D:Werner Syndrome

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Disease Term
Synonyms Adult Premature Aging Syndrome, Adult Progeria, Pangeria, PROGERIA ADULT, Syndrome Werner, SYNDROME WERNER S, WERNER S SYNDROME, Werners Syndrome
Documents 12
Hot Single Events 4
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Werner Syndrome. They are ordered first by their relevance to Werner Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT309513 Binding of Xrcc6 and Htt 1 0.30 3.69 0.21 5.00
2 INT184704 Binding of Prrx2 and Sr1 1 0.21 1.65 0.13 5.00
3 INT309511 Binding of Xrcc6 and Xrcc5 1 0.18 1.18 0.08 5.00
4 INT200211 Gh Positive_regulation of Localization of Igf1 1 0.38 2.05 0 5.00
5 INT309515 Xrcc6 Regulation of Gene_expression of Htt 1 0.32 0.08 0 5.00
6 INT309521 PRKDC Regulation of Gene_expression of Htt 1 0.41 0.08 0 5.00
7 INT309517 Binding of Bax and Xrcc6 1 0.15 0.5 0 5.00
8 INT309519 Xrcc5 Regulation of Gene_expression of Htt 1 0.18 0.08 0 5.00
9 INT309512 Negative_regulation of Xrcc6 Positive_regulation of Phosphorylation of Gopc 1 0.20 0.17 0 5.00
10 INT309518 Negative_regulation of Binding of Bax and Xrcc6 1 0.16 0.25 0 5.00
11 INT309520 Htt Negative_regulation of Binding of Xrcc6 and Xrcc5 1 0.15 0.47 0 5.00
12 INT309516 Htt Positive_regulation of Gene_expression of Xrcc6 1 0.49 0.06 0 5.00
13 INT309509 Negative_regulation of Binding of Xrcc6 and Htt 1 0.31 0.41 0 5.00
14 INT309510 Htt Regulation of Gene_expression of Xrcc6 1 0.19 0.15 0 5.00
15 INT309508 Htt Negative_regulation of Binding of Xrcc6 1 0.31 0.48 0 5.00
16 INT309514 Positive_regulation of Binding of Xrcc6 and Htt 1 0.33 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Werner Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Werner Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT97519 Binding of WRN 2 0.27 1.92 0.14 94.36
2 INT309506 Positive_regulation of Tdp1 1 0.23 1.19 0 91.80
3 INT132754 Regulation of Wrn 1 0.39 0.8 0.1 91.68
4 INT76915 Localization of Gpx3 6 0.14 4.48 0.89 82.28
5 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03 79.52
6 INT309465 Gene_expression of Xrcc6 24 0.59 5.49 0.43 73.52
7 INT309481 Binding of Rbm17 1 0.18 0.82 0 61.76
8 INT176173 Positive_regulation of Nr1h2 19 0.52 10.95 1.88 50.68
9 INT81369 Negative_regulation of HFM1 1 0.43 0 0 50.00
10 INT1643 Regulation of CSH1 10 0.26 2.45 2.53 46.76
11 INT200205 Regulation of Ercc6 1 0.08 1.65 0.05 46.76
12 INT200132 Regulation of Ercc2 2 0.36 4.56 0.05 46.76
13 INT200135 Regulation of Ercc3 2 0.34 3.47 0.05 46.76
14 INT200188 Regulation of Ercc5 1 0.19 1.64 0.05 46.76
15 INT309502 Positive_regulation of Xrcc6 1 0.38 1.58 0 44.64
16 INT181809 Gene_expression of Atxn1 81 0.77 28.66 1.42 41.76
17 INT355897 Localization of Brca2 1 0.11 1.32 0 41.12
18 INT221268 Localization of BRCA1 7 0.63 4.83 0.18 40.32
19 INT181801 Regulation of Atxn1 3 0.29 1.08 0 36.68
20 INT176212 Transcription of Nr1h2 5 0.29 2.92 0.15 28.48
21 INT309486 Positive_regulation of Chek1 1 0.22 0.6 0 17.88
22 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68 10.72
23 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06 10.72
24 INT309503 Phosphorylation of Xrcc6 1 0.54 0.55 0 10.72
25 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25 9.44
26 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 5.72
27 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
28 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
29 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
30 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
31 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 5.00
32 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 5.00
33 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 5.00
34 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
35 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
36 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 5.00
37 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
38 INT178306 Negative_regulation of Gene_expression of Gopc 71 0.37 26.43 9.74 5.00
39 INT1168 Binding of PROC 62 0.38 44.15 9.04 5.00
40 INT4534 Regulation of PROC 38 0.33 19.81 8.99 5.00
41 INT175526 Phosphorylation of Gopc 73 0.53 21.08 7.86 5.00
42 INT52465 Negative_regulation of Dio1 17 0.58 4.45 7.76 5.00
43 INT28861 Binding of Gh 61 0.46 25.61 6.38 5.00
44 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
45 INT39436 Positive_regulation of PISD 4 0.26 3.16 5.78 5.00
46 INT151032 Localization of Igf1 49 0.76 26.32 5.71 5.00
47 INT103899 Gene_expression of ERCC2 14 0.65 7.85 5.49 5.00
48 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 5.00
49 INT181414 Gene_expression of Ccl19 12 0.74 9.8 4.11 5.00
50 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 5.00
51 INT72290 Localization of Sigmar1 21 0.74 4.35 3.54 5.00
52 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 5.00
53 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 5.00
54 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 5.00
55 INT141183 Gene_expression of Casp9 9 0.75 11.96 2.46 5.00
56 INT163063 Positive_regulation of C1qa 10 0.67 6.06 2.29 5.00
57 INT184676 Transcription of Prrx2 1 0.37 3.64 2.02 5.00
58 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95 5.00
59 INT80221 Regulation of Eno2 4 0.35 4.64 1.89 5.00
60 INT103900 Positive_regulation of ERCC2 7 0.58 3.47 1.78 5.00
61 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62 5.00
62 INT200186 Binding of Igfals 5 0.19 4.46 1.52 5.00
63 INT131968 Transcription of Grik1 3 0.51 1.44 1.51 5.00
64 INT184683 Gene_expression of Prrx2 1 0.37 7.9 1.5 5.00
65 INT131671 Negative_regulation of Prlhr 3 0.59 1.61 1.48 5.00
66 INT200185 Regulation of Igfals 10 0.26 11.4 1.47 5.00
67 INT118559 Positive_regulation of Hspa5 20 0.61 15.66 1.45 5.00
68 INT117148 Gene_expression of Eef1a1 6 0.07 2.32 1.42 5.00
69 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 5.00
70 INT200189 Negative_regulation of Igfals 7 0.24 4.19 1.39 5.00
71 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
72 INT75315 Regulation of Ghr 4 0.22 1.5 1.34 5.00
73 INT45083 Gene_expression of 10S 3 0.58 5.56 1.34 5.00
74 INT125525 Positive_regulation of PRKDC 7 0.45 2.72 1.21 5.00
75 INT181400 Negative_regulation of Ccl19 3 0.43 1.97 1.13 5.00
76 INT184686 Gene_expression of Sr1 1 0.60 2.97 1.06 5.00
77 INT184696 Positive_regulation of Xbp1 12 0.60 13.6 1.06 5.00
78 INT184692 Positive_regulation of 10S 1 0.02 4.47 1.01 5.00
79 INT184698 Positive_regulation of Prrx2 1 0.38 3.21 1.01 5.00
80 INT254875 Positive_regulation of Htt 10 0.47 4.07 0.96 5.00
81 INT184677 Negative_regulation of Spaca4 2 0.02 3.19 0.91 5.00
82 INT118558 Gene_expression of Xbp1 13 0.72 7.98 0.91 5.00
83 INT184687 Transcription of Ccl19 1 0.68 1.04 0.9 5.00
84 INT184665 Positive_regulation of C4b 7 0.28 5.84 0.9 5.00
85 INT184678 Regulation of Uts2r 7 0.14 2.57 0.85 5.00
86 INT197494 Gene_expression of Apoa4 9 0.05 7.33 0.78 5.00
87 INT170388 Gene_expression of Magt1 17 0.47 8.21 0.75 5.00
88 INT125526 Gene_expression of PRKDC 5 0.58 4 0.74 5.00
89 INT184694 Gene_expression of Usf1 10 0.55 4.27 0.72 5.00
90 INT184691 Positive_regulation of Dnajb6 1 0.01 5.04 0.61 5.00
91 INT119541 Positive_regulation of Ttr 5 0.58 6.07 0.6 5.00
92 INT287206 Regulation of Gene_expression of Htt 6 0.50 3.27 0.57 5.00
93 INT184690 Transcription of Fgf1 6 0.51 1.97 0.55 5.00
94 INT215340 Localization of Htt 10 0.61 5.12 0.55 5.00
95 INT176242 Binding of Bax 10 0.42 10.18 0.52 5.00
96 INT200206 Negative_regulation of Gene_expression of Igfals 4 0.21 3.83 0.5 5.00
97 INT170736 Gene_expression of Ccl27a 3 0.48 2.05 0.47 5.00
98 INT184664 Gene_expression of Rgs5 1 0.57 0 0.47 5.00
99 INT243418 Binding of Htt 14 0.30 5.94 0.44 5.00
100 INT154748 Positive_regulation of Gene_expression of Hspa5 11 0.44 7.66 0.44 5.00
101 INT200193 Gene_expression of Col4a4 8 0.12 5.75 0.43 5.00
102 INT184701 Localization of Ccl27a 2 0.69 0.72 0.4 5.00
103 INT163160 Positive_regulation of Sr1 2 0.54 2.35 0.36 5.00
104 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34 5.00
105 INT100644 Gene_expression of Igf2bp2 3 0.19 0.68 0.31 5.00
106 INT181803 Binding of Atxn1 12 0.48 7 0.3 5.00
107 INT254877 Positive_regulation of Gene_expression of Htt 15 0.64 6.29 0.28 5.00
108 INT184703 Transcription of PISD 1 0.20 1.26 0.27 5.00
109 INT184670 Localization of Prrx2 1 0.35 0.23 0.24 5.00
110 INT184700 Localization of Sr1 1 0.67 0.23 0.24 5.00
111 INT184685 Positive_regulation of Localization of Sr1 1 0.45 0.23 0.24 5.00
112 INT184671 Positive_regulation of Localization of Prrx2 1 0.24 0.23 0.24 5.00
113 INT184699 Localization of Ccl19 1 0.72 0.47 0.24 5.00
114 INT67349 Localization of Ghr 6 0.66 2.53 0.23 5.00
115 INT184702 Positive_regulation of Gene_expression of Magt1 3 0.42 3.47 0.22 5.00
116 INT287205 Regulation of Htt 5 0.45 3.56 0.22 5.00
117 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22 5.00
118 INT309493 Binding of Xrcc6 1 0.37 3 0.2 5.00
119 INT184697 Localization of Dctn3 1 0.70 0.43 0.19 5.00
120 INT170380 Positive_regulation of Magt1 6 0.30 4.84 0.18 5.00
121 INT199768 Gene_expression of Fmo3 3 0.50 3.11 0.17 5.00
122 INT184666 Negative_regulation of Localization of Ccl19 1 0.41 0.25 0.15 5.00
123 INT196421 Negative_regulation of Cdk1 2 0.24 1.17 0.15 5.00
124 INT184674 Negative_regulation of Prrx2 1 0.23 3.14 0.14 5.00
125 INT184679 Negative_regulation of 10S 1 0.01 3.15 0.14 5.00
126 INT184673 Gene_expression of Kcnq2 1 0.45 0.1 0.13 5.00
127 INT184684 Gene_expression of Erdr1 1 0.38 0.1 0.13 5.00
128 INT309492 Positive_regulation of Gene_expression of Xrcc6 1 0.38 1.29 0.13 5.00
129 INT184693 Positive_regulation of Gene_expression of Xbp1 3 0.47 4.42 0.13 5.00
130 INT184672 Regulation of Magt1 1 0.16 2.69 0.1 5.00
131 INT184675 Transcription of 10S 1 0.01 2.69 0.1 5.00
132 INT184695 Negative_regulation of Xpnpep1 1 0.01 1.96 0.1 5.00
133 INT184667 Positive_regulation of Regulation of Magt1 1 0.28 2.7 0.1 5.00
134 INT184669 Positive_regulation of Transcription of Prrx2 1 0.27 2.71 0.1 5.00
135 INT184688 Positive_regulation of Transcription of Magt1 1 0.42 2.7 0.1 5.00
136 INT184680 Regulation of Transcription of Magt1 1 0.16 2.69 0.1 5.00
137 INT170378 Transcription of Magt1 2 0.44 3.27 0.1 5.00
138 INT184668 Localization of Galt 1 0.62 0.21 0.09 5.00
139 INT200133 Negative_regulation of Xpa 5 0.58 9.85 0.09 5.00
140 INT309460 Binding of Xrcc5 1 0.16 0.09 0.08 5.00
141 INT184689 Regulation of Prrx2 1 0.13 0.77 0.08 5.00
142 INT309478 Regulation of Gene_expression of Xrcc6 1 0.21 0.36 0.07 5.00
143 INT200184 Positive_regulation of Igf2bp2 2 0.08 1.21 0.07 5.00
144 INT287203 Negative_regulation of Gene_expression of Htt 7 0.37 5.08 0.07 5.00
145 INT200180 Negative_regulation of Localization of Ghr 3 0.35 0.89 0.07 5.00
146 INT303473 Negative_regulation of Top1 2 0.08 2.27 0.06 5.00
147 INT187999 Gene_expression of H2afx 5 0.66 1.03 0.06 5.00
148 INT207902 Binding of Mgst1 19 0.18 0.93 0.04 5.00
149 INT309494 Negative_regulation of Binding of Bax 2 0.38 1.31 0.04 5.00
150 INT184681 Positive_regulation of Kcnq2 1 0.38 1.56 0.04 5.00
151 INT188001 Phosphorylation of H2afx 10 0.80 5.6 0.04 5.00
152 INT184682 Negative_regulation of Gene_expression of Prrx2 1 0.23 1.5 0.04 5.00
153 INT176238 Gene_expression of Cdk1 5 0.46 0.94 0.04 5.00
154 INT207803 Regulation of Atm 3 0.41 1.15 0.03 5.00
155 INT309477 Positive_regulation of Cdk1 2 0.35 0.21 0.03 5.00
156 INT200203 Regulation of Pou1f1 2 0.60 1.37 0.03 5.00
157 INT309463 Regulation of Negative_regulation of Xrcc6 1 0.18 0.15 0 5.00
158 INT200197 Positive_regulation of Xpa 1 0.48 2.76 0 5.00
159 INT309499 Localization of Xrcc6 1 0.57 0.13 0 5.00
160 INT213579 Binding of FOXO1 1 0.46 1.48 0 5.00
161 INT309491 Negative_regulation of Gene_expression of Xrcc6 1 0.32 0.56 0 5.00
162 INT309475 Positive_regulation of Binding of Xrcc6 1 0.53 0 0 5.00
163 INT309464 Negative_regulation of Negative_regulation of Xrcc6 1 0.45 0.09 0 5.00
164 INT309472 Protein_catabolism of Xrcc6 1 0.67 0.43 0 5.00
165 INT309468 Transcription of Xrcc6 1 0.52 0.24 0 5.00
166 INT200204 Transcription of Igf2bp3 1 0.06 0.4 0 5.00
167 INT200182 Negative_regulation of Igf2bp3 1 0.07 0.4 0 5.00
168 INT200131 Regulation of Xpa 2 0.38 1.25 0 5.00
169 INT309507 Negative_regulation of HTRA2 1 0.57 0.8 0 5.00
170 INT203687 Positive_regulation of H2afx 3 0.40 1.87 0 5.00
171 INT200191 Gene_expression of Xpa 1 0.64 10.1 0 5.00
172 INT200195 Transcription of Igfals 1 0.22 0.39 0 5.00
173 INT200201 Binding of Xpa 1 0.36 2.34 0 5.00
174 INT309467 Gene_expression of Xrcc5 1 0.26 0.1 0 5.00
175 INT309483 Positive_regulation of Xrcc5 1 0.20 0.1 0 5.00
176 INT203684 Positive_regulation of Phosphorylation of H2afx 2 0.59 1.23 0 5.00
177 INT200199 Negative_regulation of Ercc5 1 0.31 1.09 0 5.00
178 INT200208 Regulation of Prlr 1 0.10 0.27 0 5.00
179 INT309489 Binding of Ogg1 1 0.20 1.03 0 5.00
180 INT309461 Negative_regulation of Xrcc6 1 0.45 0.92 0 5.00
181 INT309476 Positive_regulation of Protein_catabolism of Xrcc6 1 0.38 0.43 0 5.00
182 INT200190 Binding of Igf2bp3 1 0.04 0.51 0 5.00
183 INT200187 Negative_regulation of Positive_regulation of Xpa 1 0.41 0.96 0 5.00
184 INT207428 Binding of MTTP 5 0.38 2.06 0 5.00
185 INT200202 Negative_regulation of Positive_regulation of Prlhr 1 0.10 0.4 0 5.00
186 INT200209 Positive_regulation of Prlhr 1 0.12 0.4 0 5.00
187 INT213578 Binding of FOXO3 3 0.33 2.2 0 5.00
188 INT309484 Positive_regulation of Ogg1 1 0.26 1.03 0 5.00
189 INT309479 Negative_regulation of Binding of Xrcc6 1 0.28 0.25 0 5.00
190 INT200194 Regulation of Localization of Xpa 1 0.38 0.71 0 5.00
191 INT309488 Negative_regulation of Localization of Xrcc6 1 0.32 0.13 0 5.00
192 INT309485 Positive_regulation of Top1 1 0.07 0.33 0 5.00
193 INT309474 Positive_regulation of Trp73 1 0.28 0.69 0 5.00
194 INT309469 Negative_regulation of Localization of Htt 1 0.34 0.13 0 5.00
195 INT200196 Negative_regulation of Gene_expression of Xpa 1 0.41 1.64 0 5.00
196 INT309505 Positive_regulation of Positive_regulation of Ogg1 1 0.26 1.04 0 5.00
197 INT200210 Transcription of Apoa4 1 0.06 0.51 0 5.00
198 INT200181 Localization of Xpa 1 0.63 0.71 0 5.00
199 INT200207 Negative_regulation of Ercc6 1 0.06 1.09 0 5.00
200 INT309480 Positive_regulation of Negative_regulation of Xrcc6 1 0.38 0.12 0 5.00
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