D:Von Hippel-lindau Syndrome

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Disease Term
Synonyms Angiomatoses Familial Cerebello Retinal, Angiomatoses Familial Cerebelloretinal, Angiomatosis Familial Cerebello Retinal, Angiomatosis Familial Cerebelloretinal, Angiophakomatosis Retinae Et Cerebelli, Cerebello Retinal Angiomatoses Familial, Cerebello Retinal Angiomatosis Familial, CEREBELLORETINAL ANGIOMATOSES FAMILIAL, Cerebelloretinal Angiomatosis Familial, Cerebelloretinal Haemangioblastomatosis, Cerebelloretinal Hemangioblastomatosis
Documents 85
Hot Single Events 37
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Von Hippel-lindau Syndrome. They are ordered first by their relevance to Von Hippel-lindau Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT332795 Negative_regulation of Vhl Positive_regulation of Positive_regulation of Cxcr4 1 0.02 1.64 0.05 100.00
2 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11 70.80
3 INT322471 Hif1a Positive_regulation of VEGFA 1 0.05 0.26 0.03 48.48
4 INT193014 VHL Regulation of EPAS1 1 0.20 0.92 0 25.00
5 INT193013 VHL Regulation of Regulation of EPAS1 1 0.14 1.74 0 25.00
6 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04 5.00
7 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96 5.00
8 INT303656 SST Negative_regulation of Localization of GAST 1 0.12 1.45 0.82 5.00
9 INT303652 Binding of SST and SSTR2 1 0.26 0.46 0.57 5.00
10 INT303654 Binding of SST and SSTR5 1 0.22 0.46 0.57 5.00
11 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54 5.00
12 INT303651 Binding of SSTR2 and SSTR5 1 0.24 0.23 0.45 5.00
13 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41 5.00
14 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4 5.00
15 INT303659 SSTR2 Negative_regulation of Gene_expression of SST 1 0.30 0.94 0.16 5.00
16 INT303657 Gene_expression of SSTR2 Negative_regulation of Gene_expression of SST 1 0.30 0.94 0.16 5.00
17 INT200213 PAH Positive_regulation of SDHD 1 0.21 2.43 0.1 5.00
18 INT218784 Binding of TCEB2 and VHL 1 0.04 3.81 0.1 5.00
19 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05 5.00
20 INT241120 Binding of Sdhc and Sdhd 1 0.00 1.28 0 5.00
21 INT199581 Braf Negative_regulation of Phosphorylation of tk 1 0.05 0.6 0 5.00
22 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0 5.00
23 INT199576 Raf1 Negative_regulation of Akt1 1 0.00 0.79 0 5.00
24 INT199580 Braf Negative_regulation of Phosphorylation of Mdk 1 0.11 0.6 0 5.00
25 INT199577 Tnk1 Negative_regulation of Akt1 1 0.00 0.79 0 5.00
26 INT199582 Braf Negative_regulation of Akt1 1 0.00 0.79 0 5.00
27 INT199579 Tnk1 Negative_regulation of Raf1 1 0.01 0.78 0 5.00
28 INT322470 Binding of Bcl6 and Hif1a 1 0.06 0.52 0 5.00
29 INT199578 Tnk1 Negative_regulation of Braf 1 0.01 0.78 0 5.00
30 INT218785 Binding of FN1 and VHL 1 0.06 1.12 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Von Hippel-lindau Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Von Hippel-lindau Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69 100.00
2 INT241115 Regulation of Vhl 5 0.15 8.36 0.11 100.00
3 INT173102 Binding of VHLL 4 0.05 3.34 0.1 100.00
4 INT173087 Gene_expression of VHLL 5 0.62 8.44 0.67 100.00
5 INT173089 Negative_regulation of VHLL 3 0.09 2.48 0.09 100.00
6 INT241118 Negative_regulation of Vhl 3 0.11 4.01 0.08 100.00
7 INT8960 Binding of SDHB 9 0.36 9.2 1.68 100.00
8 INT8159 Binding of ELL 7 0.36 12.62 0.84 100.00
9 INT200216 Binding of SDHD 3 0.37 4.51 0.71 100.00
10 INT149200 Binding of SDHC 2 0.36 1.82 0.18 100.00
11 INT68665 Binding of Vhl 9 0.48 10.3 0.82 99.96
12 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 99.88
13 INT74016 Binding of VHL 20 0.48 15.49 0.54 99.72
14 INT126476 Positive_regulation of Cxcr4 25 0.69 19.01 1.72 99.20
15 INT58918 Gene_expression of SDHB 5 0.75 2.93 1.27 97.82
16 INT212652 Gene_expression of SDHC 1 0.40 0.73 0.43 97.70
17 INT171435 Gene_expression of SDHD 14 0.58 26.55 0.91 97.50
18 INT108344 Regulation of Sdhb 1 0.29 1.34 0.11 97.48
19 INT100376 Positive_regulation of Gene_expression of Vhl 4 0.10 6.47 1.47 95.40
20 INT219879 Positive_regulation of SPINK5 4 0.30 7.64 1.16 95.16
21 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07 94.64
22 INT232785 Localization of Hif1a 8 0.46 10.37 1.33 94.64
23 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 93.88
24 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 93.76
25 INT158764 Binding of SPINK5 7 0.35 8.84 0.37 93.72
26 INT15540 Positive_regulation of PDGFA 24 0.47 19.01 2.5 93.20
27 INT322458 Positive_regulation of Vhl 1 0.29 0.95 0.09 90.44
28 INT322451 Positive_regulation of Positive_regulation of Vhl 1 0.29 0.96 0.09 90.44
29 INT9397 Regulation of MET 17 0.60 8.36 7.04 90.08
30 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 89.28
31 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 88.64
32 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 87.84
33 INT216011 Regulation of TSC2 2 0.26 3.31 0 86.40
34 INT43637 Positive_regulation of AXL 11 0.58 11.71 1.59 85.68
35 INT52053 Positive_regulation of Positive_regulation of SDHB 2 0.49 3.11 0.14 83.32
36 INT52052 Positive_regulation of SDHB 14 0.68 14.07 2.27 83.04
37 INT241117 Regulation of Gene_expression of Vhl 1 0.06 2.5 0.07 82.48
38 INT232786 Positive_regulation of Localization of Hif1a 2 0.31 2.63 0.27 80.00
39 INT322464 Regulation of Localization of Hif1a 1 0.28 0.59 0.05 80.00
40 INT199571 Binding of Vhl 3 0.23 3.4 0.07 79.08
41 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 75.00
42 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 75.00
43 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 75.00
44 INT4097 Localization of Pth 66 0.81 47.17 4.36 75.00
45 INT12413 Gene_expression of MPG 11 0.76 3.13 1.94 75.00
46 INT49108 Gene_expression of TP53TG3 6 0.43 6.02 0.35 75.00
47 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 74.68
48 INT132885 Regulation of SYP 4 0.44 3.92 0.44 74.68
49 INT41555 Gene_expression of GRN 8 0.52 10.94 0.69 74.04
50 INT135169 Binding of Hif1a 22 0.47 12.48 0.79 72.24
51 INT247555 Positive_regulation of Binding of Hif1a 2 0.31 1.15 0.05 72.24
52 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51 71.52
53 INT247559 Regulation of Positive_regulation of Hif1a 2 0.23 1.64 0.05 71.52
54 INT322456 Localization of Egln1 1 0.42 1.86 0.15 71.48
55 INT322453 Positive_regulation of Localization of Egln1 1 0.28 1.97 0.15 71.48
56 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 70.80
57 INT84798 Gene_expression of Vhl 2 0.48 2.28 0.35 70.80
58 INT199574 Positive_regulation of Gene_expression of Vhl 1 0.24 1.42 0.12 70.80
59 INT185017 Gene_expression of TOP2B 7 0.75 4.84 1.67 70.72
60 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 69.36
61 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7 69.36
62 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 68.72
63 INT121496 Gene_expression of TERT 107 0.78 45.6 7.42 68.24
64 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 67.72
65 INT279178 Negative_regulation of Positive_regulation of MTOR 1 0.24 0.8 0 67.72
66 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 67.60
67 INT213923 Positive_regulation of MTOR 16 0.65 9.28 0.7 66.28
68 INT241113 Negative_regulation of Binding of Vhl 1 0.07 3.31 0.03 64.76
69 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 63.36
70 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 62.16
71 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 61.76
72 INT101068 Negative_regulation of CDCP1 27 0.03 17.67 3.45 61.28
73 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 59.12
74 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 58.88
75 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 58.88
76 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 58.88
77 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 58.56
78 INT691 Binding of SST 67 0.48 24.66 32.67 58.48
79 INT152215 Binding of FH 10 0.41 14.13 0.19 49.40
80 INT241100 Negative_regulation of Binding of FH 1 0.11 2.76 0.05 49.40
81 INT329916 Localization of Pgls 1 0.61 1.33 0.07 45.80
82 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44 43.92
83 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 42.80
84 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 41.84
85 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 28.88
86 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 25.00
87 INT11551 Localization of VHL 12 0.65 22.76 0.68 25.00
88 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29 25.00
89 INT193015 Positive_regulation of Gene_expression of EPAS1 6 0.32 8.77 0.21 25.00
90 INT193016 Regulation of EPAS1 9 0.15 7.38 0.06 25.00
91 INT174839 Localization of BSG 4 0.68 2.91 0.98 24.96
92 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54 23.52
93 INT101243 Regulation of STAT3 12 0.62 9.98 1.92 19.76
94 INT178186 Regulation of Stat3 7 0.44 6.23 0.74 19.76
95 INT232065 Binding of DDR1 3 0.04 0.81 0 15.44
96 INT18995 Binding of CEL 23 0.47 14.46 4.5 12.08
97 INT124407 Gene_expression of SSTR1 4 0.55 5.55 1.41 11.76
98 INT156827 Localization of MRI1 25 0.65 16.06 8.33 6.68
99 INT320784 Protein_catabolism of Hif1a 3 0.61 2.41 0.34 5.28
100 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
101 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
102 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
103 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
104 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
105 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
106 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
107 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
108 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
109 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 5.00
110 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
111 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 5.00
112 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
113 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
114 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
115 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
116 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
117 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18 5.00
118 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
119 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
120 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
121 INT17625 Localization of GCG 210 0.80 55.69 24.97 5.00
122 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 5.00
123 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75 5.00
124 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
125 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
126 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11 5.00
127 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 5.00
128 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
129 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 5.00
130 INT2243 Localization of GAST 67 0.81 34.54 16.19 5.00
131 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 5.00
132 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 5.00
133 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
134 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 5.00
135 INT4494 Regulation of GCG 41 0.45 18.38 9.68 5.00
136 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48 5.00
137 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 5.00
138 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 5.00
139 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35 5.00
140 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 5.00
141 INT14732 Positive_regulation of FN1 46 0.69 31.17 7.33 5.00
142 INT24724 Positive_regulation of Gene_expression of SST 11 0.67 7.51 6.12 5.00
143 INT3395 Negative_regulation of VIP 15 0.59 4.23 5.62 5.00
144 INT85075 Phosphorylation of Mdk 22 0.61 10.29 5.55 5.00
145 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
146 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
147 INT15652 Positive_regulation of ENO2 37 0.68 33.39 5.02 5.00
148 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 5.00
149 INT199560 Binding of Braf 4 0.30 8.83 4.8 5.00
150 INT200218 Localization of SDHD 1 0.69 48.58 4.57 5.00
151 INT29809 Gene_expression of Tspo 8 0.75 4.12 4.54 5.00
152 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13 5.00
153 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
154 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94 5.00
155 INT14930 Regulation of Gene_expression of SST 12 0.45 6.86 3.89 5.00
156 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 5.00
157 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 5.00
158 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 5.00
159 INT139807 Gene_expression of Braf 7 0.51 8.78 3.34 5.00
160 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 5.00
161 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14 5.00
162 INT61500 Binding of FN1 39 0.48 27.33 3.13 5.00
163 INT9110 Binding of PAH 32 0.41 42.1 3.1 5.00
164 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 5.00
165 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 5.00
166 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 5.00
167 INT13733 Localization of SSTR1 8 0.65 3.11 2.49 5.00
168 INT200217 Localization of PAH 10 0.36 15.51 2.46 5.00
169 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 5.00
170 INT97479 Gene_expression of Tks 11 0.52 3.66 2.44 5.00
171 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 5.00
172 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 5.00
173 INT55736 Transcription of MMP2 11 0.68 5.78 2.28 5.00
174 INT85284 Negative_regulation of ENO2 8 0.58 7.86 2.28 5.00
175 INT97973 Positive_regulation of XRCC1 24 0.40 30.95 2.26 5.00
176 INT98376 Gene_expression of tk 27 0.51 21.9 2.23 5.00
177 INT49769 Binding of SSTR2 4 0.48 1.39 2.14 5.00
178 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82 5.00
179 INT131572 Negative_regulation of Phosphorylation of Mdk 4 0.15 1.67 1.71 5.00
180 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 5.00
181 INT86368 Gene_expression of TEP1 31 0.50 16.36 1.63 5.00
182 INT69917 Negative_regulation of CREB1 8 0.58 2.28 1.59 5.00
183 INT98648 Negative_regulation of Positive_regulation of Mdk 5 0.50 3.03 1.56 5.00
184 INT75694 Regulation of Gene_expression of CEL 9 0.60 6.08 1.53 5.00
185 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51 5.00
186 INT120519 Localization of XRCC1 15 0.78 17.03 1.51 5.00
187 INT44783 Gene_expression of Chga 3 0.75 1.72 1.45 5.00
188 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42 5.00
189 INT199550 Negative_regulation of Flt1 18 0.37 12.57 1.37 5.00
190 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
191 INT199567 Binding of Kdr 18 0.47 13.81 1.34 5.00
192 INT35742 Positive_regulation of tk 8 0.43 5.53 1.33 5.00
193 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 5.00
194 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
195 INT19520 Negative_regulation of SDHB 4 0.37 1.57 1.24 5.00
196 INT74018 Binding of XRCC1 19 0.31 24.78 1.24 5.00
197 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
198 INT303667 Regulation of BCL2L11 3 0.16 1.03 1.21 5.00
199 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2 5.00
200 INT105270 Positive_regulation of KDR 25 0.49 11.49 1.2 5.00
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