D:Wasting Syndrome

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Disease Term
Synonyms Wasting Disease, Wasting Diseases, WASTING SYNDROMES
Documents 26
Hot Single Events 14
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Wasting Syndrome. They are ordered first by their relevance to Wasting Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT96833 Binding of WAS and Positive_regulation of Cnr1 1 0.02 0.69 0.39 99.56
2 INT96834 Binding of WAS and Positive_regulation of Cnr2 1 0.03 0.69 0.39 99.56
3 INT96836 WAS Positive_regulation of Cnr1 1 0.02 0.69 0.39 99.56
4 INT96835 WAS Positive_regulation of Cnr2 1 0.03 0.69 0.39 99.56
5 INT296079 IL17A Negative_regulation of Positive_regulation of Gtf3a 1 0.00 0.77 0.13 97.00
6 INT296040 IL17A Regulation of TH1L 1 0.07 0.7 0.12 97.00
7 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69 76.16
8 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13 27.16
9 INT296027 TGFB1 Regulation of TH1L 1 0.02 1 0.13 26.88
10 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12 26.56
11 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12 26.40
12 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
13 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
14 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 5.00
15 INT139069 Binding of CTLA4 and Cd86 3 0.16 0.65 0.7 5.00
16 INT351076 IK Positive_regulation of Gene_expression of Ucp3 1 0.00 0.8 0.58 5.00
17 INT27730 Binding of ALB and Shbg 2 0.01 0.44 0.5 5.00
18 INT296036 IL6 Positive_regulation of IL17A 1 0.04 0.05 0.17 5.00
19 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17 5.00
20 INT296081 Binding of FOXP3 and Gtf3a 1 0.00 1.16 0.16 5.00
21 INT296030 Binding of NFKB1 and FOXP3 1 0.17 1.18 0.16 5.00
22 INT296078 Binding of NFKB1 and Gtf3a 1 0.00 1.18 0.16 5.00
23 INT296082 Binding of Rel and FOXP3 1 0.35 1.14 0.15 5.00
24 INT296029 Binding of HLA-DQA2 and LAG3 1 0.02 0.43 0.12 5.00
25 INT296038 TGFB1 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11 5.00
26 INT296032 IL6 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11 5.00
27 INT260099 Binding of COMP and IL4 1 0.00 0.18 0.09 5.00
28 INT127143 Binding of IL6 and TGFB1 2 0.01 0.16 0.08 5.00
29 INT296041 Binding of TGFB1 and IL21 1 0.01 0.05 0.08 5.00
30 INT296026 Binding of FOXP3 and IL17RB Negative_regulation of Gene_expression of IL7R 1 0.01 0.63 0.08 5.00
31 INT296035 IL21 Positive_regulation of Gene_expression of IL23R 1 0.01 0.05 0.08 5.00
32 INT296039 Binding of FOXP3 and IL17RB 1 0.01 0.63 0.08 5.00
33 INT296034 FOXP3 Negative_regulation of Gene_expression of IL7R 1 0.10 0.63 0.08 5.00
34 INT174561 Binding of Cd28 and Ncl 1 0.00 0.62 0.07 5.00
35 INT354097 Timp1 Negative_regulation of Localization of NFKB2 1 0.04 0.94 0 5.00
36 INT260127 Binding of CD4 and Trav6-3 1 0.03 0 0 5.00
37 INT260128 Binding of ISG20 and Trav6-3 1 0.01 0 0 5.00
38 INT354096 Timp1 Negative_regulation of Positive_regulation of NFKB2 1 0.04 0.94 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Wasting Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Wasting Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT34268 Binding of WAS 14 0.47 4.41 8.67 99.56
2 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 99.54
3 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 98.20
4 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 98.16
5 INT169015 Gene_expression of FOXP3 50 0.60 33.18 8.4 97.00
6 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 97.00
7 INT296071 Negative_regulation of Positive_regulation of TBX21 1 0.05 0.71 0.12 93.96
8 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 93.32
9 INT240542 Positive_regulation of TBX21 3 0.45 2.11 0.89 93.32
10 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 93.04
11 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 92.56
12 INT79955 Localization of Cnr1 26 0.81 8.44 19.06 92.28
13 INT237902 Regulation of Gene_expression of Hrec 7 0.04 6.74 2.36 82.00
14 INT89661 Gene_expression of Hrec 102 0.21 69.91 39.57 80.84
15 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 79.28
16 INT221426 Positive_regulation of Gene_expression of FOXP3 9 0.48 5.98 1.72 65.12
17 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 51.60
18 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 42.24
19 INT192803 Negative_regulation of Gene_expression of SSRP1 1 0.05 2.36 0 42.24
20 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 41.84
21 INT192807 Gene_expression of SSRP1 14 0.49 19.28 1.15 41.84
22 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 35.88
23 INT16404 Regulation of CD4 54 0.61 33.05 10.29 35.00
24 INT2544 Localization of PTH 39 0.81 30.55 2.22 33.20
25 INT53927 Positive_regulation of Localization of PTH 8 0.69 5.33 0.09 33.20
26 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 32.44
27 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 32.40
28 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 32.16
29 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 26.16
30 INT318784 Gene_expression of ZAP70 2 0.13 1.33 0.44 23.80
31 INT130603 Binding of Timp1 9 0.35 8.52 3.04 18.92
32 INT351074 Negative_regulation of Binding of Timp1 1 0.04 1.14 0.09 18.92
33 INT16616 Negative_regulation of SRD5A1 44 0.57 34.81 2.96 8.16
34 INT260118 Regulation of Regulation of CD4 1 0.44 1.66 0.4 6.40
35 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
36 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
37 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
38 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
39 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
40 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
41 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
42 INT5127 Localization of Lhb 488 0.80 50.48 162.66 5.00
43 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
44 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
45 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
46 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
47 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
48 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
49 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 5.00
50 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
51 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
52 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 5.00
53 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
54 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
55 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
56 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
57 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
58 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
59 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
60 INT6761 Binding of CALCA 100 0.48 26.71 62.05 5.00
61 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
62 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
63 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
64 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
65 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 5.00
66 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 5.00
67 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
68 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
69 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
70 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
71 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
72 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 5.00
73 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 5.00
74 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
75 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
76 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
77 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
78 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
79 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
80 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
81 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
82 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 5.00
83 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
84 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
85 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
86 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
87 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
88 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
89 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
90 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
91 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
92 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 5.00
93 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
94 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
95 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08 5.00
96 INT70145 Gene_expression of Trav6-3 136 0.76 69.6 18.05 5.00
97 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
98 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
99 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
100 INT96155 Gene_expression of Cd86 134 0.77 50.56 17.13 5.00
101 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 5.00
102 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
103 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2 5.00
104 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
105 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
106 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
107 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 5.00
108 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 5.00
109 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15 5.00
110 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
111 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
112 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 5.00
113 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 5.00
114 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
115 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
116 INT7234 Binding of GNRH1 43 0.47 21.59 12.36 5.00
117 INT21987 Positive_regulation of Rorb 30 0.33 12.7 12.24 5.00
118 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
119 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 5.00
120 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
121 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 5.00
122 INT81929 Negative_regulation of Gene_expression of IL10 41 0.57 27.99 9.87 5.00
123 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
124 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 5.00
125 INT226463 Positive_regulation of IL23A 23 0.45 21.58 9.18 5.00
126 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
127 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
128 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
129 INT89292 Positive_regulation of CCR5 27 0.70 15.12 8.59 5.00
130 INT75907 Binding of LEP 53 0.46 46.65 8.44 5.00
131 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 5.00
132 INT81777 Negative_regulation of Gene_expression of IK 22 0.08 11.55 8.09 5.00
133 INT25152 Gene_expression of SAA1 37 0.75 53.56 8.07 5.00
134 INT94125 Gene_expression of Cd28 38 0.67 21.73 7.75 5.00
135 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
136 INT44920 Negative_regulation of IK 18 0.41 9.9 7.16 5.00
137 INT17049 Localization of CD4 57 0.75 35.33 6.89 5.00
138 INT117186 Positive_regulation of CXCR4 29 0.69 24.19 6.84 5.00
139 INT90097 Localization of PTGS2 15 0.69 6.14 6.63 5.00
140 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4 5.00
141 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 5.00
142 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96 5.00
143 INT59384 Gene_expression of Il7 23 0.75 11.42 5.87 5.00
144 INT77146 Binding of IL4 23 0.36 13.69 5.39 5.00
145 INT113186 Gene_expression of Prf1 46 0.53 21.06 5.32 5.00
146 INT126751 Regulation of Gene_expression of IL10 16 0.44 10.84 5.22 5.00
147 INT90372 Negative_regulation of Hrec 12 0.03 11.73 4.74 5.00
148 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74 5.00
149 INT91463 Positive_regulation of NFKB2 19 0.40 17.7 4.6 5.00
150 INT149197 Negative_regulation of NFKB2 14 0.25 10.55 4.46 5.00
151 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
152 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
153 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33 5.00
154 INT45975 Positive_regulation of SAA1 17 0.67 19.7 4.15 5.00
155 INT115889 Binding of Fas 27 0.36 28.87 4.08 5.00
156 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 5.00
157 INT15802 Positive_regulation of Gene_expression of ISG20 16 0.42 8.16 4.03 5.00
158 INT99509 Gene_expression of CFLAR 25 0.75 22.59 3.78 5.00
159 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
160 INT140337 Negative_regulation of Cd8a 42 0.50 25.4 3.66 5.00
161 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 5.00
162 INT16969 Negative_regulation of CRS 28 0.37 14.77 3.35 5.00
163 INT19211 Binding of Shbg 35 0.48 16.29 3.31 5.00
164 INT182233 Gene_expression of CCR4 14 0.43 6.55 3.31 5.00
165 INT157401 Gene_expression of Ctla4 21 0.65 15.43 3.2 5.00
166 INT250884 Binding of IL23A 5 0.19 7.17 3.17 5.00
167 INT28094 Binding of PTH 29 0.37 13.57 3.09 5.00
168 INT103674 Positive_regulation of Gene_expression of CXCR4 32 0.69 37.1 3.08 5.00
169 INT240544 Gene_expression of TBX21 12 0.75 5.96 2.97 5.00
170 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92 5.00
171 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 5.00
172 INT130705 Gene_expression of TFAM 50 0.77 38.85 2.79 5.00
173 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68 5.00
174 INT104476 Protein_catabolism of Timp1 6 0.41 5.75 2.61 5.00
175 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54 5.00
176 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
177 INT128864 Gene_expression of KIR2DS2 5 0.34 5.35 2.44 5.00
178 INT27230 Gene_expression of LTBR 10 0.75 8.57 2.34 5.00
179 INT74695 Gene_expression of Ace 41 0.73 53.33 2.33 5.00
180 INT250888 Negative_regulation of IL23A 4 0.30 6.13 2.15 5.00
181 INT157400 Gene_expression of Tnfrsf18 15 0.39 7.3 2.13 5.00
182 INT15799 Positive_regulation of ISG20 18 0.38 9.78 2.01 5.00
183 INT221431 Negative_regulation of FOXP3 8 0.40 9.92 1.98 5.00
184 INT43084 Binding of Ace 10 0.46 4.7 1.93 5.00
185 INT95904 Gene_expression of CD27 45 0.76 26.17 1.93 5.00
186 INT119639 Gene_expression of KIR3DL1 5 0.77 2.96 1.91 5.00
187 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 5.00
188 INT219781 Gene_expression of IL17F 6 0.65 3.32 1.59 5.00
189 INT250890 Gene_expression of IL23R 2 0.12 3.11 1.53 5.00
190 INT192762 Localization of SAA1 10 0.78 12.63 1.44 5.00
191 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
192 INT112068 Gene_expression of GIF 8 0.58 2.6 1.35 5.00
193 INT101653 Negative_regulation of SAA1 7 0.39 7 1.33 5.00
194 INT181961 Gene_expression of IL7R 10 0.75 3.9 1.29 5.00
195 INT297709 Positive_regulation of Gene_expression of Ucp3 5 0.56 4.67 1.28 5.00
196 INT260114 Regulation of ISG20 5 0.37 4.98 1.27 5.00
197 INT260111 Localization of ISG20 6 0.41 3.46 1.25 5.00
198 INT179372 Positive_regulation of Localization of PTGS2 2 0.38 0.35 1.21 5.00
199 INT174557 Negative_regulation of Gene_expression of Cd28 7 0.43 4.42 1.2 5.00
200 INT82547 Negative_regulation of Gene_expression of ISG20 7 0.29 3.04 1.18 5.00
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