D:Ureteral Obstruction

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Disease Term
Synonyms OBSTRUCTION URETERAL, Obstructions Ureteral, Ureteral Obstructions
Documents 299
Hot Single Events 167
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ureteral Obstruction. They are ordered first by their relevance to Ureteral Obstruction and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 97.88
2 INT269838 Binding of Hsp90b1 and Tlr2 1 0.26 1.75 0.03 97.68
3 INT88137 Ren Regulation of Gene_expression of Spp1 1 0.04 0.24 0.09 92.72
4 INT291616 Cby1 Positive_regulation of Gene_expression of Smad7 1 0.00 0.79 0.38 90.48
5 INT171162 Negative_regulation of Ace Negative_regulation of Gene_expression of Ccl2 1 0.02 1.18 0.1 89.84
6 INT349645 Eif2ak1 Positive_regulation of Hmox1 1 0.00 0.18 0.05 86.08
7 INT349646 Eif2ak1 Regulation of Gene_expression of Hmox1 1 0.00 0.78 0.2 84.00
8 INT349648 Eif2ak1 Positive_regulation of Gene_expression of Hmox1 1 0.00 0.17 0.04 80.80
9 INT349647 Eif2ak1 Positive_regulation of Positive_regulation of Hmox1 1 0.00 1.07 0.2 78.84
10 INT349652 Positive_regulation of Hmox1 Negative_regulation of Positive_regulation of Itk 1 0.01 0.85 0.25 29.28
11 INT349653 Nfe2l2 Positive_regulation of Itk 1 0.00 0.79 0.22 27.40
12 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16 10.80
13 INT320492 KRT7 Positive_regulation of Pip 1 0.00 1.02 0.2 6.88
14 INT74027 Creb1 Regulation of Jun 4 0.27 1.04 1.02 5.00
15 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3 5.00
16 INT287794 Binding of IGHG3 and AIP 1 0.05 2.8 0.24 5.00
17 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22 5.00
18 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22 5.00
19 INT333396 CFD Positive_regulation of Bcl2l1 1 0.05 0.98 0.13 5.00
20 INT171163 Creb1 Regulation of Sp1 1 0.03 0.62 0.1 5.00
21 INT171164 Agt Regulation of Positive_regulation of Rorb 1 0.02 0.64 0.1 5.00
22 INT171165 Agt Positive_regulation of Positive_regulation of Nfkb1 1 0.23 1.09 0.08 5.00
23 INT333395 Binding of CFD and Aes 1 0.03 0.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ureteral Obstruction. They are ordered first by their pain relevance and then by number of times they were reported in Ureteral Obstruction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62 100.00
2 INT254792 Regulation of Positive_regulation of Ecm1 2 0.06 1.86 0.07 100.00
3 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 99.98
4 INT296611 Positive_regulation of Negative_regulation of Cdh1 1 0.11 0.78 0 99.98
5 INT254818 Positive_regulation of Positive_regulation of Ecm1 4 0.06 5.27 0.24 99.98
6 INT128715 Negative_regulation of Actg2 2 0.33 0.81 0.08 99.98
7 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26 99.84
8 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71 99.84
9 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 99.84
10 INT296610 Negative_regulation of Duox2 1 0.06 2.5 0.09 99.80
11 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 99.78
12 INT349651 Positive_regulation of Gene_expression of Rela 1 0.03 1.46 0.33 99.78
13 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.78
14 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 99.78
15 INT84170 Positive_regulation of Gene_expression of Ccl2 58 0.69 48.79 32.43 99.76
16 INT39282 Negative_regulation of SOD2 27 0.59 16.89 7.03 99.74
17 INT296617 Negative_regulation of Positive_regulation of Duox2 1 0.04 1.39 0 99.74
18 INT122103 Negative_regulation of Cdh1 5 0.49 2.05 1.18 99.74
19 INT296615 Positive_regulation of Smad2 1 0.50 1.51 0 99.72
20 INT269823 Transcription of Hspd1 1 0.30 1.66 0.04 99.72
21 INT91320 Localization of Hmox1 8 0.81 4.06 1.28 99.72
22 INT141542 Negative_regulation of Pin1 2 0.29 10.92 1.1 99.68
23 INT296619 Gene_expression of Pin1 1 0.34 4.07 0.29 99.68
24 INT296620 Negative_regulation of Gene_expression of Pin1 1 0.21 2.82 0.26 99.68
25 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 99.68
26 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 99.66
27 INT333390 Positive_regulation of Col4a1 1 0.04 1.19 0.17 99.66
28 INT296618 Negative_regulation of Smad2 1 0.37 1.42 0.03 99.64
29 INT86245 Positive_regulation of Bcl2l1 15 0.46 12.67 3.11 99.60
30 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 99.58
31 INT296612 Regulation of Pin1 1 0.23 2.5 0.39 99.52
32 INT296613 Regulation of Binding of Pin1 1 0.23 0.99 0 99.52
33 INT200606 Regulation of Gene_expression of Serpine1 4 0.38 2.07 0.35 99.52
34 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25 99.50
35 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 99.44
36 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 99.44
37 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 99.42
38 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 99.42
39 INT98837 Positive_regulation of Bax 72 0.61 63.14 6.41 99.32
40 INT70760 Positive_regulation of Actg2 8 0.48 6.23 0.61 99.30
41 INT141541 Binding of Pin1 2 0.19 1.43 0.27 99.30
42 INT296616 Positive_regulation of Duox2 1 0.06 1.27 0 99.22
43 INT128061 Negative_regulation of Gene_expression of Serpine1 16 0.43 13.13 1.29 99.04
44 INT269821 Regulation of Localization of Tlr2 1 0.27 1.04 0.07 99.00
45 INT103824 Positive_regulation of SOD2 26 0.70 17.42 7.17 98.84
46 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 98.82
47 INT248678 Gene_expression of Rela 4 0.16 2.35 0.9 98.82
48 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61 98.64
49 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 98.54
50 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43 98.44
51 INT239215 Binding of Agt 9 0.38 6.75 1.35 98.44
52 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15 98.40
53 INT105134 Regulation of Ralbp1 1 0.23 1.5 0.26 98.40
54 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 98.32
55 INT143360 Regulation of Negative_regulation of Agtr2 1 0.27 0.56 0.1 98.32
56 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56 98.32
57 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72 98.24
58 INT187606 Negative_regulation of Gene_expression of Serpine1 3 0.05 1.78 0.36 98.24
59 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92 98.16
60 INT44145 Negative_regulation of Gene_expression of Ace 5 0.40 4.5 1.33 98.16
61 INT65003 Negative_regulation of Negative_regulation of Ace 5 0.37 3.45 0.23 98.16
62 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 98.04
63 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46 98.04
64 INT221131 Localization of Tlr2 17 0.80 13.82 1.28 97.92
65 INT1178 Positive_regulation of Gene_expression of Ren 16 0.60 7.71 2.41 97.92
66 INT1180 Gene_expression of Ren 63 0.77 27.33 10.51 97.92
67 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41 97.88
68 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26 97.88
69 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29 97.60
70 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 97.48
71 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 97.36
72 INT389 Gene_expression of Ace 21 0.67 10.31 8.1 97.36
73 INT256673 Positive_regulation of Hsp90b1 12 0.49 8.49 0.68 97.28
74 INT256690 Binding of Hsp90b1 11 0.30 5.94 0.55 97.28
75 INT96861 Binding of Ang 11 0.32 4.46 1.1 97.08
76 INT19511 Localization of Il6 212 0.81 118.17 67.67 97.04
77 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 97.04
78 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 96.92
79 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76 96.92
80 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21 96.92
81 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46 96.92
82 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36 96.76
83 INT349644 Negative_regulation of Atl1 1 0.02 0.69 0.14 96.44
84 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 96.40
85 INT174688 Binding of Tlr2 45 0.42 36.65 5.25 96.40
86 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 96.40
87 INT2066 Localization of Agt 56 0.80 9.95 16.25 96.40
88 INT112003 Localization of ROS1 94 0.73 66.32 12.16 96.32
89 INT7678 Localization of Alb 142 0.81 80.93 22.49 96.28
90 INT88136 Positive_regulation of Gene_expression of Spp1 8 0.66 4.5 1.57 96.04
91 INT88130 Gene_expression of Spp1 13 0.74 12.96 3.07 96.04
92 INT385 Gene_expression of Agt 182 0.78 63.62 37.91 96.04
93 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32 96.04
94 INT37215 Positive_regulation of SMN1 18 0.45 8.99 4.87 95.88
95 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67 95.36
96 INT296621 Regulation of Gene_expression of Pin1 1 0.23 1.28 0.05 95.16
97 INT15723 Gene_expression of Fn1 47 0.78 37.59 8.51 94.88
98 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 94.80
99 INT287003 Negative_regulation of Positive_regulation of Hmox1 2 0.34 3.1 0.63 94.64
100 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 94.44
101 INT53949 Positive_regulation of Gene_expression of Cpox 82 0.65 38.12 25.93 94.44
102 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 94.44
103 INT12950 Gene_expression of Cat 85 0.75 35.94 15.76 94.28
104 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 94.08
105 INT251364 Negative_regulation of Gene_expression of Cdh1 4 0.32 1.02 0.07 93.84
106 INT387 Regulation of Ace 18 0.45 5.24 4.24 93.68
107 INT296622 Positive_regulation of Gene_expression of Cdh1 3 0.52 2.24 0.09 93.44
108 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 93.24
109 INT189877 Gene_expression of Cdh1 55 0.58 9.36 0.66 93.16
110 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49 92.76
111 INT105135 Positive_regulation of Ralbp1 1 0.60 1.49 0.26 92.68
112 INT49985 Transcription of Il6 62 0.72 40.13 20.29 92.60
113 INT135409 Transcription of Ccl2 13 0.62 10.59 3.06 92.60
114 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21 92.44
115 INT11679 Negative_regulation of F13A1 55 0.54 33.69 9.43 92.40
116 INT296623 Positive_regulation of Cdh1 2 0.35 1.88 0.09 92.32
117 INT920 Localization of PLOD1 223 0.81 42.25 78.7 91.32
118 INT917 Positive_regulation of Localization of PLOD1 51 0.69 8.53 22.87 91.32
119 INT349650 Negative_regulation of Eif2ak1 1 0.00 0.59 0.03 91.20
120 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 90.80
121 INT88132 Positive_regulation of Gene_expression of Dpep1 1 0.04 0.26 0.09 90.28
122 INT128716 Transcription of Actg2 2 0.54 0.74 0.09 90.24
123 INT43084 Binding of Ace 10 0.46 4.7 1.93 90.24
124 INT99742 Negative_regulation of Gene_expression of Hmox1 12 0.58 9.94 1.77 89.92
125 INT88129 Gene_expression of Dpep1 1 0.04 0.26 0.09 89.88
126 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 89.60
127 INT178615 Binding of SOD2 12 0.48 6.93 1.51 89.28
128 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69 89.00
129 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25 89.00
130 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72 89.00
131 INT15724 Negative_regulation of Fn1 15 0.53 5.61 3.87 88.80
132 INT84171 Negative_regulation of Gene_expression of Ccl2 30 0.58 26.37 18.28 88.40
133 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 88.24
134 INT82883 Positive_regulation of Ccl2 105 0.69 84.96 42.27 88.00
135 INT296614 Gene_expression of Duox2 1 0.07 0.71 0 87.76
136 INT104386 Positive_regulation of Tnpo1 4 0.49 4.82 1.17 87.72
137 INT39879 Positive_regulation of Gene_expression of Fn1 12 0.41 12.69 0.78 87.52
138 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 87.32
139 INT157765 Negative_regulation of CDH1 32 0.53 35.72 1.15 87.20
140 INT133875 Gene_expression of POMT1 26 0.58 17.1 1.48 86.88
141 INT88134 Negative_regulation of Gene_expression of Spp1 2 0.41 1.94 0.32 86.64
142 INT251319 Negative_regulation of Gene_expression of Fn1 4 0.07 1.82 0.74 86.56
143 INT25424 Transcription of Ren 2 0.57 1.21 0.33 86.16
144 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 86.16
145 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 86.12
146 INT81443 Positive_regulation of Vcam1 29 0.63 28.4 6.35 85.80
147 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 85.76
148 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 85.52
149 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84 85.36
150 INT71115 Positive_regulation of Gene_expression of Serpine1 20 0.70 15.32 1.97 85.16
151 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 84.88
152 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 84.88
153 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 84.88
154 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 84.88
155 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 84.08
156 INT88131 Negative_regulation of Spp1 3 0.56 0.7 0.21 84.08
157 INT15941 Negative_regulation of Serpine1 42 0.58 21.07 4.95 83.84
158 INT81291 Regulation of Gene_expression of Hmox1 11 0.60 8.78 2.46 83.48
159 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44 83.36
160 INT103305 Positive_regulation of Positive_regulation of Hmox1 8 0.49 4.81 1.49 83.00
161 INT120062 Binding of AIP 4 0.42 28.86 3.91 82.84
162 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 82.72
163 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 82.72
164 INT72759 Transcription of Cpox 40 0.39 17.26 10 82.52
165 INT3152 Transcription of Agt 7 0.72 5.09 1.68 80.24
166 INT88135 Negative_regulation of Transcription of Agt 1 0.34 0.16 0.08 80.24
167 INT36663 Localization of PRB4 2 0.14 0.15 0.09 80.08
168 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 79.88
169 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 79.88
170 INT55606 Binding of Ace 14 0.37 10.73 1.82 79.60
171 INT171150 Negative_regulation of Binding of Ace 2 0.17 2.67 0.44 79.60
172 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 79.56
173 INT72758 Positive_regulation of Transcription of Cpox 15 0.34 5.46 4.75 79.56
174 INT93484 Negative_regulation of Positive_regulation of Jun 30 0.58 9.31 5.18 79.32
175 INT105133 Positive_regulation of Localization of Ralbp1 1 0.40 0.47 0.09 78.84
176 INT105132 Localization of Ralbp1 2 0.60 0.52 0.09 78.84
177 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 78.72
178 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 78.04
179 INT96269 Positive_regulation of Mcpt1 71 0.61 52.38 20.4 77.80
180 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 77.80
181 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93 77.20
182 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 77.12
183 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 77.08
184 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67 76.96
185 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 75.60
186 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01 75.00
187 INT4578 Positive_regulation of Babr 6 0.01 0.25 1.05 75.00
188 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 75.00
189 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 74.88
190 INT153201 Negative_regulation of Gene_expression of Col1a1 7 0.38 6.37 1.52 74.28
191 INT69215 Gene_expression of Col1a1 38 0.68 17.39 4.77 73.84
192 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 73.84
193 INT250771 Gene_expression of Atl1 3 0.43 2.45 0.75 73.84
194 INT148072 Gene_expression of Agtr1a 5 0.75 9.41 1.13 73.76
195 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86 72.48
196 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 72.36
197 INT171147 Binding of Syt1 7 0.35 6.11 1.36 71.76
198 INT237384 Positive_regulation of Localization of VUR 2 0.43 2.85 0 71.20
199 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 70.80
200 INT55741 Negative_regulation of Timp1 15 0.51 8.12 4.09 70.48
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