D:Vascular Malformations

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Disease Term
Synonyms Malformation Vascular, MALFORMATIONS VASCULAR, Vascular Malformation
Documents 406
Hot Single Events 27
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Vascular Malformations. They are ordered first by their relevance to Vascular Malformations and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT304776 Binding of KMS and KTWS 1 0.01 2.24 0 59.92
2 INT347531 Binding of Nrp2 and Sema3b 1 0.04 0.99 0.28 5.00
3 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27 5.00
4 INT265346 Binding of Ocln and Tjp1 7 0.05 1.11 0.09 5.00
5 INT321597 Binding of MUC1 and MIB1 1 0.19 0.98 0.08 5.00
6 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03 5.00
7 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03 5.00
8 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03 5.00
9 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03 5.00
10 INT347533 Tmem131 Negative_regulation of Gene_expression of Nrp2 1 0.04 0 0 5.00
11 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0 5.00
12 INT265344 sb Negative_regulation of Tgfbr1 1 0.00 0.06 0 5.00
13 INT265342 sb Negative_regulation of Bcl2l1 1 0.00 0.65 0 5.00
14 INT231519 Binding of PAX7 and POMT1 1 0.02 0.78 0 5.00
15 INT231521 Binding of IARS and POMT1 1 0.03 0.72 0 5.00
16 INT231520 Binding of PAX7 and GOPC 1 0.09 0.98 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Vascular Malformations. They are ordered first by their pain relevance and then by number of times they were reported in Vascular Malformations. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT125142 Gene_expression of EFNB2 1 0.24 2.59 0.62 98.88
2 INT125143 Gene_expression of EPHB2 40 0.71 13.27 6.97 98.88
3 INT125140 Gene_expression of EPHB4 7 0.62 1.65 0.62 98.88
4 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03 98.32
5 INT87356 Binding of PFM3 1 0.15 0.2 0.1 98.08
6 INT125139 Regulation of Gene_expression of EPHB2 3 0.44 1.07 0.52 97.40
7 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 95.64
8 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 95.40
9 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 95.40
10 INT89116 Regulation of Positive_regulation of VEGFA 8 0.43 6.62 1.5 95.40
11 INT112110 Positive_regulation of FIGF 3 0.18 5.28 0.37 95.40
12 INT245880 Positive_regulation of Positive_regulation of FIGF 1 0.05 1.61 0.06 95.40
13 INT129118 Negative_regulation of NF2 2 0.56 1.89 0.15 95.12
14 INT82685 Gene_expression of Pecam1 36 0.76 27.95 9.01 93.64
15 INT90021 Gene_expression of IGKV2D-40 6 0.13 3.07 1.31 93.64
16 INT87272 Binding of KRIT1 4 0.47 1.2 1.48 92.48
17 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 92.00
18 INT102336 Gene_expression of Krit1 3 0.69 2.54 0.49 90.32
19 INT206746 Gene_expression of TPM1 7 0.75 2.15 0.21 89.40
20 INT265312 Gene_expression of Myo1f 3 0.10 1.44 0.04 89.40
21 INT102337 Gene_expression of RAP1A 4 0.58 1.83 0.17 88.00
22 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 84.04
23 INT48218 Gene_expression of KRIT1 16 0.75 7.59 1.8 81.52
24 INT162998 Gene_expression of PDCD10 3 0.71 1.52 0.52 80.96
25 INT143339 Gene_expression of CCM2 2 0.13 1.24 0.42 80.96
26 INT150081 Gene_expression of Ccm2 4 0.77 1.56 0.36 80.96
27 INT87357 Binding of MSX2 1 0.48 0.97 0.22 80.08
28 INT105021 Binding of GOPC 187 0.40 60.39 20.38 79.36
29 INT246036 Positive_regulation of GRN 3 0.17 2.04 0.69 77.44
30 INT125141 Regulation of Gene_expression of EPHB4 1 0.49 0.24 0.05 77.32
31 INT77914 Binding of LRPAP1 5 0.47 1.1 0.64 77.28
32 INT16150 Positive_regulation of NKG7 10 0.69 10.26 1.73 77.04
33 INT228975 Gene_expression of SERPINA2 1 0.31 1.61 0 76.08
34 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 72.68
35 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87 67.04
36 INT320783 Binding of Flt4 2 0.26 0.98 0.05 66.56
37 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 65.44
38 INT46827 Negative_regulation of ADAMTS1 2 0.42 0.93 0.26 64.96
39 INT94085 Binding of NFASC 10 0.17 7.1 2.5 61.04
40 INT85462 Binding of KTWS 3 0.31 2.91 0.54 59.48
41 INT14916 Binding of RASA1 15 0.37 13.64 1.44 59.16
42 INT302039 Negative_regulation of Nrp2 6 0.51 1.65 0.19 57.68
43 INT245878 Binding of FLI1 2 0.11 2.57 0.1 53.04
44 INT245877 Binding of HBA1 2 0.11 2.59 0.04 53.04
45 INT245879 Binding of IGLV3-1 2 0.36 1.6 0.04 53.04
46 INT347528 Negative_regulation of Flt4 1 0.29 0.13 0 46.40
47 INT4188 Binding of NF2 7 0.46 3.52 1.79 45.28
48 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 37.80
49 INT44080 Positive_regulation of HBA1 7 0.25 2.23 0.6 37.80
50 INT275892 Positive_regulation of Gene_expression of HBA1 7 0.67 2.4 0.24 37.80
51 INT298953 Positive_regulation of Gene_expression of Lyve1 1 0.03 0.77 0 37.80
52 INT90377 Gene_expression of HBA1 26 0.75 7.34 1.51 37.32
53 INT199345 Gene_expression of Lyve1 11 0.50 8.44 0.89 35.88
54 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15 32.72
55 INT76817 Gene_expression of sb 3 0.46 0.56 0.18 32.72
56 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 30.20
57 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 29.04
58 INT242267 Localization of Slc25a16 1 0.34 6.15 0.43 24.92
59 INT244657 Regulation of Lch 3 0.40 6.63 0.13 11.28
60 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34 8.96
61 INT169862 Regulation of NPC1 13 0.53 13.61 1.84 8.64
62 INT167636 Protein_catabolism of Vwf 5 0.52 5.09 0.41 8.52
63 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
64 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
65 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
66 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
67 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
68 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
69 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
70 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
71 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
72 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
73 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
74 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
75 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 5.00
76 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
77 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
78 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
79 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
80 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
81 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
82 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
83 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79 5.00
84 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
85 INT67975 Gene_expression of Bdkrb2 38 0.68 21.69 17.94 5.00
86 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
87 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
88 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 5.00
89 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
90 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
91 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 5.00
92 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
93 INT1150 Gene_expression of ecs 42 0.59 29.38 7.73 5.00
94 INT79168 Binding of TNC 39 0.47 16.51 7.55 5.00
95 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
96 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51 5.00
97 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
98 INT79425 Gene_expression of SMN1 42 0.65 36.37 6.1 5.00
99 INT16688 Positive_regulation of Cndp2 11 0.49 1.12 5.86 5.00
100 INT128563 Binding of Mllt1 8 0.41 6.7 5.63 5.00
101 INT146340 Localization of Mllt1 10 0.69 4.6 5.45 5.00
102 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
103 INT103463 Localization of CPP 16 0.66 9.63 4.08 5.00
104 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
105 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
106 INT95423 Negative_regulation of Bcl2l1 26 0.41 21.66 3.81 5.00
107 INT32124 Negative_regulation of ecs 10 0.37 6.53 3.81 5.00
108 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75 5.00
109 INT10146 Negative_regulation of Vwf 27 0.40 17.11 3.69 5.00
110 INT184894 Localization of MCRS1 9 0.47 10.04 3.31 5.00
111 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 5.00
112 INT137609 Localization of Vegfa 22 0.78 14.67 3.01 5.00
113 INT17993 Negative_regulation of RASA1 8 0.41 7.34 2.62 5.00
114 INT102036 Positive_regulation of Dre 12 0.59 4.41 2.4 5.00
115 INT311479 Gene_expression of Mllt1 4 0.58 4.92 2.39 5.00
116 INT311478 Positive_regulation of Mllt1 4 0.60 2.38 2.34 5.00
117 INT31118 Localization of Casp3 17 0.73 11.55 2.3 5.00
118 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25 5.00
119 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09 5.00
120 INT149031 Gene_expression of Tjp1 43 0.75 19.1 2.06 5.00
121 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94 5.00
122 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 5.00
123 INT95636 Gene_expression of ACTG2 23 0.44 19.87 1.75 5.00
124 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64 5.00
125 INT311474 Positive_regulation of Localization of Mllt1 1 0.43 1.23 1.56 5.00
126 INT146511 Gene_expression of Nrp2 25 0.78 8.67 1.55 5.00
127 INT311482 Negative_regulation of Positive_regulation of Mllt1 1 0.37 0.66 1.55 5.00
128 INT133875 Gene_expression of POMT1 26 0.58 17.1 1.48 5.00
129 INT311472 Negative_regulation of Localization of Mllt1 1 0.37 0.9 1.45 5.00
130 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34 5.00
131 INT311480 Negative_regulation of Mllt1 1 0.50 0.55 1.31 5.00
132 INT209417 Gene_expression of ERG 21 0.20 6.69 1.26 5.00
133 INT11553 Negative_regulation of CCBE1 3 0.03 1.1 1.25 5.00
134 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24 5.00
135 INT212093 Positive_regulation of CASP2 6 0.17 6.87 1.14 5.00
136 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08 5.00
137 INT231528 Localization of NT5C3 2 0.73 1.78 1.06 5.00
138 INT177615 Gene_expression of PAX7 20 0.65 13.5 1.03 5.00
139 INT35713 Gene_expression of Tmem131 9 0.50 6.13 0.96 5.00
140 INT58291 Protein_catabolism of Bdkrb2 3 0.08 1.19 0.94 5.00
141 INT311475 Regulation of Localization of Mllt1 1 0.39 1.1 0.94 5.00
142 INT120175 Negative_regulation of HK1 10 0.57 2.57 0.92 5.00
143 INT153327 Gene_expression of Aspscr1 5 0.57 3.28 0.91 5.00
144 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87 5.00
145 INT137276 Binding of Acads 3 0.32 1.82 0.84 5.00
146 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83 5.00
147 INT173003 Negative_regulation of Gene_expression of MUC1 15 0.57 10.27 0.79 5.00
148 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78 5.00
149 INT311481 Positive_regulation of Positive_regulation of Ugt1a@ 1 0.03 0.38 0.77 5.00
150 INT311477 Positive_regulation of Negative_regulation of Mllt1 1 0.43 0.3 0.75 5.00
151 INT128562 Regulation of Mllt1 2 0.39 1.1 0.74 5.00
152 INT262276 Negative_regulation of CASP2 1 0.01 2.98 0.73 5.00
153 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72 5.00
154 INT311476 Positive_regulation of Positive_regulation of Mllt1 1 0.40 0.16 0.72 5.00
155 INT311473 Positive_regulation of Ugt1a@ 1 0.04 0.38 0.7 5.00
156 INT130358 Gene_expression of Tsp2 8 0.65 4.84 0.67 5.00
157 INT178196 Gene_expression of Vegfc 7 0.27 7.47 0.64 5.00
158 INT160963 Negative_regulation of UGCG 3 0.57 1.69 0.58 5.00
159 INT159143 Gene_expression of Ocln 14 0.42 5.25 0.57 5.00
160 INT90939 Positive_regulation of Eng 9 0.64 4.62 0.57 5.00
161 INT120591 Positive_regulation of Acads 2 0.40 1.25 0.56 5.00
162 INT90416 Positive_regulation of RASA1 3 0.67 1.58 0.56 5.00
163 INT134629 Positive_regulation of Gene_expression of Flt4 3 0.32 2.13 0.52 5.00
164 INT227043 Negative_regulation of Dre 2 0.19 1.13 0.49 5.00
165 INT101365 Binding of Tjp1 8 0.11 1.66 0.49 5.00
166 INT169990 Localization of POMT1 7 0.19 4.09 0.45 5.00
167 INT155293 Positive_regulation of Protein_catabolism of Casp3 3 0.45 1.7 0.4 5.00
168 INT231524 Localization of PAX7 5 0.56 4.2 0.39 5.00
169 INT262273 Positive_regulation of Strs1 1 0.01 1.52 0.39 5.00
170 INT228977 Binding of SERPINA2 1 0.25 5.42 0.35 5.00
171 INT262272 Phosphorylation of Strs1 1 0.01 1.07 0.34 5.00
172 INT262277 Regulation of CASP2 1 0.01 1.27 0.33 5.00
173 INT331991 Positive_regulation of LEFTY2 1 0.03 1.75 0.31 5.00
174 INT217501 Positive_regulation of Tjp1 8 0.49 2.91 0.28 5.00
175 INT157135 Positive_regulation of MKI67 10 0.60 7.51 0.28 5.00
176 INT265331 Gene_expression of Tnmd 6 0.30 0.06 0.28 5.00
177 INT262275 Negative_regulation of GAPDH 1 0.01 1.54 0.28 5.00
178 INT217515 Binding of Ocln 7 0.22 2.12 0.25 5.00
179 INT217504 Regulation of Tjp1 9 0.32 2.44 0.23 5.00
180 INT265327 Negative_regulation of Binding of ecs 3 0.13 2.59 0.23 5.00
181 INT265341 Negative_regulation of Gene_expression of ecs 2 0.13 1.22 0.22 5.00
182 INT262274 Gene_expression of UGCG 8 0.27 1.62 0.22 5.00
183 INT61818 Positive_regulation of Ocln 6 0.23 4.11 0.22 5.00
184 INT265311 Localization of Smad2 5 0.50 1.57 0.21 5.00
185 INT331990 Negative_regulation of Ichs 1 0.11 0.89 0.21 5.00
186 INT265334 Regulation of Phosphorylation of Smad2 2 0.17 0.96 0.2 5.00
187 INT93885 Positive_regulation of Gene_expression of MKI67 8 0.60 4.4 0.18 5.00
188 INT347525 Positive_regulation of Nrp2 1 0.50 0.81 0.18 5.00
189 INT262278 Negative_regulation of Localization of UGCG 1 0.03 0.74 0.17 5.00
190 INT262279 Localization of UGCG 2 0.30 0.9 0.17 5.00
191 INT228976 Binding of MCAT 3 0.06 3.45 0.17 5.00
192 INT242268 Binding of Slc25a16 1 0.17 1.67 0.15 5.00
193 INT334815 Binding of Artles 1 0.00 1.22 0.14 5.00
194 INT90940 Binding of Eng 5 0.35 1.92 0.13 5.00
195 INT129616 Negative_regulation of Phosphorylation of Smad2 4 0.38 0.78 0.12 5.00
196 INT302043 Negative_regulation of Gene_expression of Nrp2 5 0.59 1.53 0.1 5.00
197 INT255239 Positive_regulation of Gene_expression of Tsp2 2 0.31 0.36 0.08 5.00
198 INT337584 Positive_regulation of LYPLA2P1 1 0.49 0.95 0.07 5.00
199 INT347526 Regulation of Gene_expression of Nrp2 1 0.62 0.65 0.07 5.00
200 INT265317 Negative_regulation of Gene_expression of Smad3 2 0.41 0.9 0.06 5.00
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