D:Usher Syndrome

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Disease Term
Synonyms Dystrophia Retinae Dysacousis Syndrome, Dystrophia Retinae Pigmentosa Dysostosis Syndrome, GRAEFE USHER SYNDROME, Hallgren Syndrome, Retinitis Pigmentosa Congenital Deafness Syndrome, RETINITIS PIGMENTOSA DEAFNESS SYNDROME, SYNDROME USHER, Syndromes Usher, Usher Syndrome Type I, Usher Syndrome Type Ii, Usher Syndrome Type Iii
Documents 6
Hot Single Events 24
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Usher Syndrome. They are ordered first by their relevance to Usher Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT277555 Clrn1 Regulation of Localization of Pdc 1 0.05 0.7 0 88.12
2 INT286422 Binding of Cdc42ep5 and Dock4 1 0.01 0.84 0 86.00
3 INT286418 Gtf3a Positive_regulation of Akt1 1 0.01 0.45 0.1 5.00
4 INT286415 Binding of Fos and Fosb 1 0.23 0.08 0 5.00
5 INT286420 Binding of Fgf13 and Mapk8ip3 1 0.36 0 0 5.00
6 INT286419 Rbm39 Negative_regulation of Transcription of Fos 1 0.01 0.16 0 5.00
7 INT286417 Rbm39 Negative_regulation of Jun 1 0.00 0.16 0 5.00
8 INT286416 Rbm39 Negative_regulation of Fos 1 0.01 0.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Usher Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Usher Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT277526 Gene_expression of Clrn1 1 0.78 29.02 0.17 100.00
2 INT277539 Positive_regulation of Clrn1 1 0.50 4.04 0 100.00
3 INT277532 Positive_regulation of Positive_regulation of Clrn1 1 0.50 1.44 0 100.00
4 INT277535 Positive_regulation of Positive_regulation of Gm14374 1 0.49 1.44 0 100.00
5 INT277550 Positive_regulation of Gm14374 2 0.49 1.5 0.42 100.00
6 INT35269 Localization of SGCG 38 0.78 14.68 9.01 100.00
7 INT168523 Localization of Cdh23 2 0.22 0.27 0.15 100.00
8 INT168525 Localization of GPR98 1 0.21 0.17 0.1 100.00
9 INT168524 Localization of Ush1g 1 0.22 0.17 0.1 100.00
10 INT168521 Localization of Myo7a 1 0.18 0.17 0.1 100.00
11 INT168526 Localization of USH2A 1 0.20 0.17 0.1 100.00
12 INT168522 Localization of Ush1c 1 0.21 0.17 0.1 100.00
13 INT260172 Localization of Rpe 11 0.49 3.53 0.12 99.36
14 INT277524 Binding of Clrn1 1 0.37 1.9 0 96.60
15 INT277538 Gene_expression of Ush2a 1 0.48 0.23 0 94.96
16 INT277552 Gene_expression of Whrn 2 0.57 0.75 0.04 94.36
17 INT277537 Transcription of Clrn1 1 0.72 5.06 0 93.20
18 INT277546 Negative_regulation of Clrn1 1 0.51 2.42 0 93.08
19 INT277534 Localization of Clrn1 1 0.81 4.83 0 92.76
20 INT223459 Gene_expression of Dock4 2 0.71 1.5 0.16 88.72
21 INT286390 Gene_expression of Cdc42ep5 1 0.02 0.82 0 88.72
22 INT227405 Localization of Pdc 4 0.32 2.87 0.15 87.00
23 INT277542 Negative_regulation of Pdc 1 0.03 1.61 0 83.08
24 INT334577 Binding of KCNE1L 1 0.27 1.33 0 80.32
25 INT277547 Negative_regulation of Gene_expression of Clrn1 1 0.43 1.03 0 72.24
26 INT277551 Regulation of Gene_expression of Clrn1 1 0.45 1.18 0 68.60
27 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 68.48
28 INT193687 Gene_expression of TIMM8A 2 0.49 1.27 0.04 68.48
29 INT219498 Gene_expression of TBL1X 2 0.49 1.03 0 67.84
30 INT119827 Gene_expression of PTPN11 31 0.75 24.21 1.22 67.28
31 INT32107 Gene_expression of PTPLA 14 0.47 8.06 6.76 66.64
32 INT102839 Gene_expression of Pdc 15 0.52 6.3 1.87 65.20
33 INT277544 Positive_regulation of Gene_expression of Clrn1 1 0.70 1.89 0 60.80
34 INT50077 Gene_expression of Myb 21 0.66 7.68 1.54 50.48
35 INT286393 Positive_regulation of Myb 2 0.43 0.8 0.03 40.24
36 INT286381 Positive_regulation of Gene_expression of Myb 1 0.59 1.1 0 28.80
37 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32 26.76
38 INT277536 Regulation of Clrn1 1 0.62 0 0 8.52
39 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 5.00
40 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
41 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
42 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
43 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
44 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
45 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
46 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 5.00
47 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
48 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
49 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41 5.00
50 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 5.00
51 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 5.00
52 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 134 0.61 34.87 20.15 5.00
53 INT11275 Regulation of Fos 37 0.60 5.79 18.18 5.00
54 INT70816 Negative_regulation of Fos 32 0.58 13 11.18 5.00
55 INT82769 Positive_regulation of Grm1 20 0.00 7.78 9.82 5.00
56 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
57 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41 5.00
58 INT61264 Regulation of Jun 36 0.61 18.42 8.71 5.00
59 INT156396 Localization of Tg(CAG-EGFP)D4Nagy 61 0.55 13.63 8.17 5.00
60 INT64816 Transcription of Jun 31 0.69 16.01 7.64 5.00
61 INT155680 Gene_expression of Slc1a3 22 0.66 6.76 7.23 5.00
62 INT94649 Gene_expression of Grm1 19 0.77 5.11 6.58 5.00
63 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33 5.00
64 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
65 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97 5.00
66 INT18681 Gene_expression of Thy1 80 0.71 38.8 5.23 5.00
67 INT155681 Negative_regulation of Gene_expression of Slc1a3 5 0.36 2.26 4.86 5.00
68 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45 5.00
69 INT47766 Transcription of Fos 25 0.69 8.78 4.42 5.00
70 INT11277 Localization of Fos 22 0.78 6.58 4.19 5.00
71 INT64163 Negative_regulation of Gene_expression of Jun 13 0.58 3.86 4.03 5.00
72 INT86769 Positive_regulation of Gene_expression of Rbm39 11 0.25 5.6 3.8 5.00
73 INT25251 Binding of Fos 19 0.36 7.96 3.73 5.00
74 INT96777 Localization of Pdgfa 12 0.79 5.86 3.52 5.00
75 INT5286 Gene_expression of ANTXR2 46 0.75 21.06 3.41 5.00
76 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 5.00
77 INT153492 Gene_expression of Gmcl1 44 0.65 15.77 2.56 5.00
78 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48 5.00
79 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41 5.00
80 INT15243 Regulation of Egr1 19 0.61 7.6 2.13 5.00
81 INT114734 Localization of ANTXR2 5 0.73 3.28 1.62 5.00
82 INT37037 Positive_regulation of ANTXR2 6 0.50 5.75 1.56 5.00
83 INT57425 Binding of MYH14 12 0.11 2.33 1.26 5.00
84 INT144843 Regulation of Gmcl1 5 0.37 2.76 1.15 5.00
85 INT58174 Gene_expression of Junb 9 0.78 1.38 1.09 5.00
86 INT198324 Gene_expression of Rn28s1 5 0.65 1.3 0.96 5.00
87 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92 5.00
88 INT191831 Positive_regulation of Slc1a3 6 0.49 3.66 0.87 5.00
89 INT166833 Phosphorylation of Proc 5 0.80 3.56 0.51 5.00
90 INT168801 Localization of Egr1 4 0.78 0.7 0.48 5.00
91 INT277529 Positive_regulation of Gmcl1 5 0.19 3.67 0.42 5.00
92 INT151400 Binding of JAG1 14 0.37 7.96 0.39 5.00
93 INT239084 Localization of KAT2B 4 0.73 3.08 0.36 5.00
94 INT226933 Gene_expression of Rhod 2 0.46 0.2 0.35 5.00
95 INT273924 Gene_expression of Jund 2 0.39 0.5 0.26 5.00
96 INT286394 Negative_regulation of Negative_regulation of Fos 2 0.42 1.08 0.26 5.00
97 INT273867 Binding of Jag1 18 0.45 3.14 0.25 5.00
98 INT277530 Binding of Gmcl1 4 0.22 1.27 0.25 5.00
99 INT120425 Binding of Fgf13 2 0.33 0.07 0.24 5.00
100 INT99443 Regulation of Proc 6 0.23 5.28 0.24 5.00
101 INT243966 Binding of Trak2 5 0.34 0 0.15 5.00
102 INT161702 Gene_expression of GJB2 3 0.65 2.19 0.14 5.00
103 INT286401 Gene_expression of Akt2 8 0.72 1.36 0.13 5.00
104 INT277541 Gene_expression of Rp1 1 0.62 0.61 0.12 5.00
105 INT229458 Negative_regulation of Gene_expression of Vim 6 0.36 0.45 0.09 5.00
106 INT277528 Negative_regulation of Gene_expression of Grm1 1 0.35 0.19 0.09 5.00
107 INT107556 Transcription of ANTXR2 2 0.69 0.17 0.09 5.00
108 INT233836 Binding of Mapk7 2 0.17 0.9 0.05 5.00
109 INT198065 Binding of Slc1a3 3 0.30 0 0.05 5.00
110 INT277545 Transcription of Grm1 1 0.57 0.09 0.05 5.00
111 INT242144 Regulation of Rp1 2 0.22 1.13 0.05 5.00
112 INT266290 Positive_regulation of Localization of Tg(CAG-EGFP)D4Nagy 2 0.12 0.4 0.05 5.00
113 INT277525 Transcription of Slc1a3 1 0.59 0.09 0.05 5.00
114 INT286378 Binding of Fosb 1 0.31 0.15 0.04 5.00
115 INT207067 Localization of Akt2 2 0.69 0.59 0.04 5.00
116 INT277549 Gene_expression of Leprel2 1 0.01 0.19 0.04 5.00
117 INT286411 Binding of Akt2 1 0.34 0.23 0.04 5.00
118 INT277548 Negative_regulation of Gene_expression of Rp1 1 0.34 0.2 0.04 5.00
119 INT277543 Negative_regulation of Binding of Gmcl1 1 0.16 0.09 0.03 5.00
120 INT256366 Gene_expression of GJB6 2 0.50 0.8 0 5.00
121 INT286403 Binding of Mapk10 2 0.16 0 0 5.00
122 INT277540 Negative_regulation of Leprel2 1 0.01 0.09 0 5.00
123 INT286386 Positive_regulation of Akt2 2 0.61 0.45 0 5.00
124 INT286389 Positive_regulation of Fgf13 2 0.42 0.33 0 5.00
125 INT286395 Negative_regulation of Transcription of Mapk8ip3 1 0.55 0 0 5.00
126 INT286374 Positive_regulation of Transcription of Akt2 1 0.64 0 0 5.00
127 INT286383 Transcription of Zmym4 1 0.68 0 0 5.00
128 INT208928 Localization of Myb 2 0.64 0.2 0 5.00
129 INT286372 Gene_expression of Zmym4 1 0.73 0.28 0 5.00
130 INT286398 Positive_regulation of Transcription of Dock4 1 0.46 0 0 5.00
131 INT286409 Binding of Klf9 1 0.35 0 0 5.00
132 INT286375 Positive_regulation of Gene_expression of Akt2 1 0.43 0 0 5.00
133 INT277527 Positive_regulation of Transcription of Clrn1 1 0.47 0.69 0 5.00
134 INT206486 Transcription of Vim 2 0.56 0.06 0 5.00
135 INT286405 Binding of Fosl2 1 0.06 0.08 0 5.00
136 INT286392 Transcription of Usp36 1 0.48 0 0 5.00
137 INT232921 Gene_expression of Krt6b 2 0.65 1.5 0 5.00
138 INT286404 Negative_regulation of Gene_expression of Akt2 1 0.39 0.06 0 5.00
139 INT286414 Transcription of Akt2 1 0.66 0 0 5.00
140 INT286413 Gene_expression of Usp36 1 0.71 0.18 0 5.00
141 INT277533 Regulation of Gene_expression of Rp1 1 0.36 0.64 0 5.00
142 INT286382 Transcription of Trak2 1 0.62 0 0 5.00
143 INT286376 Positive_regulation of Positive_regulation of Akt2 1 0.43 0.17 0 5.00
144 INT286387 Protein_catabolism of Fos 1 0.64 0 0 5.00
145 INT334578 Binding of SLC26A4 1 0.21 0.83 0 5.00
146 INT277531 Regulation of Transcription of Clrn1 1 0.45 1.48 0 5.00
147 INT286400 Transcription of Mapk8ip3 1 0.68 0 0 5.00
148 INT286397 Negative_regulation of Mapk8ip3 1 0.41 0.06 0 5.00
149 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0 5.00
150 INT286410 Positive_regulation of Transcription of Fgf13 1 0.62 0 0 5.00
151 INT286399 Transcription of Stk3 1 0.64 0 0 5.00
152 INT286407 Transcription of Klf9 1 0.65 0 0 5.00
153 INT286391 Positive_regulation of Mapk8ip3 1 0.44 0.06 0 5.00
154 INT286412 Transcription of Fgf13 1 0.64 0 0 5.00
155 INT286408 Transcription of Dock4 1 0.66 0 0 5.00
156 INT286379 Gene_expression of Klf9 1 0.64 0 0 5.00
157 INT286384 Negative_regulation of Gene_expression of Krt6b 1 0.01 0.34 0 5.00
158 INT286402 Binding of Fosl1 1 0.06 0.08 0 5.00
159 INT286385 Binding of Stk3 1 0.35 0 0 5.00
160 INT286388 Transcription of Jag1 2 0.65 0.64 0 5.00
161 INT286373 Regulation of Transcription of Zmym4 1 0.58 0 0 5.00
162 INT286406 Localization of Usp36 1 0.68 0.1 0 5.00
163 INT286396 Positive_regulation of Protein_catabolism of Fos 1 0.46 0 0 5.00
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