D:Vitelliform Macular Dystrophy

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Disease Term
Synonyms Adult Onset Vitelliform Macular Dystrophy, BEST DISEASE, Best Macular Dystrophy, Best S Disease, BEST VITELLIFORM MACULAR DYSTROPHY, BESTS DISEASE, Disease Best, Disease Best S, Dystrophies Vitelliform Macular, Dystrophy Best Macular, Dystrophy Vitelliform Macular
Documents 9
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Vitelliform Macular Dystrophy. They are ordered first by their relevance to Vitelliform Macular Dystrophy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT339585 Binding of AMD1 and MDM1 1 0.06 2.02 0 77.12
2 INT339582 AMD1 Regulation of C1QTNF5 1 0.07 2 0 52.48
3 INT282129 Il10 Positive_regulation of Icam1 1 0.56 3.12 0.82 5.00
4 INT170832 Cftr Regulation of Scnn1a 2 0.16 1.2 0.67 5.00
5 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
6 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 5.00
7 INT282128 Gene_expression of Il10 Positive_regulation of Positive_regulation of Icam1 1 0.37 1.12 0.28 5.00
8 INT287381 Cxcl2 Regulation of Gene_expression of VEGFA 1 0.42 1.1 0.1 5.00
9 INT339583 Binding of ABCA1 and RPE 1 0.03 1.38 0.05 5.00
10 INT339587 Positive_regulation of Binding of ABCA1 and RPE 1 0.04 1.38 0.05 5.00
11 INT233397 Binding of ABCA4 and COL2A1 1 0.38 3.59 0.03 5.00
12 INT289836 BEST1 Positive_regulation of Gene_expression of Car2 1 0.03 0.08 0 5.00
13 INT339581 Binding of TIMP1 and TIMP3 1 0.30 0.54 0 5.00
14 INT339580 TIMP3 Positive_regulation of ABCA1 1 0.16 0.73 0 5.00
15 INT339586 TIMP3 Positive_regulation of RPE 1 0.16 0.72 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Vitelliform Macular Dystrophy. They are ordered first by their pain relevance and then by number of times they were reported in Vitelliform Macular Dystrophy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT67182 Gene_expression of Tms 10 0.53 5.14 4.29 94.40
2 INT227759 Gene_expression of Best1 26 0.42 20.36 1.73 93.92
3 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 92.88
4 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 92.80
5 INT90792 Localization of Il10 144 0.80 87.88 30.03 91.88
6 INT211968 Localization of Best1 11 0.40 9.33 0.38 91.44
7 INT156113 Gene_expression of CLCF1 3 0.65 0.28 0.06 88.72
8 INT211972 Regulation of Best1 18 0.33 12.04 0.67 86.56
9 INT282127 Regulation of Regulation of Best1 1 0.15 1.67 0.18 86.56
10 INT130300 Gene_expression of Abcc3 14 0.70 5.34 4.96 86.24
11 INT71768 Regulation of Gene_expression of Il10 27 0.62 19.17 10.4 85.12
12 INT246624 Binding of Abcc3 2 0.00 0.59 0.15 82.52
13 INT262474 Gene_expression of Aqp6 26 0.77 2.08 2.49 80.68
14 INT215807 Gene_expression of Clcn3 5 0.19 3.2 0.48 70.44
15 INT289823 Positive_regulation of Gene_expression of Clcn3 1 0.06 0.07 0.09 70.44
16 INT50080 Binding of APOE 38 0.45 29.61 2.67 66.64
17 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 57.44
18 INT250353 Regulation of Binding of 1 0.07 0.29 0 53.84
19 INT212128 Binding of Cl 5 0.11 0.92 0.75 52.84
20 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 48.52
21 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 47.52
22 INT17561 Localization of Car2 303 0.79 60.95 44.52 46.48
23 INT212124 Gene_expression of Cl 18 0.11 6.72 1.93 44.28
24 INT56433 Negative_regulation of Cl 3 0.13 1.87 0.35 16.04
25 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 11.60
26 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 11.56
27 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 10.68
28 INT164451 Positive_regulation of Gene_expression of Zmat3 7 0.02 3.38 0.44 10.68
29 INT134753 Gene_expression of TIMP3 19 0.68 15.24 0.88 6.56
30 INT250354 Regulation of Prf1 1 0.00 0.31 0 6.04
31 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
32 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
33 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
34 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
35 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
36 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
37 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
38 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
39 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
40 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
41 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
42 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65 5.00
43 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
44 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
45 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 5.00
46 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
47 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
48 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
49 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
50 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
51 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
52 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
53 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 5.00
54 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
55 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
56 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 5.00
57 INT12922 Gene_expression of Atp9a 115 0.75 50.95 17.01 5.00
58 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 5.00
59 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
60 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
61 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
62 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
63 INT69769 Positive_regulation of Pscs 61 0.56 39.32 15.93 5.00
64 INT87823 Positive_regulation of Cxcl2 51 0.66 35.47 14.79 5.00
65 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
66 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
67 INT94051 Positive_regulation of Arg1 41 0.60 36.22 13.72 5.00
68 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
69 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
70 INT91360 Negative_regulation of Slc12a2 16 0.54 10.46 12.89 5.00
71 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
72 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
73 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
74 INT111992 Gene_expression of Pscs 40 0.76 27.47 10.74 5.00
75 INT71769 Negative_regulation of Gene_expression of Il10 40 0.57 22.53 10.37 5.00
76 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
77 INT104388 Positive_regulation of Gene_expression of Cxcl2 31 0.66 25.68 7.49 5.00
78 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 5.00
79 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 5.00
80 INT10131 Gene_expression of Serpinf1 53 0.76 35.57 6.42 5.00
81 INT16573 Regulation of Cl 18 0.07 8.69 6.03 5.00
82 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72 5.00
83 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17 5.00
84 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
85 INT154527 Gene_expression of POU5F1 180 0.78 34.01 4.34 5.00
86 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
87 INT43931 Binding of CFH 49 0.48 31.85 3.96 5.00
88 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77 5.00
89 INT35683 Gene_expression of Gsr 24 0.46 16.94 3.6 5.00
90 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47 5.00
91 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 5.00
92 INT10132 Negative_regulation of Serpinf1 14 0.58 11.72 3.14 5.00
93 INT69768 Negative_regulation of Pscs 7 0.51 4.76 2.82 5.00
94 INT96693 Binding of COL2A1 45 0.46 37.11 2.61 5.00
95 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31 5.00
96 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
97 INT61684 Localization of COL1A2 20 0.73 9.31 2.26 5.00
98 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
99 INT130560 Negative_regulation of Gene_expression of Serpinf1 17 0.58 13.39 1.94 5.00
100 INT258848 Regulation of Gene_expression of Cxcl2 7 0.43 8.71 1.77 5.00
101 INT113806 Transcription of CYP2B6 7 0.67 1.75 1.73 5.00
102 INT255663 Binding of Flt1 11 0.32 6.92 1.64 5.00
103 INT82866 Localization of Atp9a 13 0.78 6.95 1.56 5.00
104 INT115659 Gene_expression of ABCB6 29 0.75 13.59 1.43 5.00
105 INT111996 Positive_regulation of Gene_expression of Pscs 8 0.34 4.37 1.42 5.00
106 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 5.00
107 INT282590 Positive_regulation of Gene_expression of POU5F1 40 0.70 8.42 1.32 5.00
108 INT260525 Gene_expression of AMD1 25 0.66 24.58 1.32 5.00
109 INT117232 Localization of COL2A1 11 0.72 7.34 1.3 5.00
110 INT205952 Gene_expression of Shbdp1 14 0.24 2.46 1.27 5.00
111 INT16572 Localization of Cl 7 0.12 0.22 1.26 5.00
112 INT143759 Gene_expression of SOX2 46 0.55 11.12 1.24 5.00
113 INT123078 Negative_regulation of Kcnj1 2 0.10 0.87 1.09 5.00
114 INT21546 Regulation of ABCA1 16 0.40 4.21 1.04 5.00
115 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 5.00
116 INT103672 Localization of Serpinf1 4 0.69 2.45 0.74 5.00
117 INT10130 Positive_regulation of Serpinf1 10 0.53 5.62 0.7 5.00
118 INT109925 Gene_expression of RPE 11 0.65 12.46 0.68 5.00
119 INT130358 Gene_expression of Tsp2 8 0.65 4.84 0.67 5.00
120 INT257447 Binding of TBCE 4 0.08 4.68 0.66 5.00
121 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66 5.00
122 INT250351 Positive_regulation of Gene_expression of Best1 5 0.27 3.14 0.65 5.00
123 INT103673 Positive_regulation of Gene_expression of Serpinf1 13 0.60 4.94 0.64 5.00
124 INT167705 Positive_regulation of Clcn2 3 0.46 1.32 0.63 5.00
125 INT197512 Gene_expression of ABCA4 19 0.75 7.08 0.57 5.00
126 INT202940 Binding of AMD1 13 0.41 16.43 0.56 5.00
127 INT109904 Localization of RPE 5 0.73 4.9 0.56 5.00
128 INT109903 Positive_regulation of Gene_expression of RPE 3 0.49 0.59 0.46 5.00
129 INT161027 Negative_regulation of RPE 7 0.37 4.34 0.38 5.00
130 INT165400 Positive_regulation of TST 13 0.68 4.25 0.35 5.00
131 INT233398 Localization of TIMP3 2 0.45 1.31 0.26 5.00
132 INT339593 Gene_expression of FBLN1 2 0.14 3.01 0.24 5.00
133 INT109569 Regulation of Om 4 0.04 0.12 0.22 5.00
134 INT205953 Regulation of Shbdp1 2 0.14 0.61 0.21 5.00
135 INT63067 Localization of MYC 13 0.78 6.93 0.19 5.00
136 INT98016 Protein_catabolism of Pth 2 0.18 2.07 0.18 5.00
137 INT189564 Binding of TIMP3 4 0.31 2.45 0.17 5.00
138 INT183817 Localization of BEST1 6 0.26 5.22 0.16 5.00
139 INT109930 Positive_regulation of RPE 4 0.49 5.88 0.15 5.00
140 INT250352 Positive_regulation of Gene_expression of Shbdp1 3 0.06 0.33 0.14 5.00
141 INT289814 Negative_regulation of Clcn3 1 0.05 2.54 0.14 5.00
142 INT262478 Binding of Clcn3 1 0.06 1.23 0.14 5.00
143 INT212131 Positive_regulation of Gene_expression of Cl 4 0.08 0.88 0.12 5.00
144 INT289815 Gene_expression of Clcnkb 1 0.10 0.97 0.1 5.00
145 INT289820 Regulation of Gene_expression of Clcnkb 1 0.07 0.97 0.1 5.00
146 INT268715 Binding of RPE 3 0.09 2.36 0.09 5.00
147 INT282593 Gene_expression of KLF4 8 0.61 1.09 0.09 5.00
148 INT250519 Negative_regulation of Igf1r 5 0.42 2.7 0.09 5.00
149 INT282591 Positive_regulation of Gene_expression of SOX2 4 0.36 1.07 0.08 5.00
150 INT289826 Binding of Clcn2 1 0.25 0.4 0.08 5.00
151 INT144322 Regulation of RPE 1 0.24 1.9 0.08 5.00
152 INT186637 Regulation of ABCA4 3 0.37 2.02 0.07 5.00
153 INT233399 Binding of ABCA4 9 0.46 9.49 0.07 5.00
154 INT289825 Positive_regulation of Aqp6 2 0.21 0.62 0.07 5.00
155 INT289819 Localization of Clcn3 1 0.09 0.25 0.06 5.00
156 INT282606 Positive_regulation of Gene_expression of KLF4 2 0.54 0.8 0.04 5.00
157 INT289822 Regulation of Gene_expression of Clcn3 1 0.05 0.91 0.04 5.00
158 INT262477 Positive_regulation of Clcn3 2 0.08 0.31 0.03 5.00
159 INT289824 Positive_regulation of Transcription of Clcn3 1 0.06 0.16 0.03 5.00
160 INT197511 Localization of ABCA4 3 0.68 1.47 0.03 5.00
161 INT289829 Transcription of Clcn3 1 0.08 0.16 0.03 5.00
162 INT289834 Positive_regulation of Protein_catabolism of LRP2 1 0.45 0.65 0.03 5.00
163 INT289835 Protein_catabolism of LRP2 1 0.96 0.58 0.03 5.00
164 INT289812 Gene_expression of Ttyh1 1 0.14 0.26 0.03 5.00
165 INT339590 Negative_regulation of Gene_expression of FBLN1 1 0.10 2.61 0 5.00
166 INT339598 Gene_expression of ARMS2 1 0.65 1.03 0 5.00
167 INT274183 Negative_regulation of Gene_expression of ELN 3 0.30 3.29 0 5.00
168 INT339592 Regulation of ARMS2 2 0.26 2.27 0 5.00
169 INT339591 Positive_regulation of Gene_expression of FBLN1 1 0.08 1.31 0 5.00
170 INT339599 Negative_regulation of CFHR3 1 0.33 1.05 0 5.00
171 INT213395 Positive_regulation of Gene_expression of ABCA4 2 0.41 1.22 0 5.00
172 INT339595 Negative_regulation of RPE65 1 0.34 0.64 0 5.00
173 INT339596 Localization of KLF4 1 0.26 0 0 5.00
174 INT289830 Negative_regulation of Clcn2 1 0.39 0.23 0 5.00
175 INT289828 Negative_regulation of Bsnd 1 0.07 0.7 0 5.00
176 INT289831 Binding of Bsnd 1 0.06 0.38 0 5.00
177 INT282585 Localization of POU5F1 3 0.67 0.08 0 5.00
178 INT189570 Positive_regulation of Gene_expression of TIMP3 3 0.44 1.57 0 5.00
179 INT289821 Regulation of Grv 1 0.00 0 0 5.00
180 INT289817 Negative_regulation of Clcnkb 1 0.09 0.7 0 5.00
181 INT339594 Localization of SOX2 2 0.69 0.7 0 5.00
182 INT339597 Gene_expression of RPE65 1 0.54 0.29 0 5.00
183 INT190446 Gene_expression of NR2E3 11 0.10 0.89 0 5.00
184 INT235353 Gene_expression of Mid1 4 0.04 0.62 0 5.00
185 INT289818 Positive_regulation of Cdk7 1 0.04 0.05 0 5.00
186 INT289827 Binding of Clcnkb 1 0.06 0.39 0 5.00
187 INT289816 Positive_regulation of Ttyh1 1 0.11 0.23 0 5.00
188 INT289813 Gene_expression of Bsnd 1 0.07 0.49 0 5.00
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