G:1565

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Official Symbol CYP2D6
Aliases CPD6, CYP2D, CYP2DL1, CYPIID6, P450C2D, P450DB1, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, P450-DB1, MGC120389, MGC120390
EntrezGene 1565
UniProt Coming Soon
Unique Molecular Interactions 26
Total Molecular Interactions 27
Total Single Events 476
Unique Interaction Partners 21

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to CYP2D6. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to CYP2D6. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to CYP2D6. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
2 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
3 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
4 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
5 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
6 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
7 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
8 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
9 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
10 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
11 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
12 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
13 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
14 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
15 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
16 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
17 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
18 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
19 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
20 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
21 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
22 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
23 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
24 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
25 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0
26 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 1565. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 1565. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
3 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
4 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
5 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
6 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
7 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
8 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
9 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
10 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
11 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
12 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
13 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
14 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
15 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
16 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
17 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
18 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17
19 INT344065 Negative_regulation of Binding of CYP2D6 1 0.15 0.05 0.17
20 INT330999 Negative_regulation of Positive_regulation of CYP2D6 1 0.40 0 0
21 INT169150 Regulation of Binding of CYP2D6 1 0.41 0 0
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