D:Unknown Primary Neoplasms

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pChart

Disease Term
Synonyms Neoplasm Metastasis Unknown Primary, Neoplasm Occult Primary, NEOPLASM UNKNOWN PRIMARY, Neoplasms Occult Primary, Occult Primary Neoplasm, Occult Primary Neoplasms, Primary Neoplasm Occult, Primary Neoplasm Unknown, PRIMARY NEOPLASMS OCCULT, Primary Neoplasms Unknown, PRIMARY TUMOR UNKNOWN
Documents 24
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Unknown Primary Neoplasms. They are ordered first by their relevance to Unknown Primary Neoplasms and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT116124 Binding of AFP and HCC 2 0.20 1.72 0.15 5.00
2 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
3 INT232914 Binding of KRT2 and KRT7 1 0.15 0.63 0.05 5.00
4 INT232916 Binding of KRT2 and KRT19 1 0.21 0.62 0.05 5.00
5 INT232907 Binding of KRT7 and KRT8 1 0.09 0.63 0.05 5.00
6 INT232918 Binding of KRT2 and KRT8 1 0.17 0.59 0 5.00
7 INT227250 Rtl1 Positive_regulation of CD8A 1 0.20 0.4 0 5.00
8 INT227218 Binding of JAG1 and CD8A 1 0.05 0.5 0 5.00
9 INT232912 Binding of KRT4 and KRT13 1 0.07 0.06 0 5.00
10 INT232910 Binding of KRT12 and KRT76 1 0.39 0.2 0 5.00
11 INT232911 Binding of KRT18 and PLAT 1 0.05 1.3 0 5.00
12 INT232915 Binding of KRT8 and PLAT 1 0.04 1.3 0 5.00
13 INT232909 Binding of KRT1 and KRT9 1 0.16 0.5 0 5.00
14 INT232913 Binding of KRT3 and NBPF14 1 0.01 0.21 0 5.00
15 INT232908 Binding of KRT19 and PLAT 1 0.05 1.31 0 5.00
16 INT232906 Binding of KRT1 and KRT10 1 0.18 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Unknown Primary Neoplasms. They are ordered first by their pain relevance and then by number of times they were reported in Unknown Primary Neoplasms. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 96.02
2 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 88.52
3 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 88.36
4 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 88.04
5 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 87.52
6 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 87.24
7 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 85.08
8 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 69.84
9 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 57.36
10 INT137382 Negative_regulation of Gene_expression of KRT20 22 0.58 12.29 1.29 55.44
11 INT216395 Negative_regulation of Gene_expression of KRT7 4 0.41 3.57 0.16 48.76
12 INT73497 Regulation of IL10 33 0.45 22.6 9.19 43.36
13 INT232950 Negative_regulation of Gene_expression of KRT8 1 0.25 0.79 0 41.44
14 INT264884 Gene_expression of LIMA1 1 0.65 0.68 0.06 29.72
15 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 29.68
16 INT227017 Gene_expression of KRT17 2 0.45 14.84 0.41 10.32
17 INT187627 Gene_expression of KRT4 5 0.37 4.54 0 10.32
18 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
19 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
20 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 5.00
21 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
22 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
23 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 5.00
24 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
25 INT45142 Gene_expression of DCPS 109 0.56 84.71 16.87 5.00
26 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
27 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
28 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
29 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 5.00
30 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
31 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 5.00
32 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
33 INT10019 Binding of CD8A 57 0.36 31.49 10.08 5.00
34 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
35 INT84894 Gene_expression of Calb2 45 0.73 24.65 7.81 5.00
36 INT86639 Gene_expression of KRT16 19 0.68 12.44 7.79 5.00
37 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
38 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 5.00
39 INT159632 Localization of DCPS 24 0.21 18.24 6.8 5.00
40 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39 5.00
41 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
42 INT64208 Gene_expression of Rtl1 18 0.75 7.51 6.16 5.00
43 INT2137 Localization of Cea 27 0.70 19.22 6.14 5.00
44 INT56149 Localization of CD8A 56 0.74 30.41 5.75 5.00
45 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
46 INT38670 Positive_regulation of Gene_expression of KRT20 68 0.69 23.25 5.55 5.00
47 INT142162 Binding of IL10 30 0.37 21.9 4.84 5.00
48 INT17182 Binding of Cea 25 0.48 14.98 4.16 5.00
49 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
50 INT97139 Gene_expression of CD83 43 0.70 22.05 3.91 5.00
51 INT143494 Binding of DCPS 24 0.29 24.41 3.67 5.00
52 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35 5.00
53 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 5.00
54 INT8477 Negative_regulation of AFP 35 0.58 31.52 3.1 5.00
55 INT86640 Positive_regulation of Gene_expression of KRT16 5 0.61 2.5 2.99 5.00
56 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86 5.00
57 INT126514 Positive_regulation of CCR7 16 0.43 16.21 2.79 5.00
58 INT11139 Gene_expression of LBR 20 0.75 5.13 2.78 5.00
59 INT27652 Gene_expression of TG 36 0.78 22.36 2.74 5.00
60 INT221269 Binding of BRCA1 14 0.40 31.77 2.7 5.00
61 INT5789 Gene_expression of PMEL 23 0.75 13.18 2.67 5.00
62 INT18969 Gene_expression of HLA-DQA1 29 0.65 12.19 2.54 5.00
63 INT70242 Localization of HCC 18 0.66 23.95 2.35 5.00
64 INT11388 Positive_regulation of PMEL 11 0.67 5.9 2.09 5.00
65 INT111143 Regulation of Gene_expression of KRT20 22 0.26 5.65 1.93 5.00
66 INT209890 Positive_regulation of Gene_expression of CD83 11 0.62 9.04 1.88 5.00
67 INT233010 Gene_expression of PERP 5 0.26 6.04 1.66 5.00
68 INT98096 Positive_regulation of CHKA 14 0.42 12.23 1.61 5.00
69 INT209896 Positive_regulation of Gene_expression of CD80 19 0.49 11.9 1.59 5.00
70 INT117033 Gene_expression of JAG1 13 0.65 11.46 1.52 5.00
71 INT28643 Positive_regulation of Gene_expression of LBR 3 0.11 2.43 1.16 5.00
72 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 5.00
73 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 5.00
74 INT127064 Gene_expression of KRT76 7 0.75 1.71 1.1 5.00
75 INT5006 Transcription of KRT20 9 0.46 7.11 1.03 5.00
76 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 5.00
77 INT186520 Gene_expression of CHKA 8 0.56 8.22 1 5.00
78 INT206467 Gene_expression of IARS 11 0.33 6.65 0.93 5.00
79 INT56148 Localization of PMEL 5 0.78 1.87 0.93 5.00
80 INT153629 Negative_regulation of CHKA 3 0.12 2.33 0.92 5.00
81 INT93559 Gene_expression of Thbd 13 0.75 6.58 0.8 5.00
82 INT125627 Gene_expression of TTF1 11 0.78 12.68 0.78 5.00
83 INT127633 Localization of KRT18 5 0.52 5.93 0.75 5.00
84 INT162609 Localization of Rtl1 2 0.73 0.64 0.74 5.00
85 INT160736 Negative_regulation of KRT7 9 0.41 10.08 0.68 5.00
86 INT206139 Phosphorylation of KRT20 8 0.48 9.1 0.66 5.00
87 INT148382 Positive_regulation of JAG1 5 0.23 3.88 0.63 5.00
88 INT117437 Protein_catabolism of KRT18 3 0.46 4.64 0.61 5.00
89 INT159190 Gene_expression of KRT5 31 0.65 26.67 0.56 5.00
90 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53 5.00
91 INT146179 Gene_expression of KRT6A 23 0.75 9.39 0.52 5.00
92 INT95692 Negative_regulation of KRT19 4 0.24 4.07 0.51 5.00
93 INT131931 Binding of KRT7 13 0.36 19.24 0.5 5.00
94 INT84730 Positive_regulation of Rtl1 5 0.49 2.06 0.48 5.00
95 INT70445 Binding of KRT1 10 0.35 5.38 0.47 5.00
96 INT189228 Positive_regulation of KRT16 5 0.44 1.89 0.41 5.00
97 INT151400 Binding of JAG1 14 0.37 7.96 0.39 5.00
98 INT233007 Negative_regulation of VIM 6 0.41 3.46 0.36 5.00
99 INT174112 Positive_regulation of Gene_expression of KRT19 4 0.44 4.28 0.31 5.00
100 INT18968 Positive_regulation of Gene_expression of HLA-DQA1 5 0.09 1.89 0.29 5.00
101 INT151793 Gene_expression of KRT3 36 0.75 2.32 0.26 5.00
102 INT162564 Gene_expression of KRT2 5 0.59 1.75 0.24 5.00
103 INT232945 Positive_regulation of Gene_expression of KRT18 2 0.49 3.54 0.23 5.00
104 INT232970 Localization of KRT19 4 0.41 3.41 0.23 5.00
105 INT232982 Localization of KRT8 2 0.44 2.65 0.23 5.00
106 INT232967 Positive_regulation of Gene_expression of KRT8 2 0.29 3.54 0.23 5.00
107 INT232944 Transcription of KRT75 1 0.43 0.59 0.18 5.00
108 INT227245 Localization of CCR7 4 0.47 0.74 0.18 5.00
109 INT232962 Binding of KRT18 4 0.26 2.38 0.18 5.00
110 INT232989 Gene_expression of KRT71 1 0.46 0.45 0.17 5.00
111 INT146180 Positive_regulation of Gene_expression of KRT6A 2 0.49 1.43 0.16 5.00
112 INT73080 Positive_regulation of TTF1 4 0.38 2.37 0.14 5.00
113 INT71389 Positive_regulation of KRT19 3 0.38 4.91 0.13 5.00
114 INT232955 Gene_expression of KRT38 1 0.47 0.12 0.13 5.00
115 INT232964 Gene_expression of KRT28 4 0.48 3.88 0.13 5.00
116 INT111770 Regulation of PMEL 2 0.44 0.4 0.12 5.00
117 INT232987 Gene_expression of KRT85 1 0.10 1.2 0.11 5.00
118 INT233008 Gene_expression of KRT75 1 0.56 1.07 0.11 5.00
119 INT232951 Gene_expression of KRT81 1 0.39 0.31 0.11 5.00
120 INT187628 Gene_expression of KRT14 15 0.75 11.54 0.1 5.00
121 INT233005 Gene_expression of CAPN9 1 0.02 1.76 0.1 5.00
122 INT233003 Negative_regulation of Gene_expression of KRT17 1 0.25 2.13 0.1 5.00
123 INT84731 Positive_regulation of Gene_expression of Rtl1 3 0.49 1.96 0.09 5.00
124 INT145490 Binding of KRT76 2 0.36 0.29 0.09 5.00
125 INT224235 Negative_regulation of Positive_regulation of CHKA 1 0.14 3.61 0.09 5.00
126 INT227247 Positive_regulation of Positive_regulation of PMEL 2 0.19 0.37 0.08 5.00
127 INT70450 Binding of KRT5 6 0.47 5.72 0.08 5.00
128 INT164348 Positive_regulation of KRT14 5 0.49 2 0.08 5.00
129 INT17181 Positive_regulation of Binding of Cea 2 0.50 2.53 0.08 5.00
130 INT232996 Gene_expression of KRT27 1 0.44 0 0.07 5.00
131 INT232974 Gene_expression of KRT25 1 0.36 0 0.06 5.00
132 INT230117 Binding of KRT8 6 0.31 2.44 0.05 5.00
133 INT232981 Positive_regulation of Gene_expression of KRT17 1 0.25 1.06 0.05 5.00
134 INT232972 Gene_expression of KRT34 1 0.30 0 0.05 5.00
135 INT232971 Negative_regulation of KRT17 1 0.22 0.45 0.05 5.00
136 INT175895 Negative_regulation of KRT1 5 0.37 3.23 0.05 5.00
137 INT232957 Binding of KRT19 3 0.23 0.97 0.05 5.00
138 INT232984 Gene_expression of KRT36 1 0.14 0 0.05 5.00
139 INT232986 Negative_regulation of KRT81 1 0.18 0 0.04 5.00
140 INT232991 Localization of KRT5 1 0.33 1.36 0.04 5.00
141 INT232952 Gene_expression of KRT40 1 0.27 0 0.04 5.00
142 INT232920 Regulation of Gene_expression of Krt27 1 0.00 0.11 0.04 5.00
143 INT232919 Gene_expression of Krt27 1 0.01 0.11 0.04 5.00
144 INT233000 Negative_regulation of KRT86 1 0.23 0 0.04 5.00
145 INT233006 Binding of KRT17 1 0.28 0.8 0.04 5.00
146 INT232994 Gene_expression of KRT10 6 0.40 8.2 0.03 5.00
147 INT232999 Positive_regulation of Localization of KRT16 1 0.32 0.37 0 5.00
148 INT233002 Binding of KRT2 1 0.29 0 0 5.00
149 INT232953 Binding of RBPJP3 1 0.03 0.26 0 5.00
150 INT233004 Localization of KRT17 1 0.36 0.19 0 5.00
151 INT232978 Localization of KRT4 1 0.35 0.2 0 5.00
152 INT232948 Positive_regulation of Phosphorylation of KRT20 1 0.41 0.67 0 5.00
153 INT232975 Binding of KRT9 2 0.14 0.8 0 5.00
154 INT225958 Gene_expression of KRT12 13 0.68 1.57 0 5.00
155 INT232949 Positive_regulation of KRT10 1 0.25 0.38 0 5.00
156 INT232980 Binding of KRT3 2 0.29 0.43 0 5.00
157 INT232947 Positive_regulation of RBPJP3 1 0.05 0.19 0 5.00
158 INT232990 Localization of KRT6A 1 0.43 0.37 0 5.00
159 INT232922 Gene_expression of Krt71 1 0.65 0 0 5.00
160 INT232983 Negative_regulation of KRT13 1 0.26 2.44 0 5.00
161 INT232997 Positive_regulation of KRT6A 1 0.40 0.82 0 5.00
162 INT232979 Gene_expression of RBPJP3 1 0.06 0.24 0 5.00
163 INT232985 Positive_regulation of Localization of KRT6A 1 0.29 0.37 0 5.00
164 INT232965 Binding of KRT10 3 0.19 1.66 0 5.00
165 INT233009 Binding of KRT13 1 0.16 1.13 0 5.00
166 INT232977 Gene_expression of KRT77 1 0.75 3.41 0 5.00
167 INT232943 Binding of KRT12 3 0.47 0.88 0 5.00
168 INT232921 Gene_expression of Krt6b 2 0.65 1.5 0 5.00
169 INT227013 Positive_regulation of KRT17 2 0.27 2.4 0 5.00
170 INT225959 Gene_expression of KRT15 7 0.48 2.01 0 5.00
171 INT232992 Localization of KRT9 1 0.29 0.47 0 5.00
172 INT232961 Localization of KRT13 1 0.38 0.2 0 5.00
173 INT232954 Binding of KRT15 1 0.17 0 0 5.00
174 INT232988 Binding of KRT77 1 0.20 0.79 0 5.00
175 INT232956 Localization of KRT16 1 0.47 0.37 0 5.00
176 INT233001 Binding of KRT14 2 0.36 0.77 0 5.00
177 INT232923 Negative_regulation of Krt27 1 0.00 0.62 0 5.00
178 INT225960 Gene_expression of KRT13 4 0.39 2.47 0 5.00
179 INT232960 Negative_regulation of Binding of KRT5 1 0.20 1.68 0 5.00
180 INT232946 Positive_regulation of Gene_expression of KRT5 1 0.23 0.33 0 5.00
181 INT232969 Positive_regulation of KRT5 1 0.27 1.24 0 5.00
182 INT232942 Negative_regulation of KRT10 3 0.21 1.19 0 5.00
183 INT232968 Negative_regulation of Gene_expression of KRT13 1 0.22 0.11 0 5.00
184 INT232995 Negative_regulation of Gene_expression of KRT15 1 0.32 0.37 0 5.00
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