E:Negative regulation

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This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Negative_regulation. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Negative_regulation. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Negative_regulation. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
3 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
4 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
5 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
6 INT64756 oh Negative_regulation of Gpi1 1 0.03 0 4.09
7 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
8 INT132228 Negative_regulation of Binding of Pik3cg and Sh2d6 1 0.07 1.96 3.6
9 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
10 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
11 INT69770 Penk Negative_regulation of Pscs 1 0.11 0.22 3.39
12 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
13 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
14 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
15 INT289979 Binding of Helt and Negative_regulation of Maoa 1 0.00 0.17 3.14
16 INT150632 Ea1 Negative_regulation of Mpo 1 0.17 1.55 2.9
17 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
18 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 0.00 0 2.64
19 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 0.01 0 2.64
20 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
21 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
22 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
23 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
24 INT92182 Mir702 Negative_regulation of Adk 1 0.07 1.29 2.47
25 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
26 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
27 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
28 INT29716 Crh Negative_regulation of Localization of Gnrh1 5 0.44 0 2.35
29 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
30 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
31 INT249013 Gabrg1 Negative_regulation of Per2 1 0.34 0.07 2.31
32 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
33 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
34 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
35 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
36 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
37 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
38 INT3576 Sst Negative_regulation of Localization of Gh1 6 0.23 0 2.13
39 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
40 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
41 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
42 INT30954 Crh Negative_regulation of LH 5 0.46 1.4 2.06
43 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
44 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
45 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
46 INT274372 Phc1 Negative_regulation of Slc6a3 1 0.06 0.47 1.99
47 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
48 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
49 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 0.03 0.42 1.97
50 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
51 INT68273 G2e3 Negative_regulation of Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
52 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
53 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
54 INT161079 Mcs18 Negative_regulation of Trpv1 1 0.40 0.82 1.9
55 INT169346 Nxn Negative_regulation of Dynll1 1 0.06 1.22 1.87
56 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
57 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83
58 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83
59 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
60 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
61 INT276674 Negative_regulation of Nkx1-1 Regulation of Nav1 1 0.11 0.68 1.81
62 INT112526 D2Mit212 Negative_regulation of Gene_expression of Fos 1 0.03 0.28 1.8
63 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
64 INT179444 Hmmr Negative_regulation of Gpr156 1 0.03 0 1.79
65 INT29715 Crh Negative_regulation of Localization of LH 5 0.43 0 1.78
66 INT146512 Tmem132a Negative_regulation of Gene_expression of Fos 1 0.23 0 1.76
67 INT149491 PNOC Negative_regulation of Gene_expression of CD14 1 0.40 0.37 1.76
68 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
69 INT140892 Penk Negative_regulation of Mnp 1 0.13 0.55 1.75
70 INT168717 Mapk8 Positive_regulation of Mapk8 Negative_regulation of Oprk1 1 0.19 0.26 1.75
71 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75
72 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
73 INT79365 Pnoc Negative_regulation of Oprl1 2 0.41 0.16 1.72
74 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 0.39 0.39 1.72
75 INT199497 Pdyn Negative_regulation of Il1 1 0.00 0.14 1.67
76 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
77 INT142437 Urb1 Negative_regulation of Faah 3 0.41 2.12 1.66
78 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
79 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
80 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
81 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
82 INT103592 CAP1 Negative_regulation of Gene_expression of CPOX 1 0.19 1.52 1.64
83 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
84 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
85 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
86 INT114396 Positive_regulation of Vta1 Negative_regulation of Positive_regulation of Nlrp1a 1 0.03 0 1.63
87 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
88 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
89 INT147654 DYT10 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.93 1.62
90 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
91 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
92 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
93 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
94 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
95 INT48790 Negative_regulation of Rtcd1 Negative_regulation of Pax3 1 0.02 0 1.59
96 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
97 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58
98 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
99 INT212287 ro Negative_regulation of Ltp 1 0.00 1.2 1.58
100 INT42928 Penk Negative_regulation of Localization of Oxt 2 0.03 0 1.57
101 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
102 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
103 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
104 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
105 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
106 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
107 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
108 INT54844 Negative_regulation of Penk Positive_regulation of Vip 1 0.26 0 1.54
109 INT33815 Vta1 Negative_regulation of Penk 1 0.25 0 1.54
110 INT41101 Mdk Negative_regulation of SST 1 0.02 0 1.53
111 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
112 INT23546 Negative_regulation of CNDP2 Negative_regulation of POMC Positive_regulation of POMC 1 0.04 0 1.52
113 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
114 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
115 INT63490 Negative_regulation of Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51
116 INT62481 Penk Negative_regulation of Slc6a7 2 0.60 0 1.5
117 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
118 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
119 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
120 INT121741 Prkaca Negative_regulation of Positive_regulation of Creb1 1 0.10 0.2 1.49
121 INT190772 Il4 Negative_regulation of Gene_expression of Ptger2 1 0.03 1.28 1.49
122 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
123 INT140332 RPL7AP5 Negative_regulation of Ltp 1 0.00 0.64 1.47
124 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
125 INT140329 Grin1 Negative_regulation of Ltp 1 0.04 0.64 1.46
126 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
127 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
128 INT107813 Sst Negative_regulation of Localization of Nppa 1 0.44 0.2 1.46
129 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
130 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
131 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
132 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
133 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
134 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
135 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
136 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
137 INT19013 Ghsr Negative_regulation of Localization of Sst 1 0.15 0 1.44
138 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44
139 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
140 INT140012 Avp Negative_regulation of Dbi 1 0.06 0.8 1.44
141 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
142 INT151514 Olfr155 Negative_regulation of Gene_expression of VEGFA 1 0.00 1.8 1.42
143 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
144 INT68723 Pomgnt1 Negative_regulation of Gene_expression of Fos 1 0.12 0 1.41
145 INT190775 Gene_expression of Il4 Negative_regulation of Positive_regulation of FOSL1 1 0.39 2.42 1.4
146 INT71543 IFNA1 Negative_regulation of Positive_regulation of TAC1 1 0.20 0.19 1.4
147 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
148 INT167528 Ppt1 Negative_regulation of Gene_expression of Tac4 1 0.06 0.49 1.39
149 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
150 INT190128 Positive_regulation of PTGER1 Negative_regulation of Gene_expression of CPOX 1 0.04 1.21 1.38
151 INT167529 Ppt1 Negative_regulation of Gene_expression of Trpv1 1 0.26 0.49 1.38
152 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
153 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 0.05 0.07 1.37
154 INT26893 OGG1 Negative_regulation of Gh1 1 0.12 0 1.37
155 INT60993 Ntf4 Negative_regulation of Positive_regulation of CRTAC1 1 0.00 0 1.37
156 INT82025 Negative_regulation of Binding of Ntrk1 and Ngf 1 0.47 0.64 1.37
157 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
158 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
159 INT126640 Negative_regulation of KNG1 Positive_regulation of Alox15 1 0.14 0.62 1.36
160 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
161 INT352196 Igkv12-66 Negative_regulation of Gm10404 1 0.00 1.62 1.34
162 INT116102 Cck Positive_regulation of Negative_regulation of Pnoc 1 0.51 0.41 1.33
163 INT59446 Rbm39 Positive_regulation of Negative_regulation of Pomc 1 0.03 0.19 1.32
164 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
165 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
166 INT194513 Timp1 Negative_regulation of Cpox 1 0.00 0.9 1.31
167 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
168 INT124925 Negative_regulation of Slc6a1 Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
169 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
170 INT49231 TAC1 Negative_regulation of Penk 1 0.00 0 1.3
171 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
172 INT57956 LOC365260 Negative_regulation of Cck 1 0.11 0 1.3
173 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
174 INT121802 DEAF1 Negative_regulation of HTR1A 1 0.46 0.88 1.29
175 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
176 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
177 INT136644 T(1;9)27H Negative_regulation of Gene_expression of Hand1 1 0.15 1.14 1.27
178 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
179 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
180 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
181 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
182 INT119713 Negative_regulation of Slc6a3 Positive_regulation of Cpu3 1 0.39 0.71 1.26
183 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
184 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
185 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
186 INT149844 Negative_regulation of Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.26
187 INT86090 SCN5A Negative_regulation of Positive_regulation of Abat 1 0.00 0 1.25
188 INT202042 CAMK2N2 Negative_regulation of MMP9 1 0.01 0.73 1.25
189 INT202041 CAMK2N2 Negative_regulation of PPP1R11 1 0.00 0.74 1.25
190 INT18324 Sst Negative_regulation of Localization of Ins1 2 0.46 1.09 1.24
191 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
192 INT104348 Pnoc Negative_regulation of Localization of Gnrh1 1 0.45 0 1.24
193 INT202039 CAMK2N2 Negative_regulation of MMP1 1 0.00 0.73 1.24
194 INT34471 Negative_regulation of Pomc Regulation of Slc3a1 1 0.05 0.12 1.24
195 INT64758 Negative_regulation of oh Negative_regulation of Gpi1 1 0.03 0 1.24
196 INT202036 CAMK2N2 Negative_regulation of MMP3 1 0.00 0.73 1.24
197 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
198 INT202040 CAMK2N2 Negative_regulation of MMP7 1 0.00 0.73 1.24
199 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
200 INT149845 Cxcl12 Negative_regulation of C19orf10 1 0.16 0.45 1.24

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to Negative_regulation. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Negative_regulation. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29
2 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81
3 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84
4 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
5 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
6 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
7 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
8 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19
9 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
10 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
11 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
12 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98
13 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24
14 INT3440 Negative_regulation of Localization of Abat 221 0.57 33.94 180.36
15 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
16 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46
17 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8
18 INT943 Negative_regulation of Cck 205 0.59 38.42 174.78
19 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8
20 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
21 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
22 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
23 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
24 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31
25 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
26 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89
27 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75
28 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
29 INT7627 Negative_regulation of Positive_regulation of Ltp 162 0.50 41.2 106.27
30 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
31 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2
32 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
33 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04
34 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66
35 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
36 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02
37 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
38 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32
39 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57
40 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
41 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01
42 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03
43 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
44 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98
45 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98
46 INT2155 Negative_regulation of Sst 111 0.59 16.58 77.74
47 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19
48 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13
49 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7
50 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28
51 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17
52 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71
53 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
54 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4
55 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
56 INT49111 Negative_regulation of Prkaca 102 0.59 27.44 71.77
57 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
58 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
59 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
60 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52
61 INT7468 Negative_regulation of Localization of Oxt 109 0.59 9.46 66.79
62 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66
63 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
64 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86
65 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66
66 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23
67 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72
68 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32
69 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
70 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27
71 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
72 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
73 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27
74 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81
75 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79
76 INT5016 Negative_regulation of Crh 129 0.59 36.74 59.28
77 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
78 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33
79 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
80 INT18883 Negative_regulation of RYBP 53 0.56 21.14 57.52
81 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
82 INT2148 Negative_regulation of Oxt 105 0.59 11.42 57
83 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82
84 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14
85 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
86 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
87 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6
88 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5
89 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
90 INT5598 Negative_regulation of Pdyn 95 0.59 14.4 55.43
91 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
92 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
93 INT6073 Negative_regulation of Localization of Penk 63 0.59 8.67 53.95
94 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
95 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
96 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
97 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
98 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
99 INT1781 Negative_regulation of Gh1 127 0.59 16.94 51.77
100 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
101 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
102 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
103 INT5098 Negative_regulation of Localization of Sst 70 0.58 3.56 51.17
104 INT5136 Negative_regulation of PDYN 71 0.59 11.22 51.14
105 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
106 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33
107 INT5033 Negative_regulation of tf 39 0.54 13.37 48.62
108 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
109 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
110 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
111 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89
112 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88
113 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27
114 INT6544 Negative_regulation of Localization of Cck 67 0.59 8.05 47.23
115 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92
116 INT5337 Negative_regulation of Npy 87 0.59 19.6 46.75
117 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
118 INT6823 Negative_regulation of Pdyn 68 0.58 13.95 46.12
119 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
120 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06
121 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94
122 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81
123 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
124 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
125 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
126 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07
127 INT127013 Negative_regulation of Slc1a3 37 0.54 14.16 43.97
128 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63
129 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56
130 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55
131 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
132 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
133 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4
134 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
135 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84
136 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
137 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71
138 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
139 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
140 INT61925 Negative_regulation of Adk 53 0.59 22.46 40.38
141 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33
142 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57
143 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
144 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
145 INT115 Negative_regulation of Maoa 65 0.59 16.27 38.66
146 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
147 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02
148 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
149 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01
150 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81
151 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
152 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78
153 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
154 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54
155 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
156 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44
157 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23
158 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72
159 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62
160 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54
161 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
162 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94
163 INT1163 Negative_regulation of Rbm39 64 0.29 16.8 34.74
164 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66
165 INT692 Negative_regulation of SST 72 0.59 28.68 34.52
166 INT946 Negative_regulation of Nts 60 0.57 4.61 34.44
167 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24
168 INT1457 Negative_regulation of Binding of Penk 40 0.57 0.25 34.24
169 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
170 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
171 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
172 INT65536 Negative_regulation of Positive_regulation of Nfkb1 77 0.59 38.86 33.33
173 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
174 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
175 INT1711 Negative_regulation of Positive_regulation of Penk 54 0.59 6.55 32.42
176 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39
177 INT45365 Negative_regulation of Cfp 68 0.57 25.44 32.11
178 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
179 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7
180 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
181 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
182 INT5069 Negative_regulation of Mthfs 69 0.57 22.54 31.36
183 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
184 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25
185 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23
186 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
187 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17
188 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1
189 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
190 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
191 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36
192 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22
193 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22
194 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21
195 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
196 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96
197 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
198 INT7664 Negative_regulation of Grip2 68 0.49 10.11 29.93
199 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78
200 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65
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