D:Wheal

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Disease Term
Synonyms WEAL, Weals, Welt, Welts, Wheals
Documents 328
Hot Single Events 77
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Wheal. They are ordered first by their relevance to Wheal and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64 89.28
2 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16 88.48
3 INT193215 Binding of CYSLTR1 and CYSLTR2 2 0.09 1.7 0.21 77.84
4 INT347514 Binding of CYSLTR1 and Ltc4s 1 0.01 0.58 0.03 77.84
5 INT61916 Binding of Fcgr1 and IgG2a 1 0.47 0.93 0.12 74.96
6 INT347516 Binding of CYSLTR2 and Ltc4s 1 0.01 0.4 0.03 72.84
7 INT61915 Binding of Fcgr1 and Slc3a2 1 0.02 0.43 0.06 68.64
8 INT38711 CYSLTR1 Positive_regulation of Gene_expression of PTGS1 1 0.08 0.14 0.25 60.72
9 INT194385 Il13 Positive_regulation of Gene_expression of IGHE 1 0.00 0.8 0.09 60.48
10 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07 5.00
11 INT168528 QRFP Regulation of FSIP1 2 0.07 1.32 0.93 5.00
12 INT341816 Binding of CEP68 and Aia1 1 0.02 4.76 0.76 5.00
13 INT168533 Binding of FSIP1 and Aia1 2 0.01 1.97 0.4 5.00
14 INT341794 Binding of SUGT1 and CEP68 1 0.00 1.1 0.33 5.00
15 INT347517 Binding of Tbxa2r and ST7L 1 0.00 0 0.32 5.00
16 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29 5.00
17 INT319221 FSIP1 Regulation of ADAM33 1 0.31 1.47 0.29 5.00
18 INT334737 Binding of Oprd1 and Gpi 1 0.01 0.71 0.28 5.00
19 INT243802 Binding of co and Decr1 1 0.00 0 0.27 5.00
20 INT319229 Binding of SNRNP70 and Aia1 2 0.00 2.92 0.25 5.00
21 INT311872 IGHE Positive_regulation of Localization of Mmp9 1 0.01 1.35 0.22 5.00
22 INT341814 Binding of CYSLTR1 and Aia1 1 0.01 1.33 0.19 5.00
23 INT347518 Regulation of Binding of Tbxa2r and ST7L 1 0.00 0 0.17 5.00
24 INT341813 Binding of SUGT1 and Aia1 1 0.00 0.48 0.16 5.00
25 INT341818 Binding of PITX2 and Aia1 1 0.00 0.53 0.16 5.00
26 INT341815 Binding of ADORA2A and Aia1 1 0.00 1.29 0.15 5.00
27 INT347462 Binding of CYSLTR1 and ST7L 1 0.00 0.1 0.13 5.00
28 INT194383 Il13 Positive_regulation of Gene_expression of Il4 1 0.00 1.75 0.13 5.00
29 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11 5.00
30 INT347515 Binding of GP1BA and Vwf 1 0.01 0.19 0.11 5.00
31 INT341811 CEP68 Regulation of Binding of CEP68 and Aia1 1 0.01 1.08 0.11 5.00
32 INT284552 Binding of Cd8a and Mthfd1 2 0.03 1.32 0.1 5.00
33 INT232917 Binding of KRT8 and KRT19 2 0.16 1.04 0.08 5.00
34 INT341812 Binding of SBF1 and Aia1 1 0.01 0.56 0.07 5.00
35 INT279767 Binding of IGHG3 and KRT19 1 0.01 0.84 0.07 5.00
36 INT341817 Binding of DCBLD2 and Aia1 1 0.01 0.56 0.07 5.00
37 INT319223 RS1 Regulation of Positive_regulation of FSIP1 1 0.05 0.42 0.05 5.00
38 INT347465 Binding of PLEK and ST7L 1 0.01 0 0.04 5.00
39 INT347464 Binding of WDTC1 and ST7L 1 0.00 0 0.04 5.00
40 INT279763 Binding of IGHG3 and KRT18 1 0.00 0.43 0.04 5.00
41 INT192263 LTC4S Positive_regulation of Gene_expression of TIMP1 1 0.00 0.28 0.04 5.00
42 INT279764 Binding of IGHG3 and BTG3 1 0.00 0.3 0.04 5.00
43 INT279766 Binding of IGHG3 and TGM1 1 0.01 0.3 0.04 5.00
44 INT347463 Binding of PTAFR and ST7L 1 0.00 0 0.04 5.00
45 INT279765 Binding of IGHG3 and KRT8 1 0.01 0.42 0.04 5.00
46 INT279762 Binding of KRT18 and KRT19 1 0.01 0.43 0.04 5.00
47 INT311870 Positive_regulation of Binding of Cd8a and Mthfd1 1 0.00 0.32 0.03 5.00
48 INT251864 Binding of HLA-DRB1 and IGHE 1 0.04 0.23 0 5.00
49 INT294065 ANGPT2 Positive_regulation of VEGFA 1 0.02 0.1 0 5.00
50 INT294066 ANGPT1 Positive_regulation of VEGFA 1 0.01 0.1 0 5.00
51 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
52 INT311816 CD79A Positive_regulation of RAB27A 1 0.01 0.47 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Wheal. They are ordered first by their pain relevance and then by number of times they were reported in Wheal. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT30526 Negative_regulation of PTAFR 15 0.58 8.15 8.19 100.00
2 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 100.00
3 INT13302 Binding of PTAFR 20 0.48 7.03 3.7 100.00
4 INT15481 Positive_regulation of asa 13 0.39 6.12 8.24 100.00
5 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 99.88
6 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 99.76
7 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.60
8 INT8699 Gene_expression of Nka1 45 0.67 6.41 22.56 99.56
9 INT9489 Gene_expression of SFTPA1 112 0.66 55.38 66.45 99.56
10 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58 99.30
11 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 99.30
12 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 99.08
13 INT169525 Positive_regulation of Serpinb1a 4 0.44 6.48 1.24 99.04
14 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 98.78
15 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 98.50
16 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 98.46
17 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 98.24
18 INT755 Regulation of HRH2 7 0.45 2.87 2.68 98.00
19 INT62800 Regulation of BAK1 7 0.41 10.12 1.47 97.64
20 INT6761 Binding of CALCA 100 0.48 26.71 62.05 97.64
21 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79 97.56
22 INT5160 Localization of PTAFR 61 0.80 42.6 19.16 96.72
23 INT43907 Binding of CD79A 28 0.48 28.11 3.04 96.56
24 INT35164 Negative_regulation of IGHE 96 0.58 76.3 9.74 96.52
25 INT24871 Negative_regulation of Binding of IGHE 10 0.58 2.87 2.64 96.52
26 INT3076 Regulation of KNG1 52 0.60 20.39 27.89 95.80
27 INT101 Negative_regulation of HRH1 8 0.57 3.48 2.55 95.56
28 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 95.52
29 INT131925 Gene_expression of COX1 3 0.54 0.66 0.36 95.32
30 INT334720 Regulation of Gene_expression of COX1 1 0.04 0.31 0 95.32
31 INT10896 Regulation of PTAFR 16 0.61 4.22 4.5 95.20
32 INT701 Localization of IGHE 87 0.80 40.5 10.62 95.08
33 INT8775 Binding of IGHE 167 0.48 102.61 23.54 94.80
34 INT8551 Negative_regulation of ACTBP7 1 0.30 0.09 0.5 94.72
35 INT30192 Regulation of H1 10 0.45 4.01 3.3 93.96
36 INT104673 Positive_regulation of Obfc1 10 0.41 4.26 5.61 93.88
37 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05 93.84
38 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 93.40
39 INT70049 Positive_regulation of Gene_expression of LTA 7 0.32 4.66 3.25 92.64
40 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 92.56
41 INT13539 Gene_expression of LTA 39 0.62 22.55 8.07 92.28
42 INT125711 Negative_regulation of TSS 6 0.51 3.64 0.12 92.24
43 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 91.36
44 INT37193 Negative_regulation of BDNF-AS 21 0.37 15.06 3.12 91.24
45 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 91.08
46 INT70812 Positive_regulation of NPVF 1 0.48 0.16 0.34 91.08
47 INT7134 Localization of KNG1 127 0.79 65.73 67.97 91.04
48 INT626 Localization of CALCA 289 0.81 125.39 221.15 90.92
49 INT64093 Localization of PSMB7 1 0.08 0.09 0.3 90.08
50 INT28510 Positive_regulation of Gpi 21 0.68 6.75 14.27 89.72
51 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 89.16
52 INT24797 Localization of HMMR 5 0.45 1.4 3.03 88.48
53 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65 88.12
54 INT4727 Regulation of TAC1 60 0.47 6.74 32.83 87.16
55 INT67183 Binding of Serpinb1a 4 0.37 4 1.77 87.12
56 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23 86.56
57 INT9996 Positive_regulation of Localization of IGHE 8 0.49 1.95 1.8 86.00
58 INT7743 Binding of Hrh2 19 0.47 7.75 7.11 85.92
59 INT8550 Localization of ACTBP7 1 0.46 0.09 0.62 85.60
60 INT6852 Localization of TNF 883 0.81 705.95 270.84 85.52
61 INT14690 Localization of CSF2 124 0.80 85.17 27.26 85.52
62 INT25503 Gene_expression of C5AR1 22 0.75 21.88 4.16 85.12
63 INT18843 Binding of H1 10 0.47 5.44 2.4 84.64
64 INT54805 Regulation of Ahr 7 0.22 4.14 1.41 84.60
65 INT61910 Binding of Slc3a2 6 0.01 3 0.7 84.08
66 INT24880 Positive_regulation of HRH2 7 0.69 1.34 2.74 83.36
67 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 83.28
68 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 83.28
69 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 82.52
70 INT26239 Positive_regulation of Gene_expression of Lta 12 0.36 8.86 4.22 82.08
71 INT88195 Gene_expression of ZAK 15 0.74 4.79 1.55 81.72
72 INT7994 Gene_expression of Lta 113 0.67 69.81 19.59 81.68
73 INT170988 Positive_regulation of CYSLTR1 15 0.34 6.23 4.44 81.40
74 INT13634 Gene_expression of CYSLTR1 19 0.75 11.24 2.88 81.40
75 INT95917 Gene_expression of CYSLTR2 10 0.64 6.1 0.82 80.96
76 INT193257 Positive_regulation of CYSLTR2 4 0.18 1.81 0.27 80.96
77 INT168418 Positive_regulation of RCT 32 0.55 20.2 4.07 80.16
78 INT10606 Localization of Ltc4s 16 0.75 10.14 5.05 79.92
79 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 79.64
80 INT20228 Negative_regulation of Gene_expression of Lta 8 0.22 3.81 1.03 79.20
81 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 78.96
82 INT54701 Localization of Ptafr 19 0.49 18.68 3.82 77.80
83 INT350380 Negative_regulation of Localization of Ear1 1 0.01 0.92 0.2 77.72
84 INT97171 Localization of Ear1 7 0.43 4.25 0.44 76.16
85 INT193251 Binding of CYSLTR1 13 0.32 8.32 2.57 75.88
86 INT15996 Binding of Ltc4s 9 0.35 5.66 1.64 75.88
87 INT10237 Binding of EDN1 40 0.48 16 8.48 75.16
88 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66 75.16
89 INT57433 Positive_regulation of Binding of EDN1 3 0.49 0.62 0.82 75.16
90 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41 74.32
91 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 73.04
92 INT193254 Binding of CYSLTR2 4 0.15 0.93 0.38 72.84
93 INT145 Negative_regulation of H1 12 0.39 5.68 5.08 72.16
94 INT61913 Binding of IgG2a 10 0.47 5.04 1.64 71.36
95 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 71.28
96 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 71.28
97 INT23191 Gene_expression of HDLCQ1 13 0.60 14.39 1.58 71.28
98 INT87235 Negative_regulation of Il4 54 0.48 31.51 13.15 69.84
99 INT62041 Negative_regulation of Gene_expression of IGHE 37 0.58 37.86 5.27 69.84
100 INT171021 Negative_regulation of IL5 18 0.41 14.74 3.39 69.84
101 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 68.56
102 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41 68.00
103 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 67.84
104 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 65.44
105 INT81399 Regulation of Vcam1 24 0.46 23.53 7.68 65.44
106 INT63977 Positive_regulation of Sele 28 0.68 18.49 4.17 65.44
107 INT63979 Regulation of Sele 13 0.54 10.64 3.7 65.44
108 INT122812 Gene_expression of SNRNP70 130 0.75 67 12.5 64.88
109 INT80745 Negative_regulation of SLTM 2 0.14 0.51 1.16 62.88
110 INT21248 Localization of Lta 15 0.59 5.16 2.5 62.56
111 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 60.92
112 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 60.72
113 INT18930 Positive_regulation of Hrh1 20 0.63 7.77 12.96 60.72
114 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 60.64
115 INT32054 Gene_expression of Tnc 14 0.59 9.36 12.22 60.64
116 INT161432 Negative_regulation of Gene_expression of Tnc 2 0.38 1.44 1.93 60.64
117 INT73830 Negative_regulation of Localization of Qrfp 2 0.10 0.65 1.01 59.92
118 INT61911 Negative_regulation of Gene_expression of Fcgr1 1 0.38 0.39 0.07 59.88
119 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 59.76
120 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 59.76
121 INT8389 Localization of Qrfp 38 0.78 5.11 21.39 59.36
122 INT61912 Gene_expression of Fcgr1 3 0.69 1.13 0.41 59.12
123 INT19250 Positive_regulation of TAL1 3 0.25 2.51 1.4 57.60
124 INT19249 Localization of TAL1 4 0.56 0.78 0.31 57.60
125 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 56.88
126 INT57434 Regulation of Regulation of EDN1 1 0.40 0.47 0.44 56.88
127 INT22004 Positive_regulation of Binding of IGHE 7 0.49 3.29 0.96 56.72
128 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 55.92
129 INT347507 Transcription of ST7L 1 0.01 0.65 0.08 54.88
130 INT34009 Binding of Tbxa2r 33 0.36 17.98 8.01 53.64
131 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 49.36
132 INT7527 Gene_expression of SLTM 12 0.25 2.9 6.07 49.36
133 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42 48.72
134 INT186808 Transcription of TLR4 22 0.69 12.77 3.73 48.72
135 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 48.24
136 INT137178 Gene_expression of TLR3 46 0.72 24.97 4.33 48.00
137 INT186803 Transcription of TLR3 6 0.67 1.54 0.2 48.00
138 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17 47.52
139 INT186805 Transcription of TLR2 12 0.63 9.66 3.04 47.52
140 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 43.64
141 INT10453 Positive_regulation of Gad1 65 0.70 10.75 31.9 39.60
142 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42 39.32
143 INT145384 Binding of LTA 10 0.32 4.4 0.66 37.60
144 INT194379 Localization of CRS 7 0.64 8.58 0.57 35.12
145 INT185877 Negative_regulation of Gene_expression of DCN 3 0.33 2.37 4.85 31.56
146 INT55655 Gene_expression of DCN 17 0.75 7.98 5.98 31.04
147 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 31.04
148 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 30.28
149 INT145768 Regulation of TLR4 19 0.45 8.31 2.96 29.44
150 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71 29.28
151 INT26789 Positive_regulation of Gene_expression of Gad1 22 0.70 7.39 9.02 29.28
152 INT341808 Negative_regulation of DNAJB1 1 0.03 0.22 0 29.28
153 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 29.12
154 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 25.20
155 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 25.00
156 INT326185 Binding of ST7L 2 0.08 1.46 1 23.20
157 INT347508 Localization of ST7L 1 0.01 0.22 0.03 23.20
158 INT322472 Negative_regulation of Localization of DCN 1 0.02 0.47 1.64 21.80
159 INT176888 Positive_regulation of MR1 29 0.67 11.68 1.71 21.64
160 INT178831 Positive_regulation of Positive_regulation of MR1 2 0.38 1.37 0.05 21.64
161 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 21.44
162 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09 21.44
163 INT13186 Positive_regulation of Il4 113 0.68 71.22 31.4 20.96
164 INT322473 Localization of DCN 1 0.03 0.76 2.9 20.92
165 INT138490 Positive_regulation of Il13 9 0.36 5.42 2.06 20.60
166 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 20.16
167 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 18.96
168 INT174112 Positive_regulation of Gene_expression of KRT19 4 0.44 4.28 0.31 15.60
169 INT232945 Positive_regulation of Gene_expression of KRT18 2 0.49 3.54 0.23 15.60
170 INT232967 Positive_regulation of Gene_expression of KRT8 2 0.29 3.54 0.23 15.60
171 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 14.68
172 INT148121 Gene_expression of KRT8 35 0.65 29.07 1.05 14.68
173 INT83479 Gene_expression of KRT18 30 0.65 27.29 1 14.68
174 INT171585 Positive_regulation of INADL 3 0.40 0.61 0.75 11.40
175 INT63816 Binding of Aia1 20 0.23 22.28 4.13 10.80
176 INT82461 Gene_expression of Gad2 40 0.78 19.12 22.79 8.24
177 INT75978 Transcription of Gad2 11 0.69 2.28 5.68 8.24
178 INT78003 Regulation of Transcription of Gad2 2 0.26 0.62 0.81 8.24
179 INT82465 Regulation of Gene_expression of Gad2 3 0.58 0.47 0.76 8.24
180 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
181 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 5.00
182 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
183 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
184 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
185 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 5.00
186 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
187 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
188 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
189 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
190 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
191 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
192 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
193 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
194 INT7362 Gene_expression of Sst 185 0.78 41.73 111.37 5.00
195 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
196 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
197 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
198 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
199 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
200 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 5.00
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