G:111343

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Official Symbol Il1
Aliases Il-1
EntrezGene 111343
UniProt Coming Soon
Unique Molecular Interactions 152
Total Molecular Interactions 184
Total Single Events 1619
Unique Interaction Partners 97

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Il1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Il1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Il1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT199497 Pdyn Negative_regulation of Il1 1 0.00 0.14 1.67
2 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
3 INT21536 Binding of Il2 and Il1 1 0.28 0 1.47
4 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
5 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
6 INT311914 Il1 Negative_regulation of Gene_expression of Col2a1 1 0.01 1.94 1.23
7 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
8 INT188803 Il1 Positive_regulation of Gene_expression of Crp 1 0.03 2.95 0.94
9 INT57746 Il1 Regulation of Gene_expression of Ltc4s 1 0.36 0.33 0.88
10 INT21534 Binding of Oprd1 and Il1 1 0.00 0 0.84
11 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83
12 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8
13 INT296786 Gopc Regulation of Positive_regulation of Il1 1 0.02 1.37 0.77
14 INT54669 Mtr Regulation of Gene_expression of Il1 1 0.02 0.2 0.77
15 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
16 INT294908 Pax3 Positive_regulation of Gene_expression of Il1 1 0.03 0.45 0.76
17 INT267630 Il1 Regulation of Gene_expression of IL8 1 0.00 0.44 0.71
18 INT171901 Binding of TNF and Il1 2 0.18 1.07 0.7
19 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7
20 INT120484 ITIH4 Positive_regulation of Il1 1 0.01 0.62 0.68
21 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
22 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66
23 INT252288 Binding of Il1 and Positive_regulation of Gene_expression of Ccl20 1 0.06 0.54 0.66
24 INT82385 Penk Positive_regulation of Gene_expression of Il1 1 0.07 0 0.65
25 INT275562 Il1 Regulation of Gene_expression of Cxcl2 1 0.02 1.41 0.64
26 INT311470 Binding of Crp and Il1 1 0.00 2.44 0.63
27 INT311466 Binding of Acsl1 and Il1 1 0.00 2.46 0.63
28 INT190526 Acot1 Positive_regulation of Il1 1 0.01 0.87 0.63
29 INT316695 Binding of Il1 and gout 1 0.00 1.55 0.62
30 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
31 INT120206 Binding of UTS2R and Il1 1 0.17 1.28 0.59
32 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
33 INT299004 Binding of Il18 and Il1 1 0.04 1.16 0.58
34 INT339290 Casp1 Regulation of Gene_expression of Il1 1 0.11 1.38 0.55
35 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
36 INT171905 TNF Positive_regulation of Gene_expression of Il1 2 0.23 1.08 0.54
37 INT316736 Il1 Positive_regulation of Timp1 1 0.04 0.63 0.54
38 INT316737 Il1 Positive_regulation of Mmp1a 1 0.01 0.64 0.54
39 INT316738 Il1 Positive_regulation of Mmp3 1 0.02 0.63 0.54
40 INT316735 Il1 Positive_regulation of Gene_expression of Il1rn 1 0.00 0.53 0.53
41 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52
42 INT171899 Binding of Ifnar1 and Il1 1 0.01 0.75 0.52
43 INT195122 Il1 Positive_regulation of Gene_expression of Gtf3a 1 0.02 1.38 0.5
44 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49
45 INT187796 Binding of Tnf and Il1 1 0.09 1.85 0.48
46 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48
47 INT187795 Positive_regulation of Binding of Tnf and Il1 1 0.13 1.87 0.48
48 INT58634 Negative_regulation of Il1 Negative_regulation of Mpo 1 0.20 0.98 0.47
49 INT224451 Il1 Positive_regulation of Gene_expression of VEGFA 1 0.10 1.08 0.45
50 INT222922 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il1 1 0.01 0.56 0.44
51 INT175802 Il1 Positive_regulation of Gene_expression of Fos 1 0.00 0.66 0.44
52 INT320695 TNF Positive_regulation of Localization of Il1 1 0.05 1.38 0.44
53 INT294910 Pax3 Regulation of Positive_regulation of Il1 1 0.02 2.03 0.42
54 INT25616 Pomc Regulation of Gene_expression of Il1 1 0.60 0 0.42
55 INT323840 Binding of Esr1 and Il1 1 0.04 0.9 0.42
56 INT171125 Il1 Positive_regulation of Localization of TNF 1 0.00 1.22 0.41
57 INT184460 Il1 Positive_regulation of Adamts1 1 0.04 0.99 0.4
58 INT209918 Positive_regulation of Nlrp3 Positive_regulation of Localization of Il1 1 0.42 1.06 0.4
59 INT230500 Il1 Positive_regulation of Gene_expression of Tnf 1 0.07 1.83 0.4
60 INT171898 Il1rn Regulation of Gene_expression of Il1 1 0.02 0.92 0.4
61 INT230501 Il1 Positive_regulation of Gene_expression of S100a8 1 0.01 1.82 0.39
62 INT302821 Mdk Negative_regulation of Il1 1 0.02 0.91 0.38
63 INT182051 Il18 Positive_regulation of Il1 1 0.18 0.77 0.38
64 INT210952 Il1 Positive_regulation of Gene_expression of Icam1 1 0.01 0.86 0.37
65 INT278389 Binding of Casp1 and Il1 2 0.09 0.82 0.36
66 INT316689 Gene_expression of Cd14 Negative_regulation of Gene_expression of Il1 1 0.09 1.31 0.35
67 INT316691 Negative_regulation of Cd14 Negative_regulation of Gene_expression of Il1 1 0.09 1.31 0.35
68 INT184459 Il1 Regulation of Gene_expression of Adamts1 1 0.03 0.73 0.34
69 INT252289 Il17a Positive_regulation of Gene_expression of Il1 1 0.02 0.75 0.34
70 INT320691 C5 Regulation of Gene_expression of Il1 1 0.06 2.15 0.34
71 INT300549 Il1 Regulation of Gene_expression of Irf4 1 0.01 0.63 0.33
72 INT187223 Il1 Positive_regulation of Gene_expression of Tnfsf11 1 0.09 0.64 0.32
73 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
74 INT300855 Il1 Regulation of Il6 1 0.01 0.81 0.3
75 INT223752 Tlr4 Positive_regulation of Il1 1 0.12 0.64 0.3
76 INT324897 Binding of Ptbp1 and Il1 1 0.01 0.62 0.3
77 INT339294 Il1 Positive_regulation of Gene_expression of Cxcl1 1 0.06 0.53 0.3
78 INT93990 Rab8a Positive_regulation of Gene_expression of Il1 1 0.05 0.48 0.3
79 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
80 INT294907 Il1 Positive_regulation of Il6 1 0.06 1.45 0.29
81 INT225794 Il1 Negative_regulation of Gene_expression of Npp 1 0.02 0.99 0.28
82 INT225777 Il1 Negative_regulation of Npp 1 0.02 0.99 0.28
83 INT225798 Il1 Negative_regulation of Gene_expression of Ppi-rs 1 0.01 1 0.28
84 INT225796 Il1 Negative_regulation of Ppi-rs 1 0.01 1 0.28
85 INT225784 Il1 Negative_regulation of Gene_expression of Enpp1 1 0.08 0.99 0.28
86 INT188802 Il1 Negative_regulation of Gene_expression of Col7a1 1 0.00 0.71 0.26
87 INT317833 Nlrp3 Positive_regulation of Localization of Il1 1 0.06 1.38 0.26
88 INT267632 Il1 Positive_regulation of Gene_expression of PLA2G6 1 0.00 0.86 0.25
89 INT267631 IRF6 Positive_regulation of Gene_expression of Il1 1 0.00 0.96 0.25
90 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
91 INT195120 Il1 Regulation of Gene_expression of Cp 1 0.06 0.98 0.25
92 INT300546 Binding of Il23a and Il1 1 0.01 0.5 0.25
93 INT177897 Binding of Il1 and Wbc1 1 0.00 0.74 0.25
94 INT278403 Hps5 Positive_regulation of Il1 1 0.04 1.48 0.24
95 INT266421 Binding of HMGB1 and Il1 1 0.02 0.37 0.24
96 INT303992 Il1 Positive_regulation of Gene_expression of IL8 1 0.00 0.55 0.23
97 INT303985 Il1 Positive_regulation of Gene_expression of ISYNA1 1 0.01 0.54 0.23
98 INT224452 Il1 Positive_regulation of Gene_expression of FBXO2 1 0.37 0.35 0.22
99 INT186358 Il1 Positive_regulation of Gene_expression of Il17a 1 0.02 0.38 0.22
100 INT224445 Il1 Positive_regulation of Gene_expression of Itgam 1 0.21 0.35 0.22
101 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21
102 INT171973 Tnfsf11 Positive_regulation of Gene_expression of Il1 1 0.06 0.21 0.21
103 INT339292 Il1 Positive_regulation of Gene_expression of Ptger2 1 0.02 0.4 0.2
104 INT25617 Pomc Positive_regulation of Gene_expression of Il1 1 0.45 0 0.2
105 INT25615 Pomc Positive_regulation of Binding of Il1 1 0.49 0 0.2
106 INT186353 Binding of Il12a and Il1 1 0.21 0.38 0.2
107 INT323613 Il1 Regulation of Localization of Hmgb1 1 0.10 0.75 0.19
108 INT267629 PTAFR Positive_regulation of Localization of Il1 1 0.00 1.32 0.18
109 INT267627 Il1 Positive_regulation of Gene_expression of TNF 1 0.02 0.45 0.17
110 INT280833 Il1 Positive_regulation of Gene_expression of Crh 1 0.05 0.09 0.17
111 INT173938 Il1rn Negative_regulation of Il1 1 0.00 0.18 0.17
112 INT49198 Binding of Pomc and Il1 1 0.30 0.2 0.16
113 INT194620 Il1 Regulation of Gene_expression of TNF 1 0.04 0 0.16
114 INT350815 Negative_regulation of Binding of TNF and Il1 1 0.05 0.37 0.16
115 INT347334 Binding of S100a9 and Il1 1 0.09 0.45 0.15
116 INT224694 Il1 Positive_regulation of Akt1 1 0.01 0 0.15
117 INT347330 Binding of S100a8 and Il1 1 0.09 0.45 0.15
118 INT205712 CAMP Positive_regulation of Localization of Il1 1 0.00 0.32 0.14
119 INT246018 Timp1 Negative_regulation of Localization of Il1 1 0.01 1.05 0.14
120 INT327309 Il1 Positive_regulation of Mapk14 1 0.01 0.36 0.14
121 INT171904 TNF Positive_regulation of Il1 1 0.35 0.52 0.14
122 INT224456 Il1 Regulation of VEGFA 1 0.04 0.52 0.14
123 INT173937 Hrt1 Regulation of Il1 1 0.00 0.28 0.13
124 INT222867 Binding of Il1 and Rpl13 1 0.00 0.39 0.13
125 INT220115 Mefv Regulation of Gene_expression of Il1 1 0.01 1.85 0.13
126 INT327330 Mapk14 Regulation of Il1 1 0.01 0.33 0.12
127 INT181740 Il1 Positive_regulation of Csf2 1 0.02 0 0.12
128 INT303966 Lep Regulation of Il1 2 0.09 0.41 0.1
129 INT278371 Binding of Il1 and Hps5 1 0.02 0.44 0.09
130 INT267626 Il1 Positive_regulation of ICAM1 1 0.00 0.79 0.09
131 INT278368 Regulation of Binding of Il1 and Hps5 1 0.02 0.44 0.09
132 INT267618 Il1 Positive_regulation of Vcam1 1 0.00 0.81 0.09
133 INT217030 Il1 Positive_regulation of Localization of Car2 1 0.00 0 0.08
134 INT217026 Car2 Positive_regulation of Localization of Il1 1 0.00 0 0.08
135 INT334260 Negative_regulation of Binding of Myd88 and Il1 1 0.01 0.4 0.06
136 INT225799 Il1 Regulation of Ppi-rs 1 0.01 0.44 0.05
137 INT225779 Il1 Regulation of Npp 1 0.03 0.43 0.05
138 INT225790 Il1 Regulation of Gene_expression of Enpp1 1 0.07 0.43 0.05
139 INT225780 Il1 Regulation of Gene_expression of Npp 1 0.03 0.43 0.05
140 INT225806 Il1 Regulation of ALPI 1 0.00 0.44 0.05
141 INT333885 Lep Positive_regulation of Il1 1 0.17 0.05 0.03
142 INT81854 Col4a1 Positive_regulation of Gene_expression of Il1 1 0.30 0 0
143 INT336296 Il1 Positive_regulation of Gene_expression of INS 1 0.05 0.14 0
144 INT278384 Il1 Negative_regulation of Ctsb 1 0.01 0.12 0
145 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0
146 INT278406 Il1 Regulation of Gene_expression of Hps5 1 0.03 0 0
147 INT278387 Syk Regulation of Positive_regulation of Il1 1 0.06 0 0
148 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
149 INT339288 Binding of Hprt1 and Il1 1 0.09 0.05 0
150 INT278383 Pigb Regulation of Il1 1 0.00 0.2 0
151 INT278375 Il1 Negative_regulation of Ctsr 1 0.01 0.12 0
152 INT278402 Akt1 Regulation of Il1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 111343. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 111343. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35
2 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05
3 INT19775 Localization of Il1 183 0.78 145.5 50.91
4 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86
5 INT17886 Negative_regulation of Il1 95 0.57 70.91 31.25
6 INT25607 Binding of Il1 82 0.47 64.4 23.9
7 INT20129 Regulation of Il1 53 0.53 44.14 19.89
8 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85
9 INT25608 Regulation of Gene_expression of Il1 37 0.44 27.76 10.1
10 INT62400 Positive_regulation of Localization of Il1 34 0.67 35.53 7.96
11 INT54662 Positive_regulation of Positive_regulation of Il1 21 0.43 19.33 7.14
12 INT53572 Negative_regulation of Localization of Il1 18 0.40 12.78 6.7
13 INT59321 Transcription of Il1 13 0.50 9.73 2.68
14 INT278106 Regulation of Regulation of Il1 3 0.06 2.9 2.02
15 INT25612 Regulation of Localization of Il1 6 0.54 3.28 2
16 INT187095 Negative_regulation of Positive_regulation of Il1 8 0.14 6.17 1.82
17 INT199459 Negative_regulation of Regulation of Il1 1 0.02 0.22 1.51
18 INT17887 Regulation of Negative_regulation of Il1 2 0.26 1.94 1.42
19 INT53236 Positive_regulation of Binding of Il1 5 0.40 3.84 1.41
20 INT205681 Regulation of Positive_regulation of Il1 4 0.23 4.96 1.29
21 INT53234 Regulation of Binding of Il1 7 0.35 5.92 1.25
22 INT209915 Protein_catabolism of Il1 6 0.57 3.97 1.17
23 INT233974 Negative_regulation of Negative_regulation of Il1 2 0.30 1.47 1.07
24 INT184435 Negative_regulation of Binding of Il1 4 0.41 2.64 1
25 INT187092 Phosphorylation of Il1 3 0.26 1.25 0.78
26 INT230497 Positive_regulation of Transcription of Il1 2 0.40 2.77 0.77
27 INT187093 Positive_regulation of Phosphorylation of Il1 2 0.16 0.81 0.63
28 INT222884 Negative_regulation of Transcription of Il1 3 0.05 2.68 0.49
29 INT173927 Positive_regulation of Negative_regulation of Il1 2 0.35 1.13 0.34
30 INT220868 Negative_regulation of Protein_catabolism of Il1 1 0.02 0.78 0.15
31 INT220864 Positive_regulation of Protein_catabolism of Il1 1 0.03 0.66 0.15
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