D:Wegener's Granulomatosis

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Disease Term
Synonyms Granulomatosis Wegener, Granulomatosis Wegener S, Granulomatosis Wegeners, Klinger S Disease, Necrotising Respiratory Granulomatosis, Necrotizing Respiratory Granulomatosis, Wegener Granulomatosis, WEGENER LIKE GRANULOMATOSIS, Wegener S Granulomatosis, Wegener S Syndrome, WEGENERS GRANULOMATOSIS
Documents 36
Hot Single Events 15
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Wegener's Granulomatosis. They are ordered first by their relevance to Wegener's Granulomatosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55 78.44
2 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86 62.72
3 INT254347 FASLG Negative_regulation of Gene_expression of CHI3L1 1 0.13 0.92 0.42 8.36
4 INT254350 FASLG Negative_regulation of Gene_expression of VEGFA 1 0.06 0.92 0.42 8.36
5 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52 5.00
6 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
7 INT254355 PF4 Positive_regulation of IFNA1 1 0.04 1.23 1.26 5.00
8 INT209883 TNF Positive_regulation of Gene_expression of TNFRSF11A 1 0.20 1.83 0.77 5.00
9 INT209882 IL4 Positive_regulation of Gene_expression of TNFRSF11A 1 0.11 1.82 0.76 5.00
10 INT254352 Binding of CXCR4 and Positive_regulation of Gene_expression of CXCL12 1 0.14 1.8 0.66 5.00
11 INT254356 Binding of IFNG and IL1B 1 0.00 1.87 0.51 5.00
12 INT254357 Binding of IFNA1 and IL1B 1 0.00 1.88 0.51 5.00
13 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48 5.00
14 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46 5.00
15 INT254353 Binding of VEGFA and MMRN1 1 0.00 0.81 0.28 5.00
16 INT254359 IL1B Positive_regulation of Localization of VEGFA 1 0.01 0.87 0.26 5.00
17 INT209884 Binding of IL4 and TNF 1 0.04 0.73 0.26 5.00
18 INT209879 CSF2 Positive_regulation of Gene_expression of TNFRSF11B 1 0.10 0.76 0.26 5.00
19 INT209880 IL4 Regulation of Gene_expression of TNFRSF11B 1 0.09 0.74 0.23 5.00
20 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23 5.00
21 INT254351 Binding of ANGPT2 and TEK 1 0.04 0.87 0.22 5.00
22 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
23 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Wegener's Granulomatosis. They are ordered first by their pain relevance and then by number of times they were reported in Wegener's Granulomatosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 99.62
2 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73 97.52
3 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 96.16
4 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 95.76
5 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 95.16
6 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67 87.72
7 INT55170 Gene_expression of NFKB1 97 0.77 52.75 23.04 87.72
8 INT209898 Gene_expression of TRAF4 1 0.52 2.11 0.64 87.72
9 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 87.04
10 INT129856 Positive_regulation of TNFRSF11A 26 0.68 16.21 4.75 87.04
11 INT209903 Positive_regulation of TRAF4 1 0.41 1.27 0.28 87.04
12 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28 87.04
13 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 83.68
14 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23 81.28
15 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 81.28
16 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03 77.12
17 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 76.92
18 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 73.20
19 INT97139 Gene_expression of CD83 43 0.70 22.05 3.91 73.20
20 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 73.20
21 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35 72.00
22 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86 71.20
23 INT209890 Positive_regulation of Gene_expression of CD83 11 0.62 9.04 1.88 70.72
24 INT209896 Positive_regulation of Gene_expression of CD80 19 0.49 11.9 1.59 70.24
25 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 69.92
26 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 69.92
27 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 69.92
28 INT209888 Positive_regulation of Gene_expression of CCR6 4 0.47 6.97 1.99 69.76
29 INT254237 Negative_regulation of trm 1 0.04 0.88 0.06 68.32
30 INT129358 Gene_expression of ELOVL1 23 0.66 29.39 2.83 66.88
31 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 66.52
32 INT17324 Negative_regulation of Plg 26 0.38 13.5 4.05 59.48
33 INT254369 Negative_regulation of COL18A1 2 0.16 1.61 0.61 58.84
34 INT209902 Positive_regulation of TRAF1 2 0.47 2.14 0.99 57.36
35 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 55.28
36 INT64186 Positive_regulation of Gene_expression of TNFRSF11A 13 0.68 7.19 2.9 53.08
37 INT254370 Gene_expression of THBS2 1 0.06 2.24 1 53.00
38 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 51.40
39 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 48.36
40 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 48.00
41 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 44.48
42 INT209899 Positive_regulation of Protein_catabolism of TNFRSF11A 1 0.49 0.77 0.42 40.64
43 INT209894 Protein_catabolism of TNFRSF11A 1 0.87 0.76 0.42 39.60
44 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 36.56
45 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 33.52
46 INT214529 Negative_regulation of DEFB4A 2 0.39 0.76 0.05 30.24
47 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 29.48
48 INT142006 Positive_regulation of COL18A1 2 0.41 3.01 0.53 26.56
49 INT89484 Gene_expression of TNFRSF11B 119 0.76 53.57 19.67 18.96
50 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 15.76
51 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 9.92
52 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 9.32
53 INT91544 Gene_expression of CHI3L1 60 0.75 77.72 13.9 7.68
54 INT173639 Positive_regulation of INCENP 40 0.14 20.97 6.7 7.60
55 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
56 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
57 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
58 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
59 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
60 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
61 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
62 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
63 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
64 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
65 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
66 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 5.00
67 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
68 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
69 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
70 INT117598 Regulation of ACR 118 0.26 41.25 48.01 5.00
71 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 5.00
72 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
73 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
74 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 5.00
75 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
76 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
77 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 5.00
78 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
79 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
80 INT157463 Gene_expression of CX3CL1 55 0.62 69.05 19.75 5.00
81 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
82 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 5.00
83 INT33542 Gene_expression of Il1rn 41 0.76 32.47 18.08 5.00
84 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.00
85 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 5.00
86 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 5.00
87 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
88 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
89 INT39733 Localization of NFKB1 59 0.79 22.76 13.99 5.00
90 INT108485 Gene_expression of CXCL12 61 0.75 49.34 13.79 5.00
91 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
92 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
93 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
94 INT92574 Gene_expression of CXCL5 51 0.78 24.87 11.89 5.00
95 INT176607 Gene_expression of Cx3cl1 27 0.75 19.51 11.32 5.00
96 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
97 INT157466 Gene_expression of CX3CR1 14 0.76 20.6 10.76 5.00
98 INT9385 Localization of LDHA 74 0.81 31.67 10.5 5.00
99 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34 5.00
100 INT5788 Gene_expression of IL2RA 60 0.75 40.67 9.98 5.00
101 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64 5.00
102 INT149138 Binding of PDX1 27 0.37 32.62 9.33 5.00
103 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
104 INT155944 Gene_expression of Foxp3 66 0.66 24.37 9.12 5.00
105 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
106 INT158796 Positive_regulation of SMUG1 67 0.70 38.97 8.98 5.00
107 INT1127 Negative_regulation of IGHG3 32 0.28 21.1 7.37 5.00
108 INT127691 Gene_expression of CXCL1 23 0.66 18.11 7.04 5.00
109 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
110 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 5.00
111 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
112 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
113 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
114 INT117189 Binding of CXCR4 34 0.37 24.27 5.81 5.00
115 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79 5.00
116 INT114180 Negative_regulation of Il1rn 22 0.57 11.06 5.44 5.00
117 INT145888 Negative_regulation of Mthfd1 27 0.41 8.98 5.4 5.00
118 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09 5.00
119 INT209893 Positive_regulation of Gene_expression of TNFRSF11B 31 0.68 11.77 4.8 5.00
120 INT2848 Localization of ABCA1 23 0.70 10.64 4.73 5.00
121 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 5.00
122 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 5.00
123 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 5.00
124 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
125 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 5.00
126 INT1149 Binding of ecs 19 0.37 13.67 3.9 5.00
127 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
128 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
129 INT158978 Localization of TNFRSF11B 19 0.78 11.8 3.32 5.00
130 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 5.00
131 INT9884 Localization of CD79A 41 0.78 21.75 3.06 5.00
132 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 5.00
133 INT208588 Binding of CXCR2 11 0.48 6.43 2.68 5.00
134 INT72165 Gene_expression of CXCL6 8 0.52 4.76 2.6 5.00
135 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
136 INT108482 Positive_regulation of Gene_expression of CXCL12 7 0.53 9.72 2.36 5.00
137 INT204175 Localization of Mri1 12 0.60 2.73 2.35 5.00
138 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
139 INT38674 Regulation of KRT20 32 0.44 19 2.15 5.00
140 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13 5.00
141 INT3723 Binding of PON1 9 0.46 5.83 2.13 5.00
142 INT161382 Localization of KRT20 25 0.61 12.97 2.13 5.00
143 INT37394 Localization of ecs 9 0.34 6.41 2.11 5.00
144 INT11390 Gene_expression of PF4 5 0.65 3.09 2.07 5.00
145 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02 5.00
146 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94 5.00
147 INT32431 Gene_expression of HTC2 17 0.75 9.72 1.93 5.00
148 INT153719 Gene_expression of TEK 10 0.49 9.82 1.88 5.00
149 INT135187 Transcription of TNFRSF11B 9 0.70 3.53 1.87 5.00
150 INT134890 Localization of TNFRSF11A 1 0.79 3.75 1.86 5.00
151 INT115130 Gene_expression of PDZK1IP1 5 0.65 1.95 1.79 5.00
152 INT113281 Binding of TNFRSF11B 9 0.47 2.97 1.78 5.00
153 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
154 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 5.00
155 INT107641 Negative_regulation of Ighg1 19 0.39 11.44 1.54 5.00
156 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
157 INT216123 Negative_regulation of Cd68 2 0.41 1.96 1.48 5.00
158 INT85829 Gene_expression of CA9 14 0.68 12.59 1.4 5.00
159 INT130926 Negative_regulation of TNFSF10 9 0.36 10.18 1.3 5.00
160 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
161 INT209900 Negative_regulation of Gene_expression of TNFRSF11B 13 0.51 4.05 1.12 5.00
162 INT209895 Transcription of TNFRSF11A 4 0.52 2.56 1.09 5.00
163 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 5.00
164 INT232636 Positive_regulation of Binding of Kit 4 0.39 1.98 0.98 5.00
165 INT274238 Positive_regulation of AIP 2 0.42 8.14 0.97 5.00
166 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
167 INT95669 Regulation of TNFRSF11A 7 0.56 10.01 0.94 5.00
168 INT193019 Positive_regulation of Positive_regulation of SMUG1 6 0.39 4.7 0.83 5.00
169 INT246524 Binding of QPCT 4 0.05 3.65 0.72 5.00
170 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 5.00
171 INT277710 Regulation of Localization of ABCA1 1 0.04 1.73 0.56 5.00
172 INT254368 Gene_expression of XCR1 1 0.20 1.03 0.55 5.00
173 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 5.00
174 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41 5.00
175 INT209901 Positive_regulation of Localization of TNFRSF11B 1 0.38 0.78 0.39 5.00
176 INT254367 Transcription of TEK 1 0.14 1.08 0.36 5.00
177 INT254372 Negative_regulation of TEK 1 0.12 1.05 0.31 5.00
178 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 5.00
179 INT182465 Negative_regulation of Cd1d1 4 0.28 1.72 0.29 5.00
180 INT209887 Positive_regulation of Transcription of TNFRSF11B 2 0.43 0.41 0.29 5.00
181 INT277711 Regulation of Localization of KRT20 1 0.37 0.87 0.28 5.00
182 INT64184 Negative_regulation of Gene_expression of TNFRSF11A 7 0.57 2.81 0.22 5.00
183 INT214557 Regulation of Binding of KRT20 3 0.37 2.25 0.22 5.00
184 INT209897 Positive_regulation of Gene_expression of IL1RAP 1 0.04 0.67 0.21 5.00
185 INT119017 Negative_regulation of CD22 4 0.39 2.16 0.21 5.00
186 INT3012 Positive_regulation of trm 2 0.49 0.98 0.2 5.00
187 INT277709 Regulation of Binding of ABCA1 1 0.04 0.52 0.19 5.00
188 INT216124 Negative_regulation of Pcna 3 0.13 2.06 0.19 5.00
189 INT214528 Negative_regulation of CCL3L1 1 0.32 1.25 0.13 5.00
190 INT254238 Positive_regulation of Il27ra 3 0.06 0.93 0.12 5.00
191 INT206270 Gene_expression of Spe1-r 6 0.75 1.24 0.11 5.00
192 INT209904 Positive_regulation of Positive_regulation of TNFRSF11B 2 0.40 0.13 0.1 5.00
193 INT293405 Transcription of URI1 1 0.03 0.74 0.07 5.00
194 INT209892 Regulation of Gene_expression of TNFRSF11A 2 0.27 0.61 0.03 5.00
195 INT283060 Positive_regulation of Atp5s 1 0.20 1.81 0 5.00
196 INT293404 Binding of Spe1-r 1 0.35 0.91 0 5.00
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