G:11651

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Official Symbol Akt1
Aliases Akt, PKB, Rac, PKB/Akt, PKBalpha
EntrezGene 11651
UniProt Coming Soon
Unique Molecular Interactions 250
Total Molecular Interactions 342
Total Single Events 1799
Unique Interaction Partners 164

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Akt1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Akt1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Akt1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
2 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
3 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
4 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
5 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
6 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
7 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
8 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
9 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
10 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
11 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
12 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
13 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
14 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
15 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
16 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
17 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
18 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
19 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
20 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
21 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
22 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
23 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
24 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
25 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
26 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
27 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
28 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
29 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
30 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
31 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
32 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
33 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
34 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
35 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
36 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
37 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
38 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
39 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
40 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
41 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
42 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
43 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
44 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
45 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
46 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
47 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
48 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
49 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
50 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
51 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
52 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
53 INT166164 Binding of Ccr9 and Ccl25 Positive_regulation of Akt1 1 0.47 1.47 0.28
54 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
55 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
56 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
57 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
58 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
59 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
60 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
61 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
62 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
63 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
64 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
65 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
66 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
67 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
68 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
69 INT221231 Pdpk1 Positive_regulation of Akt1 1 0.09 0.13 0.18
70 INT221244 Pdpk1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.13 0.18
71 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
72 INT179841 Il11 Regulation of Positive_regulation of Akt1 1 0.08 0.07 0.17
73 INT282858 Bpifa2 Negative_regulation of Akt1 1 0.05 0.91 0.17
74 INT226209 Pik3cb Positive_regulation of Phosphorylation of Akt1 1 0.10 1.16 0.17
75 INT282861 Bpifa2 Negative_regulation of Phosphorylation of Akt1 1 0.05 0.91 0.17
76 INT316484 Akt1 Positive_regulation of Positive_regulation of Stat3 1 0.01 0.87 0.16
77 INT343475 Epo Regulation of Akt1 1 0.18 0.41 0.16
78 INT343478 Epo Regulation of Gene_expression of Akt1 1 0.40 0.41 0.16
79 INT224697 TNF Positive_regulation of Akt1 1 0.01 0 0.15
80 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
81 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
82 INT231844 Pcdh8 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.63 0.15
83 INT224694 Il1 Positive_regulation of Akt1 1 0.01 0 0.15
84 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
85 INT213005 Hdl1 Positive_regulation of Akt1 3 0.19 3.81 0.14
86 INT253122 Ins1 Positive_regulation of Akt1 2 0.15 1.81 0.14
87 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
88 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
89 INT293697 Dock2 Positive_regulation of Akt1 1 0.14 0.08 0.13
90 INT252336 Il2 Positive_regulation of Akt1 1 0.01 0 0.13
91 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13
92 INT282862 Bpifa2 Negative_regulation of Positive_regulation of Akt1 1 0.05 0.75 0.13
93 INT182478 Binding of Akt1 and Cx3cr1 1 0.11 0.12 0.13
94 INT320765 Dsg2 Positive_regulation of Akt1 1 0.48 0.74 0.13
95 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
96 INT293696 Mthfd1 Positive_regulation of Akt1 1 0.05 0.08 0.13
97 INT224685 L1cam Positive_regulation of Positive_regulation of Akt1 1 0.01 0.34 0.13
98 INT182477 Binding of Akt1 and Cxcr4 1 0.10 0.12 0.13
99 INT221254 Binding of KNG1 and Akt1 1 0.00 0.13 0.13
100 INT182484 Binding of Akt1 and Cxcr4 Positive_regulation of Akt1 1 0.06 0.12 0.13
101 INT182483 Cxcr6 Positive_regulation of Akt1 1 0.22 0.12 0.12
102 INT317891 Binding of Akt1 and Mtf1 1 0.21 1.04 0.11
103 INT256544 Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
104 INT289765 Akt1 Regulation of Phosphorylation of Gsk3a 1 0.05 0.45 0.11
105 INT240941 Binding of Akt1 and Ins1 1 0.06 0.75 0.11
106 INT289768 Akt1 Regulation of Phosphorylation of Gsk3b 1 0.04 0.45 0.11
107 INT317898 Binding of Akt1 and Eef1a1 1 0.01 1.04 0.11
108 INT309662 C5 Positive_regulation of Akt1 1 0.30 0.43 0.11
109 INT256545 Positive_regulation of Pten Negative_regulation of Akt1 1 0.05 1.07 0.11
110 INT278156 Negative_regulation of Trib3 Negative_regulation of Akt1 1 0.00 0.45 0.1
111 INT286418 Gtf3a Positive_regulation of Akt1 1 0.01 0.45 0.1
112 INT226210 Akt1 Regulation of Mul1 1 0.04 0.6 0.1
113 INT255754 Negative_regulation of Ins1 Positive_regulation of Akt1 1 0.14 1.73 0.1
114 INT314594 Binding of Ifnar1 and Positive_regulation of Akt1 1 0.43 0 0.1
115 INT200811 Epo Positive_regulation of Akt1 2 0.30 1.77 0.09
116 INT202402 Binding of Akt1 and Mapk14 1 0.11 0.13 0.09
117 INT253131 Il6 Regulation of Phosphorylation of Akt1 1 0.14 0.25 0.09
118 INT202400 Binding of Akt1 and Osm 1 0.05 0.13 0.09
119 INT288210 Regulation of Tlr2 Positive_regulation of Akt1 1 0.03 0.09 0.08
120 INT253140 Il6 Positive_regulation of Akt1 1 0.35 0.2 0.08
121 INT326574 Binding of Akt1 and Hsp90ab1 1 0.13 0.17 0.08
122 INT312547 Akt1 Positive_regulation of Phosphorylation of Ide 1 0.01 0.6 0.08
123 INT288206 Tlr2 Positive_regulation of Akt1 1 0.04 0.09 0.08
124 INT240897 Akt1 Negative_regulation of Positive_regulation of Foxo1 1 0.21 0.22 0.08
125 INT331796 Akt1 Negative_regulation of Negative_regulation of Pik3r1 1 0.04 0.88 0.08
126 INT208554 Phosphorylation of YWHAQ Positive_regulation of Binding of YWHAQ and Akt1 1 0.32 1.04 0.08
127 INT208556 Binding of YWHAQ and Akt1 1 0.22 1.02 0.08
128 INT231847 Binding of Akt1 and Sergef 1 0.00 0.23 0.07
129 INT240870 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Akt1 1 0.09 0.2 0.07
130 INT301122 Tgm7 Negative_regulation of Akt1 1 0.38 2.78 0.07
131 INT340564 Akt1 Regulation of Gene_expression of Fbxo32 1 0.05 0.52 0.07
132 INT231863 Binding of ARHGDIA and Akt1 1 0.02 0.23 0.07
133 INT253125 Il6 Negative_regulation of Phosphorylation of Akt1 1 0.22 0.31 0.07
134 INT231835 Binding of Akt1 and Grlf1 1 0.01 0.35 0.07
135 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
136 INT145499 Txn1 Negative_regulation of Negative_regulation of Akt1 1 0.28 0.88 0.07
137 INT329225 Prkag1 Positive_regulation of Akt1 1 0.09 1.27 0.07
138 INT288204 Akt1 Regulation of Mapk14 1 0.01 0.09 0.07
139 INT259933 Negative_regulation of Akt1 Negative_regulation of Gene_expression of Jun 1 0.01 0.31 0.07
140 INT142348 Igf1 Positive_regulation of Akt1 2 0.50 1.16 0.06
141 INT142345 Negative_regulation of Igf1 Positive_regulation of Akt1 1 0.42 0.33 0.06
142 INT221235 Akt1 Negative_regulation of Gsk3b 1 0.06 0.14 0.06
143 INT236938 Binding of Akt1 and SPNS1 1 0.00 0.72 0.06
144 INT311296 Akt1 Positive_regulation of Gene_expression of Clcn1 1 0.11 0 0.05
145 INT253130 Regulation of Ins1 Positive_regulation of Akt1 1 0.08 0.08 0.05
146 INT199102 Negative_regulation of Akt1 Negative_regulation of Gene_expression of Ros1 1 0.04 0.08 0.05
147 INT257227 Pik3cd Positive_regulation of Akt1 1 0.01 0.33 0.05
148 INT213014 Regulation of Hdl1 Positive_regulation of Akt1 1 0.12 0.97 0.05
149 INT331793 Akt1 Positive_regulation of Binding of Ugcg 1 0.02 0.75 0.05
150 INT199107 Binding of Akt1 and Ncf2 1 0.04 0.09 0.05
151 INT253126 Regulation of Il6 Positive_regulation of Akt1 1 0.23 0.08 0.05
152 INT332411 Akt1 Positive_regulation of Phosphorylation of Met 1 0.31 0.05 0.04
153 INT199108 Akt1 Negative_regulation of Gene_expression of Arhgdia 1 0.02 0.07 0.04
154 INT253580 Csnk2a2 Negative_regulation of Jak2 Negative_regulation of Positive_regulation of Akt1 1 0.05 0 0.04
155 INT253562 Csnk2a2 Negative_regulation of Positive_regulation of Akt1 1 0.12 0 0.04
156 INT231864 Binding of ARHGEF1 and Akt1 1 0.01 0.11 0.04
157 INT285603 Akt1 Regulation of Gene_expression of Nos2 1 0.02 0.48 0.04
158 INT199103 Akt1 Positive_regulation of Ncf2 1 0.05 0.09 0.04
159 INT340556 Binding of Akt1 and Myh1 1 0.04 0.27 0.04
160 INT200813 Jak2 Positive_regulation of Akt1 1 0.26 1.46 0.03
161 INT200809 Binding of Akt1 and Epo 1 0.23 0.98 0.03
162 INT340558 Gene_expression of Fst Positive_regulation of Akt1 1 0.09 0.41 0.03
163 INT181086 Binding of Akt1 and Cdc42ep3 1 0.00 0.79 0.03
164 INT181083 Binding of Akt1 and Cdc42 1 0.00 0.79 0.03
165 INT234984 Binding of Dsg3 and Positive_regulation of Akt1 1 0.03 0.32 0.03
166 INT287674 Skor2 Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.03
167 INT181079 Binding of Akt1 and Errfi1 1 0.00 0.8 0.03
168 INT200823 Akt1 Negative_regulation of Binding of Akt1 and Insrr 1 0.00 0.98 0.03
169 INT337811 Gene_expression of Gsk3b Positive_regulation of Phosphorylation of Akt1 1 0.37 0.37 0.03
170 INT200822 Akt1 Regulation of Jak2 1 0.25 1.48 0.03
171 INT239188 Proc Positive_regulation of Akt1 3 0.01 1.72 0
172 INT327052 Gene_expression of Akt1 Positive_regulation of Gene_expression of Myod1 1 0.19 0.18 0
173 INT315163 Erbb2 Negative_regulation of Akt1 1 0.17 0.83 0
174 INT305279 Lep Regulation of Gene_expression of Akt1 1 0.18 0.83 0
175 INT314746 Akt1 Positive_regulation of Phosphorylation of MDM2 1 0.32 1.16 0
176 INT314741 Binding of VEGFA and Akt1 1 0.36 0.66 0
177 INT295045 Akt1 Positive_regulation of Protein_catabolism of Cdkn1b 1 0.09 2.06 0
178 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
179 INT290807 Positive_regulation of Akt1 Positive_regulation of Phosphorylation of Gsk3b 1 0.14 0 0
180 INT327053 Gene_expression of Akt1 Positive_regulation of Gene_expression of Txlnb 1 0.04 0.18 0
181 INT226206 Gtf3a Positive_regulation of Akt1 1 0.00 1.02 0
182 INT323120 Negative_regulation of Irs2 Positive_regulation of Positive_regulation of Akt1 1 0.37 0 0
183 INT200812 Akt1 Positive_regulation of Negative_regulation of Hck 1 0.25 1.02 0
184 INT255742 hs Positive_regulation of Phosphorylation of Akt1 1 0.10 1.11 0
185 INT221240 Akt1 Positive_regulation of Phosphorylation of Bcl2 1 0.00 0.89 0
186 INT337492 AKT1 Positive_regulation of Akt1 1 0.26 0.17 0
187 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
188 INT191061 Akt1 Positive_regulation of Bcl2 1 0.41 0.33 0
189 INT201757 Binding of BCL2L1 and Positive_regulation of Negative_regulation of Akt1 1 0.01 0.3 0
190 INT259929 Negative_regulation of Akt1 Negative_regulation of Positive_regulation of Jun 1 0.01 0.39 0
191 INT343473 Epo Positive_regulation of Gene_expression of Akt1 1 0.45 0.05 0
192 INT311381 Phosphorylation of Akt1 Regulation of Celf1 1 0.10 0.14 0
193 INT166928 Casc1 Negative_regulation of Positive_regulation of Akt1 1 0.33 0.06 0
194 INT271101 PIK3CB Regulation of Akt1 1 0.01 0.72 0
195 INT253565 Akt1 Positive_regulation of Positive_regulation of Pik3r1 1 0.10 0 0
196 INT201734 Binding of Akt1 and Cdk5 1 0.01 0.31 0
197 INT306644 Mstn Negative_regulation of Positive_regulation of Akt1 1 0.37 0.09 0
198 INT201738 Positive_regulation of Binding of Akt1 and Cdk5 1 0.01 0.31 0
199 INT199576 Raf1 Negative_regulation of Akt1 1 0.00 0.79 0
200 INT287673 Negative_regulation of Sphk1 Negative_regulation of Akt1 1 0.20 0.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 11651. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 11651. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
3 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
4 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
5 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
6 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
7 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
8 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
9 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
10 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
11 INT134657 Localization of Akt1 37 0.68 11.58 4.62
12 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
13 INT75136 Binding of Akt1 27 0.27 8.81 4.15
14 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
15 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
16 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
17 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
18 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
19 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
20 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
21 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
22 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
23 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
24 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
25 INT226185 Protein_catabolism of Akt1 7 0.53 2.43 0.14
26 INT199082 Positive_regulation of Binding of Akt1 4 0.17 1.25 0.11
27 INT288183 Positive_regulation of Regulation of Akt1 1 0.05 0.06 0.03
28 INT268244 Negative_regulation of Localization of Akt1 2 0.28 2 0
29 INT293479 Positive_regulation of Protein_catabolism of Akt1 1 0.26 0.53 0
30 INT340543 Regulation of Binding of Akt1 1 0.23 0.18 0
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