D:Urinary Calculi

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Disease Term
Synonyms Bladder Stone, Bladder Stones, Calculi Urinary, CALCULUS URINARY, Stone Urinary, Stone Urinary Tract, Stones Urinary, Stones Urinary Tract, Tract Stone Urinary, Tract Stones Urinary, Urinary Calculus
Documents 376
Hot Single Events 25
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Urinary Calculi. They are ordered first by their relevance to Urinary Calculi and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT339897 Binding of Bnc1 and Shc4 1 0.05 0.69 0.07 99.12
2 INT170992 Binding of FN1 and MMRN1 3 0.01 2.13 0.73 55.84
3 INT227928 Binding of MMRN1 and Lamb3 1 0.03 1.16 0.56 55.84
4 INT227911 Binding of VTN and MMRN1 1 0.01 1.16 0.56 55.84
5 INT227908 Binding of COL7A1 and MMRN1 1 0.00 1.11 0.53 55.84
6 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
7 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63 5.00
8 INT227906 IL10 Regulation of Gene_expression of IL1B 1 0.07 0.57 0.38 5.00
9 INT227909 IL10 Regulation of Gene_expression of TNF 1 0.21 0.57 0.38 5.00
10 INT227907 TNFRSF1B Regulation of TNF 1 0.01 0.41 0.36 5.00
11 INT227904 TNFRSF1A Regulation of TNF 1 0.01 0.41 0.36 5.00
12 INT227910 TNF Positive_regulation of Gene_expression of IL10 1 0.22 0.68 0.29 5.00
13 INT227903 TNF Positive_regulation of Gene_expression of ADAMTS5 1 0.01 0.56 0.24 5.00
14 INT227905 IL10 Positive_regulation of Gene_expression of TIMP1 1 0.01 0.48 0.22 5.00
15 INT198382 Binding of AR and SRD5A1 2 0.06 0.84 0.17 5.00
16 INT310263 Rb1 Negative_regulation of Gene_expression of Tnf 1 0.07 0.97 0.15 5.00
17 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08 5.00
18 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03 5.00
19 INT287088 Binding of EEC1 and Vamp3 1 0.09 1.02 0 5.00
20 INT273518 Binding of ALB and NBN 1 0.06 0.47 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Urinary Calculi. They are ordered first by their pain relevance and then by number of times they were reported in Urinary Calculi. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT74446 Positive_regulation of Dync1h1 25 0.59 13 2.38 99.98
2 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 99.52
3 INT6521 Negative_regulation of Gene_expression of ADRA1D 4 0.57 3.19 2.14 99.52
4 INT68217 Positive_regulation of CHRM3 9 0.39 1.36 0.99 99.40
5 INT165727 Positive_regulation of spc 3 0.21 3.24 0.25 97.60
6 INT19804 Negative_regulation of Hprt 18 0.59 20.6 2.17 96.80
7 INT3496 Negative_regulation of HPRT1 7 0.58 25.05 1.92 96.80
8 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35 96.08
9 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 93.44
10 INT36698 Binding of CHRM3 5 0.48 1.97 1.49 92.16
11 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 87.20
12 INT97318 Gene_expression of SPARC 11 0.67 5.07 1.59 87.20
13 INT180626 Gene_expression of spc 6 0.34 6.83 0.15 85.52
14 INT19803 Gene_expression of Hprt 15 0.67 4.81 1.03 84.92
15 INT212171 Gene_expression of CDIPT 5 0.37 2.58 2.92 84.76
16 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 83.36
17 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 82.16
18 INT234095 Gene_expression of Rrbp1 7 0.27 2.42 0.82 81.96
19 INT339896 Negative_regulation of Gene_expression of Rrbp1 1 0.02 0.97 0 81.96
20 INT339895 Positive_regulation of Gene_expression of Rrbp1 1 0.02 0.96 0 81.96
21 INT41314 Gene_expression of GGTLC1 9 0.59 5.61 1.79 81.84
22 INT230 Positive_regulation of GGTLC1 14 0.68 11.78 1.55 81.84
23 INT339892 Positive_regulation of Bnc1 1 0.17 3.82 0.15 81.48
24 INT339894 Negative_regulation of Positive_regulation of Bnc1 1 0.11 0.96 0 81.48
25 INT103942 Binding of BPHL 11 0.30 14.26 0.53 80.96
26 INT19590 Localization of cod 2 0.17 0.27 0.09 78.40
27 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16 77.76
28 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 75.56
29 INT159936 Positive_regulation of Shc4 8 0.50 3.43 0.04 73.12
30 INT146107 Positive_regulation of Lrp1 4 0.37 1.91 0.34 72.32
31 INT138689 Positive_regulation of Rrbp1 8 0.46 2.61 0.34 71.92
32 INT56376 Negative_regulation of AMBP 29 0.35 21.49 2.59 70.24
33 INT61684 Localization of COL1A2 20 0.73 9.31 2.26 69.36
34 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 67.76
35 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34 63.20
36 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 62.36
37 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5 58.92
38 INT97128 Localization of SPP1 32 0.80 21.75 4.02 58.84
39 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 56.04
40 INT91432 Binding of MMRN1 23 0.36 9.79 2.95 55.84
41 INT175655 Regulation of MMRN1 16 0.12 9.96 2.12 55.84
42 INT227921 Regulation of Binding of MMRN1 1 0.02 1.65 0.94 55.84
43 INT77601 Gene_expression of OR51B4 15 0.58 2.07 6.19 52.32
44 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 48.24
45 INT231412 Positive_regulation of NBN 3 0.55 3.13 0.07 44.60
46 INT339893 Binding of Bnc1 1 0.14 1.72 0.05 41.52
47 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 39.64
48 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12 39.64
49 INT273525 Regulation of NBN 1 0.49 1.28 0.05 35.68
50 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 25.00
51 INT140394 Regulation of Dync1h1 7 0.39 2.59 1.25 25.00
52 INT341871 Positive_regulation of Binding of Dync1h1 1 0.37 0.61 0.1 23.92
53 INT65642 Binding of Dync1h1 27 0.41 15.83 2.68 23.36
54 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 21.76
55 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 21.04
56 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 21.04
57 INT97768 Positive_regulation of Gene_expression of PLG 5 0.49 2.49 0.89 16.64
58 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 16.52
59 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21 16.08
60 INT79261 Positive_regulation of Gene_expression of COL1A1 24 0.36 7.49 2.45 10.96
61 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 10.40
62 INT129304 Gene_expression of CA5P 8 0.57 4.52 0.57 7.08
63 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81 6.28
64 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.68
65 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.24
66 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
67 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
68 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
69 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
70 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
71 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
72 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
73 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
74 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
75 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
76 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
77 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
78 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
79 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
80 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
81 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
82 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
83 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
84 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
85 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
86 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
87 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
88 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
89 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 5.00
90 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 5.00
91 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
92 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
93 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
94 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
95 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
96 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
97 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
98 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 5.00
99 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
100 INT6196 Regulation of Nppa 83 0.62 30.31 30.18 5.00
101 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
102 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77 5.00
103 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
104 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
105 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 5.00
106 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
107 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
108 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
109 INT7523 Regulation of ADRA1D 42 0.45 11.63 14.52 5.00
110 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43 5.00
111 INT28014 Localization of Cyp3a23/3a1 34 0.77 9.8 12.96 5.00
112 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
113 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
114 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
115 INT48912 Localization of NOS1 52 0.77 24.14 10.92 5.00
116 INT94004 Negative_regulation of Lox 31 0.59 13.76 10.45 5.00
117 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
118 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
119 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53 5.00
120 INT73497 Regulation of IL10 33 0.45 22.6 9.19 5.00
121 INT35366 Binding of AR 87 0.47 30.52 8.9 5.00
122 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 5.00
123 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 5.00
124 INT31761 Positive_regulation of Itpr3 32 0.58 5.95 8.22 5.00
125 INT6210 Binding of Nppa 39 0.47 14.35 7.21 5.00
126 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 5.00
127 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 5.00
128 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
129 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 5.00
130 INT28015 Regulation of Cyp3a23/3a1 19 0.40 6.32 5.79 5.00
131 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
132 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 5.00
133 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22 5.00
134 INT89142 Gene_expression of Lox 28 0.67 15.36 5.2 5.00
135 INT142162 Binding of IL10 30 0.37 21.9 4.84 5.00
136 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69 5.00
137 INT187346 Regulation of Dlat 12 0.29 1.82 4.28 5.00
138 INT122448 Regulation of Gene_expression of ABCB1 13 0.62 3.67 3.5 5.00
139 INT155039 Gene_expression of ADAMTS5 23 0.67 7.85 3.22 5.00
140 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 5.00
141 INT19539 Positive_regulation of Gene_expression of ADRA1D 10 0.67 9.4 2.9 5.00
142 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 5.00
143 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
144 INT101246 Gene_expression of Gata6 6 0.68 3.03 2.68 5.00
145 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33 5.00
146 INT94002 Regulation of Lox 13 0.38 8.41 2.29 5.00
147 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17 5.00
148 INT52072 Negative_regulation of Ces1c 6 0.31 1.37 2.13 5.00
149 INT68496 Binding of PGR 26 0.48 16.36 2.09 5.00
150 INT94001 Positive_regulation of Lox 15 0.60 7.46 1.92 5.00
151 INT236867 Gene_expression of AURKC 6 0.55 31.96 1.86 5.00
152 INT86247 Gene_expression of Bcl2l10 14 0.34 12.21 1.61 5.00
153 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47 5.00
154 INT242945 Localization of PDE5A 9 0.75 4.57 1.28 5.00
155 INT198387 Regulation of SRD5A1 2 0.60 1.29 1.26 5.00
156 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19 5.00
157 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 5.00
158 INT72558 Regulation of CYP2C19 6 0.54 1.97 1.14 5.00
159 INT103043 Binding of PDE5A 16 0.37 7.79 1.12 5.00
160 INT98445 Negative_regulation of BPHL 7 0.32 7.24 1.08 5.00
161 INT22095 Negative_regulation of Dync1h1 11 0.48 5.17 1.08 5.00
162 INT55688 Gene_expression of MMP11 15 0.74 10.95 1.06 5.00
163 INT133102 Negative_regulation of Gene_expression of COL1A2 8 0.08 2.56 1.02 5.00
164 INT134822 Gene_expression of Gja1 18 0.72 4.2 1 5.00
165 INT138594 Gene_expression of COP 10 0.57 1.33 0.98 5.00
166 INT286993 Localization of CA5P 23 0.63 14.38 0.89 5.00
167 INT168262 Positive_regulation of Gene_expression of BPHL 10 0.24 10.72 0.83 5.00
168 INT287087 Localization of EEC1 2 0.61 1.6 0.72 5.00
169 INT56251 Binding of NBN 4 0.38 3.16 0.62 5.00
170 INT242944 Negative_regulation of Localization of PDE5A 3 0.35 3.18 0.59 5.00
171 INT236877 Negative_regulation of Gene_expression of BPHL 12 0.32 16.43 0.56 5.00
172 INT236865 Positive_regulation of AURKC 3 0.57 18.45 0.54 5.00
173 INT148107 Binding of CDIPT 8 0.17 4.56 0.53 5.00
174 INT38837 Negative_regulation of Uox 4 0.45 1.43 0.5 5.00
175 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44 5.00
176 INT48418 Localization of Dync1h1 4 0.61 1.54 0.44 5.00
177 INT257319 Negative_regulation of Gene_expression of Lox 2 0.04 1.62 0.35 5.00
178 INT118610 Localization of BPHL 6 0.57 6.88 0.33 5.00
179 INT109476 Gene_expression of UGT1A7 5 0.78 0.9 0.32 5.00
180 INT261239 Binding of XDH 10 0.34 3.16 0.31 5.00
181 INT200806 Binding of EEC1 6 0.39 4.24 0.29 5.00
182 INT102992 Regulation of Negative_regulation of SRD5A1 4 0.60 3.59 0.29 5.00
183 INT180599 Gene_expression of EEC1 5 0.63 2.73 0.23 5.00
184 INT32334 Regulation of LILRA3 3 0.08 0 0.23 5.00
185 INT126794 Binding of SRD5A1 2 0.36 3.26 0.22 5.00
186 INT326616 Binding of CA5P 4 0.21 2.26 0.19 5.00
187 INT228916 Transcription of spc 2 0.30 1.62 0.18 5.00
188 INT185753 Negative_regulation of YOD1 4 0.03 1.67 0.17 5.00
189 INT261231 Negative_regulation of Gene_expression of Cyp2d4 2 0.42 0.36 0.14 5.00
190 INT105897 Regulation of UGT1A1 3 0.60 1.6 0.13 5.00
191 INT269743 Positive_regulation of Binding of BPHL 1 0.19 2.94 0.13 5.00
192 INT212170 Localization of CDIPT 4 0.41 1.55 0.13 5.00
193 INT114110 Negative_regulation of EEC1 2 0.37 2.35 0.12 5.00
194 INT287082 Gene_expression of Vamp3 1 0.18 0.99 0.11 5.00
195 INT231413 Negative_regulation of NBN 3 0.46 4.6 0.11 5.00
196 INT110568 Positive_regulation of Gene_expression of XDH 7 0.49 5.14 0.09 5.00
197 INT236878 Regulation of Gene_expression of AURKC 3 0.15 2.33 0.09 5.00
198 INT236864 Regulation of Gene_expression of BPHL 4 0.19 3.87 0.09 5.00
199 INT287191 Regulation of Positive_regulation of BPHL 1 0.34 1.18 0.04 5.00
200 INT287085 Negative_regulation of Myh9 1 0.21 0.6 0.03 5.00
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