D:Van Bogaert's Disease

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Disease Term
Synonyms Bogaert Scherer Epstein Disease Van, CEREBROTENDINOUS XANTHOMATOSES, Cerebrotendinous Xanthomatosis, Chenodeoxycholic Acid, Chenodiol, Cholestanol, Dihydrocholesterol, Disease Van Bogaert Scherer Epstein, Van Bogaert S Disease, Van Bogaert Scherer Epstein Disease, Xanthomatoses Cerebrotendinous
Documents 59
Hot Single Events 41
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Van Bogaert's Disease. They are ordered first by their relevance to Van Bogaert's Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT278605 CDCA2 Positive_regulation of NR1H4 1 0.01 0.36 0 100.00
2 INT278610 CDCA2 Negative_regulation of NR1H4 1 0.01 0.62 0.13 100.00
3 INT173126 CYP8B1 Positive_regulation of PPARA 1 0.25 0.39 0.1 100.00
4 INT173121 PPARA Negative_regulation of Gene_expression of CYP7A1 1 0.18 0.48 0.12 96.40
5 INT173200 PPA1 Positive_regulation of Myc 1 0.08 0.5 0.12 89.12
6 INT173122 PPA1 Positive_regulation of HRAS 1 0.08 0.5 0.12 89.12
7 INT173125 PPA1 Positive_regulation of JUN 1 0.06 0.5 0.12 89.12
8 INT321367 Positive_regulation of Ins1 Negative_regulation of Fig4 Positive_regulation of Nr0b2 1 0.02 0.16 0 86.92
9 INT321288 Fig4 Positive_regulation of Nr0b2 1 0.15 0.47 0.27 83.28
10 INT262161 Nr1i2 Positive_regulation of Gene_expression of Cyp27a1 1 0.29 0.24 0.07 77.28
11 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33 76.92
12 INT173129 PTGS2 Regulation of IER3 1 0.01 0.36 0.12 74.20
13 INT173119 PPA1 Regulation of IER3 1 0.00 0.36 0.12 74.20
14 INT278608 PPARA Positive_regulation of UGT1A9 1 0.25 0.29 0.03 71.24
15 INT262175 Nr1i2 Positive_regulation of Gene_expression of Abca1 1 0.24 0.21 0.06 68.36
16 INT262187 Nr1i2 Positive_regulation of Gene_expression of Abcg1 1 0.24 0.21 0.06 68.36
17 INT329850 APOA5 Negative_regulation of Transcription of APOC3 1 0.24 0.85 0.15 61.04
18 INT173124 PPA1 Regulation of ZFP37 1 0.00 0.44 0.1 59.32
19 INT262195 Nr1i2 Positive_regulation of Srebf1 1 0.08 0.18 0.03 57.64
20 INT262177 Nr1i2 Positive_regulation of Cd36 1 0.16 0.18 0.03 57.64
21 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38 57.20
22 INT262197 Nr1i2 Positive_regulation of Insig1 2 0.23 0 0.12 35.52
23 INT262212 Positive_regulation of Nr1i2 Positive_regulation of Insig1 1 0.12 0 0 35.52
24 INT173127 Binding of INS and SORBS1 1 0.02 0.22 0 18.52
25 INT278614 NR1I2 Regulation of Gene_expression of SULT2A1 1 0.11 0.11 0.15 13.48
26 INT278604 GSR Regulation of Gene_expression of SULT2A1 1 0.02 0.05 0.07 13.48
27 INT278613 NR3C1 Regulation of Gene_expression of SULT2A1 1 0.02 0.05 0.07 13.48
28 INT262165 Nr0b2 Negative_regulation of Nr5a2 1 0.02 0.5 0.92 5.00
29 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6 5.00
30 INT321300 Ins1 Negative_regulation of Pck1 1 0.09 0.52 0.59 5.00
31 INT321285 Ins1 Negative_regulation of G6pc 1 0.07 0.52 0.59 5.00
32 INT262155 Nr5a2 Positive_regulation of Cyp7a1 1 0.07 0.24 0.45 5.00
33 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44 5.00
34 INT321293 Binding of Nr1h4 and Nr0b2 1 0.18 0.31 0.43 5.00
35 INT262186 Nr0b2 Positive_regulation of Negative_regulation of Cyp7a1 1 0.12 0.28 0.4 5.00
36 INT321292 Fig4 Negative_regulation of Pck1 1 0.10 0.33 0.39 5.00
37 INT321301 Fig4 Negative_regulation of G6pc 1 0.07 0.33 0.39 5.00
38 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38 5.00
39 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36 5.00
40 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36 5.00
41 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34 5.00
42 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29 5.00
43 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27 5.00
44 INT262194 Rhof Positive_regulation of Nr1i2 1 0.15 0.64 0.27 5.00
45 INT262164 Positive_regulation of Rhof Positive_regulation of Nr1i2 1 0.11 0.65 0.27 5.00
46 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26 5.00
47 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25 5.00
48 INT262180 Nr1h4 Regulation of Sult2a1 1 0.11 0.11 0.25 5.00
49 INT262152 Nr1h4 Regulation of Abcc2 1 0.07 0.12 0.25 5.00
50 INT262200 Nr1i2 Regulation of Sult2a1 1 0.31 0.12 0.25 5.00
51 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25 5.00
52 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24 5.00
53 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24 5.00
54 INT262211 Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
55 INT262159 Positive_regulation of Nr1h4 Negative_regulation of Gene_expression of Cyp7a1 1 0.09 0.14 0.23 5.00
56 INT173120 Binding of PPARA and NR1H4 8 0.09 2.79 0.23 5.00
57 INT262151 Vdr Regulation of Cyp24a1 1 0.24 0.24 0.23 5.00
58 INT262178 Binding of Nr1i2 and Abcb1b 1 0.07 1.68 0.21 5.00
59 INT321286 Ins1 Negative_regulation of Transcription of G6pc 1 0.05 0.19 0.2 5.00
60 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2 5.00
61 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2 5.00
62 INT321290 Positive_regulation of Nr1h4 Positive_regulation of Nr0b2 1 0.20 0.2 0.18 5.00
63 INT278609 PPARA Positive_regulation of Gene_expression of SULT2A1 1 0.33 0 0.17 5.00
64 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14 5.00
65 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14 5.00
66 INT329847 PPARA Regulation of Gene_expression of CREB3L3 1 0.17 0.84 0.13 5.00
67 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13 5.00
68 INT262193 Binding of Nr1i2 and Sfn 1 0.15 0.26 0.13 5.00
69 INT262185 Positive_regulation of Binding of Ncoa1 and Nr1i2 1 0.04 0.56 0.12 5.00
70 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12 5.00
71 INT262148 Positive_regulation of Nr1i2 Positive_regulation of Abcb1b 1 0.09 0.69 0.12 5.00
72 INT262206 Sfn Negative_regulation of Nr1i2 1 0.17 0.28 0.12 5.00
73 INT278607 SULT2A1 Positive_regulation of Binding of PPARA 1 0.24 0 0.11 5.00
74 INT176020 IL8 Negative_regulation of Phosphorylation of HMGCR 1 0.00 0.1 0.11 5.00
75 INT262146 Binding of Ncoa1 and Nr1i2 1 0.03 0.56 0.11 5.00
76 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11 5.00
77 INT262141 Edcs1 Positive_regulation of Nr1i2 1 0.02 0 0.1 5.00
78 INT321299 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Nr0b2 1 0.02 0.31 0.1 5.00
79 INT321296 Rxfp2 Regulation of G6pc 1 0.07 0.07 0.09 5.00
80 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
81 INT321298 Rxfp2 Regulation of Pck1 1 0.10 0.07 0.09 5.00
82 INT262163 Positive_regulation of Binding of Nr1i2 and Plec 1 0.04 0.31 0.09 5.00
83 INT262142 Edcs1 Regulation of Nr1i2 1 0.01 0 0.09 5.00
84 INT262157 Binding of Nr1i2 and Plec 1 0.03 0.3 0.09 5.00
85 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
86 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08 5.00
87 INT262216 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Vdr 1 0.29 0.44 0.08 5.00
88 INT173130 Binding of INS and PPARA 2 0.04 1.8 0.08 5.00
89 INT278683 PPARA Regulation of Chst10 1 0.22 0.09 0.08 5.00
90 INT262176 Nr1i2 Regulation of Regulation of Casr 1 0.11 0.17 0.07 5.00
91 INT278611 Binding of CASR and SULT2A1 1 0.03 0 0.07 5.00
92 INT262219 Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07 5.00
93 INT262168 Nr1i2 Regulation of Casr 1 0.07 0.17 0.07 5.00
94 INT278602 Binding of SULT2A1 and NR1I3 1 0.04 0 0.07 5.00
95 INT329897 PPARA Regulation of Cpt2 1 0.09 0.05 0.07 5.00
96 INT278684 Binding of NR1I3 and Rxra 1 0.00 0 0.07 5.00
97 INT262147 Nr1i2 Regulation of Gene_expression of Cyp2j8 1 0.00 0.07 0.07 5.00
98 INT278600 Binding of CASR and SULT2A1 Positive_regulation of SULT2A1 1 0.03 0 0.07 5.00
99 INT262143 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07 5.00
100 INT278685 Binding of CASR and Rxra 1 0.00 0 0.07 5.00
101 INT321368 Fig4 Regulation of Fig4 Positive_regulation of Nr0b2 1 0.04 0.13 0.06 5.00
102 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06 5.00
103 INT262190 Foxo1 Positive_regulation of Pck1 1 0.04 0.15 0.06 5.00
104 INT278601 NR1I2 Negative_regulation of Gene_expression of SULT2A1 1 0.10 0 0.06 5.00
105 INT262145 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.45 0.06 5.00
106 INT321295 Negative_regulation of Fig4 Positive_regulation of Nr0b2 1 0.09 0.13 0.06 5.00
107 INT321284 Regulation of Fig4 Positive_regulation of Nr0b2 1 0.06 0.13 0.06 5.00
108 INT262209 Positive_regulation of Nr1i2 Positive_regulation of Transcription of Ppig 1 0.03 0 0.06 5.00
109 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06 5.00
110 INT278606 CASR Regulation of SULT2A1 1 0.04 0 0.05 5.00
111 INT262233 Nr1i2 Negative_regulation of SOD1 1 0.03 0.23 0.05 5.00
112 INT278612 NR1I2 Regulation of SULT2A1 1 0.13 0 0.05 5.00
113 INT278603 NR1I2 Positive_regulation of Transcription of SULT2A1 1 0.12 0 0.05 5.00
114 INT262230 SOD1 Regulation of Nr1i2 1 0.02 0.3 0.05 5.00
115 INT262196 Nr1i2 Negative_regulation of Vdr 1 0.27 0.14 0.04 5.00
116 INT262221 Nr1i2 Negative_regulation of Cyp24a1 1 0.27 0.15 0.04 5.00
117 INT329849 PPARA Regulation of AGXT 1 0.03 0.06 0.04 5.00
118 INT262166 Binding of Nr1i2 and Vdr 1 0.23 0.14 0.04 5.00
119 INT329848 PPARA Regulation of Localization of AGXT 1 0.03 0.06 0.04 5.00
120 INT321294 Ins1 Positive_regulation of Trh 1 0.00 0.08 0.04 5.00
121 INT262154 Vdr Negative_regulation of Cyp24a1 1 0.16 0.14 0.04 5.00
122 INT321297 Positive_regulation of Binding of Akt1 and Pdk1 1 0.15 0.13 0.03 5.00
123 INT262162 Nr1i2 Regulation of Cyp2b9 1 0.14 0.14 0.03 5.00
124 INT262198 Foxo1 Positive_regulation of Igfbp1 1 0.11 0.08 0.03 5.00
125 INT262171 Binding of Cyp3a11 and Rare1 1 0.02 0.15 0.03 5.00
126 INT262217 Casr Regulation of Cyp3a11 1 0.05 0.13 0.03 5.00
127 INT262149 Binding of Nfe2l2 and Rare1 1 0.03 0.32 0.03 5.00
128 INT173199 CNOT4 Regulation of Regulation of Myc 1 0.01 0.66 0.03 5.00
129 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
130 INT321287 Positive_regulation of Fig4 Positive_regulation of Nr0b2 1 0.10 0.07 0.03 5.00
131 INT262150 Binding of Rare1 and Sfn 1 0.01 0.33 0.03 5.00
132 INT262184 Binding of Nr1i2 and Rare1 1 0.03 0.15 0.03 5.00
133 INT321291 Binding of Akt1 and Pdk1 1 0.11 0.13 0.03 5.00
134 INT262169 Binding of Foxa2 and Nr1i2 1 0.17 0.33 0 5.00
135 INT262203 Nr1i2 Positive_regulation of Gene_expression of Hmgcs2 1 0.23 0.22 0 5.00
136 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0 5.00
137 INT262170 Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.4 0 5.00
138 INT329898 MIRLET7C Regulation of Myc 1 0.49 0.62 0 5.00
139 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0 5.00
140 INT262204 Nr1i2 Positive_regulation of Cyp3a11 1 0.33 0.08 0 5.00
141 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0 5.00
142 INT262213 Plec Positive_regulation of Cyp3a11 1 0.02 0 0 5.00
143 INT173123 Binding of HNF4A and PPARA 1 0.10 0.19 0 5.00
144 INT262215 Binding of Nr1i2 and Dnajc7 1 0.08 0.26 0 5.00
145 INT262191 Binding of Nr1i2 and Foxo1 1 0.22 0.09 0 5.00
146 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0 5.00
147 INT262156 Nr1i2 Negative_regulation of Gene_expression of Hmgcs2 1 0.22 0.22 0 5.00
148 INT262174 Binding of Casr and Foxo1 1 0.05 0.09 0 5.00
149 INT262192 Nr1i2 Regulation of Positive_regulation of Cyp3a11 1 0.32 0 0 5.00
150 INT262199 Binding of Cyp2b9 and Rare1 1 0.01 0.15 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Van Bogaert's Disease. They are ordered first by their pain relevance and then by number of times they were reported in Van Bogaert's Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT17290 Gene_expression of Ugt2b 11 0.68 1.73 3.46 100.00
2 INT278660 Gene_expression of CDCA2 1 0.04 0.36 0 100.00
3 INT16656 Negative_regulation of Gene_expression of YY1 8 0.57 2.62 2.12 99.92
4 INT278679 Negative_regulation of Gene_expression of SULT2A1 5 0.25 2.17 0.52 99.82
5 INT83745 Gene_expression of SULT2A1 34 0.59 15.96 6.66 99.62
6 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 99.48
7 INT329889 Positive_regulation of CYP8B1 1 0.41 0.47 0.37 99.44
8 INT329893 Regulation of Positive_regulation of CYP8B1 1 0.37 0.18 0.16 99.44
9 INT16177 Positive_regulation of UGT1A3 3 0.57 0.98 0.41 98.96
10 INT75773 Gene_expression of UGT1A3 12 0.78 1.75 3.54 98.80
11 INT278664 Positive_regulation of Gene_expression of UGT1A3 1 0.31 0.71 0 98.80
12 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 98.80
13 INT121943 Positive_regulation of Nr1i2 64 0.68 19.22 8.39 98.44
14 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 98.28
15 INT262096 Gene_expression of Cyp27a1 1 0.30 1.21 0.32 97.98
16 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 97.64
17 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 97.04
18 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 96.76
19 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8 96.52
20 INT52061 Negative_regulation of HSD17B6 5 0.57 1.5 1.16 96.52
21 INT173171 Gene_expression of CYP7A1 2 0.45 1.02 0.14 96.40
22 INT173188 Regulation of Gene_expression of CYP7A1 1 0.22 0.48 0.12 96.40
23 INT176038 Binding of HMGCR 1 0.03 0.72 0.14 96.00
24 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15 94.36
25 INT278681 Positive_regulation of UGT1A4 1 0.36 0.99 0 94.28
26 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 93.84
27 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 93.28
28 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 91.04
29 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94 89.76
30 INT248677 Positive_regulation of Nr0b2 3 0.42 4.49 1.91 88.80
31 INT173158 Regulation of ABCB4 1 0.39 0.76 0.18 87.68
32 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 86.92
33 INT114957 Positive_regulation of Transcription of PPARA 18 0.62 10.36 3.65 86.16
34 INT329888 Positive_regulation of Transcription of CYP7A1 1 0.20 0.9 0.46 86.16
35 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 86.16
36 INT329886 Transcription of CYP7A1 1 0.28 0.45 0.23 86.16
37 INT197010 Positive_regulation of CYP7A1 4 0.47 1.75 0.7 85.52
38 INT60478 Gene_expression of UGT1A6 26 0.78 1.57 5.98 85.20
39 INT321310 Positive_regulation of Nr1h4 1 0.49 1.75 2.75 84.56
40 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43 83.68
41 INT309245 Binding of SETX 1 0.08 1.98 0.06 81.36
42 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 79.88
43 INT17331 Positive_regulation of JUN 132 0.69 60.4 27.03 79.84
44 INT52311 Positive_regulation of JUNB 12 0.40 4.48 6.02 79.84
45 INT173197 Positive_regulation of ZFP36 1 0.26 0.45 0.12 79.84
46 INT63322 Protein_catabolism of LPL 2 0.57 0.33 0.08 79.84
47 INT142695 Gene_expression of HMGCR 17 0.65 3.75 0.32 78.68
48 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 77.92
49 INT229282 Binding of Nr1h2 7 0.17 5.11 0.66 77.92
50 INT278671 Positive_regulation of Gene_expression of SULT1A2 1 0.05 0.57 0.07 77.84
51 INT10604 Gene_expression of SULT1A2 12 0.76 0.72 0.52 77.44
52 INT219843 Gene_expression of SULT2B1 9 0.62 0.92 0.27 77.44
53 INT46650 Localization of Trf 13 0.61 4.4 2.91 76.16
54 INT107089 Gene_expression of Cyp7a1 2 0.44 1.05 0.45 76.04
55 INT188613 Gene_expression of CYP8B1 2 0.58 1.04 0.41 75.60
56 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18 75.00
57 INT60476 Positive_regulation of UGT1A6 5 0.48 1.24 2.16 74.88
58 INT229326 Negative_regulation of CYP7A1 3 0.29 1.03 0.7 74.88
59 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 73.24
60 INT100144 Negative_regulation of Positive_regulation of PPARA 17 0.49 12.71 2.68 72.04
61 INT176041 Transcription of FABP6 1 0.05 0.64 0.59 71.36
62 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 70.56
63 INT278674 Positive_regulation of Gene_expression of SULT2A1 9 0.29 2.04 0.63 70.04
64 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07 69.44
65 INT170183 Regulation of Gene_expression of SULT2A1 5 0.26 1.9 0.57 69.08
66 INT278676 Localization of UGT1A9 1 0.29 0.28 0.03 68.28
67 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45 67.56
68 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 67.52
69 INT239289 Gene_expression of Abcg1 3 0.31 2.27 0.5 67.16
70 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 66.32
71 INT99411 Positive_regulation of UGT1A9 2 0.39 0.65 0.88 65.00
72 INT194794 Binding of TTPA 7 0.08 2.56 0.57 63.04
73 INT199661 Negative_regulation of TTPA 2 0.04 1.84 0 63.04
74 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 61.72
75 INT171589 Transcription of APOC3 2 0.71 1.25 0.15 61.04
76 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43 59.88
77 INT171595 Negative_regulation of APOC3 3 0.43 1.99 0.15 59.28
78 INT63317 Positive_regulation of Negative_regulation of CYP27A1 2 0.45 1.41 0.37 58.56
79 INT63318 Regulation of Negative_regulation of CYP27A1 1 0.44 0.9 0.18 58.56
80 INT173161 Regulation of PPA1 1 0.04 0.44 0.1 58.04
81 INT105897 Regulation of UGT1A1 3 0.60 1.6 0.13 58.00
82 INT321312 Phosphorylation of Nr1h4 1 0.58 0.23 0.03 57.96
83 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 57.44
84 INT96724 Gene_expression of Cyp3a11 10 0.77 4.82 7.76 57.20
85 INT120234 Positive_regulation of Gene_expression of Cyp3a11 4 0.46 2.21 2.13 57.20
86 INT239247 Positive_regulation of APOA5 7 0.37 3.68 0.51 56.80
87 INT282679 Localization of FECH 1 0.12 9.57 0.23 56.32
88 INT115264 Binding of FECH 9 0.41 7.93 1.1 55.88
89 INT136982 Positive_regulation of Positive_regulation of Nr1i2 3 0.65 4.66 2.89 55.84
90 INT278659 Transcription of SULT2A1 1 0.40 0.25 0.21 55.68
91 INT176212 Transcription of Nr1h2 5 0.29 2.92 0.15 55.68
92 INT233881 Positive_regulation of Cd36 8 0.48 4.68 0.29 55.36
93 INT321351 Positive_regulation of Gene_expression of Nr1h4 1 0.49 0.12 0.03 52.80
94 INT206951 Gene_expression of Nr1h4 2 0.56 0.68 0.03 52.80
95 INT173170 Gene_expression of PPA1 5 0.06 3.11 0.47 51.48
96 INT173195 Positive_regulation of Gene_expression of PPA1 1 0.04 0.44 0.07 51.48
97 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 50.28
98 INT121942 Binding of Nr1i2 2 0.45 15.69 3.66 49.68
99 INT125447 Positive_regulation of CLDN4 14 0.70 4.71 4.45 49.60
100 INT128498 Regulation of CCND1 17 0.39 12.51 0.58 47.24
101 INT106733 Regulation of CDK2 6 0.44 4.76 0.23 47.24
102 INT173184 Regulation of CDK1 4 0.30 2.97 0.15 47.24
103 INT173183 Regulation of CCNE1 1 0.05 0.4 0.06 47.24
104 INT173191 Regulation of CDK4 1 0.26 0.39 0.06 47.24
105 INT321329 Positive_regulation of Positive_regulation of Nr1h4 1 0.35 0.43 1.07 46.80
106 INT199647 Regulation of Phyh 1 0.27 2.71 0 46.64
107 INT278620 Gene_expression of Sult1d1 1 0.03 0.3 0.83 45.72
108 INT103094 Binding of PPARA 308 0.47 177.26 34.75 45.16
109 INT262077 Positive_regulation of Insig1 3 0.29 0.34 0.21 45.00
110 INT262064 Negative_regulation of Positive_regulation of Insig1 1 0.09 0.05 0 45.00
111 INT278662 Positive_regulation of Transcription of UGT2B4 1 0.22 0.08 0.05 43.12
112 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 42.56
113 INT187499 Positive_regulation of Positive_regulation of Fig4 9 0.21 3.28 2.69 42.56
114 INT278661 Transcription of UGT2B4 1 0.30 0.08 0.05 42.56
115 INT278666 Positive_regulation of Positive_regulation of UGT1A4 1 0.24 0.1 0 37.60
116 INT278673 Positive_regulation of Positive_regulation of UGT1A6 1 0.21 0.1 0 34.72
117 INT262069 Positive_regulation of Transcription of Srebf1 1 0.07 0.05 0 34.28
118 INT262072 Negative_regulation of Transcription of Srebf1 1 0.06 0.05 0 33.96
119 INT176039 Regulation of HMGCR 6 0.17 2.32 0.29 33.92
120 INT176206 Transcription of Srebf1 3 0.14 0.37 0.03 33.56
121 INT278667 Positive_regulation of Negative_regulation of UGT2B4 1 0.22 0.07 0.04 33.12
122 INT176174 Gene_expression of Srebf1 16 0.66 6.53 0.82 32.88
123 INT262065 Negative_regulation of Gene_expression of Srebf1 4 0.49 1.78 0.08 32.88
124 INT278677 Negative_regulation of UGT2B4 1 0.19 0.07 0.04 32.48
125 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 31.44
126 INT278652 Regulation of UGT2B4 1 0.20 0.07 0.04 31.04
127 INT262094 Regulation of Positive_regulation of Nr1i2 2 0.42 0.52 0.13 29.76
128 INT45838 Positive_regulation of LPL 15 0.69 11.33 2 28.80
129 INT142620 Regulation of CD36 6 0.62 0.72 0.54 28.48
130 INT173196 Regulation of Gene_expression of SLC27A1 1 0.15 0.29 0.03 28.48
131 INT173168 Regulation of Gene_expression of LPL 2 0.14 0.29 0.03 28.48
132 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 27.92
133 INT38265 Gene_expression of LPL 22 0.78 10.59 1.09 27.92
134 INT173192 Gene_expression of SLC27A1 2 0.25 0.56 0.1 27.92
135 INT176040 Negative_regulation of Transcription of HMGCR 1 0.04 0.07 0.04 27.04
136 INT176037 Transcription of HMGCR 2 0.37 0.07 0.04 26.72
137 INT125006 Gene_expression of DEFA5 2 0.05 3.38 0.38 26.32
138 INT309255 Gene_expression of NDUFV1 1 0.01 2.33 0 25.92
139 INT292006 Gene_expression of ADSL 8 0.22 2.55 0.26 25.24
140 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 22.48
141 INT14572 Binding of INS 205 0.48 175.43 13.38 21.00
142 INT173193 Binding of SORBS1 2 0.14 1.29 0 18.52
143 INT88269 Binding of ASIP 4 0.19 0.41 1.82 17.40
144 INT20050 Gene_expression of UGT1A4 4 0.73 0.09 0.34 14.16
145 INT278678 Positive_regulation of Gene_expression of UGT1A1 1 0.37 0.09 0.06 12.88
146 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 12.40
147 INT261017 Regulation of Gclc 2 0.22 0.88 0.06 11.80
148 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 11.36
149 INT261026 Localization of Gclc 3 0.36 0.88 0.06 11.36
150 INT120966 Positive_regulation of Pik3cb 34 0.68 15.15 16.59 10.84
151 INT68857 Positive_regulation of Rxfp2 5 0.34 1.51 1.86 10.84
152 INT321314 Positive_regulation of Pdk1 3 0.22 0.74 0.55 10.84
153 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 9.52
154 INT262060 Positive_regulation of Vdr 8 0.58 2.84 0.67 9.52
155 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04 9.44
156 INT262054 Regulation of Gene_expression of Nr1i2 1 0.42 1.45 0.36 9.44
157 INT24332 Regulation of Hdl1 28 0.45 45.45 4.26 8.68
158 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.60
159 INT76025 Positive_regulation of Cyp3a11 20 0.69 5.88 6.91 5.36
160 INT278665 Positive_regulation of Transcription of SULT2A1 1 0.29 0 0.12 5.04
161 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
162 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
163 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 5.00
164 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
165 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
166 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
167 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
168 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
169 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
170 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
171 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
172 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
173 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
174 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 5.00
175 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
176 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 5.00
177 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
178 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 5.00
179 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
180 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
181 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
182 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
183 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
184 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34 5.00
185 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
186 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
187 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
188 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
189 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
190 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
191 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
192 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
193 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 5.00
194 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
195 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
196 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
197 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
198 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
199 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76 5.00
200 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
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