D:Wilms Tumor

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Disease Term
Synonyms EMBRYONAL ADENOSARCOMA, Embryonal Nephroma, KIDNEY ADENOMYOSARCOMA EMBRYONAL, Kidney Carcinosarcoma Embryonal, Kidney Embryoma, Kidney Embryonal Mixed Tumor, Nephroblastoma, NEPHROBLASTOMAS, Nephroma, Renal Adenosarcoma, RENAL CANCER WILMS
Documents 95
Hot Single Events 33
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Wilms Tumor. They are ordered first by their relevance to Wilms Tumor and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT340741 Binding of ATP5G3 and Gma3 1 0.00 0.96 0.03 98.08
2 INT340727 Binding of ATP5G3 and CSPG5 1 0.01 2.03 0.06 93.52
3 INT242015 Binding of Mdm2 and Trp53 3 0.16 5.74 0 54.00
4 INT276590 Binding of Wt1 and KTWS 1 0.02 0.3 0 15.76
5 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02 5.00
6 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31 5.00
7 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19 5.00
8 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13 5.00
9 INT258014 Binding of ANGPT2 and RASGRP1 1 0.00 1.58 0.1 5.00
10 INT258018 Binding of AGT and RASGRP1 1 0.00 1.59 0.1 5.00
11 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07 5.00
12 INT258015 Binding of ANGPT2 and REN 1 0.01 0.59 0.05 5.00
13 INT340726 SERPINB1 Regulation of CSPG5 1 0.00 0.35 0.05 5.00
14 INT258012 ANGPT2 Positive_regulation of Binding of AGTR1 and ANGPT2 1 0.00 0.29 0.04 5.00
15 INT258020 Binding of AGTR1 and ANGPT2 1 0.03 0.29 0.04 5.00
16 INT276583 Binding of Wt1 and IgG 1 0.07 0 0.04 5.00
17 INT276586 Binding of Wt1 and Actn1 1 0.34 0.41 0 5.00
18 INT190137 Binding of S100A12 and Gfap 1 0.00 0.65 0 5.00
19 INT276585 Binding of Trpc5 and Trpc6 1 0.17 0.26 0 5.00
20 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0 5.00
21 INT276582 Binding of Espn and Plce1 1 0.01 0.34 0 5.00
22 INT257243 Binding of COL5A2 and FN1 1 0.01 0.67 0 5.00
23 INT276591 Binding of Actn1 and KTWS 1 0.02 0.41 0 5.00
24 INT276587 Binding of Iqgap1 and Nphs1 1 0.08 0.33 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Wilms Tumor. They are ordered first by their pain relevance and then by number of times they were reported in Wilms Tumor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT114218 Gene_expression of Wt1 1 0.62 2.43 0.17 100.00
2 INT46 Localization of Ren 233 0.81 46.15 62.44 99.96
3 INT111038 Gene_expression of Cdkn1b 23 0.75 25.35 2.22 99.92
4 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 99.90
5 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 99.36
6 INT340740 Gene_expression of CSPG5 1 0.30 6.85 0.17 99.02
7 INT114701 Positive_regulation of Sdc3 1 0.14 1.14 0.16 97.72
8 INT112648 Positive_regulation of Fn1 19 0.49 13.73 1.66 97.44
9 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89 97.44
10 INT114700 Positive_regulation of Sdc1 2 0.45 1.67 0.64 97.44
11 INT114703 Positive_regulation of Wt1 5 0.46 4.25 0.24 97.44
12 INT102174 Gene_expression of FASN 11 0.65 6.4 0.67 96.40
13 INT7678 Localization of Alb 142 0.81 80.93 22.49 94.76
14 INT19847 Positive_regulation of Localization of Alb 21 0.70 13.89 4.16 94.76
15 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 94.20
16 INT13724 Positive_regulation of WT1 5 0.69 4.99 0.59 94.08
17 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 92.80
18 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 92.36
19 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 92.36
20 INT340730 Gene_expression of Gma3 1 0.01 6.67 0.21 92.32
21 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 85.80
22 INT61292 Positive_regulation of Gene_expression of Fn1 16 0.35 10.25 0.76 85.76
23 INT114699 Positive_regulation of Gene_expression of Fgf1 4 0.32 2.21 0.29 85.76
24 INT101208 Positive_regulation of Gene_expression of Wt1 3 0.47 3.08 0.15 85.76
25 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 85.36
26 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 85.36
27 INT101209 Gene_expression of Wt1 19 0.72 25.77 0.7 85.36
28 INT115948 Regulation of Gene_expression of MMRN1 7 0.26 10.37 1.33 83.28
29 INT302534 Localization of Mest 1 0.28 1.81 0 83.20
30 INT12916 Gene_expression of Thbd 8 0.58 5.16 1.39 83.04
31 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 82.96
32 INT64233 Regulation of Trp53 35 0.62 27.11 1.53 82.32
33 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 81.76
34 INT97139 Gene_expression of CD83 43 0.70 22.05 3.91 75.12
35 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 74.80
36 INT5844 Positive_regulation of Gene_expression of Vim 14 0.25 9.64 2.18 69.92
37 INT175770 Binding of Pnet-ps 1 0.00 4.91 0 68.04
38 INT198616 Gene_expression of Gvhd1 6 0.50 8.06 0.67 66.08
39 INT198617 Positive_regulation of Gene_expression of Gvhd1 2 0.37 3.17 0.07 66.08
40 INT114220 Negative_regulation of Gene_expression of Cdkn1b 4 0.33 4.11 1.23 65.20
41 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 65.12
42 INT48792 Regulation of ERBB2 48 0.57 36.56 1.8 61.92
43 INT114219 Positive_regulation of Pcna 1 0.06 0.45 0 61.72
44 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 59.40
45 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 59.08
46 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 58.00
47 INT172957 Negative_regulation of Mdm2 4 0.14 4.28 0.3 55.04
48 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 52.40
49 INT118664 Transcription of IGKV1-5 3 0.27 1.25 0 49.84
50 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 45.76
51 INT276576 Negative_regulation of KTWS 1 0.02 0.75 0 45.52
52 INT276530 Negative_regulation of Wt1 5 0.53 2.97 0 45.52
53 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 41.80
54 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71 40.72
55 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 40.24
56 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21 39.76
57 INT340732 Regulation of Gene_expression of Gma3 1 0.00 1.01 0.03 38.96
58 INT242003 Negative_regulation of Tgs1 1 0.01 1.09 0 38.96
59 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 36.64
60 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54 35.48
61 INT302535 Gene_expression of NLRP2 3 0.65 2.14 0.03 34.24
62 INT197016 Positive_regulation of Gene_expression of LDLR 13 0.50 5.82 0.24 30.00
63 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 29.24
64 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 28.32
65 INT192404 Localization of Ighm 15 0.48 5.8 0.85 28.32
66 INT192406 Regulation of Ighm 16 0.31 5.58 0.29 28.32
67 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 28.00
68 INT10870 Regulation of IgG 67 0.59 43.27 12.74 28.00
69 INT72747 Localization of IgG 55 0.53 30.88 4.19 28.00
70 INT222991 Negative_regulation of Gene_expression of MMRN1 10 0.13 4.39 1.14 27.24
71 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 24.48
72 INT97973 Positive_regulation of XRCC1 24 0.40 30.95 2.26 18.68
73 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 16.16
74 INT276574 Gene_expression of KTWS 1 0.04 0.5 0.08 14.44
75 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 12.80
76 INT12150 Negative_regulation of IGKV1-5 24 0.55 1.91 1.17 12.64
77 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
78 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
79 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
80 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
81 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
82 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
83 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
84 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
85 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
86 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
87 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
88 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
89 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
90 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
91 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
92 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
93 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
94 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
95 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
96 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
97 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
98 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
99 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
100 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 5.00
101 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
102 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
103 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
104 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
105 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
106 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 5.00
107 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 5.00
108 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
109 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
110 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
111 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
112 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
113 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
114 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
115 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
116 INT56072 Negative_regulation of NFKB1 94 0.59 53.16 28.19 5.00
117 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
118 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
119 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
120 INT5199 Gene_expression of Fosl1 44 0.78 8.66 24.8 5.00
121 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 5.00
122 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 5.00
123 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
124 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
125 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
126 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
127 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
128 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
129 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
130 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
131 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
132 INT6791 Binding of NA 55 0.46 5.36 17.59 5.00
133 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 5.00
134 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 5.00
135 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
136 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
137 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 5.00
138 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95 5.00
139 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52 5.00
140 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
141 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
142 INT19963 Gene_expression of COL1A1 118 0.59 42.11 15.15 5.00
143 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
144 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 5.00
145 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
146 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
147 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
148 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11 5.00
149 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39 5.00
150 INT12325 Gene_expression of Plec 47 0.72 11.92 13.35 5.00
151 INT62441 Gene_expression of ABCC1 56 0.78 21.01 12.93 5.00
152 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
153 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
154 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
155 INT112003 Localization of ROS1 94 0.73 66.32 12.16 5.00
156 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
157 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
158 INT57187 Positive_regulation of Gfap 49 0.69 27.59 11.46 5.00
159 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
160 INT8065 Binding of AGT 54 0.48 20.54 10.85 5.00
161 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
162 INT79656 Positive_regulation of NR3C1 14 0.68 6.38 10.83 5.00
163 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67 5.00
164 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 5.00
165 INT60198 Binding of JUN 54 0.48 11.56 10.27 5.00
166 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
167 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
168 INT3846 Positive_regulation of GSR 60 0.50 35.16 9.37 5.00
169 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
170 INT20664 Binding of ACE 60 0.48 35.27 9.16 5.00
171 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69 5.00
172 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
173 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
174 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42 5.00
175 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 5.00
176 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
177 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 5.00
178 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33 5.00
179 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
180 INT47994 Negative_regulation of Lipg 45 0.50 27.19 7.24 5.00
181 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
182 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
183 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 5.00
184 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06 5.00
185 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 5.00
186 INT131378 Negative_regulation of FN1 20 0.35 33.98 5.85 5.00
187 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65 5.00
188 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
189 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 5.00
190 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 5.00
191 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43 5.00
192 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33 5.00
193 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29 5.00
194 INT60585 Regulation of TP53 59 0.59 54.55 5.21 5.00
195 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
196 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 5.00
197 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07 5.00
198 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
199 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
200 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 5.00
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