binding of AKT1 32 0.48 15.51 2.25 100.00
5 INT276188 Negative_regulation of Foxo1 5 0.40 1.75 0.23 100.00
6 INT276173 Phosphorylation of Foxo1 7 0.56 1.79 0.15 100.00
7 INT276178 Negative_regulation of Phosphorylation of Foxo1 3 0.30 1.03 0.15 100.00
8 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12 100.00
9 INT271936 Phosphorylation of Tsc1 4 0.73 1.76 0 100.00
10 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67 100.00
11 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25 100.00
12 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12 100.00
13 INT322758 Positive_regulation of Localization of TSC1 1 0.06 1.4 0 100.00
14 INT151588 Phosphorylation of Prkag1 48 0.73 15.62 1.38 99.96
15 INT286549 Regulation of Tsc2 1 0.11 0.42 0 99.64
16 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 99.44
17 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 99.44
18 INT332297 Negative_regulation of Binding of MTOR 2 0.40 1.6 0.18 99.38
19 INT136180 Binding of MTOR 9 0.35 5.01 0.38 99.16
20 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 99.04
21 INT216011 Regulation of TSC2 2 0.26 3.31 0 98.88
22 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 98.88
23 INT20166 Negative_regulation of Mtor 32 0.56 10.64 10.25 98.88
24 INT228678 Phosphorylation of Mtor 15 0.78 3.18 2.76 98.88
25 INT228671 Negative_regulation of Phosphorylation of Mtor 8 0.50 1.77 1.2 98.88
26 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 98.84
27 INT151774 Positive_regulation of Mtor 38 0.45 20.15 1.01 98.28
28 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 98.24
29 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 98.00
30 INT290406 Positive_regulation of Utp3 1 0.04 0.26 0 97.96
31 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28 97.68
32 INT22502 Gene_expression of Hal 21 0.53 9.8 3.32 97.52
33 INT41719 Gene_expression of MTOR 27 0.77 19.43 1.44 97.48
34 INT242338 Binding of TSC2 2 0.22 1.56 0.04 97.44
35 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 97.36
36 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26 97.36
37 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 97.12
38 INT241240 Gene_expression of Pkd1 18 0.54 12.2 0.27 97.12
39 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 97.00
40 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 97.00
41 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0 96.92
42 INT71644 Gene_expression of MLANA 16 0.75 11.55 1.82 96.88
43 INT286543 Localization of Pkd1 5 0.52 3.74 0.04 96.32
44 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 95.60
45 INT214045 Negative_regulation of OGG1 5 0.36 3.49 0 95.52
46 INT276192 Transcription of Akt1 1 0.66 0.47 0.18 95.48
47 INT228251 Positive_regulation of Rps6kb1 7 0.29 4.1 0.23 94.96
48 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49 94.84
49 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04 94.84
50 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39 94.60
51 INT175423 Positive_regulation of TSC1 25 0.36 21.81 0.45 94.18
52 INT184803 Localization of TSC1 5 0.37 6.13 0.32 94.18
53 INT94573 Negative_regulation of Pik3cb 42 0.50 15.83 15.4 93.64
54 INT277586 Negative_regulation of Mef2c 36 0.59 11.03 0.86 93.48
55 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 93.28
56 INT354955 Gene_expression of Shank3 1 0.78 3.23 0.45 93.24
57 INT331195 Positive_regulation of Negative_regulation of Tsc1 1 0.18 0.15 0 93.20
58 INT74020 Negative_regulation of XRCC1 16 0.35 17.18 1.06 93.12
59 INT271921 Negative_regulation of Tsc2 2 0.26 1.19 0 92.72
60 INT271914 Negative_regulation of Tsc1 5 0.38 3.08 0.04 92.68
61 INT151586 Positive_regulation of Prkag1 51 0.54 18.7 3.34 92.12
62 INT74018 Binding of XRCC1 19 0.31 24.78 1.24 91.00
63 INT264204 Regulation of Igh-Lev 1 0.20 3.17 0.1 90.80
64 INT276182 Phosphorylation of Pdk1 1 0.59 1.04 1.5 90.76
65 INT157685 Positive_regulation of Phosphorylation of Rps6kb1 5 0.37 1.89 0.24 90.72
66 INT257276 Localization of RDH5 1 0.05 1.96 0.14 90.24
67 INT157689 Phosphorylation of Rps6kb1 5 0.61 2.08 0.24 90.12
68 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27 89.88
69 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 89.44
70 INT74016 Binding of VHL 20 0.48 15.49 0.54 89.16
71 INT74017 Regulation of VHL 4 0.43 7.59 0.16 89.16
72 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 88.84
73 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 88.80
74 INT271904 Localization of Tsc2 1 0.41 1.31 0 88.80
75 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41 88.56
76 INT70654 Gene_expression of Actg2 27 0.67 18.62 4.79 88.16
77 INT351130 Positive_regulation of TPTE 1 0.04 0.78 0 87.92
78 INT182435 Localization of OGG1 36 0.76 1.66 0.58 87.76
79 INT66193 Negative_regulation of Btd 3 0.59 3.39 0.32 87.72
80 INT119227 Gene_expression of Tsc2 8 0.68 10.67 0.03 87.60
81 INT236107 Binding of Pdpk1 2 0.26 1.38 0.39 87.60
82 INT179816 Positive_regulation of Pdpk1 4 0.31 0.36 0.35 87.60
83 INT331203 Positive_regulation of Binding of Pdpk1 1 0.15 0.17 0 87.60
84 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 87.24
85 INT276206 Negative_regulation of Phosphorylation of Pdk1 1 0.31 0.31 0.06 87.16
86 INT331199 Binding of Rraga 1 0.03 0.31 0 86.68
87 INT339266 Regulation of Gene_expression of EPAS1 3 0.11 2.92 0.14 86.64
88 INT193016 Regulation of EPAS1 9 0.15 7.38 0.06 86.64
89 INT228895 Binding of Tsc2 5 0.30 2.41 0 86.36
90 INT351118 Gene_expression of CRTC1 1 0.02 0.79 0 86.20
91 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67 85.92
92 INT156208 Gene_expression of CRTC2 2 0.03 1.17 0.09 85.76
93 INT695 Binding of POMC 304 0.48 56.66 126.85 85.68
94 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 85.48
95 INT75136 Binding of Akt1 27 0.27 8.81 4.15 85.44
96 INT199082 Positive_regulation of Binding of Akt1 4 0.17 1.25 0.11 85.44
97 INT74013 Binding of Met 1 0.06 2.01 0.09 85.44
98 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 85.28
99 INT208476 Binding of Pkd1 13 0.39 7.23 0.17 84.84
100 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 84.72
101 INT351123 Positive_regulation of PDK1 1 0.32 0.77 0 83.92
102 INT271941 Binding of Tsc2 12 0.24 2.96 0.11 83.56
103 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74 83.44
104 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 82.68
105 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09 82.16
106 INT9295 Regulation of MAOB 12 0.56 3.32 3.6 82.08
107 INT271917 Phosphorylation of Mtor 11 0.13 6.76 0.78 81.92
108 INT271939 Regulation of Tsc1 2 0.41 1.16 0.47 81.32
109 INT162831 Regulation of ARSD 13 0.35 6.17 1.19 81.16
110 INT28739 Binding of Ins1 35 0.37 22.43 2.14 80.72
111 INT271930 Gene_expression of Tsc1 1 0.69 6.88 0.04 80.32
112 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 80.24
113 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 80.24
114 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 79.44
115 INT181823 Positive_regulation of Gene_expression of Ppargc1a 20 0.67 6.45 1.33 79.44
116 INT181818 Gene_expression of Ppargc1a 50 0.78 24.33 2.71 79.12
117 INT306668 Negative_regulation of Phosphorylation of Ulk1 2 0.14 0.27 0 77.92
118 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 77.68
119 INT306665 Positive_regulation of Phosphorylation of Ulk1 3 0.23 0.58 0 77.12
120 INT306672 Phosphorylation of Ulk1 5 0.27 0.88 0 76.76
121 INT286536 Positive_regulation of Positive_regulation of Prkd1 1 0.08 1.28 0 76.40
122 INT155583 Negative_regulation of Positive_regulation of Mtor 2 0.37 0.42 0 76.00
123 INT286548 Positive_regulation of Prkd1 7 0.36 4.35 0.15 75.64
124 INT306670 Regulation of Ulk1 1 0.15 0.16 0 75.60
125 INT351121 Positive_regulation of Negative_regulation of EPAS1 1 0.09 0.86 0 75.36
126 INT224327 Negative_regulation of EPAS1 5 0.09 4.29 0.08 75.08
127 INT23650 Positive_regulation of Sdhb 2 0.17 1.34 0.43 74.56
128 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 73.68
129 INT306657 Positive_regulation of Positive_regulation of Ulk2 1 0.13 0.16 0 73.28
130 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 73.12
131 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 72.84
132 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01 72.40
133 INT306664 Positive_regulation of Ulk1 3 0.23 0.61 0 71.80
134 INT306661 Positive_regulation of Ulk2 1 0.19 0.16 0 71.80
135 INT15692 Regulation of HTC2 4 0.27 4.75 1.61 71.60
136 INT306669 Phosphorylation of Ulk2 1 0.17 0.15 0 70.84
137 INT173512 Positive_regulation of Gene_expression of Alms1 12 0.44 8.66 1.95 70.80
138 INT306671 Positive_regulation of Phosphorylation of Rb1cc1 2 0.10 0.3 0 70.24
139 INT306662 Phosphorylation of Rb1cc1 2 0.17 0.3 0 69.88
140 INT132575 Binding of NR1H4 57 0.20 22.06 2.82 69.88
141 INT132577 Binding of RXRB 12 0.30 6.58 1.25 69.88
142 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 69.60
143 INT109971 Positive_regulation of Tpt1 23 0.69 13.69 2.14 69.60
144 INT188741 Binding of ACTG2 3 0.20 3.27 0 68.56
145 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 67.80
146 INT74021 Regulation of XRCC1 15 0.44 16.91 0.88 67.52
147 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 67.36
148 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 67.36
149 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22 67.32
150 INT174156 Localization of Trp53 16 0.72 13.52 1.18 66.24
151 INT243972 Binding of Ulk1 3 0.16 0.36 0.12 66.04
152 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 66.00
153 INT150826 Positive_regulation of Pkd1 9 0.37 3.65 0.35 65.84
154 INT306660 Binding of Rb1cc1 2 0.08 0.24 0 65.60
155 INT156204 Phosphorylation of MTOR 15 0.82 3.99 0.21 64.40
156 INT322525 Phosphorylation of PIK3CB 2 0.42 1.09 0 64.40
157 INT173182 Gene_expression of ZNF638 1 0.04 0.12 0 62.08
158 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76 61.68
159 INT200220 Positive_regulation of Positive_regulation of EPAS1 2 0.09 2 0.16 60.44
160 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 60.16
161 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08 58.08
162 INT3214 Localization of Ins1 527 0.80 196.9 79.26 58.00
163 INT152215 Binding of FH 10 0.41 14.13 0.19 56.96
164 INT286535 Regulation of Prkd1 3 0.33 2.24 0.04 56.44
165 INT276179 Regulation of Pten 1 0.46 0.81 0.63 55.28
166 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54 55.16
167 INT151166 Positive_regulation of Phosphorylation of Pten 2 0.40 1.54 0.35 55.16
168 INT173162 Phosphorylation of PPARA 22 0.80 11.09 1.38 54.72
169 INT151167 Phosphorylation of Pten 3 0.72 1.69 0.35 54.64
170 INT331196 Positive_regulation of Phosphorylation of Atg13 1 0.14 0.25 0 54.56
171 INT331182 Phosphorylation of Atg13 1 0.23 0.25 0 54.56
172 INT347315 Binding of PIK3CB 2 0.19 1.57 0 53.68
173 INT228901 Positive_regulation of RPS6KB1 5 0.55 2.44 0.18 53.44
174 INT228904 Positive_regulation of PHOSPHO1 1 0.45 0.84 0 53.44
175 INT228899 Positive_regulation of Gene_expression of PHOSPHO1 1 0.49 0.84 0 53.44
176 INT228900 Positive_regulation of Gene_expression of RPS6KB1 2 0.49 1.6 0 53.44
177 INT26534 Regulation of Akt1 34 0.61 14.47 11.86 53.12
178 INT166125 Gene_expression of PHOSPHO1 4 0.75 3.06 0.24 53.08
179 INT228903 Negative_regulation of Gene_expression of PHOSPHO1 1 0.42 0.79 0 53.08
180 INT228902 Gene_expression of RPS6KB1 5 0.75 2.32 0.1 52.76
181 INT103094 Binding of PPARA 308 0.47 177.26 34.75 50.36
182 INT306659 Negative_regulation of Crtc2 1 0.01 0.17 0 50.08
183 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 50.00
184 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 50.00
185 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 50.00
186 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 50.00
187 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 50.00
188 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21 50.00
189 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79 50.00
190 INT55470 Regulation of Mtor 16 0.24 12.51 2.07 50.00
191 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16 50.00
192 INT126523 Phosphorylation of Mapkapk2 19 0.79 7.76 0.82 50.00
193 INT129174 Gene_expression of PKD1 24 0.67 14.91 0.74 50.00
194 INT184694 Gene_expression of Usf1 10 0.55 4.27 0.72 50.00
195 INT71497 Binding of Hspa1b 3 0.08 1.43 0.58 50.00
196 INT247798 Negative_regulation of Rasa1 3 0.09 1.05 0.44 50.00
197 INT230653 Phosphorylation of Rasa1 3 0.55 0.6 0.42 50.00
198 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39 50.00
199 INT126522 Positive_regulation of Phosphorylation of Mapkapk2 7 0.59 3.8 0.28 50.00
200 INT70144 Gene_expression of Sry 4 0.63 1.15 0.28 50.00
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