D:Umbilical Hernia

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Disease Term
Synonyms EXOMPHALOS, HERNIAS UMBILICAL, Omphalocele, OMPHALOCELES, UMBILICAL HERNIAS
Documents 140
Hot Single Events 32
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Umbilical Hernia. They are ordered first by their relevance to Umbilical Hernia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23 96.20
2 INT287088 Binding of EEC1 and Vamp3 1 0.09 1.02 0 90.56
3 INT356235 SLC32A1 Regulation of Localization of Gabrg1 1 0.10 1.21 0.7 79.68
4 INT356232 Slc32a1 Regulation of Localization of Gabrg1 1 0.10 1.21 0.7 79.68
5 INT356233 Slc32a1 Positive_regulation of Gabrg1 1 0.17 1.6 1.44 38.40
6 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14 5.00
7 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
8 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
9 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
10 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00
11 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
12 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0 5.00
13 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0 5.00
14 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0 5.00
15 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0 5.00
16 INT303845 Binding of PON1 and Pon1 1 0.01 1.33 0 5.00
17 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Umbilical Hernia. They are ordered first by their pain relevance and then by number of times they were reported in Umbilical Hernia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 99.20
2 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53 98.88
3 INT114201 Gene_expression of Slc32a1 8 0.78 14.2 7.21 96.88
4 INT356219 Binding of Gabrb3 1 0.29 1.25 0.23 96.20
5 INT180240 Binding of Gad1 7 0.47 2.99 0.86 96.20
6 INT356227 Regulation of Slc32a1 1 0.24 0.44 0.3 96.12
7 INT287082 Gene_expression of Vamp3 1 0.18 0.99 0.11 94.88
8 INT9033 Positive_regulation of Pcbd1 14 0.39 3.88 0.86 94.52
9 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4 94.32
10 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 92.72
11 INT255273 Transcription of Slc32a1 2 0.67 0.83 0.26 92.08
12 INT356220 Binding of Slc32a1 1 0.32 1.48 1.74 92.00
13 INT356221 Negative_regulation of Gene_expression of Slc32a1 1 0.43 0.59 0.03 90.72
14 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 89.60
15 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 89.08
16 INT114110 Negative_regulation of EEC1 2 0.37 2.35 0.12 88.28
17 INT356217 Negative_regulation of Slc32a1 1 0.59 1.91 0.27 86.96
18 INT223093 Phosphorylation of NAGLU 1 0.45 0.95 0 86.80
19 INT322321 Gene_expression of PGK1 4 0.65 1.07 0.19 84.84
20 INT222732 Positive_regulation of Negative_regulation of TAS 1 0.36 0.95 0.19 83.52
21 INT180599 Gene_expression of EEC1 5 0.63 2.73 0.23 83.32
22 INT57592 Negative_regulation of TAs 17 0.33 9.49 4.51 82.88
23 INT200806 Binding of EEC1 6 0.39 4.24 0.29 82.16
24 INT310679 Positive_regulation of ARSB 1 0.39 2.36 0.04 81.36
25 INT356218 Regulation of Gene_expression of Slc32a1 1 0.27 0.64 0.2 80.92
26 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 80.80
27 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 80.80
28 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 80.80
29 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 80.64
30 INT23647 Negative_regulation of CDA 3 0.38 1.48 0.08 80.56
31 INT310683 Protein_catabolism of ARSB 1 0.73 1.85 0.04 80.32
32 INT84248 Gene_expression of MPEG1 5 0.48 3.38 0.66 80.16
33 INT310678 Protein_catabolism of ARSH 1 0.06 1.76 0.04 78.68
34 INT114199 Positive_regulation of Gene_expression of Slc32a1 2 0.44 1.71 1.35 78.52
35 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 78.24
36 INT134086 Positive_regulation of Slc32a1 3 0.65 2.11 3.03 76.24
37 INT356229 Positive_regulation of Positive_regulation of Slc32a1 1 0.50 0.61 0.29 76.24
38 INT104143 Transcription of EWSR1 7 0.67 8.1 0.42 75.08
39 INT49706 Positive_regulation of TNNT2 22 0.69 12.65 1.56 72.04
40 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 71.04
41 INT104140 Binding of H2-Q12 1 0.03 0.83 0.08 70.56
42 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 69.52
43 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82 69.52
44 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 67.12
45 INT79502 Gene_expression of Pvalb 26 0.78 2.83 7.46 67.12
46 INT230359 Regulation of TAs 3 0.11 1.98 0.58 65.12
47 INT186862 Regulation of Pon1 5 0.60 6.15 0.51 65.12
48 INT2638 Regulation of PON1 5 0.59 5.13 0.45 65.12
49 INT303839 Negative_regulation of Regulation of Pon1 1 0.35 0.16 0.05 65.12
50 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 64.40
51 INT161648 Gene_expression of TAs 9 0.58 3.57 1.28 59.60
52 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 54.76
53 INT3983 Positive_regulation of Acot1 30 0.68 5.83 8.34 53.64
54 INT356228 Positive_regulation of Slc18a3 1 0.35 0.9 0.94 53.28
55 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 50.64
56 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 49.00
57 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 45.00
58 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54 44.00
59 INT142117 Regulation of Runx2 6 0.61 2.75 0.22 43.76
60 INT45437 Localization of Acot1 84 0.79 17.37 22.18 42.60
61 INT356226 Positive_regulation of Transcription of Acot1 1 0.06 0.28 0.54 42.60
62 INT356223 Transcription of Acot1 1 0.07 0.28 0.54 42.60
63 INT22282 Positive_regulation of Chat 8 0.67 2.82 2.12 41.64
64 INT227604 Transcription of Chat 4 0.52 1.01 1.08 41.64
65 INT222970 Localization of Chat 6 0.73 0.96 1.66 40.56
66 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 40.28
67 INT242541 Regulation of Gene_expression of Chat 3 0.43 0.67 0.67 36.12
68 INT287083 Binding of Vamp3 1 0.14 1.58 0 36.04
69 INT16266 Gene_expression of Chat 80 0.67 16.14 15.01 35.72
70 INT343017 Positive_regulation of Azi1 1 0.21 2.39 0.16 34.56
71 INT343019 Positive_regulation of Positive_regulation of Azi1 1 0.21 1.58 0.13 34.56
72 INT200595 Regulation of Gene_expression of TNNT2 1 0.24 0.95 0.08 34.28
73 INT202424 Gene_expression of HRCT1 3 0.07 3.47 0.36 33.28
74 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 31.72
75 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 31.72
76 INT93168 Gene_expression of Ttf1 24 0.63 17.18 1.14 31.72
77 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 31.72
78 INT17312 Binding of HSPG2 30 0.41 33.01 4.88 31.44
79 INT161371 Gene_expression of Glul 7 0.61 2.44 1.58 31.04
80 INT49302 Localization of TNNT2 6 0.78 3.1 0.34 30.88
81 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 22.72
82 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 10.88
83 INT196324 Localization of Cyp2b10 5 0.73 2.81 0.13 9.36
84 INT45812 Protein_catabolism of Gabrg1 12 0.79 1.93 8.76 6.96
85 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
86 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 5.00
87 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
88 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
89 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
90 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
91 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89 5.00
92 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
93 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
94 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
95 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
96 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
97 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
98 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
99 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
100 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82 5.00
101 INT10585 Localization of NAGLU 53 0.80 23.32 12.75 5.00
102 INT144689 Regulation of RCT 49 0.53 25.91 9.6 5.00
103 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
104 INT51530 Negative_regulation of Adk 11 0.56 3.83 9.07 5.00
105 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
106 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 5.00
107 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 5.00
108 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
109 INT3163 Gene_expression of NAGLU 28 0.75 15.23 4.98 5.00
110 INT68216 Binding of NF1 40 0.48 51.24 4.59 5.00
111 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 5.00
112 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75 5.00
113 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 5.00
114 INT130295 Gene_expression of Abcg2 21 0.75 9.75 3.42 5.00
115 INT117117 Positive_regulation of REM1 12 0.40 10.1 3.33 5.00
116 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 5.00
117 INT597 Positive_regulation of PON1 26 0.62 19.14 2.87 5.00
118 INT101246 Gene_expression of Gata6 6 0.68 3.03 2.68 5.00
119 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
120 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57 5.00
121 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 5.00
122 INT90566 Positive_regulation of Gene_expression of Gad1 5 0.48 1.46 2.42 5.00
123 INT105993 Gene_expression of IDS 26 0.78 10.83 2.41 5.00
124 INT150476 Positive_regulation of ELF3 32 0.56 13.61 2.39 5.00
125 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 5.00
126 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37 5.00
127 INT151449 Negative_regulation of Gene_expression of Kit 18 0.45 12.05 2.23 5.00
128 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17 5.00
129 INT15765 Localization of PON1 8 0.75 3.61 2.08 5.00
130 INT68829 Binding of ELF3 14 0.47 7.96 2 5.00
131 INT99572 Localization of Kit 13 0.75 5.23 1.95 5.00
132 INT194074 Regulation of NAGLU 5 0.38 2.93 1.87 5.00
133 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 5.00
134 INT146943 Gene_expression of Src 13 0.49 6.65 1.65 5.00
135 INT25384 Positive_regulation of Localization of Csf2 11 0.66 7.81 1.62 5.00
136 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 5.00
137 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
138 INT164325 Negative_regulation of Abcg2 6 0.39 1.88 1.2 5.00
139 INT124218 Gene_expression of Pon1 9 0.75 19.55 1.19 5.00
140 INT140288 Localization of Pon1 4 0.78 6.15 1.15 5.00
141 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1 5.00
142 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 5.00
143 INT134822 Gene_expression of Gja1 18 0.72 4.2 1 5.00
144 INT200462 Binding of IDS 13 0.31 4.95 1 5.00
145 INT164324 Negative_regulation of Gene_expression of Abcg2 4 0.45 1.03 0.99 5.00
146 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 5.00
147 INT43484 Binding of Runx2 7 0.37 3.22 0.95 5.00
148 INT153329 Gene_expression of Cm9 6 0.67 4.35 0.95 5.00
149 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87 5.00
150 INT101892 Gene_expression of PIM1 10 0.65 7.19 0.85 5.00
151 INT241499 Binding of Abl1 23 0.47 8.86 0.75 5.00
152 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75 5.00
153 INT287087 Localization of EEC1 2 0.61 1.6 0.72 5.00
154 INT303837 Negative_regulation of Pon1 4 0.57 11.08 0.71 5.00
155 INT171364 Localization of Pdgfrb 6 0.37 4.98 0.68 5.00
156 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65 5.00
157 INT47553 Gene_expression of ARSH 11 0.42 4.93 0.65 5.00
158 INT346406 Gene_expression of Mns1 2 0.12 0.27 0.6 5.00
159 INT159864 Localization of CYP3A5 2 0.73 0.33 0.52 5.00
160 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51 5.00
161 INT240765 Positive_regulation of Pon1 16 0.67 12.06 0.48 5.00
162 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44 5.00
163 INT213789 Phosphorylation of Kit 7 0.69 5.32 0.43 5.00
164 INT70884 Localization of Pdgfb 8 0.35 6.22 0.42 5.00
165 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41 5.00
166 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28 5.00
167 INT187017 Positive_regulation of Bcar1 2 0.44 2.02 0.27 5.00
168 INT241498 Regulation of Abl1 8 0.32 6.46 0.22 5.00
169 INT321259 Binding of MPEG1 1 0.20 2.25 0.21 5.00
170 INT145114 Binding of Azi1 2 0.16 0.39 0.2 5.00
171 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19 5.00
172 INT199561 Positive_regulation of Gene_expression of Abl1 8 0.36 4.77 0.16 5.00
173 INT321258 Positive_regulation of Binding of MPEG1 1 0.26 1.59 0.16 5.00
174 INT200802 Regulation of Jak2 5 0.61 2.86 0.16 5.00
175 INT186164 Phosphorylation of NOVA2 3 0.07 0.87 0.15 5.00
176 INT192194 Positive_regulation of FBXW11 3 0.34 0.84 0.14 5.00
177 INT310677 Localization of ARSB 1 0.71 5.72 0.14 5.00
178 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 5.00
179 INT241504 Negative_regulation of Aurka 2 0.09 1.54 0.11 5.00
180 INT84245 Negative_regulation of MPEG1 2 0.20 1.46 0.1 5.00
181 INT241512 Phosphorylation of Abl1 4 0.59 2.68 0.09 5.00
182 INT245785 Negative_regulation of NDUFS4 1 0.06 1.16 0.09 5.00
183 INT303836 Positive_regulation of Localization of Pon1 1 0.36 1.07 0.09 5.00
184 INT241515 Negative_regulation of Phosphorylation of Abl1 3 0.30 1.36 0.09 5.00
185 INT303841 Negative_regulation of Gene_expression of Pon1 1 0.31 0.9 0.09 5.00
186 INT175415 Negative_regulation of COX10 5 0.07 3.33 0.08 5.00
187 INT211942 Transcription of Runx2 3 0.69 2.46 0.08 5.00
188 INT278654 Phosphorylation of SULT2A1 2 0.60 0.29 0.08 5.00
189 INT241509 Negative_regulation of Gene_expression of Lyn 2 0.20 1.02 0.05 5.00
190 INT241507 Positive_regulation of Abl1 5 0.40 2.69 0.05 5.00
191 INT303840 Regulation of Gene_expression of Pon1 1 0.22 0.74 0.05 5.00
192 INT241506 Localization of Abl1 2 0.54 2.37 0.04 5.00
193 INT310682 Regulation of ARSB 1 0.43 0.98 0.04 5.00
194 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 5.00
195 INT287085 Negative_regulation of Myh9 1 0.21 0.6 0.03 5.00
196 INT343018 Gene_expression of Azi1 1 0.29 0.45 0.03 5.00
197 INT241510 Negative_regulation of Phosphorylation of Kit 3 0.31 2.06 0.03 5.00
198 INT180589 Phosphorylation of COL1A1 3 0.34 0.37 0.03 5.00
199 INT206801 Positive_regulation of Phosphorylation of NOVA2 1 0.03 0.87 0 5.00
200 INT303834 Negative_regulation of Gene_expression of TAS 1 0.09 0.46 0 5.00
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