G:13982

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Official Symbol Esr1
Aliases ERa, ESR, Estr, ER[a], Estra, Nr3a1, ERalpha, AA420328, AU041214, ER-alpha
EntrezGene 13982
UniProt Coming Soon
Unique Molecular Interactions 91
Total Molecular Interactions 105
Total Single Events 1359
Unique Interaction Partners 65

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Esr1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Esr1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Esr1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
2 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
3 INT108812 Esr1 Positive_regulation of Positive_regulation of Oprm1 1 0.42 0.38 0.78
4 INT38057 Binding of Crp and Esr1 2 0.04 1.21 0.65
5 INT309158 Binding of Esr1 and Dlat 1 0.04 1.39 0.61
6 INT154014 Binding of Esr1 and Gabrg1 1 0.07 0.07 0.5
7 INT147179 Esr1 Regulation of Gene_expression of Penk 1 0.01 0.68 0.46
8 INT323840 Binding of Esr1 and Il1 1 0.04 0.9 0.42
9 INT117361 Binding of Esr1 and sea 1 0.02 1.38 0.38
10 INT117359 Binding of Esr1 and Wbc1 1 0.00 1.38 0.37
11 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
12 INT309156 Esr1 Regulation of Gene_expression of Dlat 1 0.05 1.06 0.3
13 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26
14 INT182346 Binding of Cd3e and Esr1 1 0.06 1.26 0.25
15 INT182349 Binding of Ms4a1 and Esr1 1 0.04 1.26 0.25
16 INT309160 Binding of Esr1 and Edc4 1 0.03 0.34 0.24
17 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
18 INT197618 Binding of Esr1 and Ppt1 1 0.01 0 0.18
19 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18
20 INT309154 Esr1 Positive_regulation of Gsdmc 1 0.01 0.44 0.15
21 INT309155 Negative_regulation of Esr1 Positive_regulation of Gsdmc 1 0.01 0.45 0.15
22 INT297312 Esr1 Positive_regulation of Scap 1 0.00 1.58 0.13
23 INT236588 Binding of Esr1 and Ins1 1 0.05 0.73 0.12
24 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1
25 INT237819 Binding of Esr1 and soc 1 0.04 0 0.1
26 INT125000 Binding of Esr1 and Tas2r108 1 0.04 0.33 0.1
27 INT237812 Esr1 Positive_regulation of Positive_regulation of soc 1 0.05 0.6 0.1
28 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09
29 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09
30 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
31 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09
32 INT232557 Erbb2 Positive_regulation of Esr1 1 0.23 0.26 0.09
33 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
34 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
35 INT192865 Binding of Esr1 and Pdia3 1 0.07 0.67 0.08
36 INT192862 Binding of Esr1 and Hspa5 1 0.08 0.68 0.08
37 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
38 INT237811 Binding of Esr1 and Stim1 1 0.09 0 0.07
39 INT237809 Esr1 Positive_regulation of Localization of Car2 1 0.09 0.66 0.07
40 INT142744 Esr1 Regulation of Transcription of Trpv6 1 0.42 0 0.06
41 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05
42 INT236591 Binding of Esr1 and Positive_regulation of Tmed4 1 0.04 0.52 0.05
43 INT240726 Binding of Esr1 and Ca2 1 0.02 0.57 0.05
44 INT225493 Binding of Esr1 and Pprc1 2 0.01 0.17 0.04
45 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
46 INT236595 Binding of Esr1 and PELP1 1 0.27 0.17 0.04
47 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
48 INT278579 Esr1 Positive_regulation of Negative_regulation of Tac2 1 0.47 0.25 0.03
49 INT331960 Positive_regulation of Binding of Esr1 and Tymp 1 0.00 0.15 0.03
50 INT331958 Binding of Esr1 and Tymp 1 0.00 0.15 0.03
51 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03
52 INT221682 Binding of Esr1 and FRTS 1 0.01 0.15 0.03
53 INT215872 Atf4 Regulation of Esr1 1 0.30 0.42 0.03
54 INT306500 Clu Regulation of Esr1 1 0.22 0.13 0
55 INT332958 Binding of Esr1 and Ppara 1 0.36 0.21 0
56 INT225559 Binding of Esr1 and Ncoa6 1 0.18 0 0
57 INT342281 Binding of INS and Esr1 1 0.08 0.57 0
58 INT173771 Gh1 Regulation of Transcription of Esr1 1 0.00 0.13 0
59 INT189115 Binding of Esr1 and Tap1 1 0.07 0.05 0
60 INT197615 Esr1 Regulation of Gene_expression of Pgr 1 0.01 0.21 0
61 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0
62 INT191062 Esr1 Regulation of Gene_expression of Bcl2 1 0.12 0.73 0
63 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
64 INT208018 Col4a4 Regulation of Gene_expression of Esr1 1 0.06 0.69 0
65 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0
66 INT225533 Binding of Emr1 and Esr1 1 0.01 0 0
67 INT225621 Positive_regulation of Binding of TARBP2 and Esr1 1 0.03 0 0
68 INT225531 R3hcc1 Positive_regulation of Positive_regulation of Esr1 1 0.00 0 0
69 INT197614 Esr1 Regulation of Pgr 1 0.01 0.07 0
70 INT225626 Binding of TARBP2 and Esr1 1 0.02 0 0
71 INT225611 Binding of Esr1 and Asc2 1 0.05 0 0
72 INT225573 Rbm39 Positive_regulation of Positive_regulation of Esr1 1 0.08 0 0
73 INT202901 Binding of Esr1 and Lman1 1 0.01 0 0
74 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
75 INT232558 Binding of Erbb2 and Esr1 1 0.24 0.59 0
76 INT189104 Negative_regulation of Binding of Esr1 and Tap1 1 0.08 0.06 0
77 INT311395 Binding of Esr1 and 20S 1 0.04 0.11 0
78 INT240725 Esr1 Positive_regulation of Localization of Ca2 1 0.03 0.72 0
79 INT173770 Gh1 Regulation of Esr1 1 0.00 0.13 0
80 INT263586 Hspa5 Positive_regulation of Esr1 1 0.15 1.01 0
81 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
82 INT306503 Tnf Negative_regulation of Gene_expression of Esr1 1 0.22 0.36 0
83 INT306499 Tnf Positive_regulation of Gene_expression of Esr1 1 0.24 0.36 0
84 INT156781 Binding of Esr1 and Fshr 1 0.02 0 0
85 INT225605 Binding of Ncoa6 and Positive_regulation of Esr1 1 0.25 0 0
86 INT225529 Binding of Esr1 and Rbm39 1 0.07 0 0
87 INT176287 Cdk2 Positive_regulation of Phosphorylation of Esr1 1 0.05 0.67 0
88 INT225588 Binding of Asc2 and Positive_regulation of Esr1 1 0.07 0 0
89 INT156780 Esr1 Positive_regulation of Binding of Fshr 1 0.02 0 0
90 INT307156 Esr1 Positive_regulation of Hspa5 1 0.04 0.79 0
91 INT225534 Rbm39 Positive_regulation of Esr1 1 0.09 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 13982. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 13982. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
2 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
3 INT37296 Binding of Esr1 117 0.43 62.51 27.33
4 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
5 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
6 INT2038 Localization of Esr1 104 0.79 40.12 13.27
7 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29
8 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51
9 INT117205 Transcription of Esr1 23 0.65 9.4 4.14
10 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58
11 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23
12 INT81945 Negative_regulation of Binding of Esr1 3 0.32 0.55 1.06
13 INT173747 Regulation of Positive_regulation of Esr1 4 0.37 4.85 0.95
14 INT236576 Positive_regulation of Binding of Esr1 3 0.41 2.39 0.92
15 INT154465 Negative_regulation of Transcription of Esr1 1 0.05 0 0.92
16 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9
17 INT33818 Positive_regulation of Negative_regulation of Esr1 3 0.40 0.98 0.82
18 INT161778 Regulation of Gene_expression of Esr1 13 0.51 9.46 0.73
19 INT239494 Regulation of Localization of Esr1 4 0.19 1.15 0.72
20 INT9836 Negative_regulation of Negative_regulation of Esr1 3 0.29 0.95 0.63
21 INT173748 Phosphorylation of Esr1 11 0.77 5.7 0.55
22 INT173744 Positive_regulation of Positive_regulation of Esr1 10 0.43 7.05 0.52
23 INT240710 Positive_regulation of Regulation of Esr1 1 0.09 1.34 0.47
24 INT236580 Regulation of Binding of Esr1 4 0.39 1.1 0.34
25 INT192845 Negative_regulation of Positive_regulation of Esr1 2 0.35 1.15 0.31
26 INT291955 Positive_regulation of Protein_catabolism of Esr1 1 0.06 0.14 0.17
27 INT269777 Regulation of Regulation of Esr1 2 0.02 1.17 0.16
28 INT183400 Positive_regulation of Transcription of Esr1 4 0.30 1.06 0.14
29 INT232556 Positive_regulation of Phosphorylation of Esr1 1 0.20 0.41 0.12
30 INT221677 Negative_regulation of Protein_catabolism of Esr1 1 0.08 0.15 0.03
31 INT335681 Regulation of Negative_regulation of Esr1 1 0.03 0 0
32 INT173746 Regulation of Transcription of Esr1 1 0.04 0 0
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