D:Tumor Lysis Syndrome

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Disease Term
Synonyms SYNDROME TUMOR LYSIS, SYNDROME TUMOUR LYSIS, Syndromes Tumor Lysis, SYNDROMES TUMOUR LYSIS, Tumor Lysis Syndromes, Tumour Lysis Syndrome, TUMOUR LYSIS SYNDROMES
Documents 52
Hot Single Events 17
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tumor Lysis Syndrome. They are ordered first by their relevance to Tumor Lysis Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
2 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
3 INT193695 Il2 Positive_regulation of Ctla4 1 0.01 1.63 0.18 5.00
4 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13 5.00
5 INT193697 Apaf1 Positive_regulation of CASP9 1 0.02 1.84 0.12 5.00
6 INT193691 Positive_regulation of Positive_regulation of Bcr 1 0.01 0.07 0.08 5.00
7 INT193692 IgG2a Positive_regulation of Bcr 1 0.02 0.07 0.08 5.00
8 INT193694 IgG2a Positive_regulation of Tlr9 1 0.05 0.07 0.08 5.00
9 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
10 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00
11 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0 5.00
12 INT241500 Binding of Kit and Kitl 1 0.08 0.92 0 5.00
13 INT315868 Vhl Positive_regulation of Transcription of PDGFA 1 0.00 1.39 0 5.00
14 INT315856 FLT3 Positive_regulation of Gene_expression of PDGFA 1 0.01 1.15 0 5.00
15 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0 5.00
16 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0 5.00
17 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0 5.00
18 INT306764 Binding of Aes and ZMYND10 1 0.04 0.21 0 5.00
19 INT315867 Vhl Positive_regulation of Transcription of VEGFA 1 0.01 1.39 0 5.00
20 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0 5.00
21 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tumor Lysis Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Tumor Lysis Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT205654 Gene_expression of FUS 9 0.32 11.53 0.16 100.00
2 INT168502 Positive_regulation of FUS 3 0.39 9.22 0.59 100.00
3 INT205657 Negative_regulation of FUS 3 0.21 6.61 0.14 100.00
4 INT168503 Binding of FUS 5 0.29 5.12 0.12 100.00
5 INT205651 Localization of FUS 4 0.36 4.15 0.31 100.00
6 INT279226 Regulation of FUS 1 0.21 0.83 0.03 100.00
7 INT156293 Localization of Fus 3 0.64 6.95 1.75 100.00
8 INT205653 Negative_regulation of Localization of FUS 1 0.10 1.23 0.12 100.00
9 INT194530 Gene_expression of UOX 17 0.65 11.78 0.17 99.88
10 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 99.28
11 INT24815 Binding of LDHA 9 0.36 6.73 0.89 98.62
12 INT9254 Negative_regulation of LDHA 23 0.43 13.3 2.2 98.56
13 INT205652 Localization of UOX 1 0.50 1.74 0.06 97.80
14 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 95.04
15 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 89.84
16 INT194533 Binding of UOX 2 0.47 3.86 0.2 88.56
17 INT192809 Negative_regulation of SSRP1 2 0.04 4.06 0.33 82.24
18 INT72030 Regulation of Binding of CALCA 2 0.54 0.65 0.07 79.08
19 INT192810 Regulation of Binding of PTMS 1 0.44 0.43 0 79.08
20 INT192804 Regulation of Binding of PTH 2 0.45 0.43 0 79.08
21 INT6761 Binding of CALCA 100 0.48 26.71 62.05 78.40
22 INT28094 Binding of PTH 29 0.37 13.57 3.09 78.40
23 INT192805 Binding of PTMS 2 0.36 0.65 0 78.40
24 INT99126 Negative_regulation of Positive_regulation of LDHA 4 0.43 4.37 0.32 75.00
25 INT2480 Negative_regulation of Got1 43 0.51 14.47 16.09 75.00
26 INT27415 Negative_regulation of Positive_regulation of Got1 15 0.51 10.99 5.14 75.00
27 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 75.00
28 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 72.64
29 INT71161 Gene_expression of ITGB3 6 0.26 3.59 1.45 71.72
30 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 71.64
31 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 71.48
32 INT68846 Gene_expression of Tfrc 22 0.32 10.1 3.06 71.24
33 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 70.92
34 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 68.36
35 INT138843 Binding of CC2D1A 19 0.33 33.06 1.25 66.96
36 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13 66.56
37 INT186882 Gene_expression of RTEL1 13 0.27 13.45 0.49 65.28
38 INT232465 Positive_regulation of ZMYND10 4 0.67 2.07 0.71 64.24
39 INT117083 Localization of RTEL1 5 0.60 9.1 0.8 62.52
40 INT250743 Localization of CC2D1A 12 0.51 20.97 0.51 62.48
41 INT19775 Localization of Il1 183 0.78 145.5 50.91 60.80
42 INT261239 Binding of XDH 10 0.34 3.16 0.31 59.44
43 INT223026 Regulation of XDH 2 0.32 2.38 0.15 59.44
44 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 54.32
45 INT53927 Positive_regulation of Localization of PTH 8 0.69 5.33 0.09 51.24
46 INT2544 Localization of PTH 39 0.81 30.55 2.22 50.88
47 INT72798 Binding of ADA 12 0.47 7.84 3.39 50.00
48 INT179373 Localization of XDH 3 0.20 1.97 0.54 50.00
49 INT132392 Negative_regulation of UOX 3 0.43 1.37 0.13 50.00
50 INT205656 Regulation of UOX 2 0.44 1.3 0.04 50.00
51 INT194532 Positive_regulation of UOX 3 0.35 0.78 0.03 50.00
52 INT205655 Negative_regulation of Binding of UOX 1 0.41 0.06 0 50.00
53 INT279225 Positive_regulation of Gene_expression of UOX 1 0.02 0.52 0 50.00
54 INT205650 Phosphorylation of UOX 2 0.54 1.11 0 50.00
55 INT846 Positive_regulation of B2M 42 0.70 29.78 8.06 34.24
56 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 34.16
57 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 31.84
58 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 30.72
59 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 30.32
60 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 29.84
61 INT105884 Binding of Bcl2 19 0.35 15.67 3 29.64
62 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 29.28
63 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 28.80
64 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93 28.32
65 INT35699 Binding of Umod 3 0.41 2.3 0.46 25.96
66 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37 23.44
67 INT241512 Phosphorylation of Abl1 4 0.59 2.68 0.09 19.52
68 INT241515 Negative_regulation of Phosphorylation of Abl1 3 0.30 1.36 0.09 19.52
69 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 17.60
70 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 17.60
71 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 17.28
72 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 10.08
73 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 10.08
74 INT53196 Binding of Cd4 44 0.47 27.28 5.85 7.48
75 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
76 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
77 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
78 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
79 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
80 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
81 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
82 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
83 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
84 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
85 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
86 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
87 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
88 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
89 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
90 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
91 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
92 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
93 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
94 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
95 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
96 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
97 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
98 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
99 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
100 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
101 INT1726 Positive_regulation of Kitl 65 0.70 38.81 44.85 5.00
102 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
103 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
104 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
105 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
106 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
107 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
108 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
109 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
110 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
111 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
112 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
113 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
114 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
115 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 5.00
116 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 5.00
117 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
118 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
119 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
120 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
121 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
122 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
123 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
124 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
125 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 5.00
126 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
127 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
128 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
129 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
130 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
131 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 5.00
132 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
133 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 5.00
134 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
135 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 5.00
136 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
137 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
138 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 5.00
139 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 5.00
140 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
141 INT133156 Binding of Cd40 77 0.48 45.92 13.77 5.00
142 INT99780 Positive_regulation of Cxcl10 43 0.69 39.67 13.27 5.00
143 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
144 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82 5.00
145 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 5.00
146 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
147 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
148 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
149 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 5.00
150 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
151 INT58449 Binding of Mthfd1 47 0.47 22.02 10.29 5.00
152 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
153 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
154 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
155 INT62919 Regulation of Gnas 22 0.43 5.61 9.55 5.00
156 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
157 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
158 INT51530 Negative_regulation of Adk 11 0.56 3.83 9.07 5.00
159 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
160 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
161 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 5.00
162 INT193663 Binding of Pain1 9 0.36 8.84 8.04 5.00
163 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 5.00
164 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 5.00
165 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
166 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 5.00
167 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41 5.00
168 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39 5.00
169 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
170 INT91509 Localization of CYC1 39 0.78 34.74 7.17 5.00
171 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 5.00
172 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 5.00
173 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
174 INT160562 Localization of Cd4 49 0.71 27.58 6.78 5.00
175 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71 5.00
176 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
177 INT17618 Gene_expression of B2M 36 0.66 16.39 6.68 5.00
178 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
179 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
180 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 5.00
181 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
182 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 5.00
183 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
184 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
185 INT28088 Binding of Alb 34 0.47 11.06 5.48 5.00
186 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
187 INT54617 Positive_regulation of Gene_expression of Abcb1b 22 0.67 9.8 5.34 5.00
188 INT59891 Positive_regulation of GSTK1 46 0.67 17.66 5.33 5.00
189 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 5.00
190 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
191 INT24886 Negative_regulation of SFTPA1 11 0.12 4.35 5.03 5.00
192 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 5.00
193 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48 5.00
194 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32 5.00
195 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3 5.00
196 INT83794 Positive_regulation of Gene_expression of Bcl2l1 26 0.69 16.89 4.28 5.00
197 INT138698 Gene_expression of Txn1 15 0.77 11.71 4.24 5.00
198 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 5.00
199 INT57645 Gene_expression of GSTK1 54 0.62 21.05 4.2 5.00
200 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
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