D:Valvular Heart Disease Other Than Mitral Valve Prolapse

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Disease Term
Synonyms Cardiac Valve Disease, Cardiac Valve Disorders, Cardiac Valvular Disease, Cardiac Valvulopathy, Heart Valve Disease, Heart Valve Diseases, Heart Valve Disorder, Valvular Heart Disease Syndrome, Valvular Heart Diseases, Valvular Heart Diseases Syndromes
Documents 99
Hot Single Events 19
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Valvular Heart Disease Other Than Mitral Valve Prolapse. They are ordered first by their relevance to Valvular Heart Disease Other Than Mitral Valve Prolapse and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83 68.48
2 INT273893 ARSA Positive_regulation of HSD11B1 1 0.00 0.61 0.4 5.00
3 INT291041 IL6 Regulation of IL36RN 1 0.00 1.09 0.17 5.00
4 INT273891 WDTC1 Positive_regulation of Gene_expression of SELP 1 0.00 0.45 0.15 5.00
5 INT273892 LPA Positive_regulation of ALB 1 0.01 0.95 0.1 5.00
6 INT291040 Binding of CFH and INS 1 0.25 1.32 0.08 5.00
7 INT192309 Binding of GSTM1 and GSTT1 2 0.43 4.54 0.06 5.00
8 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 5.00
9 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Valvular Heart Disease Other Than Mitral Valve Prolapse. They are ordered first by their pain relevance and then by number of times they were reported in Valvular Heart Disease Other Than Mitral Valve Prolapse. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT84245 Negative_regulation of MPEG1 2 0.20 1.46 0.1 100.00
2 INT161218 Positive_regulation of Positive_regulation of Htr2b 1 0.67 0.69 0.43 99.80
3 INT234263 Negative_regulation of ELF3 6 0.39 3.9 0.04 99.56
4 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58 98.76
5 INT50657 Positive_regulation of HTR2B 8 0.67 3.95 4.71 98.70
6 INT223091 Gene_expression of ELF3 45 0.62 17.9 1.56 94.04
7 INT7678 Localization of Alb 142 0.81 80.93 22.49 92.96
8 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 91.04
9 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 90.80
10 INT1495 Positive_regulation of Rtcd1 91 0.54 22.93 32.43 90.32
11 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16 89.64
12 INT1116 Regulation of Ren 103 0.62 27.66 33.26 89.52
13 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14 88.52
14 INT122860 Negative_regulation of HGD 3 0.57 2.03 0.42 87.04
15 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89 86.40
16 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 86.20
17 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 84.32
18 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 83.00
19 INT310680 Gene_expression of ARSB 1 0.64 6.28 0.12 81.84
20 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 78.72
21 INT81206 Binding of ENPEP 11 0.47 5.19 0.88 77.40
22 INT310679 Positive_regulation of ARSB 1 0.39 2.36 0.04 74.36
23 INT310681 Negative_regulation of ARSB 1 0.56 6.95 0.29 73.64
24 INT310683 Protein_catabolism of ARSB 1 0.73 1.85 0.04 73.32
25 INT35744 Binding of MAOB 13 0.46 7.52 4.26 72.00
26 INT310678 Protein_catabolism of ARSH 1 0.06 1.76 0.04 71.68
27 INT69134 Positive_regulation of MPEG1 9 0.26 5.95 0.97 70.76
28 INT310677 Localization of ARSB 1 0.71 5.72 0.14 63.32
29 INT116728 Negative_regulation of ARSH 9 0.13 9.67 0.27 57.40
30 INT38255 Localization of Chkb 32 0.80 10.98 11.07 43.80
31 INT38348 Positive_regulation of Localization of Chkb 9 0.64 2.75 3.37 43.80
32 INT183436 Positive_regulation of Localization of Tnnt2 1 0.30 0.45 0.04 43.16
33 INT303530 Gene_expression of Gspt1 2 0.07 1.23 0.1 43.12
34 INT350311 Positive_regulation of Gene_expression of Gspt1 1 0.05 1.09 0 43.12
35 INT104302 Localization of Tnnt2 2 0.70 0.52 0.04 42.76
36 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81 40.96
37 INT2415 Binding of MAOA 26 0.47 13.26 11.86 40.48
38 INT105991 Negative_regulation of IDS 12 0.38 6.31 1.04 37.20
39 INT128376 Binding of KIT 26 0.48 14.24 0.47 36.20
40 INT187286 Binding of HEY1 17 0.32 31.21 4.52 32.64
41 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 28.44
42 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 26.08
43 INT47805 Positive_regulation of Gspt1 5 0.11 1.02 0.47 25.48
44 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 25.00
45 INT8725 Gene_expression of Mln 32 0.77 14.9 12.22 25.00
46 INT159661 Binding of AHA 1 0.40 0.61 0 25.00
47 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 23.72
48 INT47804 Negative_regulation of Gspt1 3 0.29 1.94 2.04 22.64
49 INT3074 Negative_regulation of Chkb 29 0.57 14 12.04 21.04
50 INT44378 Gene_expression of GSTM1 69 0.76 34.61 8.81 20.48
51 INT79017 Gene_expression of GSTT1 23 0.73 13.16 0.97 20.48
52 INT19316 Positive_regulation of Localization of Nppb 2 0.50 3.15 0.73 20.24
53 INT9085 Localization of Nppb 32 0.81 15.1 3.47 18.32
54 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 12.80
55 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 12.80
56 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 7.68
57 INT117252 Regulation of GSTT1 3 0.45 12.44 0.18 5.92
58 INT92075 Regulation of GSTM1 12 0.50 16.18 2.27 5.12
59 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
60 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
61 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
62 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
63 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
64 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
65 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
66 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
67 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
68 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
69 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
70 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 5.00
71 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
72 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
73 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
74 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
75 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
76 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
77 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
78 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
79 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
80 INT5617 Localization of Nppa 266 0.81 83.51 83.89 5.00
81 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
82 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
83 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
84 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
85 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
86 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
87 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
88 INT49436 Binding of TRPV1 145 0.48 38.35 55.08 5.00
89 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
90 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
91 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
92 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
93 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
94 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 5.00
95 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
96 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
97 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45 5.00
98 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 5.00
99 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
100 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
101 INT9650 Gene_expression of LPA 141 0.75 104.57 29 5.00
102 INT59449 Negative_regulation of Timp1 76 0.42 54.86 26.99 5.00
103 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
104 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4 5.00
105 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
106 INT67610 Positive_regulation of Pparg 53 0.70 31.91 25.2 5.00
107 INT86295 Gene_expression of Mmp2 114 0.76 73.68 24.25 5.00
108 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
109 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
110 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
111 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
112 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
113 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
114 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
115 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
116 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58 5.00
117 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
118 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 5.00
119 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 5.00
120 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89 5.00
121 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
122 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
123 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
124 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
125 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
126 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
127 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19 5.00
128 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
129 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
130 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
131 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 5.00
132 INT18830 Localization of TBXA2R 25 0.81 7.14 9.28 5.00
133 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
134 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 5.00
135 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 5.00
136 INT96068 Positive_regulation of Timp1 30 0.58 23.94 8.17 5.00
137 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86 5.00
138 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 5.00
139 INT800 Negative_regulation of Grhpr 21 0.42 10.3 7.17 5.00
140 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 5.00
141 INT11957 Negative_regulation of LPA 52 0.59 39.09 6.84 5.00
142 INT166707 Protein_catabolism of Col7a1 24 0.74 20.47 6.39 5.00
143 INT29561 Binding of GSTM1 35 0.48 25.86 6.24 5.00
144 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 5.00
145 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 5.00
146 INT65356 Localization of LEP 46 0.79 41.17 5.43 5.00
147 INT86219 Negative_regulation of GSTK1 25 0.41 8.99 4.97 5.00
148 INT11030 Binding of LPA 70 0.48 40.35 4.81 5.00
149 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 5.00
150 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 5.00
151 INT24412 Localization of WDTC1 18 0.68 12.45 4.5 5.00
152 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41 5.00
153 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 5.00
154 INT170738 Binding of Icam1 23 0.37 25.49 4.09 5.00
155 INT22838 Gene_expression of Fgg 26 0.25 19.9 3.88 5.00
156 INT28060 Positive_regulation of Hdlcl1 48 0.66 37.31 3.79 5.00
157 INT16408 Negative_regulation of Nppb 14 0.53 5.49 3.74 5.00
158 INT33735 Binding of ANGPTL5 39 0.32 14.23 3.66 5.00
159 INT63425 Positive_regulation of Gene_expression of SELP 23 0.67 15.34 3.48 5.00
160 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
161 INT240127 Binding of Nppb 19 0.37 22.42 3.3 5.00
162 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 5.00
163 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06 5.00
164 INT10893 Binding of VWF 27 0.47 25.02 2.82 5.00
165 INT44150 Regulation of TBXA2R 10 0.19 3.94 2.62 5.00
166 INT175685 Positive_regulation of Gene_expression of Timp1 11 0.57 8.18 2.58 5.00
167 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
168 INT145101 Transcription of Nos3 8 0.70 6.04 2.47 5.00
169 INT123158 Phosphorylation of VASP 7 0.80 1.57 2.37 5.00
170 INT62511 Negative_regulation of MCS 20 0.50 6.77 2.35 5.00
171 INT73809 Regulation of Nos3 18 0.45 10.05 2.27 5.00
172 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18 5.00
173 INT28739 Binding of Ins1 35 0.37 22.43 2.14 5.00
174 INT68829 Binding of ELF3 14 0.47 7.96 2 5.00
175 INT121337 Negative_regulation of HEY1 7 0.20 12.91 1.89 5.00
176 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86 5.00
177 INT61685 Positive_regulation of Gene_expression of Pah 6 0.43 4.05 1.79 5.00
178 INT207035 Gene_expression of CFB 4 0.63 18.4 1.72 5.00
179 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69 5.00
180 INT78202 Binding of GSTK1 17 0.31 5.44 1.66 5.00
181 INT86250 Regulation of WDTC1 11 0.31 4.2 1.64 5.00
182 INT66930 Positive_regulation of Tcirg1 2 0.15 1.18 1.6 5.00
183 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59 5.00
184 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56 5.00
185 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37 5.00
186 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36 5.00
187 INT33740 Negative_regulation of Binding of ANGPTL5 12 0.39 2.36 1.34 5.00
188 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33 5.00
189 INT14195 Localization of Pde2a 4 0.16 0.34 1.33 5.00
190 INT39468 Positive_regulation of hf 10 0.33 13.5 1.32 5.00
191 INT224447 Gene_expression of FBXO2 7 0.75 7.33 1.31 5.00
192 INT131351 Positive_regulation of Gene_expression of Nppb 2 0.50 13.72 1.14 5.00
193 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 5.00
194 INT98992 Binding of Vcam1 13 0.34 12.97 1.04 5.00
195 INT187289 Regulation of HEY1 5 0.39 7.8 1.03 5.00
196 INT160166 Localization of Pde9a 2 0.78 1.26 0.98 5.00
197 INT160167 Localization of Pde11a 2 0.77 1.26 0.95 5.00
198 INT160171 Localization of Pde10a 2 0.77 1.26 0.95 5.00
199 INT187288 Positive_regulation of Gene_expression of HEY1 5 0.17 8.42 0.89 5.00
200 INT93899 Negative_regulation of Tcirg1 5 0.14 4.34 0.85 5.00
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