D:Urolithiasis

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Disease Term
Synonyms Lithiasis Urinary, Urinary Lithiasis
Documents 357
Hot Single Events 34
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Urolithiasis. They are ordered first by their relevance to Urolithiasis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT270777 Binding of DMD and BPs 1 0.01 0.33 0.09 23.92
2 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 5.00
3 INT257577 CALCA Positive_regulation of DMD 1 0.01 0.57 0.26 5.00
4 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16 5.00
5 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08 5.00
6 INT269759 PTH Positive_regulation of DMD 2 0.06 0.37 0.03 5.00
7 INT270775 PTH Regulation of DMD 1 0.09 0.64 0.03 5.00
8 INT270776 PTH Regulation of Negative_regulation of DMD 1 0.09 0.3 0.03 5.00
9 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03 5.00
10 INT270780 BPs Positive_regulation of DMD 1 0.02 0 0 5.00
11 INT257589 Negative_regulation of Pth Positive_regulation of DMD 1 0.01 0 0 5.00
12 INT257590 Pth Positive_regulation of DMD 2 0.02 0.44 0 5.00
13 INT273518 Binding of ALB and NBN 1 0.06 0.47 0 5.00
14 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
15 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0 5.00
16 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
17 INT270122 Binding of Pth and Pc 1 0.05 0.1 0 5.00
18 INT270121 Binding of Pth and Pthlh 1 0.08 0.56 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Urolithiasis. They are ordered first by their pain relevance and then by number of times they were reported in Urolithiasis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 100.00
2 INT78937 Negative_regulation of Aprt 2 0.48 1.12 0.25 99.68
3 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 99.64
4 INT36698 Binding of CHRM3 5 0.48 1.97 1.49 99.58
5 INT140394 Regulation of Dync1h1 7 0.39 2.59 1.25 99.08
6 INT86670 Negative_regulation of AGXT 6 0.57 2.24 1.18 99.04
7 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 97.96
8 INT33008 Gene_expression of Dync1h1 41 0.68 23.85 3.82 97.16
9 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 96.56
10 INT115038 Regulation of SLC22A12 2 0.60 0.95 0.12 95.68
11 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 95.60
12 INT82918 Binding of AMBP 23 0.39 23.31 1.71 94.32
13 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 93.92
14 INT118217 Regulation of Cuzd1 2 0.30 2.36 0.91 93.40
15 INT85340 Positive_regulation of Slc22a13 1 0.04 0.95 0.11 93.20
16 INT19803 Gene_expression of Hprt 15 0.67 4.81 1.03 90.92
17 INT83995 Positive_regulation of Gene_expression of ACE 8 0.68 8.09 0.82 90.40
18 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 90.40
19 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 90.00
20 INT14902 Negative_regulation of XDH 38 0.55 24.19 2.86 89.52
21 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 89.28
22 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 87.84
23 INT286993 Localization of CA5P 23 0.63 14.38 0.89 87.60
24 INT286990 Negative_regulation of Localization of CA5P 3 0.36 1.57 0 87.60
25 INT156776 Regulation of Slc22a12 3 0.25 1.74 0.4 85.92
26 INT26583 Positive_regulation of Cd4 40 0.54 21.96 4.83 85.68
27 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16 85.44
28 INT182810 Gene_expression of Cuzd1 5 0.44 1.49 0.53 83.60
29 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 81.80
30 INT3496 Negative_regulation of HPRT1 7 0.58 25.05 1.92 81.44
31 INT19804 Negative_regulation of Hprt 18 0.59 20.6 2.17 81.44
32 INT212171 Gene_expression of CDIPT 5 0.37 2.58 2.92 80.84
33 INT182806 Binding of Cuzd1 3 0.24 1.45 0.53 80.80
34 INT156777 Localization of Slc22a12 1 0.70 0.78 0.18 80.28
35 INT63120 Transcription of SERPINC1 1 0.28 0.85 0.16 78.04
36 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49 76.44
37 INT110569 Gene_expression of XDH 31 0.75 18.35 1.34 76.24
38 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 75.84
39 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 75.68
40 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5 75.00
41 INT41545 Negative_regulation of APRT 8 0.57 2.99 2.88 75.00
42 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 74.52
43 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 69.68
44 INT4342 Localization of ALPP 27 0.69 15.19 5.32 69.68
45 INT171998 Binding of DMD 58 0.47 38.13 3.35 64.16
46 INT341788 Regulation of Binding of DMD 1 0.06 0.46 0.05 64.16
47 INT15775 Positive_regulation of Ren1 50 0.69 22.38 6.19 63.40
48 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 62.32
49 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 62.32
50 INT205652 Localization of UOX 1 0.50 1.74 0.06 62.00
51 INT326616 Binding of CA5P 4 0.21 2.26 0.19 58.32
52 INT326615 Negative_regulation of Binding of CA5P 2 0.24 0.86 0 58.32
53 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 57.20
54 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 57.20
55 INT83200 Positive_regulation of Gene_expression of Nos3 48 0.70 24.75 12.99 57.20
56 INT111594 Positive_regulation of Gene_expression of NOSTRIN 20 0.32 8.69 5 57.20
57 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 57.04
58 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 56.36
59 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 56.36
60 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 56.36
61 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 56.36
62 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 52.12
63 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 52.12
64 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 49.20
65 INT205654 Gene_expression of FUS 9 0.32 11.53 0.16 44.48
66 INT179373 Localization of XDH 3 0.20 1.97 0.54 43.88
67 INT273525 Regulation of NBN 1 0.49 1.28 0.05 43.36
68 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 42.96
69 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 41.52
70 INT231412 Positive_regulation of NBN 3 0.55 3.13 0.07 40.68
71 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 39.16
72 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 37.64
73 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 37.12
74 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 36.92
75 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 33.48
76 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43 31.16
77 INT135056 Positive_regulation of MTSS1 1 0.21 0.69 0 30.40
78 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 29.44
79 INT115039 Positive_regulation of FMR1 4 0.49 2.26 0.46 25.00
80 INT306170 Regulation of PRPF19 1 0.07 9.66 0.03 20.04
81 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 12.60
82 INT9884 Localization of CD79A 41 0.78 21.75 3.06 10.60
83 INT88726 Gene_expression of HPRT1 36 0.78 10.12 1.58 8.44
84 INT306171 Positive_regulation of PRPF19 1 0.08 1.01 0 7.04
85 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
86 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
87 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
88 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
89 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
90 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
91 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
92 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
93 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 5.00
94 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
95 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 5.00
96 INT2140 Regulation of REN 104 0.62 28.24 24.49 5.00
97 INT6868 Gene_expression of GFAP 136 0.78 84.65 22.7 5.00
98 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 5.00
99 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
100 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 5.00
101 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
102 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
103 INT22068 Binding of CALCRL 53 0.41 6.14 17.32 5.00
104 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
105 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 5.00
106 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 5.00
107 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43 5.00
108 INT28014 Localization of Cyp3a23/3a1 34 0.77 9.8 12.96 5.00
109 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
110 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
111 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 5.00
112 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
113 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
114 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 5.00
115 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53 5.00
116 INT22083 Regulation of Pth 55 0.62 22.32 8.9 5.00
117 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 5.00
118 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 5.00
119 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 5.00
120 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 5.00
121 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
122 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
123 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
124 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
125 INT22128 Positive_regulation of HIVEP1 61 0.43 70.52 6.07 5.00
126 INT28015 Regulation of Cyp3a23/3a1 19 0.40 6.32 5.79 5.00
127 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
128 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
129 INT13396 Gene_expression of DMD 125 0.75 57.81 5.45 5.00
130 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31 5.00
131 INT62570 Binding of Pth 48 0.48 26.45 4.85 5.00
132 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 5.00
133 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69 5.00
134 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
135 INT4097 Localization of Pth 66 0.81 47.17 4.36 5.00
136 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 5.00
137 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 5.00
138 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75 5.00
139 INT16165 Regulation of DMD 114 0.60 35.13 3.64 5.00
140 INT122448 Regulation of Gene_expression of ABCB1 13 0.62 3.67 3.5 5.00
141 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 5.00
142 INT72798 Binding of ADA 12 0.47 7.84 3.39 5.00
143 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 5.00
144 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
145 INT191807 Gene_expression of CD24 75 0.78 53.92 3.34 5.00
146 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
147 INT34809 Gene_expression of Ec 36 0.15 15.7 3.24 5.00
148 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
149 INT185407 Binding of PER1 13 0.42 9.32 2.6 5.00
150 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
151 INT48664 Negative_regulation of Gene_expression of GFAP 11 0.57 5.05 2.47 5.00
152 INT204175 Localization of Mri1 12 0.60 2.73 2.35 5.00
153 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33 5.00
154 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
155 INT229200 Gene_expression of Pc 13 0.65 8.96 2.32 5.00
156 INT2544 Localization of PTH 39 0.81 30.55 2.22 5.00
157 INT125480 Regulation of HHIP 17 0.38 6.16 2.16 5.00
158 INT81887 Gene_expression of Plvap 9 0.28 1.28 2.13 5.00
159 INT29393 Positive_regulation of APRT 18 0.67 5.28 2.13 5.00
160 INT68496 Binding of PGR 26 0.48 16.36 2.09 5.00
161 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08 5.00
162 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
163 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
164 INT3343 Regulation of PTH 24 0.62 11.18 1.62 5.00
165 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
166 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47 5.00
167 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 5.00
168 INT202200 Positive_regulation of BPs 4 0.24 1.91 1.38 5.00
169 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 5.00
170 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19 5.00
171 INT272274 Localization of NARFL 24 0.60 27.55 1.18 5.00
172 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
173 INT72558 Regulation of CYP2C19 6 0.54 1.97 1.14 5.00
174 INT13397 Localization of DMD 21 0.78 7.96 1.08 5.00
175 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 5.00
176 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 5.00
177 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
178 INT192686 Positive_regulation of Positive_regulation of DMD 8 0.41 4.66 0.93 5.00
179 INT185261 Gene_expression of OLIG2 9 0.65 5.76 0.93 5.00
180 INT233437 Binding of BPS 2 0.02 1 0.93 5.00
181 INT39369 Binding of NARFL 14 0.29 16.7 0.93 5.00
182 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87 5.00
183 INT192404 Localization of Ighm 15 0.48 5.8 0.85 5.00
184 INT52879 Negative_regulation of ATP6V0A1 2 0.24 0.64 0.82 5.00
185 INT191806 Positive_regulation of Gene_expression of CD24 13 0.70 9.94 0.79 5.00
186 INT194343 Gene_expression of ABCC8 8 0.65 8.15 0.77 5.00
187 INT57008 Positive_regulation of HPRT1 11 0.50 2.81 0.74 5.00
188 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73 5.00
189 INT211972 Regulation of Best1 18 0.33 12.04 0.67 5.00
190 INT56251 Binding of NBN 4 0.38 3.16 0.62 5.00
191 INT269465 Positive_regulation of Positive_regulation of HHIP 4 0.11 0.5 0.62 5.00
192 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 5.00
193 INT129304 Gene_expression of CA5P 8 0.57 4.52 0.57 5.00
194 INT148107 Binding of CDIPT 8 0.17 4.56 0.53 5.00
195 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 5.00
196 INT38837 Negative_regulation of Uox 4 0.45 1.43 0.5 5.00
197 INT233436 Localization of BPs 2 0.06 1.48 0.5 5.00
198 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 5.00
199 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44 5.00
200 INT122156 Binding of CA1 3 0.47 1.52 0.44 5.00
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