G:11820

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Official Symbol App
Aliases Ag, Abpp, Adap, Cvap, Abeta, betaApp, E030013M08Rik
EntrezGene 11820
UniProt Coming Soon
Unique Molecular Interactions 92
Total Molecular Interactions 149
Total Single Events 1774
Unique Interaction Partners 63

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to App. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to App. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to App. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
2 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
3 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
4 INT2700 Binding of App and Cpe 1 0.00 0 0.63
5 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
6 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
7 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
8 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
9 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
10 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
11 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
12 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
13 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
14 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
15 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
16 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
17 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
18 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
19 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
20 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
21 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
22 INT78123 Positive_regulation of App Positive_regulation of Binding of App and 20S 1 0.05 0.61 0.4
23 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
24 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
25 INT356114 Prkca Positive_regulation of Binding of App and Tg 1 0.02 0.12 0.26
26 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
27 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
28 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
29 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
30 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
31 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
32 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16
33 INT201744 Ngf Regulation of Transcription of App 1 0.06 0.39 0.15
34 INT201728 Ntrk1 Regulation of Transcription of App 1 0.03 0.39 0.15
35 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
36 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14
37 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
38 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
39 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13
40 INT220622 App Positive_regulation of Rip 2 0.14 0.24 0.12
41 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
42 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1
43 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
44 INT139850 Binding of MBTPS1 and App 1 0.00 0.16 0.1
45 INT193963 App Regulation of Gene_expression of Ps 1 0.06 0.93 0.09
46 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09
47 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09
48 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09
49 INT124036 Binding of App and Dnahc8 1 0.03 0.14 0.09
50 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
51 INT204487 Positive_regulation of Fmr1 Regulation of Gene_expression of App 1 0.30 0.8 0.08
52 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
53 INT198934 Binding of App and Lrp1b 2 0.27 1.62 0.05
54 INT288099 Binding of APP and App 1 0.01 1.04 0.05
55 INT356086 Negative_regulation of Binding of App and Lrp1b 1 0.30 1.42 0.05
56 INT356110 Binding of App and Slc5a7 1 0.02 0.25 0.05
57 INT319973 App Regulation of Gene_expression of Mapk12 1 0.02 0.98 0.04
58 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
59 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03
60 INT356113 Binding of App and Apba1 Regulation of Gene_expression of App 1 0.17 0.06 0.03
61 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03
62 INT237090 Binding of App and Bnip3l 1 0.18 1.66 0.03
63 INT356115 Binding of App and Apba1 Positive_regulation of App 1 0.18 0.06 0.03
64 INT356097 Binding of App and Apba3 1 0.12 0.12 0.03
65 INT356116 Binding of App and Apba1 Regulation of App 1 0.10 0.06 0.03
66 INT356090 Binding of Apba2 and App 1 0.00 0.12 0.03
67 INT220628 Gene_expression of Gga1 Positive_regulation of App 2 0.22 0 0
68 INT220625 Negative_regulation of Binding of App and Bace1 1 0.44 0.09 0
69 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0
70 INT333770 Bace1 Regulation of Gene_expression of App 1 0.57 0 0
71 INT204493 App Negative_regulation of Scn10a 1 0.20 0.74 0
72 INT204499 App Regulation of Fmr1 1 0.50 0.59 0
73 INT204492 Negative_regulation of Binding of App and Fmr1 1 0.42 0.28 0
74 INT356083 Binding of App and Notch1 1 0.02 0.2 0
75 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0
76 INT204502 Binding of App and RNPC3 1 0.01 0.09 0
77 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0
78 INT204481 App Negative_regulation of Positive_regulation of Scn10a 1 0.20 0.74 0
79 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0
80 INT356087 Binding of App and Ncstn 1 0.17 0.07 0
81 INT198933 Binding of Apoe and App 1 0.33 0.19 0
82 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0
83 INT204482 Fmr1 Negative_regulation of App 1 0.42 0.74 0
84 INT356118 Binding of SORL1 and App 1 0.41 0.43 0
85 INT356109 Rab6a Regulation of App 1 0.14 0.05 0
86 INT180123 Egfl7 Positive_regulation of App 1 0.02 0.07 0
87 INT356106 Gene_expression of Pld1 Positive_regulation of App 1 0.29 0.21 0
88 INT217396 Binding of Abca1 and App 1 0.26 0.83 0
89 INT262708 Bace1 Positive_regulation of Gene_expression of App 1 0.44 2.82 0
90 INT198915 Binding of App and Lrp8 1 0.24 0.17 0
91 INT262713 App Regulation of Transcription of Bace1 1 0.45 0.31 0
92 INT198925 Binding of App and Ldlr 1 0.14 0.15 0
93 INT333773 Bace1 Regulation of App 1 0.25 0 0
94 INT204491 Ass1 Positive_regulation of App 1 0.01 0.43 0
95 INT356104 Positive_regulation of Binding of App and Lrp1 1 0.40 0.52 0
96 INT220624 Eif1 Regulation of App 1 0.00 0.1 0
97 INT204496 App Positive_regulation of Scn10a 1 0.20 0.48 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 11820. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 11820. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
3 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
4 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
5 INT11625 Localization of App 98 0.78 55.46 20.86
6 INT16794 Binding of App 103 0.48 64.87 19.79
7 INT65502 Regulation of App 77 0.62 52.05 19.44
8 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
9 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
10 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
11 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
12 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
13 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
14 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
15 INT178772 Transcription of App 17 0.70 10.79 2.79
16 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
17 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
18 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
19 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
20 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
21 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
22 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
23 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41
24 INT100137 Positive_regulation of Negative_regulation of App 2 0.41 1.26 1.16
25 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86
26 INT142112 Regulation of Regulation of App 3 0.39 2.46 0.59
27 INT78117 Positive_regulation of Positive_regulation of App 4 0.48 2.6 0.51
28 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32
29 INT178774 Positive_regulation of Transcription of App 2 0.49 1.17 0.31
30 INT180104 Positive_regulation of Phosphorylation of App 2 0.54 0.87 0.16
31 INT286326 Regulation of Transcription of App 3 0.45 0.26 0.15
32 INT180116 Negative_regulation of Transcription of App 1 0.38 0 0.04
33 INT351386 Negative_regulation of Phosphorylation of App 1 0.42 0.82 0.03
34 INT286323 Negative_regulation of Protein_catabolism of App 1 0.11 0.54 0
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