D:Tumor Necrosis Factor Receptor-associated Periodic Syndrome

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Disease Term
Synonyms T R A P S, Traps, Tumor Necrosis Factor Receptor Associated Periodic Syndrome, Tumour Necrosis Factor Receptor Associated Periodic Syndrome
Documents 164
Hot Single Events 104
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tumor Necrosis Factor Receptor-associated Periodic Syndrome. They are ordered first by their relevance to Tumor Necrosis Factor Receptor-associated Periodic Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT141881 Binding of MECOM and Tnfrsf1a 1 0.00 1.17 0.13 100.00
2 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 99.62
3 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63 99.52
4 INT220116 Tnfrsf1a Negative_regulation of TNF 1 0.06 0.56 0.09 97.96
5 INT150393 Binding of CASP1 and MEFV 2 0.16 2.48 0.45 97.36
6 INT334879 CASP1 Regulation of IL1B 1 0.03 1.63 0.31 96.16
7 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1 88.16
8 INT220115 Mefv Regulation of Gene_expression of Il1 1 0.01 1.85 0.13 83.52
9 INT265729 FLT1 Positive_regulation of Binding of VEGFA 1 0.46 0.08 0 83.12
10 INT221243 Binding of Hspa9 and Ppif 1 0.01 0.67 0.03 73.28
11 INT297347 Binding of MEFV and SAA@ 1 0.03 1.33 0 71.84
12 INT285605 Binding of ROS1 and Tlr4 1 0.01 1.25 0.16 70.56
13 INT279266 CADPS Positive_regulation of Regulation of IL1B 1 0.22 1.43 0.28 68.72
14 INT265750 Binding of FLT1 and KDR 1 0.37 0.54 0.07 66.24
15 INT221247 Hspa9 Negative_regulation of Ptpn2 1 0.03 0.67 0 49.24
16 INT285604 ROS1 Positive_regulation of Gene_expression of Tlr4 1 0.01 1.14 0.2 43.20
17 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83 5.00
18 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79 5.00
19 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8 5.00
20 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44 5.00
21 INT197051 Binding of HLA-E and ATP8A1 1 0.00 6.52 1.14 5.00
22 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
23 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
24 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86 5.00
25 INT226337 Binding of IL10 and IL10RA 2 0.24 2.51 0.85 5.00
26 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85 5.00
27 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79 5.00
28 INT170992 Binding of FN1 and MMRN1 3 0.01 2.13 0.73 5.00
29 INT226540 Binding of IL24 and Il20ra 1 0.00 0.97 0.71 5.00
30 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
31 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6 5.00
32 INT197050 Binding of HLA-DOA and HLA-E 2 0.08 1.73 0.58 5.00
33 INT333476 IL12B Positive_regulation of Localization of AFP 1 0.03 0.26 0.57 5.00
34 INT333477 CXCL10 Positive_regulation of TH1L 1 0.14 0.32 0.56 5.00
35 INT226360 IL18 Positive_regulation of Gene_expression of IL4 1 0.05 2.66 0.54 5.00
36 INT226348 IL18 Positive_regulation of Gene_expression of IL13 1 0.03 2.66 0.54 5.00
37 INT226517 Binding of IL19 and Il20ra 1 0.00 0.69 0.53 5.00
38 INT269057 Il6 Positive_regulation of Crp 1 0.37 1.83 0.51 5.00
39 INT206960 Lipg Regulation of Tnf 1 0.02 0.85 0.51 5.00
40 INT206961 Lipg Regulation of Ptger2 1 0.01 0.85 0.51 5.00
41 INT206958 Lipg Regulation of Gene_expression of Ptger2 1 0.01 0.85 0.51 5.00
42 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 5.00
43 INT226341 S1PR1 Regulation of MBTPS1 1 0.00 0.76 0.44 5.00
44 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4 5.00
45 INT226381 S1PR1 Positive_regulation of Gene_expression of IK 1 0.00 0.64 0.38 5.00
46 INT226350 MBTPS1 Negative_regulation of Gene_expression of CD4 1 0.03 0.61 0.37 5.00
47 INT226374 Negative_regulation of Binding of CD4 and IFNA1 1 0.03 0.66 0.37 5.00
48 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37 5.00
49 INT285598 Maoa Negative_regulation of Aldh3a1 1 0.01 0.18 0.36 5.00
50 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 5.00
51 INT269064 Il6 Positive_regulation of Gene_expression of Cybb 1 0.75 0.79 0.31 5.00
52 INT272925 Ccl2 Positive_regulation of Gene_expression of Col7a1 1 0.00 0.72 0.3 5.00
53 INT272932 Binding of Mmp9 and COPD 1 0.01 0.78 0.29 5.00
54 INT226512 Il1rl1 Positive_regulation of Jun 1 0.12 0.34 0.29 5.00
55 INT226375 INCENP Positive_regulation of Regulation of TH1L 1 0.01 0.57 0.29 5.00
56 INT272930 Positive_regulation of Binding of Mmp1a and COPD 1 0.01 0.79 0.29 5.00
57 INT272933 Binding of Mmp1a and COPD 1 0.01 0.78 0.29 5.00
58 INT272929 Positive_regulation of Binding of Mmp9 and COPD 1 0.01 0.79 0.29 5.00
59 INT226376 INCENP Negative_regulation of Gene_expression of TH1L 1 0.00 0.61 0.29 5.00
60 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29 5.00
61 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29 5.00
62 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29 5.00
63 INT279265 Binding of MEFV and NLRP3 1 0.07 2.79 0.28 5.00
64 INT226383 IL22 Positive_regulation of Gene_expression of INCENP 1 0.00 0.85 0.28 5.00
65 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27 5.00
66 INT221236 Ros1 Positive_regulation of Localization of Prkca 1 0.01 0.15 0.27 5.00
67 INT226363 IK Positive_regulation of IL22 1 0.00 0.87 0.27 5.00
68 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
69 INT226343 Binding of IFNA1 and IL26 1 0.02 0.18 0.26 5.00
70 INT226352 Binding of IL22 and IL22RA1 1 0.00 0.17 0.26 5.00
71 INT226342 Binding of IL20RA and IL26 1 0.00 0.18 0.26 5.00
72 INT226355 IL9 Positive_regulation of IL22 1 0.02 0.86 0.26 5.00
73 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26 5.00
74 INT269060 Il6 Positive_regulation of Cybb 1 0.75 0.65 0.26 5.00
75 INT226361 Binding of IL10 and IL22RA1 1 0.00 0.17 0.26 5.00
76 INT226533 Il25 Positive_regulation of Gene_expression of IL13 1 0.01 0.64 0.24 5.00
77 INT269066 Binding of Hspa8 and Il6 1 0.00 0.74 0.23 5.00
78 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21 5.00
79 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2 5.00
80 INT226373 IL19 Positive_regulation of Gene_expression of IL5 1 0.02 0.56 0.2 5.00
81 INT226336 IL19 Positive_regulation of Gene_expression of IL13 1 0.01 0.56 0.2 5.00
82 INT226379 IL19 Positive_regulation of IL5 1 0.02 0.55 0.2 5.00
83 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2 5.00
84 INT226529 BTPs Negative_regulation of TH1L 1 0.05 0.22 0.2 5.00
85 INT226377 IL19 Positive_regulation of IL13 1 0.01 0.56 0.2 5.00
86 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2 5.00
87 INT226384 INCENP Positive_regulation of IL19 1 0.00 0.58 0.2 5.00
88 INT226368 Positive_regulation of TNF Positive_regulation of Positive_regulation of IGHE 1 0.11 0.92 0.2 5.00
89 INT226338 IL19 Positive_regulation of Gene_expression of IL10 1 0.01 0.56 0.2 5.00
90 INT226333 IL21 Positive_regulation of Binding of STAT4 1 0.03 0.57 0.2 5.00
91 INT226523 BTPs Negative_regulation of Gene_expression of TH1L 1 0.05 0.22 0.2 5.00
92 INT226542 Negative_regulation of Adora2b Positive_regulation of IL19 1 0.08 0.58 0.2 5.00
93 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2 5.00
94 INT226369 IL19 Positive_regulation of IL4 1 0.03 0.55 0.2 5.00
95 INT226525 Adora2b Positive_regulation of IL19 1 0.03 0.58 0.2 5.00
96 INT226351 IL19 Positive_regulation of IL10 1 0.01 0.55 0.2 5.00
97 INT226353 IL19 Positive_regulation of Gene_expression of IL4 1 0.03 0.56 0.2 5.00
98 INT226335 Binding of IL20 and IL20RB 1 0.03 0.29 0.19 5.00
99 INT226528 BTPs Negative_regulation of Gene_expression of IL2 1 0.04 0.22 0.19 5.00
100 INT226385 Binding of IL24 and IL22RA1 1 0.00 0.28 0.19 5.00
101 INT226362 Binding of IL20 and IL22RA1 1 0.00 0.28 0.19 5.00
102 INT226370 Binding of IL24 and IL20RB 1 0.03 0.28 0.19 5.00
103 INT353808 HLA-DMA Regulation of HLA-B 1 0.00 1.72 0.19 5.00
104 INT226345 Binding of IL24 and IL20RA 1 0.00 0.23 0.19 5.00
105 INT269071 Binding of IL6 and Il6 1 0.40 0.73 0.19 5.00
106 INT226349 Binding of IL19 and IL20RA 1 0.00 0.24 0.19 5.00
107 INT226346 Binding of IL21 and Positive_regulation of Positive_regulation of JAK3 1 0.08 0.48 0.18 5.00
108 INT272931 Binding of IL8 and Cxcr1 1 0.07 0.65 0.18 5.00
109 INT226372 INCENP Negative_regulation of Gene_expression of IL5 1 0.00 1.12 0.18 5.00
110 INT221234 Gja3 Regulation of Binding of Ptpn2 1 0.08 0.58 0.18 5.00
111 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18 5.00
112 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18 5.00
113 INT226344 Gene_expression of IL9 Positive_regulation of CCL5 1 0.07 1.03 0.18 5.00
114 INT226380 Gene_expression of IL15 Negative_regulation of Positive_regulation of CD8A 1 0.02 1.59 0.18 5.00
115 INT226538 Binding of IL22RA1 and Il20ra 1 0.00 0.28 0.18 5.00
116 INT226543 Binding of IL20 and Il20ra 1 0.00 0.28 0.18 5.00
117 INT226521 IL19 Positive_regulation of Gene_expression of Il6 1 0.01 0.41 0.17 5.00
118 INT226522 Nfatc3 Positive_regulation of Gene_expression of IFNA1 1 0.05 0.19 0.17 5.00
119 INT226536 Gene_expression of IL9 Positive_regulation of Positive_regulation of Col7a1 1 0.00 1.02 0.17 5.00
120 INT226364 IL19 Positive_regulation of Gene_expression of TNF 1 0.11 0.41 0.17 5.00
121 INT226539 Nfatc3 Positive_regulation of Gene_expression of TH1L 1 0.11 0.19 0.17 5.00
122 INT226339 Binding of IK and JAK1 1 0.00 0.46 0.16 5.00
123 INT226541 BTPs Negative_regulation of CCL11 1 0.03 0.28 0.16 5.00
124 INT226526 BTPs Negative_regulation of IL4 1 0.03 0.27 0.16 5.00
125 INT226357 Binding of IL24 and IL19 1 0.01 0.23 0.16 5.00
126 INT226503 BTPs Negative_regulation of Phosphorylation of Nfatc1 1 0.07 0.29 0.16 5.00
127 INT226524 BTPs Negative_regulation of IL8 1 0.01 0.28 0.16 5.00
128 INT226334 TH1L Negative_regulation of Localization of IL4 1 0.07 0.18 0.16 5.00
129 INT226365 Negative_regulation of PDE4A Negative_regulation of Localization of IL5 1 0.05 0.18 0.16 5.00
130 INT226358 TH1L Negative_regulation of Localization of IL5 1 0.03 0.18 0.16 5.00
131 INT226519 BTPs Negative_regulation of Gene_expression of IL8 1 0.02 0.28 0.16 5.00
132 INT226359 IL21 Negative_regulation of Gene_expression of IGHE 1 0.02 0.79 0.16 5.00
133 INT226535 BTPs Negative_regulation of IL5 1 0.03 0.28 0.16 5.00
134 INT226382 Negative_regulation of PDE4A Negative_regulation of Localization of IL4 1 0.12 0.18 0.16 5.00
135 INT226527 Il1rl1 Positive_regulation of Gene_expression of IK 1 0.00 0.42 0.15 5.00
136 INT226367 INCENP Negative_regulation of SOCS1 1 0.01 0.47 0.15 5.00
137 INT226507 Il1rl1 Positive_regulation of Gene_expression of Jun 1 0.13 0.2 0.15 5.00
138 INT226518 Il1rl1 Positive_regulation of MAPK14 1 0.04 0.2 0.15 5.00
139 INT226366 Binding of CISH and JAK1 1 0.00 0.46 0.15 5.00
140 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15 5.00
141 INT226520 Il1rl1 Positive_regulation of Gene_expression of MAPK14 1 0.03 0.2 0.15 5.00
142 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14 5.00
143 INT226516 Il1rl1 Positive_regulation of Phosphorylation of Jun 1 0.02 0.19 0.14 5.00
144 INT269054 Positive_regulation of Il6 Positive_regulation of Cybb 1 0.54 0.3 0.14 5.00
145 INT269070 Regulation of Il6 Positive_regulation of Cybb 1 0.29 0.3 0.14 5.00
146 INT272927 Mapk14 Positive_regulation of Gene_expression of TNF 1 0.16 0.53 0.14 5.00
147 INT226378 INCENP Positive_regulation of Transcription of SOCS1 1 0.01 0.41 0.13 5.00
148 INT221254 Binding of KNG1 and Akt1 1 0.00 0.13 0.13 5.00
149 INT226354 ST2 Positive_regulation of Gene_expression of IFNA1 1 0.04 0.15 0.12 5.00
150 INT226347 ST2 Positive_regulation of Gene_expression of IL4 1 0.08 0.15 0.12 5.00
151 INT269055 Il6 Positive_regulation of Gene_expression of Gopc 1 0.21 0.06 0.12 5.00
152 INT226532 T Positive_regulation of Gene_expression of IFNA1 1 0.01 0.15 0.12 5.00
153 INT269069 Binding of Cyba and Cybb 1 0.18 0.18 0.09 5.00
154 INT269056 Positive_regulation of Binding of Cyba and Cybb 1 0.24 0.18 0.09 5.00
155 INT226515 Binding of Il1rl1 and Il33 1 0.02 0.36 0.08 5.00
156 INT297589 Binding of HAT1 and Il10 1 0.00 1.14 0.08 5.00
157 INT320789 NRP2 Positive_regulation of Binding of Flt1 and Kdr 1 0.00 0.68 0.08 5.00
158 INT221258 Negative_regulation of Binding of VDAC1 and Crk 1 0.00 0.22 0.08 5.00
159 INT320785 Binding of Flt1 and Kdr 1 0.15 0.67 0.08 5.00
160 INT320788 VEGFA Positive_regulation of Binding of Flt1 and Kdr 1 0.15 0.68 0.08 5.00
161 INT309511 Binding of Xrcc6 and Xrcc5 1 0.18 1.18 0.08 5.00
162 INT221255 Binding of VDAC1 and Crk 1 0.00 0.22 0.08 5.00
163 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08 5.00
164 INT297559 Binding of IL6 and HAT1 1 0.00 1.13 0.08 5.00
165 INT269063 Gene_expression of Il6 Positive_regulation of Cybb 1 0.47 0.33 0.07 5.00
166 INT285602 Trib3 Regulation of Gene_expression of Nos2 1 0.00 0.48 0.07 5.00
167 INT226504 Binding of Nfatc1 and Nfatc4 1 0.08 0.15 0.07 5.00
168 INT226508 Binding of Nfatc1 and Nfatc3 1 0.07 0.15 0.07 5.00
169 INT221232 Ptpn2 Positive_regulation of Gene_expression of Ros1 1 0.04 1.12 0.07 5.00
170 INT226500 Binding of Nfatc1 and Nfatc2 1 0.09 0.15 0.07 5.00
171 INT297562 TNF Positive_regulation of IFNA1 1 0.00 0.62 0.06 5.00
172 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06 5.00
173 INT320795 Flt1 Negative_regulation of VEGFA 1 0.29 0.29 0.06 5.00
174 INT220081 Binding of COL1A1 and MMRN1 1 0.00 0.36 0.05 5.00
175 INT304172 Il5 Positive_regulation of Bcl2l1 1 0.02 0.91 0.05 5.00
176 INT221251 PRKG1 Negative_regulation of Positive_regulation of Ptpn2 1 0.04 0.7 0.05 5.00
177 INT221253 PRKG1 Negative_regulation of Ros1 1 0.01 0.69 0.05 5.00
178 INT226534 Binding of IL4 and Maf 1 0.02 0.21 0.04 5.00
179 INT265735 VEGFA Positive_regulation of Binding of KLKB1 1 0.04 0.36 0.04 5.00
180 INT265771 NRP1 Positive_regulation of VEGFA 1 0.46 0 0.04 5.00
181 INT265764 NRP1 Positive_regulation of FLT1 1 0.45 0 0.04 5.00
182 INT285603 Akt1 Regulation of Gene_expression of Nos2 1 0.02 0.48 0.04 5.00
183 INT226499 Binding of IL4 and Maf Positive_regulation of Positive_regulation of Il2ra 1 0.01 0.22 0.04 5.00
184 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04 5.00
185 INT265745 FLT1 Positive_regulation of Binding of KLKB1 1 0.04 0.36 0.04 5.00
186 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04 5.00
187 INT269065 Il6 Regulation of Gene_expression of Cybb 1 0.66 0.12 0.04 5.00
188 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04 5.00
189 INT265749 Binding of FLT1 and NRP1 1 0.43 0 0.04 5.00
190 INT226506 Maf Positive_regulation of Positive_regulation of Il2ra 1 0.02 0.22 0.04 5.00
191 INT269058 Positive_regulation of Il6 Positive_regulation of Gene_expression of Cybb 1 0.50 0.06 0.03 5.00
192 INT221245 Binding of Gja3 and Gopc 1 0.01 0 0.03 5.00
193 INT226530 Binding of NFATC1 and Nfatc1 1 0.06 0.08 0.03 5.00
194 INT224305 Positive_regulation of Binding of KDR and VEGFA 2 0.45 0.36 0.03 5.00
195 INT265730 Binding of AR and VEGFA 1 0.09 0 0 5.00
196 INT265744 VEGFA Regulation of Localization of NRP1 1 0.25 0 0 5.00
197 INT265708 Binding of FLT1 and VEGFA Positive_regulation of AR 1 0.13 0 0 5.00
198 INT227830 CSH1 Regulation of ERCC6 1 0.11 0 0 5.00
199 INT304170 Binding of Apaf1 and Positive_regulation of Casp9 1 0.01 0.51 0 5.00
200 INT265753 Binding of FLT1 and KL 1 0.18 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tumor Necrosis Factor Receptor-associated Periodic Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Tumor Necrosis Factor Receptor-associated Periodic Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81 100.00
2 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 100.00
3 INT15982 Positive_regulation of NLRP3 25 0.65 23.19 3.57 100.00
4 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 100.00
5 INT158764 Binding of SPINK5 7 0.35 8.84 0.37 100.00
6 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 100.00
7 INT222205 Positive_regulation of PSTPIP1 8 0.69 4.69 0.62 100.00
8 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 99.98
9 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 99.96
10 INT105538 Negative_regulation of Tnfrsf1a 16 0.56 12.51 5.61 99.92
11 INT52899 Positive_regulation of TNFRSF1A 16 0.46 19.04 3.34 99.80
12 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 99.78
13 INT187836 Binding of Tnfrsf1a 19 0.46 18.08 4.33 99.76
14 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 99.72
15 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.52
16 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 99.52
17 INT149669 Positive_regulation of MEFV 12 0.46 14.17 2.07 99.40
18 INT107924 Localization of Tnfrsf1a 5 0.70 3.86 1.37 99.38
19 INT20394 Binding of Tbce 12 0.06 5.47 1.78 99.32
20 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 99.30
21 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.16
22 INT9660 Regulation of TNF 363 0.62 312.94 139.99 99.16
23 INT220108 Positive_regulation of Negative_regulation of Tnfrsf1a 1 0.45 0.47 0.06 99.00
24 INT264435 Positive_regulation of Gene_expression of IL1R2 2 0.10 2.46 0.69 99.00
25 INT146971 Gene_expression of IL1R2 3 0.67 2.69 0.69 99.00
26 INT274601 Regulation of PSTPIP1 3 0.45 3.76 0.28 98.80
27 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9 98.78
28 INT42707 Gene_expression of Tbce 24 0.65 12.92 7.93 98.56
29 INT143841 Positive_regulation of Mtpn 17 0.17 5.46 2.68 98.40
30 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 98.40
31 INT210392 Regulation of PDGFA 10 0.36 11.41 1.12 98.40
32 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36 98.32
33 INT346981 Positive_regulation of Gene_expression of CXCR1 1 0.05 1.18 0.22 98.32
34 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 98.00
35 INT24453 Binding of NLRP3 18 0.48 13.7 1.93 97.92
36 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 97.84
37 INT77788 Regulation of Tnfrsf1a 14 0.57 11.24 3.53 97.84
38 INT110816 Gene_expression of Mefv 2 0.07 2.98 0.31 97.44
39 INT78895 Regulation of CCL5 30 0.46 20.45 10.18 97.20
40 INT90213 Negative_regulation of Mvk 3 0.05 6.28 0.59 97.20
41 INT60528 Negative_regulation of TNFRSF1A 6 0.42 4.86 1.45 97.00
42 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 96.96
43 INT125397 Binding of Zmat3 2 0.03 2.34 1.19 96.54
44 INT156416 Gene_expression of Lipg 38 0.67 18.35 4.07 96.48
45 INT86447 Binding of Lipg 3 0.18 1.51 0.25 96.48
46 INT23174 Gene_expression of NLRP3 51 0.72 35.49 6.47 96.44
47 INT10612 Localization of NLRP3 13 0.78 8.91 2.27 96.44
48 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 96.30
49 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 96.24
50 INT80005 Gene_expression of MVK 4 0.09 1.79 1.34 96.24
51 INT227877 Gene_expression of PGBD1 1 0.51 0.17 0 96.08
52 INT227873 Gene_expression of PGBD2 1 0.52 0.17 0 96.08
53 INT98224 Negative_regulation of Gene_expression of Cd79a 6 0.35 3.35 1.74 95.76
54 INT220110 Negative_regulation of Gene_expression of Ighd 1 0.13 2.55 0.57 95.76
55 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 95.72
56 INT206683 Negative_regulation of Binding of KDR 3 0.34 2.54 0.08 95.70
57 INT39416 Gene_expression of Cd79a 81 0.64 45.17 6.08 95.62
58 INT28815 Gene_expression of Ighd 18 0.65 11.02 2.48 95.46
59 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 95.44
60 INT257406 Localization of TNFRSF1A 3 0.46 2.6 0.55 95.04
61 INT173100 Binding of KDR 39 0.39 22.48 0.81 94.98
62 INT257407 Localization of MVK 1 0.22 1.78 0.18 94.64
63 INT158019 Positive_regulation of Gene_expression of FLT1 20 0.68 9.73 0.44 94.56
64 INT212043 Negative_regulation of SCYL1 1 0.08 0.17 0 94.24
65 INT111520 Regulation of Tnfrsf1a 10 0.61 7.25 5.41 94.16
66 INT335834 Gene_expression of LCP1 1 0.42 1.54 0.07 93.76
67 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 93.60
68 INT187577 Negative_regulation of Kcnk6 1 0.12 0.09 0.92 93.36
69 INT220109 Protein_catabolism of Tnfrsf1a 1 0.63 0.39 0.08 92.72
70 INT86062 Positive_regulation of Tnfrsf1a 51 0.69 40.69 26.2 91.08
71 INT36262 Positive_regulation of Tbce 35 0.49 28.79 14.33 90.96
72 INT6484 Binding of IL1B 122 0.47 75.84 35.07 90.72
73 INT43901 Negative_regulation of Ptpn2 65 0.37 56.32 7.48 90.52
74 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 90.36
75 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 90.36
76 INT57763 Gene_expression of Lmna 25 0.78 7.11 4.6 90.36
77 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 90.24
78 INT192750 Binding of TAS1R2 2 0.16 0.09 0.12 89.72
79 INT267239 Binding of LSAMP 1 0.03 0.23 0 89.36
80 INT267241 Regulation of LSAMP 1 0.02 0.23 0 89.36
81 INT212042 Gene_expression of SCYL1 2 0.09 5.78 1.38 88.80
82 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 88.08
83 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 87.80
84 INT81140 Gene_expression of CYTIP 5 0.65 1.76 0.12 87.68
85 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 86.96
86 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 86.76
87 INT227882 Gene_expression of PGBD3 1 0.63 1.05 0 86.08
88 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 85.64
89 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 85.60
90 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 83.88
91 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 83.36
92 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83 83.28
93 INT91900 Localization of Sod1 12 0.77 6.62 1.51 83.28
94 INT272876 Negative_regulation of Localization of Sod1 1 0.18 0.57 0.03 83.28
95 INT227872 Positive_regulation of MLL 7 0.01 2.44 0.19 83.20
96 INT82304 Localization of gp 5 0.64 1.25 0.6 82.92
97 INT272874 Negative_regulation of Localization of gp 1 0.02 0.57 0.03 82.92
98 INT197155 Gene_expression of NAB1 6 0.18 2.96 0 82.64
99 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 82.28
100 INT220112 Gene_expression of CREB3L3 2 0.26 1.89 0.21 81.16
101 INT60500 Negative_regulation of Tbce 21 0.41 13.3 11.1 80.88
102 INT29379 Negative_regulation of gp 3 0.03 0.56 0.91 80.76
103 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 80.36
104 INT221208 Negative_regulation of Negative_regulation of Ptpn2 1 0.25 0.76 0.04 80.36
105 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 80.00
106 INT47207 Negative_regulation of Ahr 25 0.52 16.11 3.02 79.24
107 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 78.16
108 INT346983 Negative_regulation of ISG15 1 0.19 3.69 0.35 78.16
109 INT11699 Binding of HLA-E 85 0.47 52.51 13.41 77.92
110 INT190337 Negative_regulation of IFI44 2 0.23 2.02 0.18 77.92
111 INT346978 Negative_regulation of IFIT1 1 0.13 1.83 0.17 77.64
112 INT346980 Negative_regulation of IFIT2 1 0.13 1.83 0.17 77.36
113 INT140637 Negative_regulation of IFI27 11 0.40 9.48 0.69 76.96
114 INT36221 Positive_regulation of Nlrp3 25 0.68 19.7 4.5 76.88
115 INT14867 Gene_expression of Igh-6 47 0.67 30.05 11.75 76.80
116 INT6849 Localization of IL1B 229 0.81 112.56 69.63 76.00
117 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12 76.00
118 INT78480 Localization of Nfkb1 39 0.80 23.14 13.64 76.00
119 INT116552 Positive_regulation of Localization of Nfkb1 16 0.61 12.7 7.74 76.00
120 INT156269 Regulation of Localization of Nfkb1 1 0.00 1.53 0.1 76.00
121 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 75.68
122 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 73.28
123 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 72.80
124 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35 72.80
125 INT65538 Regulation of Positive_regulation of Nfkb1 17 0.51 8.31 6.5 72.80
126 INT90289 Positive_regulation of Gene_expression of Gpx1 10 0.17 8.07 3.05 72.80
127 INT41313 Gene_expression of Gpx1 68 0.78 34.24 11.77 72.44
128 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68 72.16
129 INT117735 Positive_regulation of Regulation of Nfkb1 3 0.44 2.93 0.91 72.16
130 INT92260 Binding of Nlrp3 14 0.46 8.94 2.13 71.92
131 INT52529 Regulation of Nfkb1 48 0.61 26.2 20.89 71.68
132 INT95286 Regulation of Localization of Nfkb1 6 0.60 3.82 0.71 71.68
133 INT117736 Regulation of Localization of Il1b 1 0.02 1.33 0.18 71.68
134 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 71.12
135 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 70.56
136 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 70.32
137 INT339173 Regulation of AREG 2 0.26 1.83 0.2 70.32
138 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25 70.04
139 INT236278 Negative_regulation of CADPS 4 0.36 2.16 0.22 68.80
140 INT335830 Gene_expression of LRRFIP1 1 0.22 2.43 0.38 68.76
141 INT335828 Regulation of Gene_expression of LRRFIP1 1 0.15 0.53 0.08 68.76
142 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 68.72
143 INT48081 Localization of Il1b 46 0.80 21.59 22.4 68.40
144 INT226461 Binding of IL13RA2 1 0.01 0.94 0.13 67.68
145 INT226469 Binding of IL4R 1 0.01 0.94 0.13 67.20
146 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 65.44
147 INT274026 Positive_regulation of Gene_expression of AMD1 1 0.16 0.41 0.07 65.20
148 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 65.12
149 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 63.76
150 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 63.04
151 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 62.72
152 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 62.72
153 INT163458 Negative_regulation of Regulation of Kit 2 0.12 1.61 0.06 62.48
154 INT205603 Regulation of Pdgfa 5 0.16 4.84 0.15 61.44
155 INT140175 Regulation of Kit 23 0.62 8.59 1.79 61.44
156 INT200550 Regulation of Flt1 7 0.45 5.22 0.27 61.44
157 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52 60.64
158 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 60.52
159 INT57958 Positive_regulation of Myo5a 9 0.41 7.52 0.77 60.00
160 INT335829 Protein_catabolism of LRRFIP1 1 0.29 0.56 0.09 59.96
161 INT335833 Localization of LRRFIP1 1 0.25 0.56 0.09 59.48
162 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 58.96
163 INT115214 Gene_expression of LSAMP 4 0.63 2.5 1.14 57.00
164 INT62112 Binding of S100A8 37 0.36 17.18 3.16 56.32
165 INT227871 Positive_regulation of PGBD3 1 0.41 0.15 0 56.28
166 INT17417 Positive_regulation of Ighd 16 0.69 24.29 2.8 55.84
167 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 54.72
168 INT149591 Binding of SCYL1 2 0.06 0.2 0.06 54.20
169 INT212041 Binding of ADAM11 2 0.35 6.32 0.34 50.88
170 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 49.24
171 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 48.32
172 INT92514 Regulation of Grin2b 22 0.50 11.07 16.92 47.44
173 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 43.20
174 INT168681 Gene_expression of BMS1 5 0.37 2.7 1.62 40.48
175 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 40.08
176 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 39.76
177 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 39.60
178 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 38.56
179 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96 38.48
180 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 38.04
181 INT72455 Transcription of S100A8 3 0.69 1.66 0.36 38.04
182 INT334889 Positive_regulation of Transcription of MRPL14 1 0.07 0.79 0.21 38.04
183 INT334883 Positive_regulation of Transcription of CBFA2T2 1 0.03 0.79 0.21 38.04
184 INT334884 Transcription of CBFA2T2 1 0.04 0.78 0.21 38.04
185 INT334887 Positive_regulation of Gene_expression of CBFA2T2 1 0.03 0.79 0.21 38.04
186 INT334888 Gene_expression of CBFA2T2 1 0.05 0.78 0.21 38.04
187 INT334885 Transcription of MRPL14 1 0.10 0.79 0.21 38.04
188 INT334886 Gene_expression of MRPL14 1 0.11 0.79 0.21 38.04
189 INT334890 Positive_regulation of Gene_expression of MRPL14 1 0.07 0.79 0.21 38.04
190 INT334891 Positive_regulation of Transcription of S100A8 1 0.06 0.79 0.21 38.04
191 INT153297 Regulation of MEFV 6 0.40 11.09 0.71 37.40
192 INT227863 Localization of GPER 1 0.30 0.07 0 36.24
193 INT13607 Binding of Ack 11 0.36 5.77 6.01 35.36
194 INT171021 Negative_regulation of IL5 18 0.41 14.74 3.39 34.48
195 INT227887 Positive_regulation of ZBED1 1 0.01 0.07 0 34.48
196 INT156064 Gene_expression of LMNA 50 0.65 13.38 2.01 33.12
197 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 32.56
198 INT174653 Localization of MEFV 15 0.70 12.06 1.93 31.36
199 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 31.12
200 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35 30.52
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