G:16173

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Official Symbol Il18
Aliases Igif, Il-18
EntrezGene 16173
UniProt Coming Soon
Unique Molecular Interactions 44
Total Molecular Interactions 59
Total Single Events 420
Unique Interaction Partners 27

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Il18. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Il18. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Il18. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
2 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
3 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 0.01 1.37 0.64
4 INT299004 Binding of Il18 and Il1 1 0.04 1.16 0.58
5 INT297311 Casp1 Positive_regulation of Il18 1 0.09 1.02 0.55
6 INT206010 Foxm1 Positive_regulation of Gene_expression of Il18 1 0.03 0.72 0.5
7 INT260836 Il18 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.48
8 INT224699 Il18 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46
9 INT298999 Binding of Il18bp and Il18 1 0.02 0 0.45
10 INT178823 TNF Regulation of Il18 1 0.18 3.28 0.41
11 INT141016 Il18 Positive_regulation of Gene_expression of Ifng 1 0.39 0.27 0.39
12 INT182054 Il18 Positive_regulation of LOH19CR1 1 0.55 0.74 0.38
13 INT182052 Il18 Positive_regulation of Col7a1 1 0.03 0.74 0.38
14 INT182051 Il18 Positive_regulation of Il1 1 0.18 0.77 0.38
15 INT262824 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.39 1.56 0.37
16 INT152313 Il18 Regulation of Ednrb 1 0.30 0.22 0.36
17 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
18 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
19 INT317835 Nlrp3 Positive_regulation of Il18 1 0.08 1.49 0.31
20 INT182053 Il18 Positive_regulation of TNF 1 0.06 0.63 0.29
21 INT298996 Il18 Positive_regulation of Gene_expression of Cdk5r1 1 0.03 1.65 0.29
22 INT298995 Il18 Positive_regulation of Gene_expression of Cdk5 1 0.12 1.65 0.29
23 INT299008 Il18 Positive_regulation of Transcription of Cdk5 1 0.12 1.65 0.29
24 INT299011 Il18 Positive_regulation of Transcription of Cdk5r1 1 0.03 1.65 0.29
25 INT299013 Il18 Regulation of Ltp 1 0.05 0.39 0.25
26 INT299003 Il18 Positive_regulation of Gene_expression of Il13 1 0.11 0.73 0.24
27 INT104553 Il18 Negative_regulation of Il18bp 1 0.26 1.09 0.23
28 INT299000 Positive_regulation of Il18 Regulation of Ltp 1 0.05 0.35 0.2
29 INT298998 Il18 Positive_regulation of Cdk5 1 0.11 0.36 0.17
30 INT299001 Il18 Positive_regulation of Cdk5r1 1 0.03 0.36 0.17
31 INT331600 Il18 Regulation of IFN1@ 1 0.00 1.05 0.16
32 INT334530 Sema3a Regulation of Il18 1 0.18 1.61 0.13
33 INT299015 Binding of FAS and Il18 1 0.38 0.83 0.11
34 INT298994 Binding of Il18 and Il1f5 1 0.01 0 0.1
35 INT297317 Positive_regulation of Mthfd1 Positive_regulation of Gene_expression of Il18 1 0.07 0.79 0.08
36 INT299002 Negative_regulation of Binding of Il18bp and Il18 1 0.02 0 0.08
37 INT178821 TNF Negative_regulation of Il18 1 0.29 0.64 0.08
38 INT262821 Serpinf1 Negative_regulation of Gene_expression of Il18 1 0.54 0.85 0.08
39 INT299009 Il1f5 Negative_regulation of Il18 1 0.01 0 0.07
40 INT224679 Il18 Positive_regulation of Gene_expression of Vcam1 1 0.01 0.41 0.05
41 INT178822 TNF Regulation of Gene_expression of Il18 1 0.18 0.47 0.03
42 INT299006 Binding of Il18 and Myd88 1 0.21 0.19 0.03
43 INT334538 Il18 Positive_regulation of Localization of IFN1@ 1 0.34 0.65 0
44 INT186376 IFNA1 Positive_regulation of Il18 1 0.02 0.76 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 16173. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 16173. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95
2 INT104550 Positive_regulation of Il18 67 0.70 55.14 17.48
3 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3
4 INT104547 Negative_regulation of Il18 24 0.59 17.89 6.01
5 INT124705 Binding of Il18 29 0.47 19.02 5.59
6 INT104549 Localization of Il18 16 0.78 13.01 4.64
7 INT165891 Transcription of Il18 5 0.69 7.63 4.37
8 INT141015 Regulation of Il18 14 0.59 6.3 3.73
9 INT165892 Positive_regulation of Transcription of Il18 3 0.66 3.72 2.38
10 INT104548 Positive_regulation of Positive_regulation of Il18 7 0.66 5.74 2.13
11 INT252286 Phosphorylation of Il18 2 0.79 2.22 0.86
12 INT178818 Regulation of Gene_expression of Il18 3 0.40 2.98 0.68
13 INT182050 Negative_regulation of Gene_expression of Il18 4 0.57 1.98 0.56
14 INT252287 Positive_regulation of Phosphorylation of Il18 1 0.13 0.59 0.49
15 INT205689 Protein_catabolism of Il18 2 0.23 0.8 0.47
16 INT205684 Negative_regulation of Localization of Il18 1 0.13 0.61 0.39
17 INT182047 Negative_regulation of Negative_regulation of Il18 1 0.42 0.74 0.37
18 INT205688 Regulation of Localization of Il18 1 0.08 0.59 0.34
19 INT298985 Regulation of Regulation of Il18 1 0.26 0.32 0.22
20 INT186274 Positive_regulation of Binding of Il18 1 0.16 0 0.14
21 INT178819 Negative_regulation of Positive_regulation of Il18 1 0.38 0.58 0.13
22 INT298987 Positive_regulation of Negative_regulation of Il18 1 0.45 0 0.07
23 INT298984 Negative_regulation of Binding of Il18 1 0.41 0.1 0.04
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