D:Tyrosinemia

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pChart

Disease Term
Synonyms 4 Hydroxyphenol Pyruvic Acid Oxidase Deficiency Disease, 4 Hydroxyphenylpyruvate Dioxygenase Deficiency Disease, Deficiency Disease 4 Hydroxyphenol Pyruvic Acid Oxidase, DEFICIENCY DISEASE FUMARYLACETOACETASE, Deficiency Disease Tyrosine Transaminase, Deficiency Diseases Fumarylacetoacetase, DISEASE FUMARYLACETOACETASE DEFICIENCY, Diseases Fumarylacetoacetase Deficiency, Fumarylacetoacetase Deficiency Disease, Fumarylacetoacetase Deficiency Diseases, Hepatorenal Tyrosinaemia
Documents 30
Hot Single Events 10
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Tyrosinemia. They are ordered first by their relevance to Tyrosinemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT327112 HCCS Positive_regulation of Gene_expression of SLCO1B3 1 0.03 0.65 0.19 5.00
2 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
3 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
4 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
5 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Tyrosinemia. They are ordered first by their pain relevance and then by number of times they were reported in Tyrosinemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 99.98
2 INT56918 Negative_regulation of TAT 11 0.57 5.92 2.44 99.48
3 INT198790 Negative_regulation of Fah 1 0.20 1.19 0.21 99.08
4 INT35990 Negative_regulation of Sds 8 0.49 4.47 4.96 97.20
5 INT79140 Binding of HCC 36 0.31 46.96 1.87 95.24
6 INT134901 Negative_regulation of Fah 1 0.20 0.87 0.1 93.52
7 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66 92.52
8 INT112729 Positive_regulation of Negative_regulation of COQ7 1 0.43 1.31 0.26 91.32
9 INT112728 Negative_regulation of COQ7 1 0.50 4.8 0.89 90.88
10 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 86.08
11 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 78.16
12 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 75.00
13 INT61264 Regulation of Jun 36 0.61 18.42 8.71 75.00
14 INT116395 Negative_regulation of Ahsa1 1 0.24 1.68 0.14 75.00
15 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 75.00
16 INT198816 Gene_expression of FAH 1 0.65 0.42 0.1 74.52
17 INT198789 Positive_regulation of Fah 8 0.35 0.56 0.16 73.00
18 INT198788 Gene_expression of Fah 5 0.36 0.49 0.18 72.72
19 INT70242 Localization of HCC 18 0.66 23.95 2.35 54.24
20 INT102746 Negative_regulation of Hmbs 11 0.59 8.35 0.77 52.72
21 INT198815 Negative_regulation of Binding of FAH 1 0.41 0.05 0.16 33.24
22 INT198817 Binding of FAH 1 0.36 0.05 0.15 31.28
23 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 30.32
24 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 15.12
25 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
26 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
27 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
28 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 5.00
29 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
30 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
31 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
32 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
33 INT3845 Gene_expression of GSR 79 0.76 44.69 11.19 5.00
34 INT201130 Localization of AES 31 0.63 25.45 5.12 5.00
35 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 5.00
36 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73 5.00
37 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 5.00
38 INT196377 Gene_expression of Nrf1 4 0.68 5.97 2.63 5.00
39 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 5.00
40 INT127038 Gene_expression of Alas1 6 0.72 3.94 1.48 5.00
41 INT84130 Gene_expression of Foxo1 1 0.26 0.97 1.22 5.00
42 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 5.00
43 INT141591 Negative_regulation of Positive_regulation of GPT 2 0.42 0.83 0.8 5.00
44 INT327119 Gene_expression of HCCS 1 0.12 2.47 0.74 5.00
45 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 5.00
46 INT89100 Gene_expression of CNOT1 7 0.65 1.76 0.59 5.00
47 INT327116 Positive_regulation of Localization of AES 4 0.22 2.69 0.55 5.00
48 INT127040 Negative_regulation of Alas1 2 0.35 0.72 0.54 5.00
49 INT327120 Positive_regulation of Positive_regulation of MRI1 1 0.05 0 0.5 5.00
50 INT55807 Negative_regulation of GPT 4 0.42 4.11 0.44 5.00
51 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42 5.00
52 INT327121 Positive_regulation of Gene_expression of HCCS 1 0.07 1.3 0.37 5.00
53 INT56433 Negative_regulation of Cl 3 0.13 1.87 0.35 5.00
54 INT120525 Gene_expression of SLCO1B3 2 0.57 1.47 0.33 5.00
55 INT196376 Positive_regulation of Gene_expression of Alas1 1 0.19 1.01 0.25 5.00
56 INT196372 Positive_regulation of Alas1 1 0.19 1.91 0.22 5.00
57 INT164753 Negative_regulation of Clcn5 2 0.58 5.13 0.2 5.00
58 INT120526 Positive_regulation of Gene_expression of SLCO1B3 2 0.34 0.65 0.18 5.00
59 INT76817 Gene_expression of sb 3 0.46 0.56 0.18 5.00
60 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17 5.00
61 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16 5.00
62 INT87332 Gene_expression of Cyb5d2 8 0.65 2.85 0.15 5.00
63 INT327115 Binding of HCCS 1 0.07 2.44 0.14 5.00
64 INT327118 Transcription of HCCS 1 0.10 0.82 0.13 5.00
65 INT327117 Positive_regulation of HCCS 1 0.07 0.87 0.13 5.00
66 INT158690 Negative_regulation of 3.8-1.4 2 0.07 2.77 0.13 5.00
67 INT196374 Negative_regulation of Positive_regulation of Alas1 1 0.16 0.67 0.12 5.00
68 INT327113 Positive_regulation of Nrm 1 0.49 1.29 0.09 5.00
69 INT47948 Localization of Alad 1 0.14 1.47 0.07 5.00
70 INT340358 Negative_regulation of Positive_regulation of Cl 1 0.13 0.79 0.04 5.00
71 INT340375 Negative_regulation of Cubn 1 0.24 0.77 0.03 5.00
72 INT198787 Localization of Cyb5d2 3 0.73 0.56 0.03 5.00
73 INT196375 Negative_regulation of Ppox 2 0.08 2.73 0 5.00
74 INT340360 Positive_regulation of Clcn5 1 0.50 1.62 0 5.00
75 INT340365 Protein_catabolism of Clcn5 1 0.99 1.03 0 5.00
76 INT198818 Regulation of CD59 4 0.44 0.91 0 5.00
77 INT340363 Regulation of Clcn5 1 0.45 0.85 0 5.00
78 INT196373 Negative_regulation of Vmn2r81 1 0.02 1.96 0 5.00
79 INT340362 Gene_expression of Ocrl 3 0.67 2.27 0 5.00
80 INT340371 Regulation of Tal 1 0.10 0.85 0 5.00
81 INT340370 Negative_regulation of Ocrl 1 0.43 2.31 0 5.00
82 INT340367 Regulation of Gene_expression of Ocrl 1 0.45 1.11 0 5.00
83 INT340368 Binding of Ocrl 1 0.37 2.61 0 5.00
84 INT340359 Binding of Clcn5 1 0.48 1.91 0 5.00
85 INT340374 Binding of Rabep1 1 0.05 0.61 0 5.00
86 INT340372 Negative_regulation of Protein_catabolism of Clcn5 1 0.43 1.07 0 5.00
87 INT340361 Binding of Clcn4-2 1 0.30 0.82 0 5.00
88 INT340369 Negative_regulation of Tal 1 0.09 1.04 0 5.00
89 INT340364 Negative_regulation of Gene_expression of Ocrl 1 0.43 1.16 0 5.00
90 INT196371 Gene_expression of Ireb2 1 0.41 1.95 0 5.00
91 INT340366 Gene_expression of Clcn5 1 0.77 4.8 0 5.00
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