D:Voice Disorders

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Disease Term
Synonyms DISTURBANCE VOICE, Disturbances Voice, DYSPHONIA, Dysphonia Flaccid, DYSPHONIA HYPERKINETIC, Dysphonia Organic Tremor, DYSPHONIA SPASTIC, Dysphonia Spastic Pseudobulbar, Dysphonias Flaccid, Dysphonias Hyperkinetic, Dysphonias Organic Tremor
Documents 254
Hot Single Events 26
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Voice Disorders. They are ordered first by their relevance to Voice Disorders and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131304 Binding of Serping1 and Sele 1 0.01 1.07 0.15 64.32
2 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64 5.00
3 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
4 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66 5.00
5 INT331966 Binding of DES and SACM1L 1 0.01 1.86 0.36 5.00
6 INT326587 GYPA Regulation of DDC 1 0.08 0.83 0.33 5.00
7 INT206704 Negative_regulation of Binding of KDR and VEGFA 4 0.39 5.18 0.3 5.00
8 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
9 INT326583 GYPA Negative_regulation of Binding of GYPA and SLC6A3 1 0.03 0.22 0.22 5.00
10 INT302712 Binding of Hprt and Hrh1 1 0.25 1.07 0.2 5.00
11 INT302711 Binding of Hrh1 and Spnb4 1 0.18 1.07 0.2 5.00
12 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
13 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1 5.00
14 INT199436 Binding of Capns1 and Cysltr1 1 0.00 0.79 0.1 5.00
15 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07 5.00
16 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04 5.00
17 INT312303 Positive_regulation of FLT1 Positive_regulation of VEGFA 1 0.38 0.73 0.03 5.00
18 INT320824 VEGFA Positive_regulation of DLL4 1 0.40 0.41 0 5.00
19 INT312304 Binding of JAK2 and VEGFA 1 0.30 0.82 0 5.00
20 INT320825 VEGFA Positive_regulation of Gene_expression of DLL4 1 0.40 0.41 0 5.00
21 INT251822 Binding of POLG and C10orf2 1 0.42 0.29 0 5.00
22 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0 5.00
23 INT318806 Binding of VEGFA and NCOA1 1 0.00 0.22 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Voice Disorders. They are ordered first by their pain relevance and then by number of times they were reported in Voice Disorders. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT168520 Binding of PDE8B 1 0.30 0.78 0.22 99.92
2 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 99.88
3 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 99.52
4 INT70987 Binding of RAC1 14 0.37 12.14 2.13 99.48
5 INT6891 Binding of TTR 72 0.48 22.81 6.51 95.96
6 INT103164 Binding of UPF1 4 0.29 4.15 1.22 95.96
7 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 95.08
8 INT52180 Binding of Aes 38 0.42 23.16 6.7 94.88
9 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 94.80
10 INT56342 Gene_expression of TTR 34 0.78 16.5 2.05 94.68
11 INT103779 Positive_regulation of MEMO1 2 0.01 3.77 0.3 94.40
12 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 93.04
13 INT251831 Positive_regulation of C10orf2 1 0.50 1.23 0.08 91.96
14 INT10980 Gene_expression of GYPA 40 0.78 15.32 5.51 91.00
15 INT251829 Positive_regulation of POLG 1 0.53 1.5 0.08 90.48
16 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 90.32
17 INT136397 Gene_expression of bt2 1 0.08 1.29 0.14 90.04
18 INT27627 Binding of Rac1 41 0.41 22.88 13.68 86.72
19 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 86.72
20 INT175035 Gene_expression of Mecom 11 0.65 10.1 0.19 83.68
21 INT312299 Positive_regulation of Gene_expression of Mecom 1 0.03 1.9 0 83.68
22 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 83.48
23 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 83.48
24 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 82.96
25 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35 81.44
26 INT256742 Positive_regulation of Cdr1 10 0.27 2.89 0.81 80.24
27 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 79.56
28 INT31572 Negative_regulation of FLT1 21 0.48 16.49 1.18 79.12
29 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 74.16
30 INT184652 Binding of RRM1 5 0.22 0.55 0.23 73.68
31 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 71.68
32 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 70.84
33 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 68.84
34 INT18391 Positive_regulation of GYPA 41 0.40 16.47 8.69 66.04
35 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 62.96
36 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 62.96
37 INT138715 Gene_expression of POLG 12 0.66 6.97 0.23 62.64
38 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 62.16
39 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36 60.08
40 INT224335 Negative_regulation of Phosphorylation of KDR 5 0.35 5.24 0.09 60.08
41 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 58.00
42 INT199430 Regulation of LTA 4 0.11 2.48 0.75 57.76
43 INT251796 Regulation of FLT3 2 0.35 3.11 0.03 55.28
44 INT274773 Gene_expression of RRM2 1 0.08 0.21 0.15 55.20
45 INT131773 Regulation of KDR 12 0.49 12.01 0.39 54.64
46 INT106359 Regulation of Plau 7 0.45 3.51 1.5 54.00
47 INT131301 Binding of Serping1 3 0.28 1.86 0.3 51.36
48 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 45.48
49 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 44.96
50 INT97902 Gene_expression of AGGF1 17 0.11 13.45 2.51 44.96
51 INT163133 Gene_expression of ZBP1 28 0.65 18.59 1.25 44.96
52 INT27387 Binding of Aecp 4 0.34 5.09 1 44.88
53 INT15610 Localization of GOPC 223 0.65 68.26 28.7 44.00
54 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 42.88
55 INT111547 Negative_regulation of Phosphorylation of VEGFA 13 0.42 5.08 3.22 42.88
56 INT252166 Negative_regulation of Cdr1 6 0.17 2.42 0.69 41.80
57 INT18390 Positive_regulation of Positive_regulation of GYPA 2 0.40 1.42 0.39 38.64
58 INT251827 Regulation of POLG 3 0.59 2.94 0.04 33.36
59 INT251833 Binding of C10orf2 1 0.37 0.47 0 29.72
60 INT15654 Gene_expression of Tg 22 0.66 12.2 2.36 25.12
61 INT145384 Binding of LTA 10 0.32 4.4 0.66 21.92
62 INT13544 Localization of LTA 9 0.78 6.34 1.8 20.56
63 INT199432 Regulation of Localization of LTA 1 0.03 0.79 0.24 20.56
64 INT200373 Binding of Omd 7 0.34 7.03 0.34 19.76
65 INT239785 Regulation of RIT1 1 0.01 1.22 0.31 8.48
66 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
67 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
68 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
69 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
70 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
71 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
72 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
73 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
74 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
75 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
76 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
77 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
78 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
79 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
80 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
81 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
82 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 5.00
83 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
84 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
85 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
86 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
87 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
88 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
89 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
90 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
91 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
92 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
93 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 5.00
94 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
95 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
96 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
97 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
98 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
99 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
100 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
101 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
102 INT52722 Localization of RETNLB 54 0.38 48.63 27.98 5.00
103 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 5.00
104 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
105 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
106 INT8775 Binding of IGHE 167 0.48 102.61 23.54 5.00
107 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
108 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 5.00
109 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 5.00
110 INT49774 Binding of DRD2 48 0.48 17.42 20.73 5.00
111 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
112 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
113 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
114 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
115 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
116 INT102680 Protein_catabolism of COL7A1 49 0.69 34.68 15.78 5.00
117 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
118 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
119 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
120 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
121 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12 5.00
122 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
123 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
124 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
125 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
126 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 5.00
127 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
128 INT33358 Gene_expression of Cysltr1 46 0.62 24.18 13.36 5.00
129 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
130 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
131 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 5.00
132 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42 5.00
133 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
134 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
135 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
136 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
137 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 5.00
138 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8 5.00
139 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
140 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
141 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 5.00
142 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 5.00
143 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 5.00
144 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
145 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 5.00
146 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
147 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 5.00
148 INT14207 Gene_expression of DNM2 20 0.67 5.76 7.64 5.00
149 INT18190 Regulation of DRD2 11 0.60 9.01 7.63 5.00
150 INT76892 Gene_expression of FGFR1 45 0.69 23.6 7.56 5.00
151 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49 5.00
152 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
153 INT5822 Gene_expression of Ltb4r1 51 0.76 37.43 7.2 5.00
154 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
155 INT10505 Gene_expression of Ptafr 18 0.62 10.7 6.83 5.00
156 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
157 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55 5.00
158 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51 5.00
159 INT2513 Binding of Napa 80 0.42 4.29 6.51 5.00
160 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
161 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
162 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93 5.00
163 INT12564 Localization of Pthlh 23 0.81 4.37 5.82 5.00
164 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54 5.00
165 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
166 INT97693 Gene_expression of REST 29 0.75 5.51 5.26 5.00
167 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 5.00
168 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17 5.00
169 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 5.00
170 INT68244 Positive_regulation of Ighg1 60 0.61 48.86 5.01 5.00
171 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
172 INT9095 Regulation of Gene_expression of COL7A1 24 0.57 10.55 4.88 5.00
173 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 5.00
174 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
175 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
176 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 5.00
177 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
178 INT4097 Localization of Pth 66 0.81 47.17 4.36 5.00
179 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
180 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 5.00
181 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24 5.00
182 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 5.00
183 INT58875 Positive_regulation of FGD1 20 0.60 3.88 4.19 5.00
184 INT37907 Positive_regulation of Capns1 9 0.41 3.55 4.1 5.00
185 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 5.00
186 INT45147 Gene_expression of C2 21 0.58 6.18 3.98 5.00
187 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75 5.00
188 INT121967 Regulation of RAC1 9 0.45 6.14 3.41 5.00
189 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 5.00
190 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31 5.00
191 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 5.00
192 INT122577 Regulation of SLC6A3 9 0.53 1.47 3.09 5.00
193 INT10443 Regulation of Gene_expression of CNR1 10 0.50 3.96 3.06 5.00
194 INT103246 Positive_regulation of Protein_catabolism of COL7A1 8 0.34 8.67 3.03 5.00
195 INT161812 Positive_regulation of PER1 17 0.56 5.64 2.93 5.00
196 INT172177 Protein_catabolism of INCENP 18 0.37 6.34 2.91 5.00
197 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 5.00
198 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 5.00
199 INT45112 Positive_regulation of PRB1 20 0.60 6.49 2.85 5.00
200 INT85885 Positive_regulation of SNAP25 8 0.69 2.74 2.84 5.00
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