D:Ventricular Heart Septal Defects

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Disease Term
Synonyms Defect Intraventricular Septal, Defect Ventricular Septal, Defects Intraventricular Septal, Intraventricular Septal Defect, Intraventricular Septal Defects, Septal Defect Intraventricular, SEPTAL DEFECT VENTRICULAR, Septal Defects Intraventricular, Septal Defects Ventricular, Ventricular Septal Defect, Ventricular Septal Defects
Documents 463
Hot Single Events 49
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Ventricular Heart Septal Defects. They are ordered first by their relevance to Ventricular Heart Septal Defects and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0 97.52
2 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0 91.32
3 INT274434 Binding of Gata4 and Zfpm2 1 0.12 0.56 0 88.00
4 INT274435 Binding of Zfpm2 and Mir130a 1 0.30 0.26 0 77.92
5 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0 69.12
6 INT230723 ERVW-1 Positive_regulation of Gene_expression of EDN1 1 0.00 1.95 0 30.16
7 INT274431 Mir130a Regulation of Gene_expression of Zfpm2 1 0.50 0.79 0 25.00
8 INT274436 Mir130a Regulation of Transcription of Zfpm2 1 0.22 0 0 25.00
9 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61 5.00
10 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6 5.00
11 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39 5.00
12 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38 5.00
13 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24 5.00
14 INT231223 Binding of KCNQ1 and Nav1 1 0.03 0.59 0.11 5.00
15 INT273616 PVR Positive_regulation of Pah 1 0.10 0.86 0.07 5.00
16 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06 5.00
17 INT279889 Il6 Regulation of Socs3 1 0.21 0.17 0.05 5.00
18 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03 5.00
19 INT279885 Ctcf Regulation of H19 1 0.12 0 0 5.00
20 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0 5.00
21 INT279891 Shbdp1 Negative_regulation of PCDHB@ 1 0.01 0.09 0 5.00
22 INT274432 Mir130a Regulation of Zfpm2 1 0.22 0.08 0 5.00
23 INT279886 Shbdp1 Negative_regulation of Pcdhb1 1 0.10 0.09 0 5.00
24 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0 5.00
25 INT279884 Nipbl Regulation of Transcription of Pcdhb1 1 0.25 0.05 0 5.00
26 INT279892 Shbdp1 Negative_regulation of Gene_expression of PCDHB@ 1 0.01 0.09 0 5.00
27 INT313384 Binding of PDLIM5 and ZMYND10 1 0.04 0.82 0 5.00
28 INT273287 Binding of Atp2a2 and Pln 1 0.08 0.26 0 5.00
29 INT273290 Binding of Atp2a2 and Tlx2 1 0.05 0.26 0 5.00
30 INT311659 Egfr Positive_regulation of Mapk1 1 0.08 0.18 0 5.00
31 INT274433 Binding of Zfpm2 and Uts2r 1 0.08 0.17 0 5.00
32 INT273291 Atp2a2 Regulation of Car2 1 0.10 0.31 0 5.00
33 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0 5.00
34 INT279888 Binding of Rec8 and Nipbl 1 0.01 0.81 0 5.00
35 INT273286 Tlx2 Regulation of Car2 1 0.06 0.31 0 5.00
36 INT279890 Nipbl Regulation of Gene_expression of PCDHB@ 1 0.07 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Ventricular Heart Septal Defects. They are ordered first by their pain relevance and then by number of times they were reported in Ventricular Heart Septal Defects. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT45342 Binding of AVSD1 6 0.31 7.23 0.27 100.00
2 INT300167 Binding of FBXL15 2 0.39 5 0.19 100.00
3 INT158059 Negative_regulation of ASD1 2 0.08 1.11 0.4 100.00
4 INT47010 Negative_regulation of Gusb 6 0.43 4.16 1.2 100.00
5 INT65605 Negative_regulation of Negative_regulation of Sysbp1 1 0.00 0.61 0.12 99.98
6 INT9748 Negative_regulation of Sysbp1 28 0.35 8.93 3.87 99.98
7 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43 99.84
8 INT162831 Regulation of ARSD 13 0.35 6.17 1.19 99.84
9 INT3364 Binding of SGCG 87 0.47 31.93 17.24 99.76
10 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 99.60
11 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 99.60
12 INT68592 Negative_regulation of asa 8 0.37 3.75 2.1 99.60
13 INT199746 Gene_expression of REV1 17 0.33 9.53 0.05 99.36
14 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 99.28
15 INT4173 Binding of Cys1 3 0.37 2.8 0.15 98.84
16 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 98.20
17 INT4046 Positive_regulation of HBG2 42 0.69 13.66 8.51 97.96
18 INT37863 Regulation of HBG2 11 0.61 3.95 4.34 97.96
19 INT274421 Gene_expression of Mir130a 1 0.55 15.48 0 97.12
20 INT274407 Positive_regulation of Gene_expression of Mir130a 1 0.49 5.1 0 97.12
21 INT170625 Binding of SERPINA5 8 0.32 8.42 0.69 96.64
22 INT67953 Gene_expression of SPEG 1 0.00 1.8 0.1 95.80
23 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86 95.64
24 INT274418 Regulation of Gene_expression of Zfpm2 1 0.45 1.42 0 95.56
25 INT274405 Gene_expression of Zfpm2 1 0.77 6.51 0 95.00
26 INT293079 Negative_regulation of Gene_expression of SERPINA5 1 0.21 1.36 0.16 94.44
27 INT219581 Binding of Ryr2 2 0.27 4.54 0 94.40
28 INT274417 Negative_regulation of Zfpm2 1 0.43 6.99 0 93.60
29 INT202628 Gene_expression of Wnt1 20 0.67 9.2 0.82 93.40
30 INT115908 Localization of TCO 3 0.48 1.76 1.39 93.32
31 INT63779 Localization of Ado 6 0.64 4.8 3.81 92.72
32 INT163544 Binding of Psen1 40 0.36 15.28 2.42 92.16
33 INT199681 Gene_expression of SERPINA5 13 0.36 15.42 1.25 91.96
34 INT78649 Binding of Psen2 7 0.36 5.9 0.73 91.84
35 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 90.00
36 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 89.60
37 INT228404 Gene_expression of Slc12a3 6 0.35 7.18 1 88.36
38 INT274404 Binding of Gata4 2 0.16 0.89 0 88.00
39 INT251522 Positive_regulation of MED13L 1 0.35 0.82 0.11 85.72
40 INT251521 Positive_regulation of GDF1 1 0.14 0.82 0.1 85.72
41 INT274408 Binding of Zfpm2 1 0.37 0.77 0 84.80
42 INT279846 Gene_expression of Nipbl 1 0.68 11.1 0.56 82.56
43 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83 82.16
44 INT65500 Gene_expression of App 605 0.78 429.94 98.31 82.16
45 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19 82.16
46 INT47712 Positive_regulation of App 135 0.69 101.38 28.94 81.40
47 INT60724 Gene_expression of Psen2 30 0.72 27 5.79 81.20
48 INT18872 Negative_regulation of Asap1 18 0.43 8.48 5.42 80.96
49 INT215844 Gene_expression of Ex 12 0.65 9.24 0.54 80.16
50 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 79.20
51 INT193856 Localization of Psen1 19 0.73 9.79 0.41 79.04
52 INT208643 Gene_expression of Gt(ROSA)26Sor 11 0.65 4.85 0.37 77.84
53 INT20612 Positive_regulation of Asap1 36 0.68 24.35 6.06 75.00
54 INT311644 Positive_regulation of Gene_expression of Spry1 1 0.46 2.54 0.13 74.48
55 INT3962 Regulation of AGT 50 0.62 20.96 13.01 72.00
56 INT50849 Negative_regulation of Regulation of AGT 2 0.42 1.26 0.08 72.00
57 INT259848 Regulation of Slc12a3 2 0.12 2.1 0.3 69.12
58 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 65.76
59 INT17399 Positive_regulation of Positive_regulation of REN 13 0.69 7.05 1.9 65.76
60 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 63.12
61 INT274406 Negative_regulation of Mir130a 1 0.31 0.4 0 62.88
62 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 61.76
63 INT274426 Regulation of Binding of Mir130a 1 0.32 0.41 0 59.52
64 INT168933 Positive_regulation of Car5b 2 0.15 0.64 0.05 57.36
65 INT274410 Binding of Mir130a 1 0.27 0.66 0 57.28
66 INT103907 Negative_regulation of Upf1 15 0.37 4.3 1.4 56.28
67 INT238058 Negative_regulation of Shbdp1 4 0.10 1.36 0.42 56.28
68 INT279869 Negative_regulation of Nipbl 1 0.43 4.3 0.03 56.28
69 INT311647 Negative_regulation of Gene_expression of Spry1 1 0.39 0.18 0.04 53.92
70 INT311654 Regulation of Spry2 1 0.21 0.75 0 53.04
71 INT274414 Regulation of Zfpm2 1 0.61 0.59 0 51.88
72 INT23598 Binding of SCN5A 32 0.40 16 5.35 50.16
73 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 49.52
74 INT279841 Transcription of Nipbl 1 0.63 1.21 0 49.36
75 INT279871 Negative_regulation of Transcription of Nipbl 1 0.43 1.22 0 49.36
76 INT274422 Negative_regulation of Localization of Mir208a 1 0.09 0.55 0 48.16
77 INT311645 Gene_expression of Spry2 1 0.70 1.81 0 46.72
78 INT279838 Protein_catabolism of Rec8 1 0.02 0.81 0 45.44
79 INT274411 Positive_regulation of Zfpm2 1 0.46 0.53 0 44.60
80 INT274420 Positive_regulation of Gene_expression of Zfpm2 1 0.49 0.51 0 44.24
81 INT279853 Negative_regulation of Gene_expression of Nipbl 1 0.51 2.37 0.19 43.96
82 INT274416 Localization of Mir208a 1 0.16 0.54 0 43.84
83 INT200247 Negative_regulation of Dbp 5 0.15 0.8 0.5 43.68
84 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 42.56
85 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 41.88
86 INT293077 Regulation of SERPINA5 2 0.24 1.42 0.29 41.84
87 INT16854 Gene_expression of Uts2r 17 0.26 3.1 1.31 37.76
88 INT274423 Positive_regulation of Gene_expression of Uts2r 3 0.09 0.58 0 37.76
89 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 36.08
90 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 34.08
91 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 33.84
92 INT274427 Negative_regulation of Gene_expression of Mir130a 1 0.30 0.14 0 30.96
93 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05 30.84
94 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 30.16
95 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 25.00
96 INT274412 Transcription of Zfpm2 1 0.53 0 0 25.00
97 INT279862 Binding of Nipbl 1 0.36 1.22 0.04 24.04
98 INT294897 Negative_regulation of Slc12a3 2 0.20 1.77 0.2 21.04
99 INT86601 Positive_regulation of KCNH2 7 0.49 1.56 0.52 20.56
100 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 20.48
101 INT230730 Negative_regulation of Gene_expression of Pah 2 0.28 1.54 0.12 20.48
102 INT293401 Regulation of Gene_expression of Ar 1 0.06 0.07 0 20.16
103 INT10598 Gene_expression of Ar 10 0.64 3.44 1.61 19.92
104 INT274419 Regulation of Gene_expression of Mir130a 1 0.32 1.02 0 19.36
105 INT274403 Gene_expression of Mir375 7 0.11 1.07 0 19.20
106 INT274429 Gene_expression of Mir24-1 7 0.20 5.43 0 19.20
107 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 18.44
108 INT273614 Regulation of PVR 1 0.17 0.84 0.14 18.28
109 INT29651 Regulation of Pah 11 0.37 9.95 2.79 16.44
110 INT279863 Localization of Pds5a 1 0.47 0.93 0 14.72
111 INT279844 Localization of Pds5b 1 0.65 0.94 0 14.72
112 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 14.64
113 INT274413 Regulation of Mir130a 1 0.32 0.21 0 12.96
114 INT18025 Binding of Pah 32 0.45 30.72 7.93 11.28
115 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 11.16
116 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 9.56
117 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
118 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
119 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
120 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
121 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
122 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
123 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
124 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
125 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
126 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
127 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
128 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
129 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
130 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 5.00
131 INT5617 Localization of Nppa 266 0.81 83.51 83.89 5.00
132 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35 5.00
133 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
134 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
135 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
136 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
137 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
138 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 5.00
139 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
140 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
141 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
142 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
143 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
144 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
145 INT29743 Negative_regulation of App 91 0.59 65.56 31.26 5.00
146 INT6196 Regulation of Nppa 83 0.62 30.31 30.18 5.00
147 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
148 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
149 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
150 INT7894 Negative_regulation of Vip 59 0.59 11.76 27.36 5.00
151 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
152 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72 5.00
153 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
154 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9 5.00
155 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
156 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
157 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
158 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
159 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86 5.00
160 INT11625 Localization of App 98 0.78 55.46 20.86 5.00
161 INT79349 Gene_expression of Sert1 58 0.77 12.7 20.65 5.00
162 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 5.00
163 INT16794 Binding of App 103 0.48 64.87 19.79 5.00
164 INT65502 Regulation of App 77 0.62 52.05 19.44 5.00
165 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 5.00
166 INT15470 Regulation of CPP 42 0.48 26.1 18.25 5.00
167 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38 5.00
168 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 95 0.43 24.83 15.69 5.00
169 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
170 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02 5.00
171 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
172 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47 5.00
173 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
174 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15 5.00
175 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 5.00
176 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 5.00
177 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
178 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 5.00
179 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
180 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68 5.00
181 INT73497 Regulation of IL10 33 0.45 22.6 9.19 5.00
182 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 5.00
183 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 5.00
184 INT228870 Negative_regulation of Lpar1 17 0.51 20.97 8.77 5.00
185 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71 5.00
186 INT73508 Negative_regulation of Gene_expression of ISYNA1 32 0.51 19.67 7.57 5.00
187 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
188 INT6210 Binding of Nppa 39 0.47 14.35 7.21 5.00
189 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 5.00
190 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37 5.00
191 INT13406 Negative_regulation of CASP1 25 0.57 10.61 6.36 5.00
192 INT49468 Negative_regulation of Pah 28 0.55 24.95 6.29 5.00
193 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15 5.00
194 INT111069 Regulation of Psen1 19 0.44 7.78 5.87 5.00
195 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75 5.00
196 INT12157 Positive_regulation of SELL 16 0.67 14.54 5.74 5.00
197 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69 5.00
198 INT170516 Negative_regulation of Gene_expression of Car2 35 0.35 9.4 5.48 5.00
199 INT19541 Gene_expression of Ptgir 22 0.65 15.42 5.39 5.00
200 INT171562 Regulation of IL4 19 0.36 12.12 5.33 5.00
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