G:15289

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Official Symbol Hmgb1
Aliases DEF, p30, Hmg1, HMG-1, SBP-1, MGC103168, MGC103169, MGC117896, MGC117897, amphoterin
EntrezGene 15289
UniProt Coming Soon
Unique Molecular Interactions 44
Total Molecular Interactions 88
Total Single Events 459
Unique Interaction Partners 23

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Hmgb1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Hmgb1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Hmgb1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
2 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
3 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
4 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
5 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
6 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
7 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
8 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
9 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
10 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
11 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
12 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
13 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
14 INT324819 Hmgb1 Positive_regulation of Gene_expression of Maob 1 0.09 0.44 0.37
15 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
16 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
17 INT323612 Negative_regulation of Tlr4 Positive_regulation of Hmgb1 1 0.23 0.2 0.25
18 INT323610 Tlr4 Positive_regulation of Hmgb1 1 0.25 0.2 0.25
19 INT253765 Apex1 Positive_regulation of Hmgb1 1 0.09 1.27 0.24
20 INT343914 Hmgb1 Positive_regulation of Gene_expression of IL12A 1 0.01 0.41 0.24
21 INT253771 Gopc Positive_regulation of Hmgb1 1 0.03 1.27 0.24
22 INT343906 Hmgb1 Positive_regulation of Gene_expression of Cd40 1 0.05 0.41 0.24
23 INT253773 TNF Positive_regulation of Hmgb1 1 0.09 1.21 0.23
24 INT344833 Binding of Ager and Hmgb1 1 0.08 0.72 0.22
25 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
26 INT324815 Binding of Hmgb1 and Caprin1 1 0.01 0.65 0.19
27 INT324797 Binding of Cd24a and Hmgb1 1 0.19 0.66 0.19
28 INT323613 Il1 Regulation of Localization of Hmgb1 1 0.10 0.75 0.19
29 INT215094 Il6 Positive_regulation of Hmgb1 1 0.18 1.84 0.17
30 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
31 INT343920 Binding of TLR4 and Hmgb1 1 0.39 0.97 0.13
32 INT324866 Hmgb1 Positive_regulation of Tlr4 1 0.16 1.29 0.13
33 INT343917 Binding of IRF6 and Hmgb1 1 0.05 0.98 0.13
34 INT253761 Hmgb1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.73 0.12
35 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12
36 INT253775 Negative_regulation of Binding of THBD and Hmgb1 1 0.06 0.69 0.12
37 INT215095 Negative_regulation of Il6 Positive_regulation of Hmgb1 1 0.13 1.03 0.09
38 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09
39 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
40 INT324859 Hmgb1 Positive_regulation of ecs 1 0.03 0.74 0.03
41 INT324798 Hmgb1 Positive_regulation of Positive_regulation of Mthfd1 1 0.04 0.16 0.03
42 INT324561 Hmgb1 Positive_regulation of Gene_expression of Arc 1 0.18 0.65 0
43 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0
44 INT324558 Hmgb1 Positive_regulation of Gene_expression of Kiss1 1 0.24 0.65 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 15289. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 15289. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
2 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
3 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15
4 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41
5 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6
6 INT215071 Positive_regulation of Localization of Hmgb1 34 0.63 22.03 4.15
7 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13
8 INT215074 Negative_regulation of Localization of Hmgb1 28 0.57 15.09 4
9 INT253755 Regulation of Hmgb1 7 0.55 6.23 1.8
10 INT215077 Negative_regulation of Positive_regulation of Hmgb1 3 0.42 5.09 1.05
11 INT215078 Negative_regulation of Gene_expression of Hmgb1 4 0.41 4.3 0.96
12 INT190522 Regulation of Gene_expression of Hmgb1 1 0.39 1.47 0.77
13 INT215070 Regulation of Localization of Hmgb1 4 0.26 2.23 0.49
14 INT352592 Positive_regulation of Negative_regulation of Hmgb1 1 0.44 1.31 0.42
15 INT258283 Positive_regulation of Positive_regulation of Hmgb1 3 0.44 3.1 0.3
16 INT331591 Transcription of Hmgb1 1 0.28 0.92 0.3
17 INT258272 Negative_regulation of Binding of Hmgb1 1 0.53 1.82 0.15
18 INT344828 Protein_catabolism of Hmgb1 1 0.48 0.67 0.14
19 INT344810 Positive_regulation of Protein_catabolism of Hmgb1 1 0.27 0.67 0.14
20 INT318343 Regulation of Binding of Hmgb1 1 0.11 0.41 0.1
21 INT258279 Positive_regulation of Binding of Hmgb1 1 0.45 0.26 0
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