D:With Excess Of Blasts Refractory Anemia

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pChart

Disease Term
Synonyms Leukemia Smoldering, Leukemia Smouldering, Leukemias Smoldering, RAEB, Raem, Refractory Anemia With Excess Of Blasts, Smoldering Leukemia, Smoldering Leukemias, Smouldering Leukemia
Documents 20
Hot Single Events 5
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for With Excess Of Blasts Refractory Anemia. They are ordered first by their relevance to With Excess Of Blasts Refractory Anemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 5.00
2 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 5.00
3 INT173430 Binding of FLT4 and VEGFA 10 0.25 9.38 0.19 5.00
4 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1 5.00
5 INT279286 Binding of TXK and VEGFA 3 0.05 2.35 0.07 5.00
6 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07 5.00
7 INT279284 TXK Regulation of KDR 3 0.05 2.22 0.04 5.00
8 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03 5.00
9 INT312303 Positive_regulation of FLT1 Positive_regulation of VEGFA 1 0.38 0.73 0.03 5.00
10 INT284919 XRCC6 Negative_regulation of BAX 1 0.01 0.64 0 5.00
11 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0 5.00
12 INT284918 RUNX1T1 Regulation of DNMT1 1 0.21 1.09 0 5.00
13 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0 5.00
14 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0 5.00
15 INT312304 Binding of JAK2 and VEGFA 1 0.30 0.82 0 5.00
16 INT284915 Binding of CDKN2B and HIST2H3C 1 0.05 0.43 0 5.00
17 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for With Excess Of Blasts Refractory Anemia. They are ordered first by their pain relevance and then by number of times they were reported in With Excess Of Blasts Refractory Anemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.80
2 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 93.64
3 INT68913 Gene_expression of Cd14 55 0.76 38.99 15.67 90.44
4 INT54366 Gene_expression of Anpep 6 0.77 1.38 1.52 90.44
5 INT97189 Gene_expression of Cd33 10 0.73 7.7 0.44 90.44
6 INT90889 Positive_regulation of Rxrg 1 0.11 0.95 0 78.56
7 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2 76.56
8 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 69.04
9 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 65.00
10 INT175035 Gene_expression of Mecom 11 0.65 10.1 0.19 64.24
11 INT312299 Positive_regulation of Gene_expression of Mecom 1 0.03 1.9 0 64.24
12 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 59.92
13 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 59.92
14 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 59.92
15 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 40.92
16 INT174100 Gene_expression of YWHAE 14 0.31 12.42 0.08 38.40
17 INT284991 Localization of YWHAE 1 0.06 3.22 0 38.40
18 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 20.60
19 INT86805 Localization of HGF 49 0.71 28.48 6.35 20.60
20 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 20.60
21 INT61884 Positive_regulation of HIST2H4A 3 0.10 2.87 0.48 10.60
22 INT31572 Negative_regulation of FLT1 21 0.48 16.49 1.18 7.92
23 INT12082 Localization of IL6 365 0.81 241.78 105.78 6.96
24 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
25 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
26 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
27 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
28 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
29 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
30 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
31 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
32 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
33 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
34 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
35 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
36 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
37 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 5.00
38 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
39 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
40 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
41 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
42 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
43 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
44 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
45 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 5.00
46 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
47 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 5.00
48 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
49 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 5.00
50 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
51 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 5.00
52 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
53 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12 5.00
54 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
55 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
56 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51 5.00
57 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
58 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 5.00
59 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38 5.00
60 INT7083 Positive_regulation of HBM 35 0.66 20.96 4.3 5.00
61 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 5.00
62 INT170455 Gene_expression of Atp8a1 66 0.75 24.63 3.94 5.00
63 INT103350 Gene_expression of DNMT1 15 0.67 9.77 3.83 5.00
64 INT193281 Binding of CAP1 7 0.07 4.57 3.53 5.00
65 INT12923 Negative_regulation of Atp9a 17 0.35 7.87 3.52 5.00
66 INT124579 Localization of BAX 35 0.78 30.31 3.43 5.00
67 INT200443 Positive_regulation of AES 27 0.60 22.46 3.22 5.00
68 INT172551 Negative_regulation of INCENP 38 0.07 20.83 3.14 5.00
69 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88 5.00
70 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84 5.00
71 INT8112 Regulation of EPO 38 0.58 22.04 2.76 5.00
72 INT221097 Negative_regulation of Atp8a1 15 0.57 10.52 2.65 5.00
73 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 5.00
74 INT8111 Localization of EPO 32 0.81 19.53 2.54 5.00
75 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16 5.00
76 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97 5.00
77 INT143127 Positive_regulation of FLT1 44 0.66 21.7 1.92 5.00
78 INT183753 Regulation of HBM 24 0.39 13.13 1.79 5.00
79 INT62712 Negative_regulation of HGF 19 0.58 7.21 1.67 5.00
80 INT82866 Localization of Atp9a 13 0.78 6.95 1.56 5.00
81 INT143443 Localization of HIF1A 14 0.78 10.93 1.49 5.00
82 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 5.00
83 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45 5.00
84 INT260447 Binding of HDAC1 8 0.23 4.47 1.12 5.00
85 INT116512 Gene_expression of MVD 4 0.75 1.61 1.06 5.00
86 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 5.00
87 INT112717 Negative_regulation of Binding of VEGFA 21 0.56 11.07 0.99 5.00
88 INT192564 Binding of HAT1 5 0.15 2.77 0.96 5.00
89 INT103882 Gene_expression of MECP2 17 0.76 10.47 0.96 5.00
90 INT173100 Binding of KDR 39 0.39 22.48 0.81 5.00
91 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79 5.00
92 INT74019 Regulation of TSC1 27 0.35 23.61 0.79 5.00
93 INT201859 Positive_regulation of Gene_expression of DNMT1 4 0.60 6.43 0.75 5.00
94 INT284955 Localization of HDAC1 2 0.47 1.71 0.74 5.00
95 INT230001 Binding of DEFA1 3 0.06 3.53 0.68 5.00
96 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64 5.00
97 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57 5.00
98 INT111609 Gene_expression of CTNNA1 3 0.46 3.2 0.57 5.00
99 INT143125 Binding of FLT1 48 0.40 13.6 0.51 5.00
100 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49 5.00
101 INT231565 Positive_regulation of YWHAE 4 0.23 3.07 0.49 5.00
102 INT45111 Gene_expression of PRB1 15 0.58 4.16 0.47 5.00
103 INT146400 Positive_regulation of DNMT1 4 0.45 0.91 0.43 5.00
104 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 5.00
105 INT39150 Gene_expression of Pcbd1 5 0.28 1.3 0.38 5.00
106 INT148797 Phosphorylation of KDR 7 0.80 5.15 0.36 5.00
107 INT163489 Binding of CDH1 13 0.19 8.63 0.35 5.00
108 INT283244 Gene_expression of Pgf 7 0.52 2.41 0.32 5.00
109 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32 5.00
110 INT179687 Negative_regulation of Gene_expression of KDR 6 0.22 5.37 0.31 5.00
111 INT173097 Localization of KDR 20 0.73 12.73 0.31 5.00
112 INT278723 Binding of HIST2H3C 2 0.04 1.74 0.28 5.00
113 INT284938 Regulation of DNMT1 2 0.22 1.17 0.24 5.00
114 INT312302 Gene_expression of Prss27 2 0.02 3.95 0.19 5.00
115 INT284968 Positive_regulation of CDA 2 0.05 0.34 0.15 5.00
116 INT197103 Binding of FLT4 2 0.29 3.08 0.14 5.00
117 INT59286 Regulation of Gene_expression of EPO 7 0.62 6.13 0.13 5.00
118 INT284981 Protein_catabolism of RAF1 2 0.08 1.62 0.12 5.00
119 INT258077 Negative_regulation of Gene_expression of DNMT1 2 0.30 1.27 0.12 5.00
120 INT284989 Localization of INTS2 2 0.43 1.64 0.11 5.00
121 INT258063 Negative_regulation of DNMT1 3 0.28 1.36 0.11 5.00
122 INT265803 Positive_regulation of Positive_regulation of FLT1 5 0.41 2.85 0.1 5.00
123 INT284953 Protein_catabolism of CDA 1 0.07 1.18 0.1 5.00
124 INT224335 Negative_regulation of Phosphorylation of KDR 5 0.35 5.24 0.09 5.00
125 INT151948 Positive_regulation of Gene_expression of MVD 2 0.49 1.35 0.09 5.00
126 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08 5.00
127 INT181214 Negative_regulation of HLA-DQA2 4 0.03 1.46 0.08 5.00
128 INT284484 Positive_regulation of Gene_expression of YWHAE 3 0.23 3.4 0.08 5.00
129 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08 5.00
130 INT184989 Positive_regulation of CDKN2B 3 0.47 2.77 0.07 5.00
131 INT245123 Gene_expression of CDKN2B 6 0.68 3.62 0.07 5.00
132 INT198034 Positive_regulation of Localization of KDR 3 0.29 2.17 0.05 5.00
133 INT189580 Positive_regulation of Gene_expression of KDR 9 0.49 5.9 0.05 5.00
134 INT284952 Phosphorylation of HAT1 1 0.05 0 0.05 5.00
135 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04 5.00
136 INT284958 Negative_regulation of HDAC6 1 0.25 1.56 0.04 5.00
137 INT284992 Negative_regulation of HDAC8 1 0.21 2.36 0.04 5.00
138 INT284979 Binding of HIST2H4A 2 0.05 2 0.04 5.00
139 INT284961 Protein_catabolism of FLT3 1 0.01 0.58 0.03 5.00
140 INT208568 Gene_expression of LINS 3 0.06 0.38 0.03 5.00
141 INT312307 Positive_regulation of Regulation of HBM 2 0.01 1.94 0.03 5.00
142 INT284971 Positive_regulation of Protein_catabolism of MTTP 1 0.45 0.54 0.03 5.00
143 INT284984 Protein_catabolism of MTTP 1 0.64 0.53 0.03 5.00
144 INT284937 Negative_regulation of Positive_regulation of CDKN2B 1 0.37 0.31 0 5.00
145 INT284943 Gene_expression of DNMT3A 2 0.39 1.46 0 5.00
146 INT169503 Gene_expression of MBD1 2 0.57 0.53 0 5.00
147 INT277612 Localization of HDAC9 3 0.45 0.55 0 5.00
148 INT185001 Gene_expression of CDH13 5 0.46 4.71 0 5.00
149 INT232975 Binding of KRT9 2 0.14 0.8 0 5.00
150 INT284983 Phosphorylation of UCK1 1 0.05 0 0 5.00
151 INT284945 Protein_catabolism of DNMT1 2 0.32 0.47 0 5.00
152 INT274683 Localization of HIST2H4A 5 0.12 1.54 0 5.00
153 INT284957 Localization of HIST2H3C 1 0.07 0.42 0 5.00
154 INT284977 Binding of DNMT1 3 0.17 0.86 0 5.00
155 INT284974 Negative_regulation of YWHAE 1 0.04 0.59 0 5.00
156 INT284986 Positive_regulation of Localization of HIST2H4A 1 0.07 0.42 0 5.00
157 INT284939 Binding of RUNX1T1 1 0.36 1.19 0 5.00
158 INT280987 Positive_regulation of ITIH1 1 0.49 0 0 5.00
159 INT284993 Positive_regulation of Protein_catabolism of DNMT1 1 0.22 0.26 0 5.00
160 INT284941 Transcription of CDKN2B 1 0.63 1.59 0 5.00
161 INT284970 Positive_regulation of Gene_expression of CDKN2B 1 0.61 0.55 0 5.00
162 INT284951 Positive_regulation of Positive_regulation of HIST2H3C 1 0.05 0.52 0 5.00
163 INT284959 Positive_regulation of Localization of INTS2 1 0.03 0.5 0 5.00
164 INT284963 Binding of XRCC6 2 0.36 1.57 0 5.00
165 INT284972 Negative_regulation of CDKN2B 3 0.44 1.13 0 5.00
166 INT284966 Phosphorylation of DCK 1 0.03 0 0 5.00
167 INT284950 Gene_expression of MBD4 1 0.29 0.31 0 5.00
168 INT284988 Positive_regulation of Transcription of CDKN2B 1 0.44 1.1 0 5.00
169 INT284947 Positive_regulation of Gene_expression of DNMT3A 2 0.25 1.29 0 5.00
170 INT284990 Positive_regulation of Positive_regulation of HIST2H4A 1 0.07 0.52 0 5.00
171 INT284942 Positive_regulation of Localization of HIST2H3C 1 0.05 0.42 0 5.00
172 INT284967 Positive_regulation of HIST2H3C 1 0.07 1.45 0 5.00
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