G:18126

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Official Symbol Nos2
Aliases iNOS, Nos-2, Nos2a, i-NOS, NOS-II
EntrezGene 18126
UniProt Coming Soon
Unique Molecular Interactions 100
Total Molecular Interactions 127
Total Single Events 1789
Unique Interaction Partners 66

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Nos2. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Nos2. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Nos2. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
2 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
3 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
4 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
5 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
6 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
7 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
8 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
9 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
10 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
11 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
12 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
13 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
14 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
15 INT135829 Cat2 Regulation of Nos2 1 0.47 0 0.65
16 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
17 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
18 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
19 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
20 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
21 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
22 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
23 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
24 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43
25 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
26 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
27 INT135972 Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.41
28 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4
29 INT168462 Sult1a1 Negative_regulation of Arr3 Positive_regulation of Nos2 1 0.05 1 0.4
30 INT168426 RYBP Regulation of Nos2 1 0.01 0.4 0.36
31 INT168424 Ptger2 Regulation of Binding of Nos2 1 0.22 0.52 0.36
32 INT152240 Nfasc Regulation of Gene_expression of Nos2 1 0.06 0.19 0.36
33 INT168423 Ptger2 Regulation of Nos2 1 0.13 0.52 0.36
34 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34
35 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
36 INT110758 Tnfaip8 Positive_regulation of Positive_regulation of Nos2 1 0.14 0.88 0.34
37 INT303126 Nos2 Positive_regulation of Gene_expression of Il6 1 0.13 4.38 0.34
38 INT110761 Tnfaip8 Positive_regulation of Nos2 1 0.13 0.88 0.34
39 INT354821 Nos2 Positive_regulation of Eif2ak2 1 0.06 0.64 0.3
40 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
41 INT228530 Gopc Positive_regulation of Gene_expression of Nos2 2 0.22 0.67 0.28
42 INT156439 Positive_regulation of Cpox Positive_regulation of Nos2 1 0.14 0.52 0.28
43 INT349506 S100a8 Positive_regulation of Gene_expression of Nos2 1 0.02 0.67 0.28
44 INT290708 Binding of Tlr4 and Cd200r1 Positive_regulation of Positive_regulation of Nos2 1 0.01 0.78 0.27
45 INT314305 Ptger2 Positive_regulation of Nos2 1 0.00 0.07 0.26
46 INT127101 Memo1 Negative_regulation of Gene_expression of Nos2 1 0.10 0.55 0.24
47 INT327321 Binding of Elavl1 and Nos2 1 0.05 0.6 0.24
48 INT327320 Positive_regulation of Binding of Elavl1 and Nos2 1 0.06 0.6 0.24
49 INT331767 Hand1 Positive_regulation of Nos2 1 0.08 0.48 0.23
50 INT201273 Nos2 Regulation of Nos1 1 0.17 0.99 0.23
51 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 0.27 0.34 0.22
52 INT159348 Binding of Nos1 and Nos2 1 0.23 0.29 0.22
53 INT159350 Zfp956 Negative_regulation of Nos2 1 0.03 0.3 0.21
54 INT183644 Nos2 Positive_regulation of Gene_expression of Macf1 1 0.05 0.84 0.21
55 INT135973 Dpys Negative_regulation of Gene_expression of Nos2 1 0.06 0.26 0.17
56 INT135974 S100a4 Negative_regulation of Nos2 1 0.00 0.26 0.17
57 INT135971 S100a4 Negative_regulation of Gene_expression of Nos2 1 0.00 0.26 0.17
58 INT119130 Binding of Nos2 and Ptgs2 1 0.33 0.07 0.17
59 INT331766 Binding of Arg1 and Nos2 1 0.17 0.6 0.17
60 INT135970 Dpys Negative_regulation of Nos2 1 0.05 0.25 0.17
61 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
62 INT290670 Binding of Nos2 and Ppara 1 0.17 0.41 0.16
63 INT261577 Nos2 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.16
64 INT303122 Nos2 Positive_regulation of Gene_expression of Gpt 1 0.37 1.86 0.16
65 INT303129 Nos2 Positive_regulation of Gene_expression of Gpt 1 0.17 1.86 0.16
66 INT199105 Decr1 Positive_regulation of Positive_regulation of Nos2 1 0.01 0.23 0.16
67 INT303128 Tnrc6a Regulation of Gene_expression of Nos2 1 0.00 0.57 0.14
68 INT156588 Hst1 Positive_regulation of Gene_expression of Nos2 1 0.27 0.48 0.12
69 INT212807 Rngtt Negative_regulation of Nos2 1 0.03 0.08 0.1
70 INT303125 Nos2 Positive_regulation of Gene_expression of Mpo 1 0.34 0.99 0.08
71 INT310310 Serpina10 Regulation of Gene_expression of Nos2 1 0.01 0.24 0.08
72 INT320659 Vsig2 Positive_regulation of Transcription of Nos2 1 0.07 0.65 0.07
73 INT297330 Apoe Positive_regulation of Gene_expression of Nos2 1 0.26 0.34 0.07
74 INT285602 Trib3 Regulation of Gene_expression of Nos2 1 0.00 0.48 0.07
75 INT186364 Binding of Irf2 and Nos2 1 0.04 1.02 0.07
76 INT234602 Tlr4 Positive_regulation of Transcription of Nos2 1 0.34 0.09 0.05
77 INT254161 Epo Positive_regulation of Nos2 1 0.37 0.54 0.05
78 INT314134 Negative_regulation of Nos2 Positive_regulation of Ucp3 1 0.36 0.45 0.05
79 INT314135 Negative_regulation of Nos2 Positive_regulation of Lep 1 0.52 0.44 0.05
80 INT186383 Binding of Nos2 and GORASP1 1 0.12 0.93 0.05
81 INT186350 Gtf3a Negative_regulation of Transcription of Nos2 1 0.00 0.77 0.04
82 INT186352 Il13 Negative_regulation of Transcription of Nos2 1 0.05 0.76 0.04
83 INT186362 Il4 Negative_regulation of Transcription of Nos2 1 0.04 0.77 0.04
84 INT186356 Gtf3a Regulation of Positive_regulation of Nos2 1 0.00 0.91 0.04
85 INT285603 Akt1 Regulation of Gene_expression of Nos2 1 0.02 0.48 0.04
86 INT186360 Stat6 Negative_regulation of Transcription of Nos2 1 0.08 0.78 0.04
87 INT314073 Peo1 Negative_regulation of Nos2 1 0.11 0.32 0.04
88 INT186348 Irf1 Regulation of Positive_regulation of Nos2 1 0.02 0.91 0.04
89 INT235233 Gopc Positive_regulation of Nos2 1 0.06 0.15 0.04
90 INT186387 IFNA1 Positive_regulation of Transcription of Nos2 1 0.03 0.7 0.04
91 INT314067 Stat1 Regulation of Nos2 1 0.13 0.2 0.03
92 INT314065 Peo1 Regulation of Nos2 1 0.18 0.2 0.03
93 INT186342 Il13 Negative_regulation of Positive_regulation of Nos2 1 0.03 0.65 0.03
94 INT108103 Mir1893 Negative_regulation of Gene_expression of Nos2 1 0.05 0.12 0
95 INT235075 Ptger2 Positive_regulation of Positive_regulation of Nos2 1 0.00 0.43 0
96 INT108104 Mir1893 Negative_regulation of Positive_regulation of Nos2 1 0.05 0.37 0
97 INT282288 Binding of Hmgcr and Nos2 1 0.03 1.99 0
98 INT295262 Tlr4 Positive_regulation of Positive_regulation of Nos2 1 0.07 0.19 0
99 INT186343 Irf1 Positive_regulation of Nos2 1 0.04 0.83 0
100 INT161416 Oprm1 Negative_regulation of Gene_expression of Nos2 1 0.33 0 0
101 INT186381 TNF Positive_regulation of Nos2 1 0.04 1.17 0
102 INT186389 IFNA1 Regulation of Positive_regulation of Nos2 1 0.02 1.38 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 18126. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 18126. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
2 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
3 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
4 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
5 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
6 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
7 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
8 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
9 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
10 INT116605 Binding of Nos2 28 0.37 16.88 8.18
11 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
12 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
13 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
14 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14
15 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83
16 INT89852 Localization of Nos2 22 0.78 14.89 2.56
17 INT144392 Negative_regulation of Negative_regulation of Nos2 2 0.42 1.83 1.24
18 INT89856 Positive_regulation of Localization of Nos2 6 0.49 1.79 0.9
19 INT92836 Regulation of Transcription of Nos2 3 0.58 1.79 0.85
20 INT229773 Positive_regulation of Regulation of Nos2 3 0.41 2.97 0.5
21 INT108735 Regulation of Localization of Nos2 3 0.42 0.52 0.46
22 INT186288 Negative_regulation of Binding of Nos2 3 0.35 1.08 0.42
23 INT149650 Protein_catabolism of Nos2 3 0.55 0.79 0.42
24 INT235457 Negative_regulation of Regulation of Nos2 3 0.42 1.55 0.39
25 INT227750 Positive_regulation of Binding of Nos2 1 0.18 0.8 0.23
26 INT183632 Phosphorylation of Nos2 3 0.61 0.79 0.15
27 INT161414 Negative_regulation of Localization of Nos2 2 0.30 0.9 0.13
28 INT291956 Positive_regulation of Negative_regulation of Nos2 1 0.41 0.54 0.08
29 INT149640 Regulation of Protein_catabolism of Nos2 1 0.23 0 0
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