G:16333

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Official Symbol Ins1
Aliases Ins-1, Ins2-rs1
EntrezGene 16333
UniProt Coming Soon
Unique Molecular Interactions 179
Total Molecular Interactions 264
Total Single Events 2339
Unique Interaction Partners 89

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Ins1. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Ins1. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Ins1. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
2 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
3 INT18324 Sst Negative_regulation of Localization of Ins1 2 0.46 1.09 1.24
4 INT19494 Pomc Positive_regulation of Localization of Ins1 2 0.62 0.38 1.02
5 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
6 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
7 INT115656 Glp1r Positive_regulation of Localization of Ins1 2 0.42 5.23 0.91
8 INT54854 Sorbs1 Regulation of Ins1 1 0.34 0.23 0.9
9 INT26991 Pomc Negative_regulation of Localization of Ins1 1 0.38 0 0.89
10 INT18325 Grem2 Positive_regulation of Ins1 1 0.02 0.9 0.88
11 INT26987 Pomc Regulation of Ins1 1 0.40 0 0.87
12 INT26984 Cpe Regulation of Ins1 1 0.02 0 0.87
13 INT115655 Glp1r Positive_regulation of Ins1 1 0.42 0 0.84
14 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83
15 INT164996 Ins1 Regulation of Gria2 1 0.05 0.05 0.76
16 INT26983 Cpe Regulation of Localization of Ins1 1 0.02 0 0.75
17 INT31417 Cocia8 Positive_regulation of Ins1 1 0.01 0 0.7
18 INT31415 Regulation of Cocia8 Positive_regulation of Ins1 1 0.00 0 0.7
19 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63
20 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
21 INT340291 Ea1 Regulation of Gene_expression of Ins1 1 0.03 0.62 0.46
22 INT340292 Ea1 Positive_regulation of Ins1 1 0.04 0.6 0.43
23 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43
24 INT51167 Defb35 Regulation of Localization of Ins1 1 0.02 0.08 0.42
25 INT323491 Olfr781 Positive_regulation of Localization of Ins1 1 0.01 0.87 0.4
26 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
27 INT309003 Ins1 Positive_regulation of TNF 1 0.05 1.74 0.35
28 INT253944 Positive_regulation of Prkca Positive_regulation of Gene_expression of Ins1 1 0.01 1.53 0.35
29 INT24530 Gal Negative_regulation of Localization of Ins1 1 0.16 0.18 0.34
30 INT323502 Ghrl Positive_regulation of Localization of Ins1 1 0.15 1.58 0.33
31 INT282420 Spp1 Positive_regulation of Ins1 1 0.20 1.25 0.32
32 INT227339 Binding of TNF and Ins1 1 0.28 4.08 0.31
33 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31
34 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29
35 INT26942 Adra2c Positive_regulation of Localization of Ins1 1 0.13 0 0.28
36 INT337884 Ins1 Negative_regulation of Gene_expression of Nr2f2 1 0.11 0.08 0.27
37 INT337896 Ins1 Negative_regulation of Nr2f2 1 0.15 0.1 0.27
38 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27
39 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26
40 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26
41 INT24529 Gal Regulation of Localization of Ins1 1 0.23 0.1 0.25
42 INT309000 Ins1 Positive_regulation of Gene_expression of Mmp9 1 0.20 1.03 0.22
43 INT309002 Ins1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.22
44 INT228457 Negative_regulation of Ins1 Positive_regulation of Gene_expression of Trpv1 1 0.05 1.01 0.21
45 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
46 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
47 INT129364 Ea1 Positive_regulation of Localization of Ins1 1 0.02 0.49 0.2
48 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
49 INT253128 Il6 Positive_regulation of Gene_expression of Ins1 1 0.14 3.2 0.19
50 INT308646 Car2 Regulation of Gene_expression of Ins1 1 0.00 0 0.19
51 INT226903 Txnl1 Regulation of Ins1 1 0.01 0.59 0.19
52 INT55295 Slc2a1 Regulation of Ins1 1 0.17 0.41 0.19
53 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19
54 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 0.01 0 0.19
55 INT55296 Slc2a4 Regulation of Ins1 1 0.17 0.41 0.19
56 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17
57 INT323494 Ghrl Regulation of Ins1 1 0.16 2.12 0.17
58 INT215901 Ins1 Positive_regulation of Igfals 1 0.02 0.81 0.15
59 INT337894 Ins1 Regulation of Gene_expression of Nr2f2 1 0.07 0.22 0.15
60 INT253122 Ins1 Positive_regulation of Akt1 2 0.15 1.81 0.14
61 INT240872 Ins1 Negative_regulation of Gene_expression of Ppargc1a 1 0.13 0.47 0.14
62 INT337900 Ins1 Regulation of MC3R 1 0.12 0.07 0.12
63 INT24531 Sst Regulation of Localization of Ins1 1 0.24 0.1 0.12
64 INT236588 Binding of Esr1 and Ins1 1 0.05 0.73 0.12
65 INT317259 Pyy Positive_regulation of Ins1 1 0.02 0.33 0.12
66 INT228455 Ins1 Positive_regulation of Prkca 1 0.02 0.98 0.12
67 INT228458 Ins1 Positive_regulation of Trpv1 1 0.06 0.98 0.12
68 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
69 INT240941 Binding of Akt1 and Ins1 1 0.06 0.75 0.11
70 INT337897 Ins1 Positive_regulation of Gene_expression of Pomc 1 0.11 0.27 0.11
71 INT301637 Positive_regulation of Ros1 Positive_regulation of Phosphorylation of Ins1 1 0.00 0.91 0.1
72 INT253124 Ins1 Negative_regulation of Positive_regulation of Prkag1 1 0.02 0.12 0.1
73 INT253151 Ins1 Negative_regulation of Il6 Positive_regulation of Prkag1 1 0.02 0.12 0.1
74 INT332637 Negative_regulation of Dpp4 Negative_regulation of Localization of Ins1 1 0.06 1.66 0.1
75 INT255754 Negative_regulation of Ins1 Positive_regulation of Akt1 1 0.14 1.73 0.1
76 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09
77 INT253135 Ins1 Regulation of Il6 1 0.13 0.42 0.09
78 INT253141 Ins1 Positive_regulation of Phosphorylation of Tbc1d4 1 0.09 0.29 0.09
79 INT240962 Positive_regulation of Ffar1 Positive_regulation of Localization of Ins1 1 0.10 0.09 0.09
80 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09
81 INT253148 Ins1 Regulation of Phosphorylation of Tbc1d4 1 0.09 0.42 0.09
82 INT242961 Ffar1 Regulation of Localization of Ins1 1 0.23 2.08 0.08
83 INT246840 Binding of Ins1 and Gopc 1 0.05 0.15 0.08
84 INT67243 Ncoa6 Positive_regulation of Localization of Ins1 1 0.22 0.1 0.08
85 INT160730 Galr2 Regulation of Localization of Ins1 1 0.06 0 0.08
86 INT337888 Ins1 Positive_regulation of Gene_expression of Ldlrap1 1 0.06 0 0.08
87 INT337889 Binding of Ins1 and Ldlrap1 1 0.06 0.27 0.08
88 INT301656 Ins1 Positive_regulation of Srebf1 1 0.02 0.73 0.07
89 INT253138 Il6 Regulation of Ins1 1 0.13 0.76 0.07
90 INT323486 Ghrl Regulation of Localization of Ins1 1 0.21 2.07 0.07
91 INT323490 Ghsr Regulation of Ins1 1 0.26 0.54 0.07
92 INT301623 Ins1 Positive_regulation of Slc27a2 1 0.01 0.37 0.07
93 INT240877 Negative_regulation of Ros1 Positive_regulation of Phosphorylation of Ins1 1 0.03 0.2 0.07
94 INT301658 Ins1 Positive_regulation of Slc27a4 1 0.01 0.37 0.07
95 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06
96 INT55297 Gene_expression of Slc2a4 Positive_regulation of Ins1 1 0.19 0.36 0.06
97 INT246842 Binding of Ins1 and Irs1 1 0.16 0.63 0.06
98 INT236147 Binding of Ins1 and Ptpn1 2 0.03 1.29 0.05
99 INT332641 Binding of PPARG and Ins1 1 0.12 1.05 0.05
100 INT253130 Regulation of Ins1 Positive_regulation of Akt1 1 0.08 0.08 0.05
101 INT240873 Ins1 Positive_regulation of Phosphorylation of Irs1 1 0.05 0 0.05
102 INT270664 Ensa Positive_regulation of Localization of Ins1 1 0.02 0.89 0.05
103 INT323498 Ghsr Positive_regulation of Ins1 1 0.24 0.23 0.05
104 INT178969 Slc7a2 Regulation of Ins1 1 0.01 0.56 0.05
105 INT323482 Ghrl Negative_regulation of Ins1 1 0.13 0.24 0.05
106 INT268326 Ins1 Regulation of Gene_expression of VEGFA 1 0.01 0.32 0.05
107 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
108 INT253149 Regulation of Ins1 Positive_regulation of Prkag1 1 0.03 0.08 0.05
109 INT323485 Ghrl Negative_regulation of Localization of Ins1 1 0.15 1.99 0.05
110 INT329219 Ins1 Positive_regulation of Gene_expression of Slc2a4 1 0.04 0.93 0.05
111 INT253133 Ins1 Positive_regulation of Prkag1 1 0.04 0.08 0.04
112 INT230818 Ins1 Positive_regulation of Gene_expression of Agt 1 0.07 1.11 0.04
113 INT240888 Sod1 Regulation of Gene_expression of Ins1 1 0.08 0.18 0.04
114 INT242960 Binding of Ins1 and Ffar1 1 0.19 1.33 0.04
115 INT256578 Bglap Positive_regulation of Gene_expression of Ins1 1 0.38 0.43 0.04
116 INT256571 Bglap Positive_regulation of Localization of Ins1 1 0.53 0.25 0.04
117 INT240906 Ros1 Positive_regulation of Gene_expression of Ins1 1 0.03 0.51 0.04
118 INT230820 Ins1 Positive_regulation of ras 1 0.12 1.1 0.04
119 INT230817 Ins1 Positive_regulation of Regulation of Agt 1 0.07 1.11 0.04
120 INT256577 Bglap Regulation of Localization of Ins1 1 0.47 0.44 0.04
121 INT332640 Glp1r Regulation of Localization of Ins1 1 0.04 0.52 0.04
122 INT314771 Glp1r Positive_regulation of Gene_expression of Ins1 2 0.04 1.23 0.03
123 INT323483 Slc2a2 Positive_regulation of Localization of Ins1 1 0.07 0.1 0.03
124 INT246838 Iars Positive_regulation of Phosphorylation of Ins1 1 0.05 0.86 0.03
125 INT337901 Ins1 Regulation of Ins1 Regulation of Nr2f2 1 0.02 0 0.03
126 INT323497 Negative_regulation of Ghsr Positive_regulation of Ins1 1 0.24 0 0.03
127 INT73426 GRP Positive_regulation of Localization of Ins1 1 0.17 0 0.03
128 INT246834 Phosphorylation of Irs1 Negative_regulation of Ins1 1 0.14 0.44 0.03
129 INT246835 Iars Positive_regulation of Ins1 1 0.06 0.86 0.03
130 INT253134 Il6 Positive_regulation of Ins1 1 0.13 0.12 0.03
131 INT73424 Grp Positive_regulation of Localization of Ins1 1 0.40 0 0.03
132 INT253136 Binding of Il6 and Ins1 1 0.11 0.6 0.03
133 INT337887 Ins1 Regulation of Nr2f2 1 0.07 0 0.03
134 INT253152 Il6 Regulation of Il6 Regulation of Ins1 1 0.07 0.36 0
135 INT256573 Gopc Regulation of Ins1 1 0.10 0.71 0
136 INT335013 Fgf21 Positive_regulation of Localization of Ins1 1 0.06 0.58 0
137 INT174285 Agrp Positive_regulation of Positive_regulation of Ins1 1 0.09 0.49 0
138 INT174292 Ins1 Positive_regulation of Pomc 1 0.02 0.47 0
139 INT305163 Ins1 Positive_regulation of Phosphorylation of Olfr473 1 0.01 1.02 0
140 INT121478 Binding of Pde3a and Positive_regulation of Localization of Ins1 1 0.24 0 0
141 INT174286 Agrp Positive_regulation of Ins1 1 0.09 0.49 0
142 INT253146 Il6 Regulation of Gene_expression of Ins1 1 0.13 0.36 0
143 INT323489 Ghrl Regulation of Regulation of Ins1 1 0.09 0.07 0
144 INT332636 Binding of Glp1r and Positive_regulation of Localization of Ins1 1 0.03 0.47 0
145 INT226207 Binding of Ins1 and Positive_regulation of Pik3cb 1 0.01 2.08 0
146 INT255738 hs Positive_regulation of Phosphorylation of Ins1 1 0.05 1.34 0
147 INT174284 Ins1 Positive_regulation of Npy 1 0.08 0.45 0
148 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
149 INT323493 Binding of Ins1 and Ghrl 1 0.12 1.25 0
150 INT321718 Ins1 Regulation of Gene_expression of Pten 1 0.04 0.23 0
151 INT332634 Dpp4 Positive_regulation of Localization of Ins1 1 0.06 0.76 0
152 INT270657 Casp8 Regulation of Localization of Ins1 1 0.03 0.68 0
153 INT301629 Ins1 Positive_regulation of Mlxipl 1 0.00 0.36 0
154 INT335012 Fgf21 Positive_regulation of Gene_expression of Ins1 1 0.06 0.57 0
155 INT310276 Gcg Positive_regulation of Localization of Ins1 1 0.25 0 0
156 INT121479 Twist1 Negative_regulation of Ins1 1 0.10 0 0
157 INT337885 Ins1 Positive_regulation of Gene_expression of Nr2f2 1 0.18 0.27 0
158 INT242959 Ffar1 Positive_regulation of Localization of Ins1 1 0.26 0.97 0
159 INT323499 Ghrl Positive_regulation of Ins1 1 0.21 0.25 0
160 INT240942 Ins1 Regulation of Transcription of Pck1 1 0.08 0.73 0
161 INT301650 Ins1 Positive_regulation of Dbi 1 0.02 0.23 0
162 INT323492 Ins1 Regulation of Gene_expression of Pck1 1 0.08 0.16 0
163 INT323253 Binding of Ins1 and Isl1 1 0.00 0.59 0
164 INT329224 Prkag1 Positive_regulation of Localization of Ins1 1 0.03 1.14 0
165 INT321716 Ins1 Positive_regulation of Ppp1r13b 1 0.02 0.05 0
166 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
167 INT332627 Positive_regulation of Ins1 Positive_regulation of Phosphorylation of Hk2 1 0.01 0.83 0
168 INT19495 Pomc Negative_regulation of Ins1 1 0.25 0.27 0
169 INT305164 Ins1 Regulation of Phosphorylation of Olfr473 1 0.01 0.49 0
170 INT256572 Bglap Regulation of Gene_expression of Ins1 1 0.47 0.44 0
171 INT291173 Ins1 Regulation of Baat 1 0.12 0.83 0
172 INT256579 Negative_regulation of Bglap Negative_regulation of Localization of Ins1 1 0.33 0.38 0
173 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
174 INT321713 Ins1 Positive_regulation of Irs1 1 0.04 0.05 0
175 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
176 INT256574 Lep Regulation of Ins1 1 0.36 0.83 0
177 INT255751 hs Regulation of Ins1 1 0.05 1.24 0
178 INT337893 Ins1 Positive_regulation of Nr2f2 1 0.12 0.16 0
179 INT321717 Positive_regulation of Ins1 Positive_regulation of Gtf3a 1 0.00 0.17 0
180 INT174289 Ins1 Positive_regulation of Agrp 1 0.09 0.45 0
181 INT321723 Ins1 Positive_regulation of Gtf3a 1 0.00 0.34 0
182 INT178967 Slc7a2 Regulation of Localization of Ins1 1 0.01 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 16333. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 16333. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT3214 Localization of Ins1 527 0.80 196.9 79.26
2 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32
3 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63
4 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15
5 INT3217 Regulation of Ins1 154 0.62 87.11 27.29
6 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04
7 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59
8 INT8742 Regulation of Localization of Ins1 65 0.61 14.98 16.43
9 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26
10 INT74250 Negative_regulation of Gene_expression of Ins1 47 0.40 39.27 5.37
11 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85
12 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51
13 INT31412 Negative_regulation of Positive_regulation of Ins1 10 0.40 7.14 2.82
14 INT28739 Binding of Ins1 35 0.37 22.43 2.14
15 INT8741 Regulation of Positive_regulation of Ins1 5 0.41 1.36 1.67
16 INT18586 Negative_regulation of Regulation of Ins1 8 0.43 2.89 1.15
17 INT54851 Positive_regulation of Positive_regulation of Ins1 6 0.46 1.22 1.12
18 INT46470 Positive_regulation of Regulation of Ins1 8 0.46 4.51 1.01
19 INT253106 Negative_regulation of Phosphorylation of Ins1 6 0.17 5.62 0.87
20 INT20145 Regulation of Negative_regulation of Ins1 1 0.27 0.68 0.65
21 INT83658 Positive_regulation of Negative_regulation of Ins1 5 0.69 2.48 0.63
22 INT130072 Transcription of Ins1 12 0.54 6.84 0.62
23 INT240920 Positive_regulation of Phosphorylation of Ins1 12 0.42 10.71 0.52
24 INT230812 Regulation of Regulation of Ins1 6 0.28 2.46 0.44
25 INT236141 Positive_regulation of Binding of Ins1 3 0.27 3 0.23
26 INT144096 Regulation of Transcription of Ins1 2 0.35 0.86 0.15
27 INT174276 Negative_regulation of Negative_regulation of Ins1 5 0.38 3.19 0.11
28 INT130071 Negative_regulation of Transcription of Ins1 3 0.42 1.09 0.08
29 INT246822 Negative_regulation of Binding of Ins1 2 0.13 0.65 0.07
30 INT230811 Regulation of Phosphorylation of Ins1 1 0.08 0.53 0.05
31 INT236582 Regulation of Binding of Ins1 2 0.28 2.25 0.03
32 INT224977 Positive_regulation of Transcription of Ins1 2 0.16 0.58 0
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