G:16846

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Official Symbol Lep
Aliases ob, obese
EntrezGene 16846
UniProt Coming Soon
Unique Molecular Interactions 75
Total Molecular Interactions 98
Total Single Events 499
Unique Interaction Partners 52

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Lep. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Lep. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Lep. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
2 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
3 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
4 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
5 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
6 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
7 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
8 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
9 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
10 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
11 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
12 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
13 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
14 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
15 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
16 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
17 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
18 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
19 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
20 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
21 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
22 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
23 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
24 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
25 INT303991 Lep Negative_regulation of SELL 1 0.04 0.35 0.2
26 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
27 INT333888 Lep Regulation of Localization of GAG 1 0.68 0.38 0.19
28 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
29 INT303981 Lep Positive_regulation of Localization of CXCL1 1 0.02 0.34 0.18
30 INT303967 Lep Positive_regulation of Gene_expression of Icam1 1 0.24 0.58 0.16
31 INT303980 Lep Positive_regulation of Transcription of IL2 1 0.10 0.24 0.16
32 INT214141 Binding of Lep and Lepr 1 0.32 0.82 0.12
33 INT303989 Lep Positive_regulation of IL12A 1 0.05 0.39 0.11
34 INT303966 Lep Regulation of Il1 2 0.09 0.41 0.1
35 INT303990 Binding of Lep and Positive_regulation of Gene_expression of LPL 1 0.03 0.35 0.1
36 INT304000 Lep Negative_regulation of Positive_regulation of CASP8 1 0.04 0.25 0.1
37 INT213482 Lep Positive_regulation of Mapk1 1 0.06 0.08 0.09
38 INT303999 Lep Positive_regulation of Gene_expression of ITGA2 1 0.06 0.29 0.08
39 INT268325 Lep Positive_regulation of Ptgs2 1 0.09 0.39 0.08
40 INT303970 Lep Positive_regulation of Gene_expression of Itga2 1 0.09 0.29 0.08
41 INT303997 IL1RL1 Positive_regulation of Lep 1 0.01 0.2 0.07
42 INT214153 Lep Regulation of Transcription of Nucb2 1 0.35 0.15 0.06
43 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05
44 INT314135 Negative_regulation of Nos2 Positive_regulation of Lep 1 0.52 0.44 0.05
45 INT303986 Lep Positive_regulation of Gene_expression of TNF 1 0.49 0.29 0.04
46 INT303996 Lep Positive_regulation of Gene_expression of IL12A 1 0.08 0.29 0.04
47 INT303965 Lep Positive_regulation of Gene_expression of Il6 1 0.07 0.29 0.04
48 INT333885 Lep Positive_regulation of Il1 1 0.17 0.05 0.03
49 INT174290 Lep Positive_regulation of Pomc 2 0.50 0.47 0
50 INT305279 Lep Regulation of Gene_expression of Akt1 1 0.18 0.83 0
51 INT305273 Binding of Lep and Leprot 1 0.06 0.92 0
52 INT214139 Lep Regulation of Localization of Pomc 1 0.20 0.4 0
53 INT214155 Lep Regulation of Gene_expression of Pomc 1 0.20 0.4 0
54 INT314133 Lep Positive_regulation of Gene_expression of Ppargc1a 1 0.51 0.79 0
55 INT305278 Lep Negative_regulation of Obsty1 1 0.07 0.94 0
56 INT303963 Lep Positive_regulation of Gene_expression of Il7 1 0.02 0.41 0
57 INT174287 Agrp Positive_regulation of Lep 1 0.19 0.49 0
58 INT163585 Lep Positive_regulation of Gene_expression of Epm2a 1 0.03 0.14 0
59 INT305272 Gene_expression of Lep Positive_regulation of Positive_regulation of Stat3 1 0.40 0.46 0
60 INT305264 Positive_regulation of Binding of Lep and Leprot 1 0.08 0.93 0
61 INT305280 Lep Positive_regulation of Gene_expression of Leprot 1 0.07 1.03 0
62 INT305258 Lep Regulation of Gene_expression of Stat3 1 0.24 0.92 0
63 INT305277 Positive_regulation of Binding of Lep and Obsty1 1 0.08 0.93 0
64 INT305271 Binding of Lep and Obsty1 1 0.06 4.86 0
65 INT174288 Lep Positive_regulation of Npy 1 0.36 0.45 0
66 INT305267 Lep Regulation of Obsty1 1 0.04 0.97 0
67 INT174283 Lep Negative_regulation of Agrp 1 0.32 0.48 0
68 INT305261 Gene_expression of Lep Positive_regulation of Gene_expression of Stat3 1 0.40 0.46 0
69 INT163584 Lep Positive_regulation of Epm2a 1 0.03 0.13 0
70 INT174291 Lep Positive_regulation of Agrp 1 0.40 0.45 0
71 INT305269 Lep Positive_regulation of Phosphorylation of Stat3 1 0.40 1.03 0
72 INT174282 Negative_regulation of Lep Positive_regulation of Agrp 1 0.35 0.27 0
73 INT256574 Lep Regulation of Ins1 1 0.36 0.83 0
74 INT307212 Ide Regulation of Lep 1 0.00 0.51 0
75 INT305270 Lep Negative_regulation of Localization of Car2 1 0.16 1.28 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 16846. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 16846. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
2 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
3 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
4 INT91338 Binding of Lep 31 0.48 26.86 5.39
5 INT102935 Regulation of Lep 31 0.60 18.47 5.24
6 INT163581 Localization of Lep 27 0.79 18.99 4.08
7 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
8 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
9 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
10 INT213465 Transcription of Lep 4 0.68 2.11 1.15
11 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
12 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
13 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
14 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
15 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
16 INT102934 Positive_regulation of Regulation of Lep 2 0.50 0.55 0.42
17 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42
18 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31
19 INT213467 Negative_regulation of Localization of Lep 2 0.40 1.11 0.31
20 INT333880 Protein_catabolism of Lep 1 0.65 0.34 0.17
21 INT333882 Regulation of Binding of Lep 1 0.45 0.07 0.16
22 INT213475 Negative_regulation of Positive_regulation of Lep 2 0.40 1.79 0.07
23 INT213466 Negative_regulation of Regulation of Lep 1 0.41 0 0.06
24 INT150408 Regulation of Regulation of Lep 1 0.27 0 0
25 INT305226 Negative_regulation of Phosphorylation of Lep 1 0.42 1.89 0
26 INT305239 Positive_regulation of Phosphorylation of Lep 1 0.43 1.09 0
27 INT332954 Regulation of Transcription of Lep 1 0.11 1.4 0
28 INT174279 Positive_regulation of Negative_regulation of Lep 1 0.46 0.16 0
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