G:16193

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Official Symbol Il6
Aliases Il-6
EntrezGene 16193
UniProt Coming Soon
Unique Molecular Interactions 253
Total Molecular Interactions 354
Total Single Events 2809
Unique Interaction Partners 135

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Il6. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Il6. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Il6. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
2 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
3 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
4 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
5 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
6 INT182097 Binding of Il6 and Il1 4 0.07 4.67 1.55
7 INT135276 Gt(pU21)50Imeg Negative_regulation of Gene_expression of Il6 1 0.02 0.52 1.52
8 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
9 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46
10 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35
11 INT182096 Positive_regulation of Binding of Il6 and Il1 2 0.09 4.26 1.31
12 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
13 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
14 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
15 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14
16 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
17 INT182024 TNF Positive_regulation of Gene_expression of Il6 1 0.05 1.58 0.94
18 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
19 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
20 INT91272 Ifng Positive_regulation of Localization of Il6 1 0.29 0 0.88
21 INT76652 Cpe Positive_regulation of Il6 1 0.08 0 0.87
22 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86
23 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
24 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85
25 INT135278 Gt(pU21)50Imeg Negative_regulation of Positive_regulation of Il6 1 0.02 0.26 0.8
26 INT160411 Tat Positive_regulation of Il6 1 0.17 0.89 0.8
27 INT135277 Gt(pU21)50Imeg Negative_regulation of Il6 1 0.02 0.23 0.78
28 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
29 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
30 INT237325 Il6 Positive_regulation of Gene_expression of Ik 2 0.00 2.09 0.72
31 INT209057 Il6 Positive_regulation of Csf2 1 0.03 0.38 0.72
32 INT209039 Il6 Positive_regulation of Il17a 1 0.05 0.38 0.72
33 INT209056 Il6 Positive_regulation of Elf1 1 0.10 0.38 0.72
34 INT209059 Il6 Positive_regulation of Cxcl1 1 0.06 0.38 0.72
35 INT209060 Il6 Positive_regulation of Ccr1 1 0.01 0.38 0.72
36 INT260551 Igh-Dex Negative_regulation of Il6 1 0.09 0.37 0.72
37 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
38 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
39 INT325270 Il33 Positive_regulation of Gene_expression of Il6 1 0.20 1.59 0.69
40 INT76655 POMC Positive_regulation of Transcription of Il6 1 0.01 0 0.68
41 INT76654 Cpe Positive_regulation of Transcription of Il6 1 0.05 0 0.68
42 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
43 INT82384 Penk Positive_regulation of Gene_expression of Il6 1 0.15 0 0.66
44 INT209054 Il17a Positive_regulation of Gene_expression of Il6 1 0.10 0.45 0.65
45 INT209055 S100a8 Positive_regulation of Gene_expression of Il6 1 0.01 0.45 0.64
46 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63
47 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63
48 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
49 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
50 INT140890 Il10 Regulation of Il6 1 0.35 0.73 0.58
51 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
52 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58
53 INT297331 Apoe Negative_regulation of Gene_expression of Il6 1 0.14 0.61 0.57
54 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56
55 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
56 INT182021 Binding of TNF and Il6 2 0.04 0.74 0.53
57 INT261608 Il6 Negative_regulation of Gene_expression of TNF 1 0.03 1.27 0.53
58 INT269057 Il6 Positive_regulation of Crp 1 0.37 1.83 0.51
59 INT254125 Binding of Bcl2a1a and Tlr4 Positive_regulation of Localization of Il6 1 0.00 1.23 0.5
60 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49
61 INT339275 Il6 Regulation of KRT20 1 0.00 3.11 0.49
62 INT184105 Il6 Positive_regulation of Socs3 2 0.42 1.34 0.48
63 INT184094 Gene_expression of Socs3 Negative_regulation of Positive_regulation of Il6 1 0.12 1.49 0.48
64 INT351771 Il6 Positive_regulation of Localization of Crp 1 0.01 0.94 0.48
65 INT295270 S100a8 Regulation of Il6 1 0.01 0.56 0.48
66 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48
67 INT280826 Il6 Positive_regulation of Localization of Avp 1 0.01 0.64 0.47
68 INT260843 Il6 Positive_regulation of Localization of VEGFA 1 0.06 1.67 0.47
69 INT261603 Il6 Regulation of Gene_expression of Vcam1 1 0.16 1.74 0.46
70 INT288350 IFNA1 Positive_regulation of Localization of Il6 1 0.01 1.49 0.46
71 INT355672 Il6 Negative_regulation of Transcription of TNF 1 0.05 0.98 0.46
72 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45
73 INT142608 Apoe Regulation of Gene_expression of Il6 1 0.25 1.01 0.44
74 INT297689 Atn1 Regulation of Gene_expression of Il6 1 0.02 1.13 0.44
75 INT253145 Il6 Positive_regulation of Prkag1 1 0.11 0.73 0.44
76 INT184124 Socs3 Regulation of Il6 1 0.13 1.4 0.43
77 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43
78 INT352986 IL10 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43
79 INT352985 IL4 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.43
80 INT186373 Il6 Positive_regulation of Gene_expression of Il17a 2 0.14 1.52 0.42
81 INT239042 Il17a Negative_regulation of Gene_expression of Il6 1 0.03 0.82 0.42
82 INT231752 TNF Regulation of Il6 1 0.05 0.99 0.41
83 INT132730 Plat Positive_regulation of Il6 1 0.08 0.76 0.41
84 INT182100 Positive_regulation of Binding of TNF and Il6 1 0.03 0.66 0.41
85 INT316493 Il6 Positive_regulation of Il11ra1 1 0.64 1.69 0.4
86 INT165566 Tnf Regulation of Gene_expression of Il6 1 0.32 1.15 0.39
87 INT300547 Il6 Positive_regulation of Il21 1 0.02 0.78 0.39
88 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
89 INT303994 Il6 Positive_regulation of JAK2 1 0.03 0.41 0.37
90 INT303982 Il6 Positive_regulation of STAT3 1 0.03 0.41 0.37
91 INT323774 Binding of Il6 and OPA6 1 0.01 0.85 0.37
92 INT169646 Binding of Csrp1 and Il6 1 0.00 1.69 0.36
93 INT255804 DSP Negative_regulation of Gene_expression of Il6 1 0.01 0.36 0.36
94 INT204943 Il6 Regulation of Slc39a14 1 0.00 0.54 0.36
95 INT231748 LOC690550 Negative_regulation of Il6 1 0.01 0.95 0.36
96 INT110994 Tnf Regulation of Il6 1 0.17 0.67 0.36
97 INT184128 Socs3 Negative_regulation of Il6 1 0.12 1.14 0.36
98 INT255803 Cat Negative_regulation of Gene_expression of Il6 1 0.05 0.35 0.35
99 INT184142 Il6 Negative_regulation of Positive_regulation of TNF 1 0.02 0.48 0.35
100 INT320693 C5 Regulation of Gene_expression of Il6 1 0.04 2.15 0.34
101 INT303126 Nos2 Positive_regulation of Gene_expression of Il6 1 0.13 4.38 0.34
102 INT303127 Gpt Positive_regulation of Gene_expression of Il6 1 0.09 4.38 0.34
103 INT184082 Binding of Socs3 and Il6 1 0.11 0.49 0.33
104 INT269064 Il6 Positive_regulation of Gene_expression of Cybb 1 0.75 0.79 0.31
105 INT185319 Il6 Positive_regulation of Gene_expression of Tlr4 1 0.11 0.36 0.31
106 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
107 INT300855 Il1 Regulation of Il6 1 0.01 0.81 0.3
108 INT210935 Il6 Positive_regulation of Smpd1 1 0.02 0.46 0.3
109 INT93986 Rab8a Positive_regulation of Gene_expression of Il6 1 0.08 0.48 0.3
110 INT132732 Binding of Il1b and Il6 1 0.35 0.6 0.3
111 INT261605 Il6 Regulation of smc 1 0.02 1.19 0.3
112 INT178342 Positive_regulation of Tlr4 Positive_regulation of Il6 1 0.13 0.25 0.3
113 INT260841 Il6 Positive_regulation of Localization of NRP2 1 0.00 0.7 0.29
114 INT164433 Il12a Positive_regulation of Il6 1 0.01 1.71 0.29
115 INT301277 Il6 Positive_regulation of Positive_regulation of Clec5a 1 0.16 0.37 0.29
116 INT301287 Positive_regulation of Clec5a Positive_regulation of Gene_expression of Il6 1 0.14 0.58 0.29
117 INT294907 Il1 Positive_regulation of Il6 1 0.06 1.45 0.29
118 INT351770 Binding of Il6 and Ikbkb 1 0.10 1.06 0.29
119 INT164431 Ifng Positive_regulation of Il6 1 0.01 1.71 0.29
120 INT184141 Il6 Positive_regulation of Gene_expression of IFNA1 1 0.01 0.43 0.28
121 INT182019 Il6 Negative_regulation of Gene_expression of Tnfrsf11b 1 0.22 0.22 0.28
122 INT285241 Binding of Crp and Il6 1 0.00 1.78 0.27
123 INT301276 Il6 Positive_regulation of Gene_expression of Tnfrsf11a 1 0.06 0.37 0.26
124 INT301280 Il6 Positive_regulation of Gene_expression of Acp5 1 0.04 0.37 0.26
125 INT301291 Il6 Positive_regulation of Gene_expression of TNF 1 0.01 0.37 0.26
126 INT269060 Il6 Positive_regulation of Cybb 1 0.75 0.65 0.26
127 INT300958 IL1B Positive_regulation of Il6 1 0.04 0.25 0.25
128 INT346912 Il6 Positive_regulation of Gene_expression of Il4 1 0.07 0.62 0.24
129 INT226911 Slc11a1 Positive_regulation of Gene_expression of Il6 1 0.09 1.12 0.24
130 INT344797 Gene_expression of Il6 Negative_regulation of Mmp9 1 0.01 0.41 0.24
131 INT333274 Binding of Tlr4 and Tlr4 Positive_regulation of Localization of Il6 1 0.21 0.59 0.23
132 INT269066 Binding of Hspa8 and Il6 1 0.00 0.74 0.23
133 INT289246 Il6 Positive_regulation of Gopc 1 0.06 1 0.22
134 INT182020 Tnfrsf11b Regulation of Il6 1 0.27 0.16 0.22
135 INT276968 Il6 Positive_regulation of Gene_expression of Stat3 2 0.20 1.54 0.21
136 INT307765 Myoz1 Positive_regulation of Gene_expression of Il6 1 0.01 0.71 0.21
137 INT329323 ecs Positive_regulation of Gene_expression of Il6 1 0.00 0.52 0.21
138 INT307764 Myoz1 Positive_regulation of Transcription of Il6 1 0.01 0.72 0.21
139 INT316054 Eif1 Positive_regulation of Il6 1 0.00 0.78 0.21
140 INT316062 Ps Positive_regulation of Il6 1 0.04 0.77 0.21
141 INT314070 Gopc Negative_regulation of Il6 1 0.10 0.63 0.21
142 INT171972 Tnfsf11 Positive_regulation of Gene_expression of Il6 1 0.08 0.21 0.21
143 INT314076 Peo1 Negative_regulation of Il6 1 0.35 0.62 0.21
144 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21
145 INT265603 Msc Positive_regulation of Gene_expression of Il6 1 0.16 1.79 0.2
146 INT237202 LGALS4 Positive_regulation of Localization of Il6 1 0.10 0.83 0.2
147 INT185323 TNF Negative_regulation of Positive_regulation of Il6 1 0.02 0.5 0.2
148 INT253128 Il6 Positive_regulation of Gene_expression of Ins1 1 0.14 3.2 0.19
149 INT237194 LGALS4 Positive_regulation of Gene_expression of Il6 1 0.07 0.96 0.19
150 INT280839 Il6 Positive_regulation of Gene_expression of Crh 1 0.09 0.1 0.19
151 INT269071 Binding of IL6 and Il6 1 0.40 0.73 0.19
152 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19
153 INT210933 Tlr4 Regulation of Il6 1 0.19 0.33 0.18
154 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18
155 INT289251 Ptpn11 Regulation of Il6 1 0.09 0.86 0.18
156 INT290672 Stat3 Negative_regulation of Il6 1 0.08 0.4 0.18
157 INT289241 Cish Regulation of Il6 1 0.03 0.85 0.18
158 INT226521 IL19 Positive_regulation of Gene_expression of Il6 1 0.01 0.41 0.17
159 INT253127 Il6 Regulation of Gene_expression of Ptpn1 1 0.24 1.31 0.17
160 INT215094 Il6 Positive_regulation of Hmgb1 1 0.18 1.84 0.17
161 INT261577 Nos2 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.16
162 INT49200 Binding of Il6 and Pomc 1 0.19 0.2 0.16
163 INT249599 Ifng Positive_regulation of Gene_expression of Il6 1 0.15 0.38 0.16
164 INT289255 Il6 Positive_regulation of Gene_expression of VEGFA 1 0.06 1.3 0.15
165 INT316479 Il6 Positive_regulation of Snai1 1 0.24 0.33 0.15
166 INT347339 Binding of Il6 and S100a9 1 0.29 0.46 0.15
167 INT316482 Il6 Positive_regulation of Cdh1 1 0.03 0.33 0.15
168 INT289256 Il6 Positive_regulation of VEGFA 1 0.05 1.3 0.15
169 INT253123 Il6 Positive_regulation of Phosphorylation of Tbc1d4 1 0.38 0.63 0.15
170 INT289248 Il6 Positive_regulation of Gene_expression of Il21 1 0.06 0.69 0.15
171 INT316490 Il6 Positive_regulation of Positive_regulation of Stat3 1 0.50 0.33 0.15
172 INT347337 Binding of Il6 and S100a8 1 0.29 0.46 0.15
173 INT188700 Il6 Positive_regulation of H2-Eb1 1 0.01 0.18 0.14
174 INT188697 Il6 Positive_regulation of Cd40 1 0.05 0.18 0.14
175 INT188701 Il6 Positive_regulation of Cd86 1 0.12 0.18 0.14
176 INT269054 Positive_regulation of Il6 Positive_regulation of Cybb 1 0.54 0.3 0.14
177 INT178351 Binding of Il6 and Hp 1 0.00 0.61 0.14
178 INT269070 Regulation of Il6 Positive_regulation of Cybb 1 0.29 0.3 0.14
179 INT327322 Mapkapk2 Regulation of Il6 1 0.02 0.26 0.13
180 INT75739 Ltf Negative_regulation of Il6 1 0.35 0.39 0.13
181 INT300859 Il6 Positive_regulation of Ngf 1 0.18 0.3 0.12
182 INT333764 Il6 Regulation of Gene_expression of Il6ra 1 0.02 0.52 0.12
183 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12
184 INT75737 Ltf Negative_regulation of Gene_expression of Il6 1 0.35 0.32 0.12
185 INT300857 Il6 Positive_regulation of Bdnf 1 0.09 0.3 0.12
186 INT300872 Bdnf Positive_regulation of Il6 1 0.09 0.24 0.12
187 INT269055 Il6 Positive_regulation of Gene_expression of Gopc 1 0.21 0.06 0.12
188 INT333759 Il6 Positive_regulation of Il27 1 0.09 0.68 0.12
189 INT300858 Ngf Positive_regulation of Il6 1 0.17 0.24 0.12
190 INT300545 Il6 Positive_regulation of Gene_expression of Il1r1 1 0.02 0.42 0.11
191 INT321862 Timp1 Negative_regulation of Il6 1 0.12 0.79 0.11
192 INT182023 Binding of TNF and Positive_regulation of Gene_expression of Il6 1 0.05 0.07 0.11
193 INT253151 Ins1 Negative_regulation of Il6 Positive_regulation of Prkag1 1 0.02 0.12 0.1
194 INT289249 Il6 Regulation of Gene_expression of Ptger2 1 0.01 0.77 0.1
195 INT289242 Il6 Positive_regulation of Gene_expression of Prtn3 1 0.00 0.5 0.09
196 INT253135 Ins1 Regulation of Il6 1 0.13 0.42 0.09
197 INT215095 Negative_regulation of Il6 Positive_regulation of Hmgb1 1 0.13 1.03 0.09
198 INT289254 Il6 Regulation of Gene_expression of VEGFA 1 0.05 1.32 0.09
199 INT253131 Il6 Regulation of Phosphorylation of Akt1 1 0.14 0.25 0.09
200 INT289243 Il6 Positive_regulation of Prtn3 1 0.00 0.5 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 16193. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 16193. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
2 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
3 INT11937 Localization of Il6 228 0.81 139.83 64.39
4 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
5 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
6 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58
7 INT9655 Regulation of Il6 98 0.62 70.92 31.95
8 INT49985 Transcription of Il6 62 0.72 40.13 20.29
9 INT11938 Positive_regulation of Localization of Il6 61 0.70 35.72 18.25
10 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71
11 INT49376 Negative_regulation of Localization of Il6 37 0.59 12.66 14.99
12 INT54763 Binding of Il6 82 0.48 63.27 12.89
13 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59
14 INT87139 Negative_regulation of Positive_regulation of Il6 18 0.59 10.65 7.76
15 INT49375 Regulation of Localization of Il6 16 0.62 4.54 5.08
16 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53
17 INT174687 Regulation of Positive_regulation of Il6 10 0.61 9.07 2.61
18 INT52197 Negative_regulation of Transcription of Il6 8 0.43 3.8 2.05
19 INT135275 Regulation of Negative_regulation of Il6 4 0.45 0.89 1.67
20 INT216932 Positive_regulation of Negative_regulation of Il6 3 0.38 4.88 1.55
21 INT192851 Phosphorylation of Il6 7 0.68 3.12 0.82
22 INT300843 Regulation of Transcription of Il6 3 0.37 3.4 0.76
23 INT52196 Negative_regulation of Regulation of Il6 3 0.42 3.42 0.74
24 INT261602 Positive_regulation of Binding of Il6 2 0.50 1.75 0.62
25 INT138730 Negative_regulation of Negative_regulation of Il6 3 0.09 1.04 0.61
26 INT220268 Regulation of Regulation of Il6 2 0.12 0.89 0.49
27 INT285471 Negative_regulation of Binding of Il6 2 0.21 1.33 0.41
28 INT194162 Protein_catabolism of Il6 2 0.12 0.79 0.27
29 INT211287 Regulation of Binding of Il6 1 0.06 0.1 0.27
30 INT201071 Positive_regulation of Regulation of Il6 2 0.39 0.45 0.25
31 INT253097 Negative_regulation of Phosphorylation of Il6 1 0.35 0.23 0.06
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