D:Xanthomatosis

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Disease Term
Synonyms XANTHOMA, Xanthomas, XANTHOMATOSES
Documents 115
Hot Single Events 28
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Xanthomatosis. They are ordered first by their relevance to Xanthomatosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT165619 Binding of LPL and TGS1 1 0.04 0.61 0.09 93.36
2 INT286444 PCSK9 Positive_regulation of Apob 1 0.02 0.49 0 23.36
3 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23 5.00
4 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23 5.00
5 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23 5.00
6 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
7 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09 5.00
8 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09 5.00
9 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
10 INT325027 Apoc3 Negative_regulation of Pnlip 1 0.01 1.02 0.04 5.00
11 INT325026 Apoc3 Negative_regulation of Lpl 1 0.03 1.01 0.04 5.00
12 INT325025 Apoa2 Positive_regulation of Hdl1 1 0.05 1.03 0.04 5.00
13 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 5.00
14 INT344643 Egfl7 Regulation of CIMT 1 0.00 0.2 0 5.00
15 INT344644 CIMT Positive_regulation of Positive_regulation of Asap1 1 0.02 0.4 0 5.00
16 INT185468 Fabp6 Regulation of Abcg5 1 0.00 0.44 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Xanthomatosis. They are ordered first by their pain relevance and then by number of times they were reported in Xanthomatosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT45176 Negative_regulation of LPL 34 0.59 22.22 2.01 99.76
2 INT38265 Gene_expression of LPL 22 0.78 10.59 1.09 98.16
3 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71 95.76
4 INT9466 Binding of APOB 27 0.41 19.36 1.56 95.76
5 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 95.52
6 INT181817 Negative_regulation of Gene_expression of Ppara 58 0.58 43.24 7.67 95.52
7 INT17890 Negative_regulation of HMGCR 26 0.42 12.05 1.94 94.64
8 INT233765 Binding of HAP1 1 0.03 4.11 0.42 93.28
9 INT165621 Negative_regulation of TGS1 4 0.14 4.5 0.72 92.72
10 INT165620 Negative_regulation of Gene_expression of HSD11B1 10 0.41 14.52 0.45 92.72
11 INT165622 Negative_regulation of Gene_expression of TGS1 2 0.14 1.54 0.13 92.72
12 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 92.32
13 INT165623 Gene_expression of TGS1 5 0.22 3.42 0.13 92.32
14 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 92.00
15 INT101693 Gene_expression of Ggt1 2 0.65 4.92 0.81 91.68
16 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 91.32
17 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 91.28
18 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 88.28
19 INT4012 Negative_regulation of Psd 23 0.52 14.12 3.81 87.60
20 INT19131 Localization of CYP27A1 14 0.80 8.19 2.15 84.00
21 INT183933 Binding of CD68 8 0.31 8.74 1.06 83.76
22 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 82.96
23 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 82.40
24 INT149332 Gene_expression of CD163 19 0.75 13.63 3.65 82.16
25 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 81.04
26 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 81.04
27 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 81.04
28 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 81.04
29 INT112962 Regulation of Positive_regulation of Ppara 17 0.45 10.63 2.58 75.24
30 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 75.04
31 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 75.00
32 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 75.00
33 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 75.00
34 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 75.00
35 INT113858 Positive_regulation of SLC4A1 6 0.49 3.44 1.22 75.00
36 INT113859 Positive_regulation of SLC4A3 3 0.21 2.6 0.39 75.00
37 INT147909 Gene_expression of Lpl 21 0.58 9.35 1.14 74.96
38 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 74.88
39 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 74.80
40 INT45838 Positive_regulation of LPL 15 0.69 11.33 2 72.88
41 INT80047 Regulation of Cyp4a3 5 0.45 2.11 1 72.56
42 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 70.32
43 INT1928 Negative_regulation of Lpl 18 0.51 11.22 2.49 70.08
44 INT17562 Negative_regulation of Lipg 32 0.51 16.91 3.17 69.68
45 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 69.36
46 INT12035 Regulation of F2 21 0.45 12.66 1.47 68.12
47 INT21756 Regulation of Alb 15 0.43 8.21 1.19 68.12
48 INT32709 Negative_regulation of Hbb 30 0.54 18.27 6.97 68.04
49 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 67.28
50 INT63317 Positive_regulation of Negative_regulation of CYP27A1 2 0.45 1.41 0.37 67.20
51 INT63318 Regulation of Negative_regulation of CYP27A1 1 0.44 0.9 0.18 67.20
52 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 65.48
53 INT130300 Gene_expression of Abcc3 14 0.70 5.34 4.96 64.52
54 INT342842 Negative_regulation of Protein_catabolism of Lpl 1 0.37 0.73 0.07 64.00
55 INT235505 Protein_catabolism of Lpl 2 0.76 1.4 0.1 63.12
56 INT143395 Regulation of CYP27A1 25 0.53 9.01 2.18 58.28
57 INT142800 Positive_regulation of Ldlr 21 0.68 14.75 0.6 57.52
58 INT180287 Negative_regulation of Negative_regulation of Psd 1 0.00 1.09 0.05 55.52
59 INT46350 Gene_expression of Msr1 32 0.65 29.39 4.55 54.92
60 INT44612 Positive_regulation of APOE 16 0.67 5.73 0.72 50.24
61 INT44609 Negative_regulation of Positive_regulation of APOE 1 0.16 0.9 0.09 50.24
62 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 50.00
63 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 50.00
64 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 50.00
65 INT4047 Binding of F13A1 105 0.43 66.54 11.81 50.00
66 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 50.00
67 INT38672 Binding of KRT20 69 0.39 48.01 6.31 50.00
68 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 50.00
69 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 50.00
70 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 50.00
71 INT27217 Negative_regulation of LYZ 6 0.42 3.1 2.26 50.00
72 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96 50.00
73 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 50.00
74 INT37253 Negative_regulation of PTPRC 12 0.37 6.13 1.26 50.00
75 INT211198 Localization of SERPINH1 2 0.66 4.33 1.25 50.00
76 INT28788 Regulation of LYZ 5 0.42 1.8 1.24 50.00
77 INT51066 Binding of S100B 24 0.48 13.5 0.97 50.00
78 INT248322 Negative_regulation of CD68 4 0.34 4.2 0.44 50.00
79 INT285743 Regulation of CD68 2 0.33 1.82 0.2 50.00
80 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 49.36
81 INT79780 Gene_expression of Cyp4a3 14 0.56 5.19 1.12 48.68
82 INT38299 Negative_regulation of FCGR2C 6 0.21 3.92 0.52 46.12
83 INT44610 Positive_regulation of APOC1P1 1 0.02 0.82 0.09 46.08
84 INT44613 Gene_expression of APOC1P1 1 0.02 0.83 0.09 44.24
85 INT44611 Negative_regulation of APOC1P1 1 0.02 0.84 0.09 44.24
86 INT176183 Gene_expression of Abcg5 1 0.77 5.01 1.08 42.20
87 INT176190 Gene_expression of Abcg8 1 0.78 10.4 3.19 41.96
88 INT37800 Positive_regulation of Apob 7 0.18 11.01 0.48 41.76
89 INT161811 Positive_regulation of Gene_expression of Msr1 5 0.49 6.38 0.38 40.84
90 INT309245 Binding of SETX 1 0.08 1.98 0.06 37.44
91 INT199650 Negative_regulation of Phyh 1 0.42 2.2 0.04 36.48
92 INT317660 Positive_regulation of Localization of Lpl 1 0.40 0.49 0 36.12
93 INT274529 Localization of Lpl 2 0.46 2.31 0.32 35.48
94 INT342845 Positive_regulation of Fut9 1 0.42 0.52 0 29.20
95 INT44608 Gene_expression of C2 45 0.75 15.84 5.05 27.04
96 INT44614 Gene_expression of FCGR2C 7 0.29 5.6 0.68 25.00
97 INT317659 Protein_catabolism of Lpl 1 0.65 0.72 0 22.96
98 INT286443 Positive_regulation of PCSK9 1 0.16 0.48 0 20.84
99 INT37799 Gene_expression of Apob 13 0.56 10.59 1.36 17.60
100 INT317658 Positive_regulation of Gene_expression of Apob 1 0.17 1.59 0 17.60
101 INT129425 Negative_regulation of Ldlr 22 0.42 17.15 0.97 16.16
102 INT176203 Positive_regulation of Gene_expression of Abcg5 1 0.69 0.34 0.03 15.88
103 INT176199 Positive_regulation of Gene_expression of Abcg8 1 0.50 0.34 0.03 15.88
104 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 9.96
105 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
106 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
107 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
108 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
109 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
110 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
111 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
112 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
113 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 5.00
114 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
115 INT102546 Gene_expression of Ccl2 197 0.78 192.8 67.41 5.00
116 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
117 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
118 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
119 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
120 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
121 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
122 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
123 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
124 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 5.00
125 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
126 INT133876 Positive_regulation of Gene_expression of Ros1 141 0.32 75.55 27.45 5.00
127 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26 5.00
128 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 5.00
129 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
130 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
131 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
132 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
133 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
134 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
135 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
136 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
137 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
138 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 5.00
139 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
140 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 5.00
141 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 5.00
142 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
143 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
144 INT174844 Binding of Fig4 81 0.41 18.03 12.87 5.00
145 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
146 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 5.00
147 INT32203 Negative_regulation of Crp 48 0.58 32.77 11.89 5.00
148 INT37390 Regulation of Crp 39 0.46 28.74 11.45 5.00
149 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
150 INT135022 Gene_expression of Cd14 79 0.76 36.37 10.63 5.00
151 INT135407 Negative_regulation of Ccl2 33 0.57 32.74 9.45 5.00
152 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42 5.00
153 INT138700 Negative_regulation of Gene_expression of Ccl2 27 0.57 24.1 9.08 5.00
154 INT1224 Gene_expression of Fabp6 34 0.64 23.69 9.08 5.00
155 INT20371 Gene_expression of Cd8a 125 0.60 67.59 8.97 5.00
156 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87 5.00
157 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 5.00
158 INT111377 Positive_regulation of Ifih1 16 0.60 11.22 6.99 5.00
159 INT142264 Positive_regulation of Apoe 47 0.50 26.35 6.94 5.00
160 INT84685 Regulation of BCL2 67 0.60 72.96 6.65 5.00
161 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 5.00
162 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
163 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
164 INT31582 Gene_expression of Hdl1 103 0.66 118.95 6.42 5.00
165 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
166 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
167 INT20612 Positive_regulation of Asap1 36 0.68 24.35 6.06 5.00
168 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 5.00
169 INT120550 Negative_regulation of Rock1 27 0.42 18.38 5.66 5.00
170 INT56803 Positive_regulation of Bcl2a1a 12 0.47 7.29 5.65 5.00
171 INT35536 Negative_regulation of CAT 26 0.57 14.39 5.38 5.00
172 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
173 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16 5.00
174 INT180379 Gene_expression of Olr1 31 0.36 36.46 4.84 5.00
175 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
176 INT181886 Gene_expression of Apoa1 40 0.64 40.53 4.56 5.00
177 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
178 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 5.00
179 INT24332 Regulation of Hdl1 28 0.45 45.45 4.26 5.00
180 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
181 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84 5.00
182 INT1727 Gene_expression of Cndp2 22 0.74 4.28 3.34 5.00
183 INT43985 Regulation of LPA 29 0.62 20.79 3.29 5.00
184 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
185 INT181355 Regulation of Gene_expression of Ccl2 12 0.44 10.37 3.21 5.00
186 INT224413 Positive_regulation of CIMT 25 0.68 23.61 3.14 5.00
187 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
188 INT80550 Positive_regulation of Gene_expression of Asap1 8 0.42 5.8 3.09 5.00
189 INT120201 Gene_expression of Aco1 54 0.35 26.29 2.95 5.00
190 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 5.00
191 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
192 INT182667 Binding of DLAT 11 0.31 40.75 2.8 5.00
193 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
194 INT27207 Gene_expression of Psd 31 0.73 15.44 2.75 5.00
195 INT115300 Negative_regulation of Napa 7 0.23 1 2.68 5.00
196 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
197 INT1540 Positive_regulation of SAFB 9 0.43 1.97 2.56 5.00
198 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
199 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
200 INT176205 Gene_expression of Cyp7a1 8 0.69 2.5 2.45 5.00
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