G:18171

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Official Symbol Nr1i2
Aliases PXR, SXR, PXR1, mPXR, PXR.1, PXR.2
EntrezGene 18171
UniProt Coming Soon
Unique Molecular Interactions 67
Total Molecular Interactions 77
Total Single Events 238
Unique Interaction Partners 35

This page displays the top molecular interactions and top single events that were mentioned in the literature that are relevant to Nr1i2. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported that are relevant to Nr1i2. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to Nr1i2. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
2 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49
3 INT262220 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Abcc2 1 0.14 0.25 0.44
4 INT262205 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.33 0.11 0.38
5 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38
6 INT262182 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp7a1 1 0.23 0.36 0.36
7 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36
8 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34
9 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29
10 INT262144 Nr1h4 Positive_regulation of Positive_regulation of Nr1i2 1 0.19 0.19 0.27
11 INT262194 Rhof Positive_regulation of Nr1i2 1 0.15 0.64 0.27
12 INT262164 Positive_regulation of Rhof Positive_regulation of Nr1i2 1 0.11 0.65 0.27
13 INT262202 Nr1i2 Regulation of Abcc2 1 0.19 0.12 0.25
14 INT262200 Nr1i2 Regulation of Sult2a1 1 0.31 0.12 0.25
15 INT262167 Binding of Nr1i2 and Nr0b2 1 0.15 0.11 0.25
16 INT262179 Nr1i2 Regulation of Gene_expression of Nr0b2 1 0.09 0.07 0.24
17 INT262178 Binding of Nr1i2 and Abcb1b 1 0.07 1.68 0.21
18 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2
19 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
20 INT281194 Casr Positive_regulation of Positive_regulation of Nr1i2 1 0.27 0 0.13
21 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
22 INT262193 Binding of Nr1i2 and Sfn 1 0.15 0.26 0.13
23 INT281193 Nr1i2 Positive_regulation of Positive_regulation of Casr 1 0.27 0 0.13
24 INT262197 Nr1i2 Positive_regulation of Insig1 2 0.23 0 0.12
25 INT262185 Positive_regulation of Binding of Ncoa1 and Nr1i2 1 0.04 0.56 0.12
26 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
27 INT262148 Positive_regulation of Nr1i2 Positive_regulation of Abcb1b 1 0.09 0.69 0.12
28 INT262206 Sfn Negative_regulation of Nr1i2 1 0.17 0.28 0.12
29 INT262146 Binding of Ncoa1 and Nr1i2 1 0.03 0.56 0.11
30 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
31 INT262141 Edcs1 Positive_regulation of Nr1i2 1 0.02 0 0.1
32 INT262163 Positive_regulation of Binding of Nr1i2 and Plec 1 0.04 0.31 0.09
33 INT262142 Edcs1 Regulation of Nr1i2 1 0.01 0 0.09
34 INT262157 Binding of Nr1i2 and Plec 1 0.03 0.3 0.09
35 INT262216 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Vdr 1 0.29 0.44 0.08
36 INT262176 Nr1i2 Regulation of Regulation of Casr 1 0.11 0.17 0.07
37 INT262219 Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07
38 INT262161 Nr1i2 Positive_regulation of Gene_expression of Cyp27a1 1 0.29 0.24 0.07
39 INT262168 Nr1i2 Regulation of Casr 1 0.07 0.17 0.07
40 INT262147 Nr1i2 Regulation of Gene_expression of Cyp2j8 1 0.00 0.07 0.07
41 INT262143 Positive_regulation of Nr1i2 Negative_regulation of Gene_expression of Cyp2d9 1 0.01 0.28 0.07
42 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
43 INT262175 Nr1i2 Positive_regulation of Gene_expression of Abca1 1 0.24 0.21 0.06
44 INT262187 Nr1i2 Positive_regulation of Gene_expression of Abcg1 1 0.24 0.21 0.06
45 INT262145 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.45 0.06
46 INT262209 Positive_regulation of Nr1i2 Positive_regulation of Transcription of Ppig 1 0.03 0 0.06
47 INT262233 Nr1i2 Negative_regulation of SOD1 1 0.03 0.23 0.05
48 INT262230 SOD1 Regulation of Nr1i2 1 0.02 0.3 0.05
49 INT262196 Nr1i2 Negative_regulation of Vdr 1 0.27 0.14 0.04
50 INT262221 Nr1i2 Negative_regulation of Cyp24a1 1 0.27 0.15 0.04
51 INT262166 Binding of Nr1i2 and Vdr 1 0.23 0.14 0.04
52 INT262162 Nr1i2 Regulation of Cyp2b9 1 0.14 0.14 0.03
53 INT262195 Nr1i2 Positive_regulation of Srebf1 1 0.08 0.18 0.03
54 INT262177 Nr1i2 Positive_regulation of Cd36 1 0.16 0.18 0.03
55 INT262184 Binding of Nr1i2 and Rare1 1 0.03 0.15 0.03
56 INT262169 Binding of Foxa2 and Nr1i2 1 0.17 0.33 0
57 INT262203 Nr1i2 Positive_regulation of Gene_expression of Hmgcs2 1 0.23 0.22 0
58 INT262170 Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.4 0
59 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0
60 INT262212 Positive_regulation of Nr1i2 Positive_regulation of Insig1 1 0.12 0 0
61 INT262204 Nr1i2 Positive_regulation of Cyp3a11 1 0.33 0.08 0
62 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
63 INT262215 Binding of Nr1i2 and Dnajc7 1 0.08 0.26 0
64 INT262191 Binding of Nr1i2 and Foxo1 1 0.22 0.09 0
65 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
66 INT262156 Nr1i2 Negative_regulation of Gene_expression of Hmgcs2 1 0.22 0.22 0
67 INT262192 Nr1i2 Regulation of Positive_regulation of Cyp3a11 1 0.32 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported that are relevant to 18171. They are ordered first by their pain relevance and then by number of times they were reported that are relevant to 18171. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT121943 Positive_regulation of Nr1i2 64 0.68 19.22 8.39
2 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04
3 INT121942 Binding of Nr1i2 2 0.45 15.69 3.66
4 INT136982 Positive_regulation of Positive_regulation of Nr1i2 3 0.65 4.66 2.89
5 INT129902 Regulation of Nr1i2 16 0.58 6.3 2.31
6 INT262127 Negative_regulation of Gene_expression of Nr1i2 1 0.55 6.92 1.57
7 INT136981 Positive_regulation of Gene_expression of Nr1i2 2 0.65 3.63 1.34
8 INT262114 Negative_regulation of Nr1i2 1 0.55 4.72 1.12
9 INT136980 Negative_regulation of Positive_regulation of Nr1i2 1 0.48 0.33 0.72
10 INT262054 Regulation of Gene_expression of Nr1i2 1 0.42 1.45 0.36
11 INT262086 Negative_regulation of Binding of Nr1i2 1 0.40 0.62 0.27
12 INT262092 Regulation of Binding of Nr1i2 1 0.42 0 0.14
13 INT262094 Regulation of Positive_regulation of Nr1i2 2 0.42 0.52 0.13
14 INT262044 Transcription of Nr1i2 1 0.50 0.58 0.12
15 INT262046 Positive_regulation of Transcription of Nr1i2 1 0.44 0.59 0.12
16 INT262068 Localization of Nr1i2 1 0.75 0.35 0.03
17 INT262073 Positive_regulation of Localization of Nr1i2 1 0.47 0.23 0
18 INT262126 Positive_regulation of Negative_regulation of Nr1i2 1 0.47 0.54 0
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